CN1087289C - 制备非晶性[R－(R*,R*)]－2－(4－氟苯基)－β,δ－二羟基－5－(1－甲基乙基)－3－苯基－4－[(苯氨基)羰基]－1H－吡咯－1－庚酸钙盐(2∶1)的新方法 - Google Patents

制备非晶性[R－(R*,R*)]－2－(4－氟苯基)－β,δ－二羟基－5－(1－甲基乙基)－3－苯基－4－[(苯氨基)羰基]－1H－吡咯－1－庚酸钙盐(2∶1)的新方法 Download PDF

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CN1087289C
CN1087289C CN96195631A CN96195631A CN1087289C CN 1087289 C CN1087289 C CN 1087289C CN 96195631 A CN96195631 A CN 96195631A CN 96195631 A CN96195631 A CN 96195631A CN 1087289 C CN1087289 C CN 1087289C
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amorphous
methylethyl
fluorophenyl
pyrrole
dihydroxy
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CN1190956A (zh
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M·林
D·施维斯
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Warner Lambert Co LLC
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
CN96195631A 1995-07-17 1996-07-16 制备非晶性[R－(R*,R*)]－2－(4－氟苯基)－β,δ－二羟基－5－(1－甲基乙基)－3－苯基－4－[(苯氨基)羰基]－1H－吡咯－1－庚酸钙盐(2∶1)的新方法 Expired - Lifetime CN1087289C (zh)

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Application Number Priority Date Filing Date Title
US145395P 1995-07-17 1995-07-17
US60/001,453 1995-07-17

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CN1190956A CN1190956A (zh) 1998-08-19
CN1087289C true CN1087289C (zh) 2002-07-10

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CN96195631A Expired - Lifetime CN1087289C (zh) 1995-07-17 1996-07-16 制备非晶性[R－(R*,R*)]－2－(4－氟苯基)－β,δ－二羟基－5－(1－甲基乙基)－3－苯基－4－[(苯氨基)羰基]－1H－吡咯－1－庚酸钙盐(2∶1)的新方法

