JP4900962B2 - 神経衰弱症、身体化障害および他のストレス関連疾患の予防および治療のためのラベンダー油の使用 - Google Patents
神経衰弱症、身体化障害および他のストレス関連疾患の予防および治療のためのラベンダー油の使用 Download PDFInfo
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/26—Psychostimulants, e.g. nicotine, cocaine
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- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Psychiatry (AREA)
- Anesthesiology (AREA)
- Medicines Containing Plant Substances (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Description
繰り返し発現し、かつ、頻繁に変化する複数の身体症状の存在は、身体化障害と呼ばれる。前記症状は、身体の各部分または身体の各系に関連していることがある。
神経衰弱症および身体化障害が様々な原因で発症するのに対し、ストレスは誘発要因であることが多い。
Roche Lexikon、Medizin、4th edition 1998 G. A. Carrasco et al. (2003), Eur. J. Pharmacol. 463, 235−272 B. S. McEwen (1998), New Engl. J. Med. 338, 171−179 S. Sephton et al. (2003), Brain Behav. Immun. 17, 321−328 P. H. Black et al. (2002), J. Psychosom. Res. 52, 1−23
この目的は、ラベンダー油の使用によって達成される。
ドイツでは、情動不安状態、入眠障害、腹部の機能疾患、鼓腸に適応するための、および、温泉治療法のための抽出物および入浴剤であるラベンダーの花を煎じて得られた調製物についての肯定的なモノグラフが書かれている(monograph of commission E of the former German Federal Health Authority)。
ラベンダー油のストレス低減効果を、いわゆる「強制水泳ストレス」モデルによって、ラットで試験した(R. D. Porsolt et al. (1978), Eur. J. Pharmacol. 47, 379−391)。この試験でラットに実験的に引き出されたストレス反応は、ストレスによって生じる行動変化を試験するための公知の方法である。用いられる試験システムの原理には、ラットが勝手に逃げ出すことのできない水を張ったガラス製シリンダーに入れられたラットは、短時間泳いだ後に静止状態に陥ること(不動期間)に関係している。この不動状態は、置かれた状況に対する絶望感を認識したことに対する反応であると解釈される(実施例2を参照)。
ラベンダー油は、それ自体が周知である調製法、好ましくは、摘みたてのラベンダーの花を水蒸気蒸留することによって調製することができる。
ラベンダー油は、ゼラチン、セルロース誘導体またはカプセル化に適した他の材料でできたカプセルに充填された状態で、または、溶液として、好ましくは経口で投与することができる。
投与量としては、1日当たり、10mg〜2g、好ましくは20〜500mg、特に好ましくは50〜100mgのラベンダー油が投与される。
実施例1: 人間に対するラベンダー油の効力
神経衰弱症および/または心的外傷後ストレス障害(PTSD)および/または身体化障害を患っている患者50名を、European Pharmacopoeia, edition 4 (Lavendelol WS(登録商標) 1265)に従って、1日当たり80mgのラベンダー油を用いて、6週間治療した。下記公知の試験法、すなわち、Symptom Checklist (SCL 90), State−Trait−Anxiety Inventory (STAI; A. M. Sesti (2000), QoL Newsletter 25, 10−16), depression scale (D−S), Maslach Burnout Inventory (MBI), 36 Item Short Form Survey (SF−36), state check and sleep diaryを用いて、病状の改善を測定および記録した。さらに、患者たちを入院させて、症状を医師に検査させる(第三者評価)か、若しくは、患者たちに所定のアンケートに記入させた(自己評価)。6週間の治療の前および後の病状の変化を、Wilcoxon Signed Rank Testを用いて試験した。症状の大部分が、統計的に有意に改善された。
ラベンダー油のストレス低減効果を試験するために、ラットを、European Pharmacopoeia, edition 4(WS(登録商標) 1265)に従って、1日1回、合計9日間にわたって、異なる量ではあるがいずれも高投与量であるラベンダー油で治療した。比較のために、一部のラットを、ストレス治療に用いられる三環系抗うつ剤であるイミプラミンまたは活性成分を含有しない対照溶液のいずれかで治療した。治療の7日目に、前記ラットを、水を張ったガラス製シリンダーに15分間入れて慣れさせた。治療の最終日に、前記ラットを再び目盛り付きシリンダーに5分間入れて、静止している時間を、ストレス反応の尺度として測定した。10〜100mg/kgの投与量のラベンダー油を9日間にわたって投与することによって、静止時間が大幅に、有意に減少した。
約10,000個のカプセルを調製するのに必要な800gの量のラベンダー油を、しっかりと密封された不活性容器(例えば、ステンレス鋼でできた攪拌容器)内で、1,200gの中鎖トリグリセリドと混ぜ合わせ、15分間攪拌した。得られた均質の液体混合物を、好適なカプセル充填装置を用いて、カプセル1個当たり200mgの量でゼラチンカプセルに充填した。(例えばゼラチンまたはセルロース誘導体でできた)硬質カプセル剤の場合、カプセルは、充填後、スリーブによって密封した。軟質ゼラチンでできたカプセルの場合、カプセルの充填および密封を一工程で行った。
