CN108578685A - 用于革兰氏阳性菌检测和治疗的链球菌属细菌噬菌体溶素 - Google Patents

用于革兰氏阳性菌检测和治疗的链球菌属细菌噬菌体溶素 Download PDF

Info

Publication number
CN108578685A
CN108578685A CN201810396150.7A CN201810396150A CN108578685A CN 108578685 A CN108578685 A CN 108578685A CN 201810396150 A CN201810396150 A CN 201810396150A CN 108578685 A CN108578685 A CN 108578685A
Authority
CN
China
Prior art keywords
lysin
polypeptide
seq
plyss2
gram
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201810396150.7A
Other languages
English (en)
Chinese (zh)
Inventor
V·A·菲谢蒂
J·施米茨
D·吉尔默
C·尤勒
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Rockefeller University
Original Assignee
Rockefeller University
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rockefeller University filed Critical Rockefeller University
Publication of CN108578685A publication Critical patent/CN108578685A/zh
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
    • C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
    • C12N9/2462—Lysozyme (3.2.1.17)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/50—Hydrolases (3) acting on carbon-nitrogen bonds, other than peptide bonds (3.5), e.g. asparaginase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
    • C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
    • C12Y302/01017—Lysozyme (3.2.1.17)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
CN201810396150.7A 2011-04-21 2012-04-20 用于革兰氏阳性菌检测和治疗的链球菌属细菌噬菌体溶素 Pending CN108578685A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161477836P 2011-04-21 2011-04-21
US61/477,836 2011-04-21
CN201280027294.6A CN103857410A (zh) 2011-04-21 2012-04-20 用于革兰氏阳性菌检测和治疗的链球菌属细菌噬菌体溶素

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201280027294.6A Division CN103857410A (zh) 2011-04-21 2012-04-20 用于革兰氏阳性菌检测和治疗的链球菌属细菌噬菌体溶素

Publications (1)

Publication Number Publication Date
CN108578685A true CN108578685A (zh) 2018-09-28

Family

ID=47042182

Family Applications (4)

Application Number Title Priority Date Filing Date
CN201810396150.7A Pending CN108578685A (zh) 2011-04-21 2012-04-20 用于革兰氏阳性菌检测和治疗的链球菌属细菌噬菌体溶素
CN202211173250.6A Pending CN115887627A (zh) 2011-04-21 2012-04-20 用于革兰氏阳性菌检测和治疗的链球菌属细菌噬菌体溶素
CN201710504268.2A Pending CN107189997A (zh) 2011-04-21 2012-04-20 用于革兰氏阳性菌检测和治疗的链球菌属细菌噬菌体溶素
CN201280027294.6A Pending CN103857410A (zh) 2011-04-21 2012-04-20 用于革兰氏阳性菌检测和治疗的链球菌属细菌噬菌体溶素

Family Applications After (3)

Application Number Title Priority Date Filing Date
CN202211173250.6A Pending CN115887627A (zh) 2011-04-21 2012-04-20 用于革兰氏阳性菌检测和治疗的链球菌属细菌噬菌体溶素
CN201710504268.2A Pending CN107189997A (zh) 2011-04-21 2012-04-20 用于革兰氏阳性菌检测和治疗的链球菌属细菌噬菌体溶素
CN201280027294.6A Pending CN103857410A (zh) 2011-04-21 2012-04-20 用于革兰氏阳性菌检测和治疗的链球菌属细菌噬菌体溶素

Country Status (12)

Country Link
US (7) US9034322B2 (enExample)
EP (2) EP3252155A1 (enExample)
JP (4) JP6139509B2 (enExample)
CN (4) CN108578685A (enExample)
AU (3) AU2012245357B2 (enExample)
CA (1) CA2833409A1 (enExample)
DK (1) DK2699253T3 (enExample)
ES (1) ES2682670T3 (enExample)
HK (2) HK1244503A1 (enExample)
IL (4) IL228869B (enExample)
MX (4) MX383544B (enExample)
WO (1) WO2012145630A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116640754A (zh) * 2023-07-21 2023-08-25 临沂大学 一种链球菌前噬菌体裂解酶lys224及应用
CN117051043A (zh) * 2023-10-11 2023-11-14 圆因(北京)生物科技有限公司 一种基于环状rna编码耐甲氧西林金黄色葡萄球菌内溶素及其应用

