CN108524867A - 一种治疗肝癌的药物及其制备方法 - Google Patents
一种治疗肝癌的药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗肝癌的药物及其制备方法,其主要是由鸡骨草、马鞭草、八月札、半枝莲、薏苡仁、龙葵、五倍子、陈皮、儿茶、水蛭、徐长卿、山豆根、茵陈蒿、丹参、白芍、佛手柑、鳖甲、三棱、龟版、乳香、没药、天仙藤、青黛、桃仁、川芎、郁金、红花、泽泻、党参、赤芍按一定重量配比制备而成,本发明药物具有清热解毒、疏肝理气、活血散瘀、滋阴潜阳、通经的功能,用于治疗肝癌见效快、疗效好,不复发。
Description
技术领域
本发明涉及一种治疗肝癌的药物及其制备方法,属中药领域。
技术背景
肝癌即肝脏恶性肿瘤,可分为原发性和继发性两大类。原发性肝脏恶性肿瘤起源于肝脏的上皮或间叶组织,前者称为原发性肝癌,是我国高发的,危害极大的恶性肿瘤;后者称为肉瘤,与原发性肝癌相比较较为少见。继发性或称转移性肝癌系指全身多个器官起源的恶性肿瘤侵犯至肝脏。中医则认为肝癌与肝气郁结、气滞血瘀、湿热聚毒、肝阴亏虚有关。由于西药治疗副作用大,因此人们对有效治疗肝癌的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗肝癌的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗肝癌的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明是选择鸡骨草、马鞭草、八月札、半枝莲、薏苡仁、龙葵、五倍子、陈皮、儿茶、水蛭、徐长卿、山豆根、茵陈蒿、丹参、白芍、佛手柑、鳖甲、三棱、龟版、 乳香、没药、天仙藤、青黛、桃仁、川芎、郁金、红花、泽泻、党参、赤芍、香附、甘草、僵蚕、五灵脂药物进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗肝癌。其中,选用鸡骨草是因为其性味甘,凉,有清热解毒,舒肝散瘀的功能,治黄疸肝炎,胃痛,乳痈,瘰疬,跌打伤瘀血疼痛。选用马鞭草是因为其性味苦,凉,入肝、脾经,有清热解毒,活血散瘀,利水消肿的功能,治外感发热,湿热黄疸,水肿,痢疾,疟疾,白喉,喉痹,淋病,经闭,癥瘕,痈肿疮毒牙疳。选用八月札是因为其性味甘,寒,有舒肝理气,活血止痛,除烦利尿的功能,治肝胃气痛,胃热食呆,烦渴,赤白痢疾,腰痛,胁痛,疝气,痛经,子宫下坠。选用半枝莲是因为其性味辛、苦,性寒。归肺经、肝经、肾经,有清热解毒、活血化瘀、利尿的功能,用于治疗晚期血吸虫病腹水、肝硬化腹水、毒蛇咬伤、疮疖痈肿。选用薏苡仁是因为其性味甘淡,凉,入脾、肺、肾经,有健脾,补肺,清热,利湿的功能,治泄泻,湿痹,筋脉拘挛,屈伸不利,水肿,脚气,肺痿,肺痈,肠痈,淋浊,白带。选用龙葵是因为其性味苦,寒,有清热,解毒,活血,消肿的功能,治疔疮,痈肿,丹毒,跌打扭伤,慢性气管炎,急性肾炎。选用五倍子是因为其性味酸,平。入肺,胃,大肠经。敛肺,涩肠,止血,解毒。治肺虚久咳,久痢,久泻,脱肛,自汗,盗汗,遗精,便血,衄血,崩漏,外伤出血,肿毒,疮疖,睫毛倒卷。选用陈皮是因为其性味苦、辛,温,归肺、脾经,有理气健脾,燥湿化痰的功能,治胸脘胀满,食少吐泻,咳嗽痰多。选用儿茶是因为其性味苦、涩,微寒,归肺经,有收湿生肌敛疮的功能,治溃疡不敛,湿疹,口疮,跌扑伤痛,外伤出血。选用水蛭是因为其性味咸苦,平,有毒,入肝、膀胱经,有破血,逐瘀,通经的功能,治蓄血,癥瘕,积聚,妇女经闭,干血成痨,跌扑损伤,目赤痛,云翳。