CN108324917A - 一种治疗大动脉炎的药物及其制备方法 - Google Patents
一种治疗大动脉炎的药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗大动脉炎的药物及其制备方法,其是由忍冬藤、黄芪、蒲公英、丹参、党参、生地黄、鸡血藤、川牛膝、石斛、桂枝、赤芍、白花蛇舌草、干姜、延胡索、川楝子、玄参、川芎、紫花地丁、地龙、陈皮、郁金、菊花、白薇、酸枣仁、肉桂、鹿角胶按一定重量配比制备而成,本发明药物具有清热解毒,清热利湿,祛风通络,痛经活血,益卫固表,补中益的功能,用于治疗大动脉炎见效快、疗效好,不复发。
Description
技术领域
本发明涉及一种治疗大动脉炎的药物及其制备方法,属中药领域。
背景技术
大动脉炎是指主动脉及其主要分支和肺动脉的慢性非特异性炎性疾病。中医则认为大动脉炎与热毒阻络,气血两虚,湿热瘀阻有关。由于西药治疗副作用大,因此人们对有效治疗大动脉炎的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗大动脉炎的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗大动脉炎的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择忍冬藤、黄芪、蒲公英、丹参、党参、生地黄、鸡血藤、川牛膝、石斛、桂枝、赤芍、白花蛇舌草、干姜、延胡索、川楝子、玄参、川芎、紫花地丁、地龙、陈皮、郁金、菊花、白薇、酸枣仁、肉桂、鹿角胶、红花、桃仁、莪术、土鳖虫进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗大动脉炎。其中选用忍冬藤是因为其性味甘,寒,入心、肺经,有清热,解毒,通络的功能,治温病发热,热毒血痢,传染性肝炎,痈肿疮毒,筋骨疼痛。选用黄芪是因为其性味甘,微温,入肺、脾经,生用有益卫固表,利水消肿,托毒,生肌的功能,治自汗,盗汗,血痹,浮肿,痈疽不溃或溃久敛;炙用有补中益的功能,治内伤劳倦,脾虚泄泻,脱肛,气虚血脱,崩带及一切气衰血虚之症。选用蒲公英是因为其性味苦甘,寒,入肝、胃经,有清热解毒,利尿散结的功能,治急性乳腺炎,淋巴腺炎,瘰疬,疔毒疮肿,急性结膜炎,感冒发热,急性扁桃体炎,急性支气管炎,胃炎,肝炎,胆囊炎,尿路感染。选用丹参是因为其性味苦,微温,入心、肝经,有活血去瘀,安神宁心,排脓,止痛的功能,治心绞痛,月经不调,痛经,以闭,血崩带下,癥瘕,积聚,瘀血腹痛,骨节疼痛,惊悸不眠,恶疮肿毒。选用党参是因为其性味甘,平,入手、足太阴经气分,有补中益气,生津的功能,治脾胃虚弱,气血两亏,体倦无力,食少,口渴,久泻,脱肛。选用生地黄是因为其性味甘,寒,归心、肝、肾经,有清热凉血,养阴,生津的功能,治热病烦渴,阴虚内热,骨蒸劳热,内热消渴,吐血,衄血,发斑发疹。选用鸡血藤是因为其性味苦甘,温,入心、脾二经,有活血、舒筋的功能,治腰膝酸痛,麻木瘫痪,月经不调。选用川牛膝是因为其性味平,味苦微苦,无毒,入肝、肾二经,有祛风,利湿,通经,活血的功能,治风湿腰膝疼痛,脚痿筋挛,血淋,尿血,妇女经闭,癥瘕。选用石斛是因为其性味甘淡微咸,寒,入有、肺、肾经,有生津益胃,清热养阴的功能,治热病伤津,口干烦喝,病后虚热,阴伤目暗。选用桂枝是因为其性味辛甘,温,入膀胱、心、肺经,有发汗解肌,温经通脉的功能,治风寒表证,肩背肢节酸疼,胸痹痰饮,经闭癥瘕。