Claims (1)
- 神経衰弱症、身体化障害またはPTSD(心的外傷後ストレス障害)の予防または治療のための、ラベンダー油と薬学的に許容可能なアジュバントとを含んでなる経口投与の形態の配合物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE102004048716.2 | 2004-10-06 | ||
DE102004048716A DE102004048716A1 (de) | 2004-10-06 | 2004-10-06 | Verwendung von Lavendelöl zur Prophylaxe und Behandlung von Neurasthenie, Somatisierungsstörungen und von anderen stress-assoziierten Erkrankungen |
PCT/EP2005/010732 WO2006037629A1 (de) | 2004-10-06 | 2005-10-05 | Verwendung von lavendelöl zur prophylaxe und behandlung von neurasthenie, somatisierungsstörungen und von anderen stress-assoziierten erkrankungen |
Publications (2)
Publication Number | Publication Date |
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JP2008515833A JP2008515833A (ja) | 2008-05-15 |
JP4900962B2 true JP4900962B2 (ja) | 2012-03-21 |
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Application Number | Title | Priority Date | Filing Date |
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JP2007535081A Active JP4900962B2 (ja) | 2004-10-06 | 2005-10-05 | 神経衰弱症、身体化障害および他のストレス関連疾患の予防および治療のためのラベンダー油の使用 |
Country Status (16)
Country | Link |
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US (1) | US20080124410A1 (ja) |
EP (1) | EP1796702B1 (ja) |
JP (1) | JP4900962B2 (ja) |
KR (1) | KR101291338B1 (ja) |
CN (1) | CN101068557B (ja) |
AT (1) | ATE447963T1 (ja) |
AU (1) | AU2005291420B2 (ja) |
BR (1) | BRPI0516545A (ja) |
CA (1) | CA2582993C (ja) |
DE (2) | DE102004048716A1 (ja) |
ES (1) | ES2333141T3 (ja) |
MX (1) | MX2007004104A (ja) |
PT (1) | PT1796702E (ja) |
RU (1) | RU2406521C2 (ja) |
UA (1) | UA91028C2 (ja) |
WO (1) | WO2006037629A1 (ja) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
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RU2553625C2 (ru) * | 2013-10-02 | 2015-06-20 | Дмитрий Александрович Никифоров | Эфирно-масляная композиция "биозащита" для лечения астенического синдрома у больных с дисциркуляторной энцефалопатией |
EP2946775A1 (de) | 2014-05-20 | 2015-11-25 | LTS LOHMANN Therapie-Systeme AG | Lavendelöl enthaltendes transdermales therapeutisches System |
HUE031669T2 (en) * | 2014-07-14 | 2017-07-28 | Dr Willmar Schwabe Gmbh & Co Kg | Cataract extract and lavender oil combination for sleeping disorders |
JP7164973B2 (ja) * | 2018-06-12 | 2022-11-02 | エスエス製薬株式会社 | 錠剤組成物 |
DE202019101081U1 (de) | 2019-02-25 | 2019-04-29 | Tim Farkas | Lavendelkaugummi |
IT202200010973A1 (it) | 2022-05-25 | 2023-11-25 | Cristalfarma S R L | Composizione a base di erbali per uso nel trattamento della depressione post-partum |
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JPH1025246A (ja) * | 1996-07-11 | 1998-01-27 | Kobayashi Pharmaceut Co Ltd | 催眠剤、催眠性飲食物及び催眠性餌料 |