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3252076B1 (en) 2011-01-14 2019-09-04 The Regents Of The University Of California Diagnostic use of antibodies against ror-1 protein
EP2699689A4 (en) * 2011-04-21 2014-12-17 Univ Utrecht Holding Bv STREPTOCOCCUS BACTERIOPHAGEN LYSINE FOR THE TREATMENT OF GRAM-POSITIVE BACTERIA IN PETS AND UTILITIES
NL2007038C2 (en) * 2011-07-04 2013-01-07 Vereniging Voor Christelijk Hoger Onderwijs System and method for predicting the viability of a body tissue in a patient, and measuring device used therein.
AU2013259512B2 (en) * 2012-05-09 2018-01-25 Contrafect Corporation Bacteriophage lysin and antibiotic combinations against gram positive bacteria
RU2646102C2 (ru) * 2012-05-09 2018-03-01 Контрафект Корпорейшн Предотвращение, разрушение и обработка биопленки лизином бактериофага
CN104073478A (zh) * 2014-06-13 2014-10-01 上海交通大学 杀灭革兰氏阳性菌的酶抗生素及其制备、用途
BR112016030580B1 (pt) * 2014-06-26 2023-12-19 The Rockefeller University Polipeptídeo de lisina e fragmento de polipeptídeo com atividade para matar bactérias gram-negativas
CN104726439B (zh) * 2015-04-13 2017-11-14 武汉菲吉乐科生物科技有限公司 一种广谱的链球菌裂解酶及其应用
CN104805066B (zh) * 2015-05-18 2018-04-24 武汉菲吉乐科生物科技有限公司 一种葡萄球菌裂解酶及其应用
WO2017023680A1 (en) * 2015-07-31 2017-02-09 The Regents Of The University Of California Mycobacterium lysterase: a novel treatment for acne
WO2017044989A1 (en) * 2015-09-13 2017-03-16 The Rockefeller University Clostridium difficile BACTERIOPHAGE LYSINS FOR DETECTION AND TREATMENT OF Clostridium difficile BACTERIA INFECTION
ES2934714T3 (es) 2015-09-17 2023-02-24 Contrafect Corp Polipéptidos de lisina activos contra bacterias Gram-negativas
CN109152822B (zh) 2016-05-12 2023-12-05 抗非特公司 用于评估和确定抗菌多肽的最小抑制浓度的肉汤微量稀释法
RU2020104587A (ru) * 2017-07-10 2021-08-10 Контрафект Корпорейшн Потенцирование компонентами крови антибактериальной активности литических белков, соответствующие способы и применения
BR112020011433A2 (pt) 2017-12-12 2020-12-01 Contrafect Corporation identificação de lisinas e seus derivados com atividade bacteriana contra pseudomonas aeruginosa
CN117866859A (zh) * 2018-01-05 2024-04-12 阿兹特拉公司 葡萄球菌属细菌的营养缺陷型菌株
CN112118861A (zh) * 2018-02-26 2020-12-22 康特拉费克特公司 修饰的PlySs2溶素及其用途
KR102073086B1 (ko) * 2018-06-04 2020-02-04 (주)인트론바이오테크놀로지 신규한 스트렙토코커스 수이스 박테리오파지 Str-SUP-1 및 이의 스트렙토코커스 수이스 균 증식 억제 용도
KR102073088B1 (ko) * 2018-06-04 2020-02-04 (주)인트론바이오테크놀로지 신규한 스트렙토코커스 수이스 박테리오파지 Str-SUP-2 및 이의 스트렙토코커스 수이스 균 증식 억제 용도
KR102073094B1 (ko) * 2018-06-04 2020-02-04 (주)인트론바이오테크놀로지 신규한 스트렙토코커스 수이스 박테리오파지 Str-SUP-3 및 이의 스트렙토코커스 수이스 균 증식 억제 용도
CN112789350A (zh) * 2018-08-17 2021-05-11 贝克顿·迪金森公司 利用微滴的抗微生物剂敏感性测试
WO2020077286A1 (en) 2018-10-12 2020-04-16 Quidel Corporation Extraction reagent for use in an assay for detection of group a streptococcus
EP3941504A4 (en) * 2019-03-22 2022-12-07 Contrafect Corporation METHOD FOR TREATING INFECTIOUS ENDOCARDITIS
MX2021012166A (es) * 2019-04-05 2021-11-03 Contrafect Corp Lisinas y sus derivados con actividad bactericida contra pseudomona aeruginosa, en la presencia de suero humano.
AU2020271116A1 (en) * 2019-04-11 2021-11-11 Contrafect Corporation Method of treating and preventing bone and joint infections
US20230277632A1 (en) * 2020-05-19 2023-09-07 Contrafect Corporation MODIFIED PlySs2 LYSINS AND ANTIBIOTIC COMBINATIONS FOR USE AGAINST GRAM-POSITIVE BACTERIA
US20220087266A1 (en) * 2020-09-22 2022-03-24 Mars, Incorporated Compositions and methods for controlling mycotoxin production
CN114480299B (zh) * 2020-10-27 2023-08-29 暨南大学 一种蜡样芽胞杆菌噬菌体及其应用
AU2021387969A1 (en) * 2020-11-25 2023-06-22 Laboratory Corporation Of America Holdings Methods and systems for the detection of microorganisms using infectious agents
CN112760312B (zh) * 2021-01-20 2022-06-17 华中农业大学 一种裂解革兰氏阳性菌的裂解酶plyssX609及其应用
CA3203248A1 (en) * 2021-01-25 2022-07-28 Nitin K. RAJAN Apparatus, systems, and methods for preparing an output sample with aeration
WO2023049747A1 (en) * 2021-09-22 2023-03-30 Elanco Us Inc. Streptococcus suis lytic enzyme compositions and methods of use thereof
KR102742550B1 (ko) * 2022-07-26 2024-12-18 주식회사 인트론바이오테크놀로지 연쇄상구균에 대하여 용균 활성을 갖는 항균단백질
EP4588068A1 (en) * 2022-09-16 2025-07-23 The Johns Hopkins University Machine learning systems and related aspects for the detection of disease states
CN118272361B (zh) * 2024-05-13 2026-01-09 内蒙古农业大学 一种发酵粘液乳杆菌噬菌体裂解酶LysLFP01及其制备方法和应用