选用赤芍是因为其性味苦,微寒,归肝经,有清热凉血,散瘀止痛的功能,治温毒发狂,吐血衄血,目赤肿痛,肝郁胁痛,经闭痛经,癎瘕腹痛,跌扑损伤,痈肿疮疡。选用白花蛇舌草是因为其性味苦甘,寒,入心、肝、脾三经,有清热,利湿,解毒的功能,治肺热喘咳,扁桃体炎,咽喉炎,阑尾炎,痢疾,黄疸,盆腔炎,附件炎,痈肿疔疮,毒蛇咬伤。选用干姜是因为其性味辛,热,入脾、胃、肺经,有温中逐寒,回阳通脉的功能,治心腹冷痛,吐泻,肢冷脉微,寒饮喘咳,风寒湿痹,阳虚吐、衄、下血。选用延胡索是因为其性味辛苦,温,入肝、胃经,有活血,散瘀,理气,止痛的功能,治心腹腰膝诸痛,月经不调,癥瘕,崩中,产后血晕,恶露不尽,跌打损伤。选用川楝子是因为其性味苦,寒,有毒,入肝、胃、小肠经,有降湿热,清肝火,止痛,杀虫的功能,治热厥心痛,胁痛,疝痛,虫积腹痛。选用玄参是因为其性味苦,咸,凉,入肺、肾经,有滋阴,降火,除烦,解毒的功能,治热病烦渴,发斑,骨蒸劳热,夜寐不宁,自汗盗汗,津伤便秘,吐血衄血,咽喉肿痛,痈肿,瘰疬。选用川芎是因为其性味辛,温,入肝、胆经,有行气开郁,祛风燥湿,活血止痛的功能,治风冷头痛旋晕,胁痛腹疼,寒痹筋挛,经闭,难产,产后瘀阻块痛,痈疽疮疡。选用紫花地丁是因为其性味苦、辛、寒,归心、肝经,有清热解毒,凉血消肿的功能,治疔疮肿毒,痈疽发背,丹毒,毒蛇咬伤。选用地龙是因为其性味咸,寒,入肝、脾、肺经,有清热,平肝,止喘,通络的功能,治高热狂躁,惊风抽搐,风热头痛,目赤,中风半身不遂,喘息,喉痹,关节疼痛,齿衄,小便不通,瘰疬,痄腮,疮疡。选用陈皮是因为其性味苦、辛,温,归肺、脾经,有理气健脾,燥湿化痰的功能,治胸脘胀满,食少吐泻,咳嗽痰多。选用郁金是因为其性味辛苦,凉,入心、肺、肝经,有行气解随,凉血破瘀的功能,治胸腹胁肋诸痛,失心癫狂,热病神昏,吐血,衄血,尿血,血淋,妇女倒经,黄疸。选用菊花是因为其性味甘苦,凉,入肺,肝经,有疏风,消热,明目,解毒的功能,治头痛,眩晕,目赤,心胸烦热,疔疮,肿毒。选用白薇是因为其性味苦咸,寒,入肺、胃、肾经,有清热,凉血的功能,治阴虚内热,风湿灼热多眠,肺热咳血,温疟,瘅疟,产后虚烦血厥,热淋,血淋,风湿痛,瘰疬。选用酸枣仁是因为其性味甘,平,入心、脾、肝、胆经,有养肝,宁心,安神,敛汗的功能,治虚烦不眠,惊悸怔忡,烦渴,虚汗。选用肉桂是因为其性味辛甘,热,入肾、脾、膀胱经,有补元阳,暖脾胃,除积冷,通血脉的功能,治命门火衰,肢冷脉微,亡阳虚脱,腹痛泄泻,寒疝奔豚,腰膝冷痛,经闭癥瘕,阴疽,流注,及虚阳浮越,上热下寒。选用鹿角胶是因为其性味甘咸,温,入肝、肾经,有补血,益精的功能,治肾气不足,虚劳羸瘦,腰痛,阴疽,男子阳痿、滑精,妇女子宫虚冷,崩漏,带下。选用红花是因为其性味辛,温,入心、肝经,有活血通经,去瘀止痛的功能,治经闭,癥瘕,难产,死胎,产后恶露不行,瘀血作痛,痈肿,跌扑损伤。选用桃仁是因为其性味苦甘,平,入心、肝、大肠经,有破血行瘀,润燥滑经功能,治经闭,癥瘕,热病蓄血,血痹,疟疾,跌打损伤,瘀血肿痛,血燥便秘的。选用莪术是因为其性味辛、苦,温,归肝、脾经,有行气破血,消积止痛的功能,治癥瘕痞块,瘀血经闭,食积肛痛,跌打肿痛,早期宫颈癌。选用土鳖虫是因为其性味咸、寒,有小毒,归肝经,有破瘀血,续筋骨的功能,治筋骨折伤,瘀血经闭,癥瘕痞块。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
