CN109195945A - 稠合三环γ-氨基酸衍生物及其制备方法和在医药上的应用 - Google Patents

稠合三环γ-氨基酸衍生物及其制备方法和在医药上的应用 Download PDF

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CN109195945A
CN109195945A CN201780033351.4A CN201780033351A CN109195945A CN 109195945 A CN109195945 A CN 109195945A CN 201780033351 A CN201780033351 A CN 201780033351A CN 109195945 A CN109195945 A CN 109195945A
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yuan
compound
amino
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CN109195945B (zh
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李瑶
石宗军
徐波
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Sichuan Haisco Pharmaceutical Co Ltd
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Sichuan Haisco Pharmaceutical Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C229/50—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms being part of the same condensed ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

公开了一种稠合三环γ‑氨基酸衍生物及其在医药上的应用，具体而言涉及如通式(I)所示的稠合环γ‑氨基酸衍生物，或者其立体异构体、溶剂化物、代谢产物、前药、药学上可接受的盐或共晶，包含其的药物组合物以及化合物或组合物在镇痛领域的用途，其中，通式(I)中各取代基的定义与说明书的定义相同

Description

PCT国内申请，说明书已公开。

Claims (12)

  1. PCT国内申请，权利要求书已公开。
CN201780033351.4A 2016-09-14 2017-09-12 稠合三环γ-氨基酸衍生物及其制备方法和在医药上的应用 Active CN109195945B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201610825611 2016-09-14
CN2016108256119 2016-09-14
PCT/CN2017/101364 WO2018050046A1 (zh) 2016-09-14 2017-09-12 稠合三环γ-氨基酸衍生物及其制备方法和在医药上的应用

Publications (2)

Publication Number Publication Date
CN109195945A true CN109195945A (zh) 2019-01-11
CN109195945B CN109195945B (zh) 2022-02-25

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Country Link
US (1) US10654794B2 (zh)
EP (1) EP3527552B1 (zh)
JP (1) JP7001679B2 (zh)
KR (1) KR102335089B1 (zh)
CN (1) CN109195945B (zh)
AU (1) AU2017325913B2 (zh)
CA (1) CA3035121C (zh)
EA (1) EA036525B1 (zh)
ES (1) ES2939260T3 (zh)
MX (1) MX2019002915A (zh)
MY (1) MY196788A (zh)
PT (1) PT3527552T (zh)
TW (1) TWI662015B (zh)
WO (1) WO2018050046A1 (zh)
ZA (1) ZA201901861B (zh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111517932A (zh) * 2019-02-01 2020-08-11 四川海思科制药有限公司 一种稠合三环衍生物制备方法及中间体
CN111517939A (zh) * 2019-02-01 2020-08-11 四川海思科制药有限公司 一种稠合三环衍生物制备方法及中间体

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020011258A1 (zh) * 2018-07-12 2020-01-16 四川海思科制药有限公司 稠合三环γ-氨基酸衍生物的盐的晶型及制备和应用
WO2020011257A1 (zh) * 2018-07-12 2020-01-16 四川海思科制药有限公司 一种稠合三环γ-氨基酸衍生物的组合物及其制备
CN112384493B (zh) * 2018-08-09 2023-06-06 四川海思科制药有限公司 稠合三环γ-氨基酸衍生物的制备方法及中间体
WO2020155953A1 (zh) * 2019-01-30 2020-08-06 四川海思科制药有限公司 一种稠合三环氘代衍生物及其组合物和应用
CN111517930B (zh) * 2019-02-01 2023-03-24 四川海思科制药有限公司 一种稠合三环衍生物制备方法及中间体
CN113348164B (zh) * 2019-02-01 2023-08-29 四川海思科制药有限公司 一种稠合三环衍生物的制备方法及中间体
WO2021043117A1 (zh) * 2019-09-03 2021-03-11 四川海思科制药有限公司 2-((1s,2s,3r,6s,8s)-2-(氨甲基)三环[4.2.1.03,8]壬烷-2-基)乙酸苯磺酸盐或其组合物杂质检测方法
WO2022017364A1 (zh) 2020-07-20 2022-01-27 四川海思科制药有限公司 一种稠合三环γ-氨基酸衍生物的缓释药物制剂及其制备方法