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1352567A (zh) * 1999-02-25 2002-06-05 新眼界诊断公司 预防性和治疗性治疗链球菌感染的方法
WO2004104213A2 (en) * 2003-05-15 2004-12-02 The Rockefeller University Nucleic acids and polypeptides of c1 bacteriophage and uses thereof
CN1711105A (zh) * 2002-11-07 2005-12-21 新纳几美国公司 治疗或预防肺炎球菌感染的组合物与方法
CN101018863A (zh) * 2004-05-07 2007-08-15 利-安·柯卡姆 突变体肺炎链球菌溶血素蛋白质
WO2008001342A1 (en) * 2006-06-29 2008-01-03 Teagasc, The Agriculture And Food Development Authority Recombinant staphylococcal phage lysin as an antibacterial agent
US7582291B2 (en) * 2005-06-30 2009-09-01 The Rockefeller University Bacteriophage lysins for Enterococcus faecalis, Enterococcus faecium and other bacteria
US20100172918A1 (en) * 2009-01-08 2010-07-08 Intron Biotechnology, Inc. Novel lysin protein having broad antibacterial activity specific to bacteria
CN102197132A (zh) * 2008-08-26 2011-09-21 勒芬天主教大学，K.U.勒芬R&D 抗微生物剂

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3278378A (en) 1962-04-19 1966-10-11 Schindler Charles Alvin Staphylococcus-derived antibiotic
US3398056A (en) 1964-07-10 1968-08-20 Mead Johnson & Co Process for producing lysostaphin by fermentation
US3594284A (en) 1968-06-04 1971-07-20 Mead Johnson & Co Lysostaphin fermentation with accelerated time cycle
US3654090A (en) 1968-09-24 1972-04-04 Organon Method for the determination of antigens and antibodies
NL154598B (nl) 1970-11-10 1977-09-15 Organon Nv Werkwijze voor het aantonen en bepalen van laagmoleculire verbindingen en van eiwitten die deze verbindingen specifiek kunnen binden, alsmede testverpakking.
US4016043A (en) 1975-09-04 1977-04-05 Akzona Incorporated Enzymatic immunological method for the determination of antigens and antibodies
NZ201918A (en) 1981-09-18 1987-04-30 Genentech Inc N-terminal methionyl analogues of bovine growth hormone
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
JPH0830004B2 (ja) 1983-11-14 1996-03-27 コロンビア ラボラトリーズ インコーポレイテッド 生物接着性組成物およびそれにより治療する方法
DE3587814T2 (de) 1985-03-30 1994-11-10 Marc Ballivet Verfahren zum erhalten von dns, rns, peptiden, polypeptiden oder proteinen durch dns-rekombinant-verfahren.
AU8108587A (en) 1986-10-08 1988-05-06 David Bernstein Method for exposing group a streptococcal antigens and an improved diagnostic test for the identification of group a streptococci
US4948580A (en) 1988-12-08 1990-08-14 E. R. Squibb & Sons, Inc. Muco-bioadhesive composition
JPH02258718A (ja) 1989-03-31 1990-10-19 Nippon Kayaku Co Ltd ペースト状基剤及び製剤
US5264563A (en) 1990-08-24 1993-11-23 Ixsys Inc. Process for synthesizing oligonucleotides with random codons
ATE199392T1 (de) 1992-12-04 2001-03-15 Medical Res Council Multivalente und multispezifische bindungsproteine, deren herstellung und verwendung
US5605793A (en) 1994-02-17 1997-02-25 Affymax Technologies N.V. Methods for in vitro recombination
US5554380A (en) 1994-08-04 1996-09-10 Kv Pharmaceutical Company Bioadhesive pharmaceutical delivery system
US5863560A (en) 1996-09-11 1999-01-26 Virotex Corporation Compositions and methods for topical application of therapeutic agents