忍冬藤15-20克,黄芪15-25克,蒲公英10-20克,丹参10-20克,党参10-20克,生地黄10-15克,鸡血藤10-20克,川牛膝10-15克,石斛10-15克,桂枝5-15克,赤芍10-15克,白花蛇舌草15-20克,干姜10-20克,延胡索10-20克,川楝子10-15克,玄参5-15克,川芎10-15克,紫花地丁10-20克,地龙5-15克,陈皮10-15克,郁金10-20克,菊花5-15克,白薇10-15克,酸枣仁5-15克,肉桂10-15克,鹿角胶10-20克,红花5-15克,桃仁10-20克,莪术5-15克,土鳖虫5-10克。
优选为:
忍冬藤18克,黄芪20克,蒲公英15克,丹参15克,党参15克,生地黄12克,鸡血藤15克,川牛膝12克,石斛12克,桂枝10克,赤芍12克,白花蛇舌草18克,干姜15克,延胡索15克,川楝子12克,玄参10克,川芎12克,紫花地丁15克,地龙10克,陈皮12克,郁金15克,菊花10克,白薇12克,酸枣仁10克,肉桂12克,鹿角胶15克,红花10克,桃仁15克,莪术10克,土鳖虫8克。本发明药物的制备方法如下
一、备料
1、忍冬藤:拣去杂质,用水浸泡,润透,切片,晒干;
2、黄芪:拣净杂质,除去残留的根头和空心较大者,用水浸泡;
3、蒲公英:拣去杂质,洗净泥土,切段,晒干;
4、丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干;
5、党参:洗净泥沙后润透去芦,切片或切段,晒干;
6、生地黄:取原药材,除去杂质,洗净,稍润,切厚片,干燥,筛去碎屑;
7、鸡血藤:用水润透,切片,或蒸软后乘热切片,晒干;
8、川牛膝:拣去杂质,晾干;
9、石斛:取干燥的石斛,用水泡约至八成透,焖润,除去残根及黑枝,切段,撞去薄膜,晒干;
10、桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去屑;
11、赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑;
12、白花蛇舌草:取原药材,除去杂质,抢水洗净,稍晾,切段,干燥,筛去灰屑;
13、干姜:拣净杂质,用水浸泡3—6小时,捞出,闷润后切片或切成小方块,晒干;
14、延胡索:拣去杂质,用水浸泡,洗净,晒晾,润至内外湿度均匀,切片或打碎;
15、川楝子:拣去杂质,洗净,烘干,轧碎或劈成两半;
16、玄参:拣净杂质,除去芦头,洗净润透,切片,晾干;
17、川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥;
18、紫花地丁:取原药材,除去杂质,洗净,稍晾,切段,干燥;
19、地龙:拣去杂质,用水漂净,及时捞出,晒干,切段;
20、陈皮:取原药材,除去杂质及变黑的果皮,抢水洗净,润软,切丝,晒干或低温干燥,筛去灰屑;
21、郁金:用水浸泡,洗净,捞出晒晾,润透,切片,晒干;
22、菊花:拣净叶梗、花柄及泥屑杂质;
23、白薇:拣净杂质,除去茎苗,洗净,稍浸,润透,切段,晒干;
24、酸枣仁:原药放入竹箩内,沉入清水缸中,使仁浮在水面,壳沉水底,将刺仁捞出,晒干;
25、肉桂:拣净杂质,刮去粗皮,用时打碎,或刮去粗皮,用温开水浸润片刻,切片,晾干;
26、鹿角胶:取原药材,除去杂质,用时捣碎或研粉;
27、红花:拣净杂质,除去茎叶、蒂头,晒干;
28、桃仁:除去硬壳杂质,置沸水锅中煮至外皮微皱,捞出,浸入凉水中,搓去种皮,晒干,簸净;
29、莪术:取原药材,除去杂质,大小分档,洗净,略浸泡,取出,润透,切薄片,干燥,筛去碎屑;
