CN109152933B - 诱导抗细胞凋亡bcl-2家族蛋白的降解的化合物及其用途 - Google Patents

诱导抗细胞凋亡bcl-2家族蛋白的降解的化合物及其用途 Download PDF

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CN109152933B
CN109152933B CN201780024822.5A CN201780024822A CN109152933B CN 109152933 B CN109152933 B CN 109152933B CN 201780024822 A CN201780024822 A CN 201780024822A CN 109152933 B CN109152933 B CN 109152933B
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CN109152933A (zh
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郑广荣
周道洪
张翾
王营营
常建辉
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
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    • A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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CN201780024822.5A 2016-04-21 2017-04-21 诱导抗细胞凋亡bcl-2家族蛋白的降解的化合物及其用途 Active CN109152933B (zh)

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US201662325856P 2016-04-21 2016-04-21
US62/325,856 2016-04-21
PCT/US2017/028875 WO2017184995A1 (en) 2016-04-21 2017-04-21 Compounds that induce degradation of anti-apoptotic bcl-2 family proteins and the uses thereof

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EP (1) EP3445452A4 (https=)
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CN (1) CN109152933B (https=)
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