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CN1720219A (zh) * 2001-04-19 2006-01-11 沃纳-兰伯特公司 稠合二环或三环氨基酸
CN101878193A (zh) * 2007-09-28 2010-11-03 第一三共株式会社 双环γ-氨基酸衍生物

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PL366406A1 (en) * 2001-04-19 2005-01-24 Warner-Lambert Company Llc Fused bicyclic or tricyclic amino acids
JP5250363B2 (ja) 2008-09-26 2013-07-31 京セラドキュメントソリューションズ株式会社 テキスト入力システム及びテキスト入力プログラム
WO2010079668A1 (ja) 2009-01-08 2010-07-15 第一三共株式会社 オレフィン化合物
WO2010084798A1 (ja) * 2009-01-21 2010-07-29 第一三共株式会社 ３環性化合物
WO2017107907A1 (zh) 2015-12-25 2017-06-29 四川海思科制药有限公司 稠合环γ-氨基酸衍生物及其制备方法和在医药上的应用

Patent Citations (2)

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Publication number Priority date Publication date Assignee Title
CN1720219A (zh) * 2001-04-19 2006-01-11 沃纳-兰伯特公司 稠合二环或三环氨基酸
CN101878193A (zh) * 2007-09-28 2010-11-03 第一三共株式会社 双环γ-氨基酸衍生物

Non-Patent Citations (2)

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MANFRED GEISEL等: "Die Cyclopropylcarbinyl-Cyclobutyl-Homoallyl-Umlagerung.I. Teit. Synthese von Tricyclo[3.2.1.02,7]octan-3-ol, endo- und exo-Tricyclo[3.2.1.03,6]octan-4-ol und exo-Bicyclo[3.2.l]-oct-2-en-7-ol", 《HELVETICA CHIMICA ACTA》 *
PETER YATES等: "DECOMPOSITION OF l-DIAZO-3-(2,2,3-TRIMETHYLCYCLOPENT-3-ENYL)PROPAN-2-ONE. A NOVEL SYNTHESIS AND REARRANGEMENT OF A TRICYCLO[3.2.1.03,6]0CTAN-4-ONE", 《TETRAHEDRON LETTERS》 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111517932A (zh) * 2019-02-01 2020-08-11 四川海思科制药有限公司 一种稠合三环衍生物制备方法及中间体
CN111517939A (zh) * 2019-02-01 2020-08-11 四川海思科制药有限公司 一种稠合三环衍生物制备方法及中间体
CN111517932B (zh) * 2019-02-01 2023-03-24 四川海思科制药有限公司 一种稠合三环衍生物制备方法及中间体
CN111517939B (zh) * 2019-02-01 2023-03-31 四川海思科制药有限公司 一种稠合三环衍生物制备方法及中间体

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Publication number Publication date
KR102335089B1 (ko) 2021-12-02
EA201990455A1 (ru) 2019-09-30
ZA201901861B (en) 2020-10-28
TW201811733A (zh) 2018-04-01
US10654794B2 (en) 2020-05-19
PT3527552T (pt) 2023-02-28
CN109195945B (zh) 2022-02-25
ES2939260T3 (es) 2023-04-20
AU2017325913B2 (en) 2020-04-09
TWI662015B (zh) 2019-06-11
US20190218172A1 (en) 2019-07-18
CA3035121A1 (en) 2018-03-22
CA3035121C (en) 2021-02-16
KR20190046892A (ko) 2019-05-07
MX2019002915A (es) 2019-07-18
EP3527552A1 (en) 2019-08-21
AU2017325913A1 (en) 2019-05-02
JP2019532925A (ja) 2019-11-14
JP7001679B2 (ja) 2022-02-04
EP3527552B1 (en) 2022-11-30
MY196788A (en) 2023-05-03
WO2018050046A1 (zh) 2018-03-22
EP3527552A4 (en) 2020-05-06
BR112019004860A2 (pt) 2019-06-11
EA036525B1 (ru) 2020-11-19

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