US5942243A (en) 1996-11-12 1999-08-24 Polytherapeutics, Inc. Mucoadhesive compositions for administration of biologically active agents to animal tissue
US6264945B1 (en) 1997-10-31 2001-07-24 Vincent A Fischetti Parenteral use of bacterial phage associated lysing enzymes for the therapeutic treatment of bacterial infections
US5997862A (en) 1997-10-31 1999-12-07 New Horizons Diagnostics Corporation Therapeutic treatment of group A streptococcal infections
US6254866B1 (en) 1997-10-31 2001-07-03 New Horizons Diagnostics Corporation Use of phage associated lytic enzymes for treating bacterial infections of the digestive tract
US20060292135A1 (en) * 1997-10-31 2006-12-28 Lawrence Loomis Use of bacterial phage-associated lysing proteins for preventing and treating bacterial infections in humans, animals and fowl
US6248324B1 (en) 1997-10-31 2001-06-19 Vincent Fischetti Bacterial phage associated lysing enzymes for treating dermatological infections
JP2002537350A (ja) 1999-02-25 2002-11-05 ニュー ホライズンズ ダイアグノスティックス インコーポレーティッド 連鎖球菌感染の予防的及び治療的な処置のための手段
US6056955A (en) 1999-09-14 2000-05-02 Fischetti; Vincent Topical treatment of streptococcal infections
EP1501925A4 (en) 2002-05-17 2006-10-25 New Horizons Diagnostics Corp IDENTIFICATION OF A LYTIC ENZYME ASSOCIATED WITH A PHAGE TO DETECT AND ELIMINATE RAPIDLY AND SPECIFICALLY BACILLUS ANTHRACIS
US8326388B2 (en) 2002-10-31 2012-12-04 Toshiba Medical Systems Corporation Method and apparatus for non-invasive measurement of living body characteristics by photoacoustics
US7569223B2 (en) 2004-03-22 2009-08-04 The Rockefeller University Phage-associated lytic enzymes for treatment of Streptococcus pneumoniae and related conditions
US7638600B2 (en) 2004-03-24 2009-12-29 The Rockefeller University Lytic enzymes and spore surface antigen for detection and treatment of Bacillus anthracis bacteria and spores
WO2008018854A2 (en) 2005-06-06 2008-02-14 The Rockefeller University Bactiophage lysins for bacillus anthracis
CN101297034A (zh) * 2005-08-24 2008-10-29 洛克菲勒大学 Ply-gbs突变溶素
DE102006061002A1 (de) * 2006-12-22 2008-06-26 Profos Ag Verfahren und Mittel zur Anreicherung, Entfernung und zum Nachweis von gram-positiven Bakterien
EP2225263A1 (en) 2007-11-26 2010-09-08 Plant Bioscience Limited Novel polypeptides having endolysin activity and uses thereof
EP2103308A1 (de) * 2008-03-20 2009-09-23 PhytoLine GmbH Verfahren zur Herstellung eines Gemisches von Bakteriophagen und deren Verwendung für die Therapie von Antibiotika-resistenten Staphylococcen
WO2010002959A2 (en) 2008-07-03 2010-01-07 The Rockefeller University A chimeric bacteriophage lysin with activity against staphylococci bacteria
WO2010011960A2 (en) * 2008-07-24 2010-01-28 The United State Of America, As Represented By The Secretary Of Agriculture Triple acting antimicrobials that are refractory to resistance development
EP2539446B1 (en) * 2010-01-25 2017-11-01 Alere Scarborough Inc. A25 bacteriophage lysin
EP2699689A4 (en) * 2011-04-21 2014-12-17 Univ Utrecht Holding Bv STREPTOCOCCUS BACTERIOPHAGEN LYSINE FOR THE TREATMENT OF GRAM-POSITIVE BACTERIA IN PETS AND UTILITIES