选用徐长卿是因为其性味辛,温,有镇痛,止咳,利水消肿,活血解毒的功能,治胃痛,牙痛,风湿疼痛,经期腹痛,慢性气管炎,腹水,水肿,痢疾,肠炎,跌打损伤,湿疹,荨麻疹,毒蛇咬伤。选用山豆根是因为其性味苦,寒,入心、肺、大肠三经,有清火,解毒,消肿,止痛的功能,治喉痈,喉风,喉痹,牙龈肿痛,喘满热咳,黄疸,下痢,痔疾,热肿,秃疮,疥癣,蛇、虫、犬咬伤。选用茵陈蒿是因为其性味苦辛,凉,入肝、脾、膀胱经,有清热利湿的功能,治湿热黄疸,小便不利,风痒疮疥。选用丹参是因为其性味苦,微温,入心、肝经,有活血去瘀,安神宁心,排脓,止痛的功能,治心绞痛,月经不调,痛经,以闭,血崩带下,癥瘕,积聚,瘀血腹痛,骨节疼痛,惊悸不眠,恶疮肿毒。选用白芍是因为其性味苦酸,凉,入肝、脾经,有养血柔肝,缓中止痛,敛阴收汗的功能,治胸腹胁肋疼痛,泻痢腹痛,自汗盗汗,阴虚发热,月经不调,崩漏,带下。选用佛手柑,异名佛手、佛手香橼,是因为其性味辛苦酸,温,入肝、胃经,有理气,化痰的功能,治胃痛,胁胀,呕吐,噎膈,痰饮咳喘,并能解酒。选用鳖甲是因为其性味咸,平,入肝、脾经,有养阴清热,平肝熄风,软坚散结的功能,治劳热骨蒸,阴虚风动,劳疟疟母,癥瘕痃癖,经闭经漏,小儿惊癎。选用三棱是因为其性味苦辛,平,入肝、脾经,有破血,行气,消积,止痛的功能,治癥瘕积聚,气血凝带,心腹疼痛,胁下胀疼,经闭,产后瘀血腹痛,跌打损伤,疮肿坚硬。选用龟版是因为其性味咸甘,平,入肝、肾经,有滋阴,潜阳,补肾,健骨的功能,治肾阴不足,骨蒸劳热,吐血,衄血,久咳,遗精,崩漏,带下,腰痛,骨痿,阴虚风动,久痢,久疟,痔疮,小儿囟门不合。选用乳香是因为其性味辛苦,温,入心、肝、脾经,有调气活血,定痛,追毒的功能,治气血凝滞,心腹疼痛,痈疮肿毒,跌打损伤,痛经,产后瘀血刺痛。选用没药是因为其性味苦,平,入肝经,有散血去瘀,消肿定痛的功能,治跌损,金疮,筋骨,心腹诸痛,癥瘕,经闭,痈疽肿痛,痔漏,目障。选用天仙藤是因为其性味苦,温,入肝、脾、肾三经,有行气化湿,活血止痛的功能,治胃痛,疝气痛,妊娠水肿,产后血气腹痛,风湿疼痛。选用青黛是因为其性味咸,寒,入肝、肺、胃经,有清热,凉血,解毒的功能,治温病热盛,斑疹,吐血、咯血,小儿惊癎,疮肿,丹毒,蛇虫咬伤。选用桃仁是因为其性味苦甘,平,入心、肝、大肠经,有破血行瘀,润燥滑经的功能,治经闭,癥瘕,热病蓄血,血痹,疟疾,跌打损伤,瘀血肿痛,血燥便秘。选用川芎是因为其性味辛,温,入肝、胆经,有行气开郁,祛风燥湿,活血止痛的功能,治风冷头痛旋晕,胁痛腹疼,寒痹筋挛,经闭,难产,产后瘀阻块痛,痈疽疮疡。选用郁金是因为其性味辛苦,凉,入心、肺、肝经,有行气解随,凉血破瘀的功能,治胸腹胁肋诸痛,失心癫狂,热病神昏,吐血,衄血,尿血,血淋,妇女倒经,黄疸。选用红花是因为其性味辛,温,入心、肝经,有活血通经,去瘀止痛的功能,治经闭,癥瘕,难产,死胎,产后恶露不行,瘀血作痛,痈肿,跌扑损伤。选用泽泻是因为其性味甘,寒,入膀胱经,有利水,渗湿,泄热的功能,治小便不利,水肿肛满,呕吐,泻痢,痰饮,脚气,淋病,尿血。选用党参是因为其性味甘,平,入手、足太阴经气分,有补中益气,生津的功能,治脾胃虚弱,气血两亏,体倦无力,食少,口渴,久泻,脱肛。选用赤芍是因为其性味苦,微寒,归肝经,有清热凉血,散瘀止痛的功能,治温毒发狂,吐血衄血,目赤肿痛,肝郁胁痛,经闭痛经,癎瘕腹痛,跌扑损伤,痈肿疮疡。选用香附是因为其性味辛微苦干,平,入肝、三焦经,有理气解郁,止痛调经的功能,治肝胃不和,气郁不舒,胸腹胁肋胀痛,痰饮痞满,月经不调,崩漏带下。选用甘草是因为其性味甘平,入脾、胃、肺经,有和中缓急,润肺,解毒,调和诸药的功能,炙用治脾胃虚弱,食少,腹痛便溏,劳倦发热,肺痿咳嗽,心悸,惊痈,生用治咽喉肿痛,消化性溃疡,痈疽疮疡,解药毒及食物中毒。选用僵蚕是因为其性味辛、咸,平,归肝,肺经。祛风解痉,化痰散结。用于中风口眼歪斜,惊痫抽搐,头赐,喉痹,瘰疠结核,风疹丹毒。选用五灵脂是因为其性味苦甘,温,入肝、脾经,生用有行血止痛的功能,治心腹血气诸痛,妇女经闭,产后瘀血作痛;外治蛇、蝎、蜈蚣咬伤,炒用止血,治妇女血崩,经水过多,赤带不绝。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