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US7411075B1 (en) 2000-11-16 2008-08-12 Teva Pharmaceutical Industries Ltd. Polymorphic form of atorvastatin calcium
SI20425A (sl) * 1999-12-10 2001-06-30 LEK tovarna farmacevtskih in kemi�nih izdelkov d.d. Priprava amorfnega atorvastatina
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US7501450B2 (en) * 2000-11-30 2009-03-10 Teva Pharaceutical Industries Ltd. Crystal forms of atorvastatin hemi-calcium and processes for their preparation as well as novel processes for preparing other forms
IL156055A0 (en) 2000-11-30 2003-12-23 Teva Pharma Novel crystal forms of atorvastatin hemi calcium and processes for their preparation as well as novel processes for preparing other forms
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SI20814A (sl) 2001-01-23 2002-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Priprava amorfnega atorvastatina
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US7361772B2 (en) 2001-08-16 2008-04-22 Biocon Limited Process for the production of atorvastatin calcium
AU2001284385A1 (en) 2001-08-31 2003-03-10 Morepen Laboratories Ltd. An improved process for the preparation of amorphous atorvastatin calcium salt (2:1)
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CZ296967B6 (cs) 2002-02-01 2006-08-16 Zentiva, A.S. Zpusob výroby amorfní formy hemivápenaté soli (3R,5R) 7-[3-fenyl-4-fenylkarbamoyl-2-(4-fluorfenyl)-5-isopropylpyrrol-1-yl]-3,5-dihydroxyheptanové kyseliny (atorvastatinu)
RU2309141C2 (ru) * 2002-03-18 2007-10-27 Байокон Лимитид АМОРФНЫЕ ИНГИБИТОРЫ ГМГ-КоА-РЕДУКТАЗЫ И СПОСОБ ИХ ПОЛУЧЕНИЯ
JP4308021B2 (ja) 2002-03-18 2009-08-05 バイオコン・リミテッド 望ましい粒子サイズのアモルファスＨＭＧ−ＣｏＡレダクターゼ阻害剤
ITMI20020907A1 (it) * 2002-04-29 2003-10-29 Chemi Spa Processo di preparazione della forma amorfa del sale di calcio della atorvastatina
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EA013500B1 (ru) * 2003-04-11 2010-06-30 Лек Фармасьютиклз Д.Д. Способ получения аморфной кальциевой соли аторвастатина
US7232920B2 (en) 2003-04-22 2007-06-19 Biocon Process for stereoselective reduction of β-ketoesters
US7790197B2 (en) * 2003-06-09 2010-09-07 Warner-Lambert Company Llc Pharmaceutical compositions of atorvastatin
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US20050271717A1 (en) * 2003-06-12 2005-12-08 Alfred Berchielli Pharmaceutical compositions of atorvastatin
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AU2003272080A1 (en) 2003-09-18 2005-04-06 Biocon Limited Novel process for the preparation of tert-butyl 6-cyano-5-hydroxy-3-oxohexanoate
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CZ298382B6 (cs) * 2004-03-10 2007-09-12 Zentiva, A. S. Zpusob prípravy amorfní formy hemivápenaté soli atorvastatinu a její stabilizace
CA2666359A1 (en) 2004-03-17 2005-10-06 Yatendra Kumar Process for the production of atorvastatin calcium in amorphous form
US7875731B2 (en) 2004-05-05 2011-01-25 Pfizer Inc. Salt forms of [R-(R*,R*)]-2-(4-fluorophenyl)-β, δ-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)Carbonyl]-1H-pyrrole-1-heptanoic acid
AU2005263550C1 (en) * 2004-07-16 2013-01-17 Lek Pharmaceuticals D.D. Oxidative degradation products of atorvastatin calcium
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KR20070106680A (ko) * 2004-09-30 2007-11-05 닥터 레디스 레보러터리즈 리미티드 비정질 아토르바스타틴 칼슘
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PL191017B1 (pl) 2006-03-31
KR19990029045A (ko) 1999-04-15
UA50743C2 (uk) 2002-11-15
DK0839132T5 (da) 2006-03-20
IL122161A0 (en) 1998-04-05
AR002849A1 (es) 1998-04-29
HUP9903017A3 (en) 2001-01-29
MX9708959A (es) 1998-03-31
SK5898A3 (en) 1998-08-05
JP4064459B2 (ja) 2008-03-19
EE03605B1 (et) 2002-02-15
DE69611999T2 (de) 2001-07-26
HRP960312B1 (en) 2001-10-31
EA199800128A1 (ru) 1998-08-27
NO980209D0 (no) 1998-01-16
RO120069B1 (ro) 2005-08-30
ES2156997T3 (es) 2001-08-01
ATE199542T1 (de) 2001-03-15
NZ313008A (en) 2000-01-28
BR9609714A (pt) 1999-02-23
CZ12298A3 (cs) 1998-12-16
PE1698A1 (es) 1998-02-19
EA000625B1 (ru) 1999-12-29
UY24286A1 (es) 1997-01-17
IL122161A (en) 1999-07-14
IN185276B (enExample) 2000-12-16
CO4700441A1 (es) 1998-12-29
NO980209L (no) 1998-01-16
WO1997003960A1 (en) 1997-02-06
EE9700369A (et) 1998-06-15
SK283204B6 (sk) 2003-03-04
BG63631B1 (bg) 2002-07-31
HRP960312A2 (en) 1998-02-28
BG102188A (en) 1998-08-31
ZA966043B (en) 1997-02-03
PT839132E (pt) 2001-06-29
AU700794B2 (en) 1999-01-14
DE69611999D1 (de) 2001-04-12
CA2220455C (en) 2002-09-24
CA2220455A1 (en) 1997-02-06
PL324463A1 (en) 1998-05-25
AU6497896A (en) 1997-02-18
CZ289421B6 (cs) 2002-01-16
US6274740B1 (en) 2001-08-14
HK1018054A1 (en) 1999-12-10
NO309322B1 (no) 2001-01-15
DK0839132T3 (da) 2001-04-09
GEP20002027B (en) 2000-04-10
EP0839132A1 (en) 1998-05-06
EP0839132B1 (en) 2001-03-07
JPH11510486A (ja) 1999-09-14
KR100400805B1 (ko) 2003-12-24
SI0839132T1 (enExample) 2001-06-30
HU220343B (hu) 2001-12-28
GR3035859T3 (en) 2001-08-31
CN1190956A (zh) 1998-08-19

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