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1352567A (zh) * 1999-02-25 2002-06-05 新眼界诊断公司 预防性和治疗性治疗链球菌感染的方法
CN1711105A (zh) * 2002-11-07 2005-12-21 新纳几美国公司 治疗或预防肺炎球菌感染的组合物与方法
WO2004104213A2 (en) * 2003-05-15 2004-12-02 The Rockefeller University Nucleic acids and polypeptides of c1 bacteriophage and uses thereof
CN101018863A (zh) * 2004-05-07 2007-08-15 利-安·柯卡姆 突变体肺炎链球菌溶血素蛋白质
US7582291B2 (en) * 2005-06-30 2009-09-01 The Rockefeller University Bacteriophage lysins for Enterococcus faecalis, Enterococcus faecium and other bacteria
WO2008001342A1 (en) * 2006-06-29 2008-01-03 Teagasc, The Agriculture And Food Development Authority Recombinant staphylococcal phage lysin as an antibacterial agent
CN102197132A (zh) * 2008-08-26 2011-09-21 勒芬天主教大学，K.U.勒芬R&D 抗微生物剂
US20100172918A1 (en) * 2009-01-08 2010-07-08 Intron Biotechnology, Inc. Novel lysin protein having broad antibacterial activity specific to bacteria

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
律清宇等: "猪链球菌2型溶血素的纯化及生物学活性研究", 《细胞与分子免疫学杂志》 *
罗正等: "单核增生性李氏杆菌溶血素的原核表达及其单克隆抗体的制备", 《生物工程学报》 *
陈希等: "细菌溶血素的分类及代表性溶血素研究进展", 《中国农学通报》 *

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116640754A (zh) * 2023-07-21 2023-08-25 临沂大学 一种链球菌前噬菌体裂解酶lys224及应用
CN116640754B (zh) * 2023-07-21 2023-10-10 临沂大学 一种链球菌前噬菌体裂解酶lys224及应用
CN117051043A (zh) * 2023-10-11 2023-11-14 圆因(北京)生物科技有限公司 一种基于环状rna编码耐甲氧西林金黄色葡萄球菌内溶素及其应用
CN117051043B (zh) * 2023-10-11 2024-01-30 圆因(北京)生物科技有限公司 一种基于环状rna编码耐甲氧西林金黄色葡萄球菌内溶素及其应用
CN117866985A (zh) * 2023-10-11 2024-04-12 圆因(北京)生物科技有限公司 一种用于表达耐甲氧西林金黄色葡萄球菌内溶素的rna序列
CN117965624A (zh) * 2023-10-11 2024-05-03 圆因(北京)生物科技有限公司 一种用于编码耐甲氧西林金黄色葡萄球菌内溶素的线性dna、线性rna及其质粒表达载体
CN117866985B (zh) * 2023-10-11 2024-08-30 圆因(北京)生物科技有限公司 一种用于表达耐甲氧西林金黄色葡萄球菌内溶素的rna序列
CN117965624B (zh) * 2023-10-11 2024-12-17 圆因(北京)生物科技有限公司 一种用于编码耐甲氧西林金黄色葡萄球菌内溶素的线性dna、线性rna及其质粒表达载体

