BR112019004860A2 - derivado de y-aminoácido tricíclico fusionado, método de preparação para o mesmo e uso médico do mesmo - Google Patents
derivado de y-aminoácido tricíclico fusionado, método de preparação para o mesmo e uso médico do mesmoInfo
- Publication number
- BR112019004860A2 BR112019004860A2 BR112019004860A BR112019004860A BR112019004860A2 BR 112019004860 A2 BR112019004860 A2 BR 112019004860A2 BR 112019004860 A BR112019004860 A BR 112019004860A BR 112019004860 A BR112019004860 A BR 112019004860A BR 112019004860 A2 BR112019004860 A2 BR 112019004860A2
- Authority
- BR
- Brazil
- Prior art keywords
- amino acid
- acid derivative
- medical use
- preparation
- tricyclic fused
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C229/50—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups and carboxyl groups bound to carbon atoms being part of the same condensed ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/28—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C309/29—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton of non-condensed six-membered aromatic rings
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pain & Pain Management (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Epidemiology (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
são revelados um derivado de y-aminoácido tricíclico fusionado e um uso médico do mesmo, em particular, a presente invenção se refere a um derivado de ?-aminoácido cíclico fusionado como mostrado na fórmula geral (i), ou um estereoisômero, solvato, metabólito, pró-fármaco, sal farmaceuticamente aceitável ou eutético do mesmo, uma composição farmacêutica que contém o mesmo, e o uso de um composto ou da composição no campo de analgesia, em que as definições de cada substituinte na fórmula geral (i) são as mesmas das definições na descrição.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610825611.9 | 2016-09-14 | ||
| CN201610825611 | 2016-09-14 | ||
| PCT/CN2017/101364 WO2018050046A1 (zh) | 2016-09-14 | 2017-09-12 | 稠合三环γ-氨基酸衍生物及其制备方法和在医药上的应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112019004860A2 true BR112019004860A2 (pt) | 2019-06-11 |
| BR112019004860B1 BR112019004860B1 (pt) | 2023-09-05 |
Family
ID=
Also Published As
| Publication number | Publication date |
|---|---|
| PT3527552T (pt) | 2023-02-28 |
| CN109195945B (zh) | 2022-02-25 |
| AU2017325913A1 (en) | 2019-05-02 |
| US20190218172A1 (en) | 2019-07-18 |
| TWI662015B (zh) | 2019-06-11 |
| EA036525B1 (ru) | 2020-11-19 |
| ES2939260T3 (es) | 2023-04-20 |
| KR20190046892A (ko) | 2019-05-07 |
| EP3527552B1 (en) | 2022-11-30 |
| ZA201901861B (en) | 2020-10-28 |
| KR102335089B1 (ko) | 2021-12-02 |
| CA3035121C (en) | 2021-02-16 |
| JP2019532925A (ja) | 2019-11-14 |
| US10654794B2 (en) | 2020-05-19 |
| WO2018050046A1 (zh) | 2018-03-22 |
| EP3527552A1 (en) | 2019-08-21 |
| TW201811733A (zh) | 2018-04-01 |
| JP7001679B2 (ja) | 2022-02-04 |
| CA3035121A1 (en) | 2018-03-22 |
| MY196788A (en) | 2023-05-03 |
| MX2019002915A (es) | 2019-07-18 |
| CN109195945A (zh) | 2019-01-11 |
| AU2017325913B2 (en) | 2020-04-09 |
| EA201990455A1 (ru) | 2019-09-30 |
| EP3527552A4 (en) | 2020-05-06 |
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Legal Events
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| B350 | Update of information on the portal [chapter 15.35 patent gazette] | ||
| B06W | Patent application suspended after preliminary examination (for patents with searches from other patent authorities) chapter 6.23 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 12/09/2017, OBSERVADAS AS CONDICOES LEGAIS |