鸡骨草20-30克、马鞭草15-20克、八月札10-20克、半枝莲10-20克、薏苡仁5-15克、龙葵10-20克、五倍子5-10克、陈皮10-15克、儿茶5-15克、水蛭5-10克、徐长卿10-20克、山豆根10-15克、茵陈蒿10-20克、丹参5-15克、白芍10-15克、佛手柑10-20克、鳖甲10-15克、三棱10-15克、龟版10-15克、 乳香5-10克、没药5-10克、天仙藤10-20克、青黛5-10克、桃仁5-15克、川芎10-15克、郁金10-20克、红花5-10克、泽泻10-15克、党参10-20克、赤芍5-10克、香附5-15克、甘草10-15克、僵蚕5-10克、五灵脂5-15克。
优选为:
鸡骨草25克、马鞭草18克、八月札15克、半枝莲15克、薏苡仁10克、龙葵15克、五倍子8克、陈皮12克、儿茶10克、水蛭8克、徐长卿15克、山豆根12克、茵陈蒿15克、丹参10克、白芍12克、佛手柑15克、鳖甲12克、三棱12克、龟版12克、 乳香8克、没药8克、天仙藤15克、青黛8克、桃仁10克、川芎12克、郁金15克、红花8克、泽泻12克、党参15克、赤芍8克、香附10克、甘草12克、僵蚕8克、五灵脂10克。
本发明药物的制备方法如下
一、备料
1、鸡骨草:洗净,切片,晒干;
2、马鞭草:拣净杂质,洗净,润软切段,晒干;
3、八月札:洗净,稍浸,闷润至透,切片晒干,或洗净晒干,用时捣碎;
4、半枝莲:春、夏季开花期采收,拔取全株,除去泥沙,晒干;
5、薏苡仁:取原药材,除去残留皮壳、杂质;
6、龙葵:取原药材,除去老梗、杂质,洗净,稍润,切段,干燥;
7、五倍子:拣净、敲开、剔去其中杂质;
8、陈皮:取原药材,除去杂质及变黑的果皮,抢水洗净,润软,切丝,晒干或低温干燥,筛去灰屑;
9、儿茶:除去杂质,用时捣碎;
10、水蛭:洗净,闷软,切段,晒干;
11、徐长卿:拣净杂质,洗净,润透,切成1.5厘米段,晒干;
12、山豆根:拣净杂质,粗细分档,用水浸泡,捞出,润透后切片,晒干;
13、茵陈蒿:过筛,拣去杂质,除去残根,碾碎,再过箩去净泥屑;
14、丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干;
15、白芍:拣去杂质,分开大小个,用水浸泡至八成透,捞出,晒晾,润至内外湿度均匀,切片,干燥;
16、佛手柑:拣去杂质,用水喷润后,切碎,晒干;
17、鳖甲:用水浸泡,去净皮肉,洗净,晒干;
18、三棱:拣净杂质,用水浸泡,捞出润透,切片,晒干;
19、龟版:用清水浸泡,刮去残肉,洗净,晒干,敲成小块;
20、乳香:拣去砂子杂质;
21、没药:拣去杂质,打成碎块;
22、天仙藤:拣去杂质,洗净泥土,闷润,切段晒干;
23、青黛:拣去杂质,过箩;
24、桃仁:除去硬壳杂质,置沸水锅中煮至外皮微皱,捞出,浸入凉水中,搓去种皮,晒干,簸净;
25、川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥;
26、郁金:用水浸泡,洗净,捞出晒晾,润透,切片,晒干;
27、红花:拣净杂质,除去茎叶、蒂头,晒干;
28、泽泻:拣去杂质,大小分档,用水浸泡至八成透,捞出,晒凉,闷润至内外湿度均匀,切片,晒干;
