CN107848953A - 稠合环γ‑氨基酸衍生物及其制备方法和在医药上的应用 - Google Patents

稠合环γ‑氨基酸衍生物及其制备方法和在医药上的应用 Download PDF

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Publication number
CN107848953A
CN107848953A CN201680042369.6A CN201680042369A CN107848953A CN 107848953 A CN107848953 A CN 107848953A CN 201680042369 A CN201680042369 A CN 201680042369A CN 107848953 A CN107848953 A CN 107848953A
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hept
base
bicyclic
added
tert
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CN201680042369.6A
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CN107848953B (zh
Inventor
李瑶
范江
李升�
徐波
陈清平
朱凤飞
肖志阳
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Tibet Haisike Pharmaceutical Co ltd
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Sichuan Haisco Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/32—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/02—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D305/04—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D305/06—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

本发明涉及一种稠合环γ‑氨基酸衍生物及其在医药上的应用，具体而言涉及如通式(I)所示的稠合环γ‑氨基酸衍生物，或者其立体异构体、溶剂化物、代谢产物、前药、药学上可接受的盐或共晶，包含其的药物组合物以及本发明化合物或组合物在镇痛领域的用途，其中，通式(I)中各取代基的定义与说明书的定义相同。

Description

PCT国内申请，说明书已公开。

Claims (12)

  1. PCT国内申请，权利要求书已公开。
CN201680042369.6A 2015-12-25 2016-12-21 稠合环γ-氨基酸衍生物及其制备方法和在医药上的应用 Active CN107848953B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2015109923596 2015-12-25
CN201510992359 2015-12-25
PCT/CN2016/111218 WO2017107907A1 (zh) 2015-12-25 2016-12-21 稠合环γ-氨基酸衍生物及其制备方法和在医药上的应用

Publications (2)

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CN107848953A true CN107848953A (zh) 2018-03-27
CN107848953B CN107848953B (zh) 2021-05-18

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Country Status (2)

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CN (1) CN107848953B (zh)
WO (1) WO2017107907A1 (zh)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10654794B2 (en) 2016-09-14 2020-05-19 Sichuan Haiso Pharmaceutical Co., Ltd. Fused tricyclic Γ-amino acid derivative, preparation method therefor, and medical use thereof
BR112021019722A2 (pt) 2019-04-09 2021-12-14 Nurix Therapeutics Inc Compostos de piperidina 3-substituídos para inibição de cbl-b, e uso de inibidor de cbl-b em combinação com vacina contra câncer e/ou vírus oncolítico
US20220387395A1 (en) 2019-07-30 2022-12-08 Nurix Therapeutics, Inc. Urea, amide, and substituted heteroaryl compounds for cbl-b inhibition
JP2023534548A (ja) * 2020-07-20 2023-08-09 四川海思科制▲薬▼有限公司 縮合三環式アミノ酸誘導体の徐放性医薬製剤及びそれらの製剤方法
CN114264751B (zh) * 2021-12-28 2024-02-27 江苏威凯尔医药科技有限公司 一种高效液相色谱法分离米洛巴林中间体及其对映异构体的方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1720219A (zh) * 2001-04-19 2006-01-11 沃纳-兰伯特公司 稠合二环或三环氨基酸
WO2010079668A1 (ja) * 2009-01-08 2010-07-15 第一三共株式会社 オレフィン化合物
JP2010241796A (ja) * 2009-03-17 2010-10-28 Daiichi Sankyo Co Ltd 二環性γ−アミノ酸誘導体含有医薬組成物
CN101878193A (zh) * 2007-09-28 2010-11-03 第一三共株式会社 双环γ-氨基酸衍生物
US20110130454A1 (en) * 2009-11-24 2011-06-02 Xenoport, Inc. Prodrugs of gamma-amino acid, alpha-2-delta ligands, pharmaceutical compositions and uses thereof
CN104755456A (zh) * 2013-07-08 2015-07-01 第一三共株式会社 光学活性的二环γ-氨基酸衍生物的制备方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1720219A (zh) * 2001-04-19 2006-01-11 沃纳-兰伯特公司 稠合二环或三环氨基酸
CN101878193A (zh) * 2007-09-28 2010-11-03 第一三共株式会社 双环γ-氨基酸衍生物
WO2010079668A1 (ja) * 2009-01-08 2010-07-15 第一三共株式会社 オレフィン化合物
JP2010241796A (ja) * 2009-03-17 2010-10-28 Daiichi Sankyo Co Ltd 二環性γ−アミノ酸誘導体含有医薬組成物
US20110130454A1 (en) * 2009-11-24 2011-06-02 Xenoport, Inc. Prodrugs of gamma-amino acid, alpha-2-delta ligands, pharmaceutical compositions and uses thereof
CN104755456A (zh) * 2013-07-08 2015-07-01 第一三共株式会社 光学活性的二环γ-氨基酸衍生物的制备方法

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WO2017107907A1 (zh) 2017-06-29
CN107848953B (zh) 2021-05-18

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Effective date of registration: 20231222

Address after: 856099 Xingfu Jiayuan Economic Development Zone, Gyerba, Nedong District, Shannan City, Tibet Autonomous Region

Patentee after: Tibet Haisike Pharmaceutical Co.,Ltd.

Address before: 611130 Sichuan Chengdu Wenjiang District Science and Technology Park cross strait Bailey Road 136

Patentee before: SICHUAN HAISCO PHARMACEUTICAL Co.,Ltd.