CN108420996A - 一种治疗忧郁症的药物及其制备方法 - Google Patents
一种治疗忧郁症的药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗忧郁症的药物及其制备方法,其是由百合、郁金、枳壳、桔梗、川芎、当归、乌药、夏枯草、海螵蛸、牡蛎、柴胡、青皮、陈皮、甘草、藿香、肉桂、石斛、益智仁、菊花、淫羊藿按一定重量配比制备而成,本发明药物具有行气解随,凉血破瘀,理气健脾,快气和中,辟秽祛湿的功能,用于治疗忧郁症见效快、疗效好,不复发。
Description
技术领域
本发明涉及一种治疗忧郁症的药物及其制备方法,属中药领域。
背景技术
忧郁症又称抑郁障碍,以显著而持久的心境低落为主要临床特征,是心境障碍的主要类型。临床可见心境低落与其处境不相称,情绪的消沉可以从闷闷不乐到悲痛欲绝,自卑抑郁,甚至悲观厌世,可有自杀企图或行为;甚至发生木僵;部分病例有明显的焦虑和运动性激越;严重者可出现幻觉、妄想等精神病性症状。每次发作持续至少2周以上、长者甚或数年,多数病例有反复发作的倾向,每次发作大多数可以缓解,部分可有残留症状或转为慢性。由于西药治疗副作用大,因此人们对有效治疗忧郁症的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗忧郁症的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗忧郁症的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择百合、郁金、枳壳、桔梗、川芎、当归、乌药、夏枯草、海螵蛸、牡蛎、柴胡、青皮、陈皮、甘草、藿香、肉桂、石斛、三棱、莪术、枳实、槟榔、益智仁、菊花、淫羊藿进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗忧郁症。其中选用百合是因为其性味甘微苦,平,入心、肺经,有润肺止咳,清心安神的功能,治肺痨久嗽,咳唾痰血,热病后余热未清,虚烦惊悸,神志恍惚,脚气浮肿。选用郁金是因为其性味辛苦,凉,入心、肺、肝经,有行气解随,凉血破瘀的功能,治胸腹胁肋诸痛,失心癫狂,热病神昏,吐血,衄血,尿血,血淋,妇女倒经,黄疸。选用枳壳是因为其性味苦辛,凉,入肺、脾、大肠经,有破气,行痰,消积的功能,治胸膈痰滞,胸痞,胁胀,食积,噫气,呕逆,下痢后重,脱肛,子宫脱垂。选用桔梗是因为其性味苦辛,平,入肺、胃经,有开宣肺气,祛痰排脓的功能,治外感咳嗽,咽喉肿痛,肺痈吐脓,胸满胁痛,痢疾腹痛。选用川芎是因为其性味辛,温,入肝、胆经,有行气开郁,祛风燥湿,活血止痛的功能,治风冷头痛旋晕,胁痛腹疼,寒痹筋挛,经闭,难产,产后瘀阻块痛,痈疽疮疡。选用当归是因为其性味甘辛,温,入心、肝、脾经,有补血和血,调经止痛,润燥滑肠的功能,治月经不调,经闭腹痛,癥瘕结聚,崩漏,血虚头痛,眩晕,痿痹,肠燥难便,赤痢后重,痈疽疮疡,金疮,跌扑损伤。选用乌药是因为其性味辛,温,入脾、肺、肾、膀胱经,有顺气,开郁,散寒,止痛的功能,治气逆胸腹胀痛,宿食不满,反胃吐食,寒疝,脚气,小便频数。选用夏枯草是因为其性味苦辛,寒,入肝、胆经,有清肝,散结的功能,治瘰疬,瘿瘤,乳痈,乳癌,目珠夜痛,羞明流泪,头目眩晕,口眼歪斜,筋骨疼痛,肺结核,急性黄疸型传染性肝炎,血崩,带下。选用海螵蛸是因为其性味咸,微温,入肝、肾经,有除湿,制酸,止血,敛疮的功能,治胃痛吞酸,吐、衄、呕血,便血,崩漏带下,血枯经闭,腹痛癥瘕,虚疟泻痢,阴蚀烂疮。选用牡蛎是因为其性味咸涩,凉,入肝、肾经,有敛阴,潜阳,止汗,涩精,化痰,软坚的功能,治惊癎,眩晕,自汗,盗汗,遗精,淋浊,崩漏,带下,瘰疬,瘿瘤。