30、土鳖虫:取原药材,洗净,干燥。
二、制备
1、将所述重量的忍冬藤、黄芪、蒲公英、丹参、党参、生地黄、鸡血藤、川牛膝、石斛、桂枝、赤芍、白花蛇舌草、干姜、延胡索、川楝子、玄参、川芎、紫花地丁、地龙、陈皮、郁金、菊花、白薇、酸枣仁、肉桂、鹿角胶、红花、桃仁、莪术、土鳖虫放入煎药容器内,第一次加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
2、将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
3、将两次煎煮液混合搅拌均匀,分为4剂服用。
组方中忍冬藤有清热,解毒,通络的功能为君药;黄芪益卫固表,利水消肿,托毒,生肌,补中益;白花蛇舌草有清热,利湿,解毒的功能,二者为臣药,三味药共同发挥清热解毒,通络,清热利湿,益卫固表,补中益,托毒生肌的作用,治疗大动脉炎效力全面,且以清热解毒,通络,清热利湿,益卫固表,补中益为主可治本,红花有活血通经,去瘀止痛功能为佐药,川牛膝有祛风,利湿,通经,活血的功能为使药,与下余诸药是治标。
本发明药物具有清热解毒,清热利湿,祛风通络,痛经活血,益卫固表,补中益的功能,用于治疗大动脉炎,疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治大动脉炎门诊患者共17例。
2、诊断标准
典型症状为头臂动脉型:锁骨下动脉受累较为常见,上肢缺血可出现单侧或双侧上肢无力、发凉、酸痛、麻木甚至肌肉萎缩;头臂动脉型:由于缺血,下肢出现无力、酸痛、皮肤发凉和间歇性跛行;肺动脉型:出现心悸、气短,重者心功能衰竭,肺动脉瓣区可闻及收缩期杂音和肺动脉瓣第二音亢进。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,7天为一个疗程,连续服用3个疗程。
4、疗效评定标准
显效:大动脉炎症状消失,体质恢复正常,痊愈;
好转:患者头臂动脉型,头臂动脉型和肺动脉型出现的异常现象减轻,大动脉炎症状明显好转,体质逐步恢复正常;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗大动脉炎患者17例,结果显效14例,显效率为82.36%,好转2例,好转率为11.76%,无效1例,总有效率为94.12%。
Claims (3)
1.一种治疗大动脉炎的药物,其特征在于:它是由下列重量范围内的原料药制成:
忍冬藤15-20克,黄芪15-25克,蒲公英10-20克,丹参10-20克,党参10-20克,生地黄10-15克,鸡血藤10-20克,川牛膝10-15克,石斛10-15克,桂枝5-15克,赤芍10-15克,白花蛇舌草15-20克,干姜10-20克,延胡索10-20克,川楝子10-15克,玄参5-15克,川芎10-15克,紫花地丁10-20克,地龙5-15克,陈皮10-15克,郁金10-20克,菊花5-15克,白薇10-15克,酸枣仁5-15克,肉桂10-15克,鹿角胶10-20克,红花5-15克,桃仁10-20克,莪术5-15克,土鳖虫5-10克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