ES2154484T3 (es) * | 1997-06-21 | 2001-04-01 | Bad Neuenahr Ag | Compresa a base de fango y procedimiento para su produccion. |
GB2355189B (en) * | 1999-08-20 | 2004-07-28 | Yousef Haik Babikian | Herbal preparation for the treatment of diabetes mellitus |
US6582736B2 (en) * | 2001-03-23 | 2003-06-24 | Terra De Sol | Therapeutic oil composition |
EP1275308A1 (en) * | 2001-07-13 | 2003-01-15 | The Procter & Gamble Company | Food composition offering stress relaxation to mammals |
US6565829B2 (en) * | 2001-08-03 | 2003-05-20 | Pharmacia & Upjohn Company | 5-arylsulfonyl indoles useful for treating disease |
JP2005029513A (ja) * | 2003-07-07 | 2005-02-03 | Kobayashi Pharmaceut Co Ltd | 口息清涼剤およびその製造方法 |
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2004
- 2004-10-06 DE DE102004048716A patent/DE102004048716A1/de not_active Withdrawn
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2005
- 2005-10-05 EP EP05791751A patent/EP1796702B1/de active Active
- 2005-10-05 ES ES05791751T patent/ES2333141T3/es active Active
- 2005-10-05 WO PCT/EP2005/010732 patent/WO2006037629A1/de active Application Filing
- 2005-10-05 BR BRPI0516545-8A patent/BRPI0516545A/pt not_active Application Discontinuation
- 2005-10-05 CN CN200580033566.3A patent/CN101068557B/zh active Active
- 2005-10-05 CA CA2582993A patent/CA2582993C/en active Active
- 2005-10-05 AU AU2005291420A patent/AU2005291420B2/en active Active
- 2005-10-05 US US11/664,884 patent/US20080124410A1/en not_active Abandoned
- 2005-10-05 AT AT05791751T patent/ATE447963T1/de active
- 2005-10-05 PT PT05791751T patent/PT1796702E/pt unknown
- 2005-10-05 DE DE502005008500T patent/DE502005008500D1/de active Active
- 2005-10-05 MX MX2007004104A patent/MX2007004104A/es active IP Right Grant
- 2005-10-05 UA UAA200703392A patent/UA91028C2/ru unknown
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Also Published As
Publication number | Publication date |
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MX2007004104A (es) | 2007-06-14 |
DE102004048716A1 (de) | 2006-04-20 |
CN101068557A (zh) | 2007-11-07 |
WO2006037629A1 (de) | 2006-04-13 |
US20080124410A1 (en) | 2008-05-29 |
BRPI0516545A (pt) | 2008-09-09 |
KR20070074580A (ko) | 2007-07-12 |
PT1796702E (pt) | 2009-11-20 |
RU2007116726A (ru) | 2008-11-20 |
AU2005291420A1 (en) | 2006-04-13 |
CA2582993C (en) | 2013-08-20 |
EP1796702B1 (de) | 2009-11-11 |
JP2008515833A (ja) | 2008-05-15 |
UA91028C2 (ru) | 2010-06-25 |
AU2005291420B2 (en) | 2012-03-29 |
DE502005008500D1 (de) | 2009-12-24 |
RU2406521C2 (ru) | 2010-12-20 |
ATE447963T1 (de) | 2009-11-15 |
KR101291338B1 (ko) | 2013-07-31 |
ES2333141T3 (es) | 2010-02-17 |
CN101068557B (zh) | 2016-05-11 |
EP1796702A1 (de) | 2007-06-20 |
CA2582993A1 (en) | 2006-04-13 |
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