选用柴胡是因为其性味苦,凉,入肝、胆经,有和解表里,疏肝,升阳的功能,治寒热往来,胸满胁痛,口苦耳聋,头痛目眩,疟疾,下利脱肛,月经不调,子宫下垂。选用青皮是因为其性味苦辛,微温,入肝、胆经,有疏肝破气,散结消痰的功能,治胸胁胃脘疼痛,疝气,食积,乳肿,乳核,久疟癖块。选用陈皮是因为其性味苦、辛,温,归肺、脾经,有理气健脾,燥湿化痰的功能,治胸脘胀满,食少吐泻,咳嗽痰多。选用甘草是因为其性味甘平,入脾、胃、肺经,有和中缓急,润肺,解毒,调和诸药的功能,炙用治脾胃虚弱,食少,腹痛便溏,劳倦发热,肺痿咳嗽,心悸,惊痈,生用治咽喉肿痛,消化性溃疡,痈疽疮疡,解药毒及食物中毒。选用藿香是因为其性味辛,微温,入肺、脾、胃经,有快气,和中,辟秽,祛湿的功能,治感冒暑湿,寒热,头痛,胸脘痞闷,呕吐泄泻,疟疾,痢疾,口臭。选用肉桂是因为其性味辛甘,热,入肾、脾、膀胱经,有补元阳,暖脾胃,除积冷,通血脉的功能,治命门火衰,肢冷脉微,亡阳虚脱,腹痛泄泻,寒疝奔豚,腰膝冷痛,经闭癥瘕,阴疽,流注,及虚阳浮越,上热下寒。选用石斛是因为其性味甘淡微咸,寒,入有、肺、肾经,有生津益胃,清热养阴的功能,治热病伤津,口干烦喝,病后虚热,阴伤目暗。选用三棱是因为其性味苦辛,平,入肝、脾经,有破血,行气,消积,止痛的功能,治癥瘕积聚,气血凝带,心腹疼痛,胁下胀疼,经闭,产后瘀血腹痛,跌打损伤,疮肿坚硬。选用莪术是因为其性味辛、苦、温。归肝、脾经。行气破血,消积止痛。用于癥瘕痞块,瘀血经闭,食积胀痛,跌打肿痛,早期宫颈癌。选用枳实是因为其性味苦,寒,入脾、胃经,有破气,散痞,泻痰,消积的功能,治胸腹胀痛,胸痹,痞痛,痰癖,水肿,食积,便秘,胃下垂,子宫下垂,脱肛。选用槟榔是因为其性味苦辛,温,入脾、胃、大肠经,有杀虫,破积,下气,行水的功能,治虫积、食滞,脘腹胀痛,泻痢后重,疟疾,水肿,脚气,痰癖,癥结。选用益智仁是因为其性味辛,温,入脾、肾经,有温脾,暖肾,固气,涩精的功能,治冷气腹痛,中寒吐泻,多唾,遗精,小便余沥,夜多小便。选用菊花是因为其性味甘苦,凉,入肺,肝经,有疏风,消热,明目,解毒的功能,治头痛,眩晕,目赤,心胸烦热,疔疮,肿毒。选用淫羊藿是因为其性味辛甘,温,入肝、肾经,有补肾壮阳,祛风除湿的功能,治阳痿不举,小便淋沥,筋骨挛急,半身不遂,腰膝无力,风湿痹痛,四脚不仁。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
百合25-35克,郁金5-15克,枳壳4-8克,桔梗4-8克,川芎4-8克,当归5-15克,乌药5-15克,夏枯草10-20克,海螵蛸5-15克,牡蛎10-20克,柴胡5-15克,青皮5-15克,陈皮5-15克,甘草5-15克,藿香5-15克,肉桂5-15克,石斛5-15克,三棱5-15克,莪术10-20克,枳实10-20克,槟榔10-20克,益智仁5-15克,菊花5-15克,淫羊藿10-20克。
优选为:
百合30克,郁金10克,枳壳6克,桔梗6克,川芎6克,当归10克,乌药10克,夏枯草15克,海螵蛸10克,牡蛎15克,柴胡10克,青皮10克,陈皮10克,甘草10克,藿香10克,肉桂10克,石斛10克,三棱10克,莪术15克,枳实15克,槟榔15克,益智仁10克,菊花10克,淫羊藿15克。
本发明药物的制备方法如下
一、备料
1、百合:拣去杂质,黑瓣,簸除灰屑;
2、郁金:用水浸泡,洗净,捞出晒晾,润透,切片,晒干;
3、枳壳:除去瓤、核,冼净,稍浸,捞出,润软,以手能捏对折为度,切片,晾干;
4、桔梗:拣净杂质,除去芦头,洗净捞出,润透后切片,晒干;
5、川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥;
6、当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