忍冬藤18克,黄芪20克,蒲公英15克,丹参15克,党参15克,生地黄12克,鸡血藤15克,川牛膝12克,石斛12克,桂枝10克,赤芍12克,白花蛇舌草18克,干姜15克,延胡索15克,川楝子12克,玄参10克,川芎12克,紫花地丁15克,地龙10克,陈皮12克,郁金15克,菊花10克,白薇12克,酸枣仁10克,肉桂12克,鹿角胶15克,红花10克,桃仁15克,莪术10克,土鳖虫8克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)忍冬藤:拣去杂质,用水浸泡,润透,切片,晒干;
(2)黄芪:拣净杂质,除去残留的根头和空心较大者,用水浸泡;
(3)蒲公英:拣去杂质,洗净泥土,切段,晒干;
(4)丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干;
(5)党参:洗净泥沙后润透去芦,切片或切段,晒干;
(6)生地黄:取原药材,除去杂质,洗净,稍润,切厚片,干燥,筛去碎屑;
(7)鸡血藤:用水润透,切片,或蒸软后乘热切片,晒干;
(8)川牛膝:拣去杂质,晾干;
(9)石斛:取干燥的石斛,用水泡约至八成透,焖润,除去残根及黑枝,切段,撞去薄膜,晒干;
(10)桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去屑;
(11)赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑;
(12)白花蛇舌草:取原药材,除去杂质,抢水洗净,稍晾,切段,干燥,筛去灰屑;
(13)干姜:拣净杂质,用水浸泡3—6小时,捞出,闷润后切片或切成小方块,晒干;
(14)延胡索:拣去杂质,用水浸泡,洗净,晒晾,润至内外湿度均匀,切片或打碎;
(15)川楝子:拣去杂质,洗净,烘干,轧碎或劈成两半;
(16)玄参:拣净杂质,除去芦头,洗净润透,切片,晾干;
(17)川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥;
(18)紫花地丁:取原药材,除去杂质,洗净,稍晾,切段,干燥;
(19)地龙:拣去杂质,用水漂净,及时捞出,晒干,切段;
(20)陈皮:取原药材,除去杂质及变黑的果皮,抢水洗净,润软,切丝,晒干或低温干燥,筛去灰屑;
(21)郁金:用水浸泡,洗净,捞出晒晾,润透,切片,晒干;
(22)菊花:拣净叶梗、花柄及泥屑杂质;
(23)白薇:拣净杂质,除去茎苗,洗净,稍浸,润透,切段,晒干;
(24)酸枣仁:原药放入竹箩内,沉入清水缸中,使仁浮在水面,壳沉水底,将刺仁捞出,晒干;
(25)肉桂:拣净杂质,刮去粗皮,用时打碎,或刮去粗皮,用温开水浸润片刻,切片,晾干;
(26)鹿角胶:取原药材,除去杂质,用时捣碎或研粉;
(27)红花:拣净杂质,除去茎叶、蒂头,晒干;
(28)桃仁:除去硬壳杂质,置沸水锅中煮至外皮微皱,捞出,浸入凉水中,搓去种皮,晒干,簸净;
(29)莪术:取原药材,除去杂质,大小分档,洗净,略浸泡,取出,润透,切薄片,干燥,筛去碎屑;
(30)土鳖虫:取原药材,洗净,干燥;
(二)制备
(1)将所述重量的忍冬藤、黄芪、蒲公英、丹参、党参、生地黄、鸡血藤、川牛膝、石斛、桂枝、赤芍、白花蛇舌草、干姜、延胡索、川楝子、玄参、川芎、紫花地丁、地龙、陈皮、郁金、菊花、白薇、酸枣仁、肉桂、鹿角胶、红花、桃仁、莪术、土鳖虫放入煎药容器内,加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合搅拌均匀,分为4剂服用。
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