29、党参:洗净泥沙后润透去芦,切片或切段,晒干;
30、赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑;
31、香附:拣去杂质,碾成碎粒,簸去细毛及细末;
32、甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,凉干;
33、僵蚕:取原药材,除去残丝,杂质;
34、五灵脂:拣净杂质,打碎或筛去灰屑。
二、制备
1、将所述重量的鸡骨草、马鞭草、八月札、半枝莲、薏苡仁、龙葵、五倍子、陈皮、儿茶、水蛭、徐长卿、山豆根、茵陈蒿、丹参、白芍、佛手柑、鳖甲、三棱、龟版、 乳香、没药、天仙藤、青黛、桃仁、川芎、郁金、红花、泽泻、党参、赤芍、香附、甘草、僵蚕、五灵脂放入煎药容器内,加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
2、将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
3、将两次煎煮液混合搅拌均匀,分为4剂服用。
组方中鸡骨草清热解毒,舒肝散瘀,马鞭草有清热解毒,活血散瘀,利水消肿的功能二者为君药;八月舒肝理气,活血止痛,除烦利尿,半枝莲有清热解毒、活血化瘀、利尿的功能,与薏苡仁、龙葵、五倍子、陈皮、儿茶为臣药,九味药共同发挥清热解毒、疏肝理气、活血散瘀、利水消肿、除烦利尿的作用,治疗肝癌效力全面,且以清热解毒、疏肝理气、活血散瘀为主,可治本;水蛭有破血,逐瘀,通经的功能与徐长卿、山豆根、茵陈蒿、丹参、白芍、佛手柑、鳖甲、三棱为佐药;龟版有滋阴,潜阳,补肾,健骨的功能与余下诸药为使药,是治标。
本发明药物具有清热解毒、疏肝理气、活血散瘀、滋阴潜阳、通经的功能,用于治疗肝癌,疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治肝癌门诊患者共52例。
2、诊断标准
典型症状为:肝区疼痛、腹胀、纳差、乏力、消瘦,进行性肝大或上腹部包块等。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,20天为一个疗程,连续服用3个疗程。
4、疗效评定标准
显效:肝癌症状消失,恢复正常,随访二年无复发;
好转:患者肝区疼痛、腹胀、纳差、乏力、消瘦,进行性肝大或上腹部包的现象减轻,肝癌症状明显好转,逐步恢复正常;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗肝癌患者52例,结果显效45例,显效率为86.53%,好转4例,好转率为7.7%,无效3例,总有效率为94.23%。
Claims (3)
1.一种治疗肝癌的药物,其特征在于:它是由下列重量范围内的原料药制成:
鸡骨草20-30克、马鞭草15-20克、八月札10-20克、半枝莲10-20克、薏苡仁5-15克、龙葵10-20克、五倍子5-10克、陈皮10-15克、儿茶5-15克、水蛭5-10克、徐长卿10-20克、山豆根10-15克、茵陈蒿10-20克、丹参5-15克、白芍10-15克、佛手柑10-20克、鳖甲10-15克、三棱10-15克、龟版10-15克、 乳香5-10克、没药5-10克、天仙藤10-20克、青黛5-10克、桃仁5-15克、川芎10-15克、郁金10-20克、红花5-10克、泽泻10-15克、党参10-20克、赤芍5-10克、香附5-15克、甘草10-15克、僵蚕5-10克、五灵脂5-15克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