Also Published As

Publication number Publication date
NZ731111A (en) 2019-06-28
IL266476B (en) 2020-01-30
US20220064615A1 (en) 2022-03-03
EP2699253B1 (en) 2018-03-28
US20170298334A1 (en) 2017-10-19
JP2016147903A (ja) 2016-08-18
US9914915B2 (en) 2018-03-13
US9034322B2 (en) 2015-05-19
HK1244503A1 (zh) 2018-08-10
MX370442B (es) 2019-12-13
IL228869B (en) 2019-05-30
JP6284976B2 (ja) 2018-02-28
MX383544B (es) 2025-03-14
JP6735796B2 (ja) 2020-08-05
WO2012145630A3 (en) 2014-05-01
MX336427B (es) 2016-01-18
CA2833409A1 (en) 2012-10-26
IL271300B (en) 2021-12-01
JP6587655B2 (ja) 2019-10-09
JP2017171686A (ja) 2017-09-28
HK1247956A1 (en) 2018-10-05
JP2019022504A (ja) 2019-02-14
JP6139509B2 (ja) 2017-05-31
AU2017202728B2 (en) 2019-04-04
CN103857410A (zh) 2014-06-11
US11155799B2 (en) 2021-10-26
US20200002694A1 (en) 2020-01-02
CN115887627A (zh) 2023-04-04
US20220127590A1 (en) 2022-04-28
AU2012245357A1 (en) 2013-11-14
US20150267185A1 (en) 2015-09-24
US11111484B2 (en) 2021-09-07
ES2682670T3 (es) 2018-09-21
WO2012145630A2 (en) 2012-10-26
DK2699253T3 (en) 2018-07-16
EP3252155A1 (en) 2017-12-06
IL271300A (en) 2020-01-30
US20200149025A1 (en) 2020-05-14
AU2012245357B2 (en) 2017-06-08
MX2013012241A (es) 2014-05-07
US20230167427A9 (en) 2023-06-01
AU2019204660B2 (en) 2021-01-28
EP2699253A4 (en) 2015-07-01
IL228869A0 (en) 2013-12-31
NZ713076A (en) 2017-05-26
JP2014518849A (ja) 2014-08-07
EP2699253A2 (en) 2014-02-26
CN107189997A (zh) 2017-09-22
MX2021007008A (es) 2022-06-02
US10544407B2 (en) 2020-01-28
AU2017202728A1 (en) 2017-05-18
US20140072549A1 (en) 2014-03-13
AU2019204660A1 (en) 2019-07-18
NZ616945A (en) 2015-11-27
IL266476A (en) 2019-06-30
IL287530A (en) 2021-12-01

Similar Documents

Publication Publication Date Title
US11111484B2 (en) Streptococcus bacteriophage lysins for detection and treatment of gram positive bacteria
US20140179594A1 (en) Streptococcus bacteriophage lysins for treatment of gram positive bacteria in companion animals and livestock
HK40090815A (en) Streptococcus bacteriophage lysins for detection and treatment of gram positive bacteria
HK1259718A1 (zh) 用於革兰氏阳性菌检测和治疗的链球菌属细菌噬菌体溶素
HK1194997A (en) Streptococcus bacteriophage lysins for detection and treatment of gram positive bacteria
HK1194997B (en) Streptococcus bacteriophage lysins for detection and treatment of gram positive bacteria
NZ731111B2 (en) Streptococcus bacteriophage lysins for detection and treatment of gram positive bacteria
NZ713076B2 (en) Streptococcus bacteriophage lysins for detection and treatment of gram positive bacteria
NZ616945B2 (en) Streptococcus bacteriophage lysins for detection and treatment of gram positive bacteria

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 1259718

Country of ref document: HK

WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20180928

WD01 Invention patent application deemed withdrawn after publication
REG Reference to a national code

Ref country code: HK

Ref legal event code: WD

Ref document number: 1259718

Country of ref document: HK