7、乌药:拣去杂质,分开大小条,用水泡透,根据季节注意换水,防止发臭,及时捞出切片,筛去灰屑;
8、夏枯草:取原药材,除去枝梗、叶片及杂质,筛去灰屑;
9、海螵蛸:刷洗干净,晒干,砸成小块;
10、牡蛎:洗净,晒干,打碎用;
11、柴胡:拣去杂质,除去残茎,洗净泥沙,捞出,润透后及时切片,随即晒干;
12、青皮:拣净杂质,用水浸泡,捞出,润透,切片,晒干;
13、陈皮:取原药材,除去杂质及变黑的果皮,抢水洗净,润软,切丝,晒干或低温干燥,筛去灰屑;
14、甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,晾干;
15、藿香:拣去杂质,除去残根及老茎,先将叶摘下另放,茎用水润透,切段,晒干,然后与叶和匀;
16、肉桂:拣净杂质,刮去粗皮,用时打碎,或刮去粗皮,用温开水浸润片刻,切片,晾干;
17、石斛:取干燥的石斛,用水泡约至八成透,焖润,除去残根及黑枝,切段,撞去薄膜,晒干;
18、三棱:拣净杂质,用水浸泡,捞出润透,切片,晒干;
19、莪术:取原药材,除去杂质,大小分档,洗净,略浸泡,取出,润透,切薄片,干燥,筛去碎屑;
20、枳实:拣净杂质,用水浸泡至八成透,捞出,润至内无硬心,切片,晾干;
21、槟榔:拣去杂质,以清水浸泡,按气温情况换水,至泡透为止,捞起,切片,晾干;
22、益智仁:取益智仁置锅内,炒至外壳焦黑,取出冷透,除去果壳,取仁捣碎用;
23、菊花:拣净叶梗、花柄及泥屑杂质;
24、淫羊藿:拣净杂质,去梗,切丝,筛去碎屑。
二、制备
1、将所述重量的百合、郁金、枳壳、桔梗、川芎、当归、乌药、夏枯草、海螵蛸、牡蛎、柴胡、青皮、陈皮、甘草、藿香、肉桂、石斛、三棱、莪术、枳实、槟榔、益智仁、菊花、淫羊藿放入煎药容器内,加水6倍量,浸泡120分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
2、将过滤的药渣加水5倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
3、将两次煎煮液混合搅拌均匀,分为2剂服用。
组方中郁金有行气解随,凉血破瘀的功能为君药;陈皮有理气健脾,燥湿化痰的功能;甘草有缓急,润肺,解毒,调和诸药的功能,二者为臣药,三味药共同发挥行气解随,凉血破瘀,理气健脾,燥湿化痰的作用,治疗忧郁症效力全面,且以行气解随,凉血破瘀,理气健脾为主可治本,藿香有快气,和中,辟秽,祛湿的功能为佐药,菊花有疏风,消热,明目,解毒的功能为使药,与下余诸药是治标。
本发明药物具有行气解随,凉血破瘀,理气健脾,快气和中,辟秽祛湿的功能,用于治疗忧郁症,疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治忧郁症门诊患者共48例。
2、诊断标准
典型症状可见心境低落与其处境不相称,情绪的消沉可以从闷闷不乐到悲痛欲绝,自卑抑郁,甚至悲观厌世,可有自杀企图或行为;甚至发生木僵;部分病例有明显的焦虑和运动性激越;严重者可出现幻觉、妄想等精神病性症状。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,20天为一个疗程,连续服用2个疗程。
4、疗效评定标准
显效:忧郁症症状消失,情绪恢复正常,痊愈;
好转:忧郁症症状明显好转,悲观厌世状况、自卑抑郁减轻,情绪逐步恢复正常;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗忧郁症患者48例,结果显效41例,显效率为85.4%,好转4例,好转率为8.3%,无效3例,总有效率为93.7%。
Claims (3)
1.一种治疗忧郁症的药物,其特征在于:它是由下列重量范围内的原料药制成:
百合25-35克,郁金5-15克,枳壳4-8克,桔梗4-8克,川芎4-8克,当归5-15克,乌药5-15克,夏枯草10-20克,海螵蛸5-15克,牡蛎10-20克,柴胡5-15克,青皮5-15克,陈皮5-15克,甘草5-15克,藿香5-15克,肉桂5-15克,石斛5-15克,三棱5-15克,莪术10-20克,枳实10-20克,槟榔10-20克,益智仁5-15克,菊花5-15克,淫羊藿10-20克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
百合30克,郁金10克,枳壳6克,桔梗6克,川芎6克,当归10克,乌药10克,夏枯草15克,海螵蛸10克,牡蛎15克,柴胡10克,青皮10克,陈皮10克,甘草10克,藿香10克,肉桂10克,石斛10克,三棱10克,莪术15克,枳实15克,槟榔15克,益智仁10克,菊花10克,淫羊藿15克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)百合:拣去杂质,黑瓣,簸除灰屑;
(2)郁金:用水浸泡,洗净,捞出晒晾,润透,切片,晒干;
(3)枳壳:除去瓤、核,冼净,稍浸,捞出,润软,以手能捏对折为度,切片,晾干;
(4)桔梗:拣净杂质,除去芦头,洗净捞出,润透后切片,晒干;
(5)川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥;
(6)当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
(7)乌药:拣去杂质,分开大小条,用水泡透,根据季节注意换水,防止发臭,及时捞出切片,筛去灰屑;
(8)夏枯草:取原药材,除去枝梗、叶片及杂质,筛去灰屑;
(9)海螵蛸:刷洗干净,晒干,砸成小块;
(10)牡蛎:洗净,晒干,打碎用;
(11)柴胡:拣去杂质,除去残茎,洗净泥沙,捞出,润透后及时切片,随即晒干;
(12)青皮:拣净杂质,用水浸泡,捞出,润透,切片,晒干;
(13)陈皮:取原药材,除去杂质及变黑的果皮,抢水洗净,润软,切丝,晒干或低温干燥,筛去灰屑;
(14)甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,晾干;
(15)藿香:拣去杂质,除去残根及老茎,先将叶摘下另放,茎用水润透,切段,晒干,然后与叶和匀;
(16)肉桂:拣净杂质,刮去粗皮,用时打碎,或刮去粗皮,用温开水浸润片刻,切片,晾干;
(17)石斛:取干燥的石斛,用水泡约至八成透,焖润,除去残根及黑枝,切段,撞去薄膜,晒干;
(18)三棱:拣净杂质,用水浸泡,捞出润透,切片,晒干;
(19)莪术:取原药材,除去杂质,大小分档,洗净,略浸泡,取出,润透,切薄片,干燥,筛去碎屑;
(20)枳实:拣净杂质,用水浸泡至八成透,捞出,润至内无硬心,切片,晾干;
(21)槟榔:拣去杂质,以清水浸泡,按气温情况换水,至泡透为止,捞起,切片,晾干;
(22)益智仁:取益智仁置锅内,炒至外壳焦黑,取出冷透,除去果壳,取仁捣碎用;
(23)菊花:拣净叶梗、花柄及泥屑杂质;
(24)淫羊藿:拣净杂质,去梗,切丝,筛去碎屑;
(二)制备
(1)将所述重量的百合、郁金、枳壳、桔梗、川芎、当归、乌药、夏枯草、海螵蛸、牡蛎、柴胡、青皮、陈皮、甘草、藿香、肉桂、石斛、三棱、莪术、枳实、槟榔、益智仁、菊花、淫羊藿放入煎药容器内,加水6倍量,浸泡120分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水5倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合搅拌均匀,分为2剂服用。
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