鸡骨草25克、马鞭草18克、八月札15克、半枝莲15克、薏苡仁10克、龙葵15克、五倍子8克、陈皮12克、儿茶10克、水蛭8克、徐长卿15克、山豆根12克、茵陈蒿15克、丹参10克、白芍12克、佛手柑15克、鳖甲12克、三棱12克、龟版12克、 乳香8克、没药8克、天仙藤15克、青黛8克、桃仁10克、川芎12克、郁金15克、红花8克、泽泻12克、党参15克、赤芍8克、香附10克、甘草12克、僵蚕8克、五灵脂10克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)鸡骨草:洗净,切片,晒干;
(2)马鞭草:拣净杂质,洗净,润软切段,晒干;
(3)八月札:洗净,稍浸,闷润至透,切片晒干,或洗净晒干,用时捣碎;
(4)半枝莲:春、夏季开花期采收,拔取全株,除去泥沙,晒干;
(5)薏苡仁:取原药材,除去残留皮壳、杂质;
(6)龙葵:取原药材,除去老梗、杂质,洗净,稍润,切段,干燥;
(7)五倍子:拣净、敲开、剔去其中杂质;
(8)陈皮:取原药材,除去杂质及变黑的果皮,抢水洗净,润软,切丝,晒干或低温干燥,筛去灰屑;
(9)儿茶:除去杂质,用时捣碎;
(10)水蛭:洗净,闷软,切段,晒干;
(11)徐长卿:拣净杂质,洗净,润透,切成1.5厘米段,晒干;
(12)山豆根:拣净杂质,粗细分档,用水浸泡,捞出,润透后切片,晒干;
(13)茵陈蒿:过筛,拣去杂质,除去残根,碾碎,再过箩去净泥屑;
(14)丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干;
(15)白芍:拣去杂质,分开大小个,用水浸泡至八成透,捞出,晒晾,润至内外湿度均匀,切片,干燥;
(16)佛手柑:拣去杂质,用水喷润后,切碎,晒干;
(17)鳖甲:用水浸泡,去净皮肉,洗净,晒干;
(18)三棱:拣净杂质,用水浸泡,捞出润透,切片,晒干;
(19)龟版:用清水浸泡,刮去残肉,洗净,晒干,敲成小块;
(20)乳香:拣去砂子杂质;
(21)没药:拣去杂质,打成碎块;
(22)天仙藤:拣去杂质,洗净泥土,闷润,切段晒干;
(23)青黛:拣去杂质,过箩;
(24)桃仁:除去硬壳杂质,置沸水锅中煮至外皮微皱,捞出,浸入凉水中,搓去种皮,晒干,簸净;
(25)川芎:拣去杂质,分开大、小个,用水浸泡,晒晾,闷润后切片,干燥;
(26)郁金:用水浸泡,洗净,捞出晒晾,润透,切片,晒干;
(27)红花:拣净杂质,除去茎叶、蒂头,晒干;
(28)泽泻:拣去杂质,大小分档,用水浸泡至八成透,捞出,晒凉,闷润至内外湿度均匀,切片,晒干;
(29)党参:洗净泥沙后润透去芦,切片或切段,晒干;
(30)赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑;
(31)香附:拣去杂质,碾成碎粒,簸去细毛及细末;
(32)甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,凉干;
(33)僵蚕:取原药材,除去残丝,杂质;
(34)五灵脂:拣净杂质,打碎或筛去灰屑;
(二)制备
(1)将所述重量的鸡骨草、马鞭草、八月札、半枝莲、薏苡仁、龙葵、五倍子、陈皮、儿茶、水蛭、徐长卿、山豆根、茵陈蒿、丹参、白芍、佛手柑、鳖甲、三棱、龟版、 乳香、没药、天仙藤、青黛、桃仁、川芎、郁金、红花、泽泻、党参、赤芍、香附、甘草、僵蚕、五灵脂放入煎药容器内,加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合搅拌均匀,分为4剂服用。
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