CN108815467A - 一种治疗慢性胆囊炎的药物及其制备方法 - Google Patents

一种治疗慢性胆囊炎的药物及其制备方法 Download PDF

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CN108815467A
CN108815467A CN201810935164.1A CN201810935164A CN108815467A CN 108815467 A CN108815467 A CN 108815467A CN 201810935164 A CN201810935164 A CN 201810935164A CN 108815467 A CN108815467 A CN 108815467A
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陈怀银
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陈怀银
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Abstract

本发明公开了一种治疗慢性胆囊炎的药物及其制备方法,其主要是由茵陈蒿、黄芪、金钱草、生地黄、威灵仙、茯苓、瓦楞子、虎杖、薏苡仁、延胡索、大青叶、知母、郁金、牡蛎、紫花地丁、败酱、玉米须、龙胆、川楝子、莱菔子、鸡内金、乌药、牡丹皮、枳实、青皮、厚朴、陈皮按一定重量配比制备而成,本发明药物具有清热利湿、解毒、养阴生津、平肝利胆、理气健脾的功能,用于治疗慢性胆囊炎见效快、疗效好,不复发。

Description

一种治疗慢性胆囊炎的药物及其制备方法
技术领域
[0001] 本发明涉及一种治疗慢性胆囊炎的药物及其制备方法,属中药领域。 技术背景
[0002] 慢性胆囊炎是由急性或亚急性胆囊炎反复发作,或长期存在的胆囊结石所致胆囊 功能异常,约25%的患者存在细菌感染,其发病基础是胆囊管或胆总管梗阻。中医则认为慢 性胆囊炎与饮食停滞、肝气犯胃、肝胃郁热有关。由于西药治疗副作用大,因此人们对有效 治疗慢性胆囊炎的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报 道。
发明内容
[0003] 本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗慢性 胆囊炎的药物,从而完成了本发明。
[0004] 本发明的目的就是提供一种有效治疗慢性胆囊炎的中药组合药物。
[0005] 本发明的另一目的就是提供了该中药组合药物的制备方法。
[0006] 本发明是选择茵陈蒿、黄芪、金钱草、生地黄、威灵仙、茯苓、瓦楞子、虎杖、薏苡仁、 延胡索、大青叶、知母、郁金、牡蛎、紫花地丁、败酱、玉米须、龙胆、川楝子、莱菔子、鸡内金、 乌药、牡丹皮、枳实、青皮、厚朴、陈皮、香橼、火麻仁、海藻、甘草药物进行组合制备的,将这 些药物组合使得各药物功效产生协同作用,从而能够有效治疗慢性胆囊炎。其中选用茵陈 蒿是因为其性味苦辛,凉,入肝、脾、膀胱经,有清热利湿的功能,治湿热黄疸,小便不利,风 痒疮疥。选用黄芪是因为其性味甘,微温,入肺、脾经,生用有益卫固表,利水消肿,托毒,生 肌的功能,治自汗,盗汗,血痹,浮肿,痈疽不溃或溃久敛;炙用有补中益的功能,治内伤劳 倦,脾虚泄泻,脱肛,气虚血脱,崩带及一切气衰血虚之症。选用金钱草是因为其性味苦辛, 凉,有清热,利尿,镇咳,消肿,解毒的功能,治黄疸,水肿,膀胱结石,疟疾,肺痈,咳嗽,吐血, 淋浊,带下,风湿痹痛,小儿疳积,惊癎,痈肿,疮癣,湿疹。选用生地黄是因为其性味甘,寒, 归心、肝、肾经,有清热凉血,养阴,生津的功能,治热病烦渴,阴虚内热,骨蒸劳热,内热消 渴,吐血,衄血,发斑发疹。选用威灵仙是因为其性味辛咸,温,有毒,入膀胱经,有祛风湿,通 经络,消痰涎,散癖积的功能,治痛风、顽痹、腰膝冷痛,脚气,疟疾,癥瘕积聚,破伤风,扁桃 体炎,诸骨鲠咽。选用茯苓是因为其性味甘淡,平,入心、脾、肺经,有渗湿利水,益脾和胃,宁 心安神的功能,治小便不利水肿胀痛,痰饮咳逆,呕哕,泄泻,遗精,淋浊,惊悸,健忘。选用瓦 楞子是因为其性味甘,咸,平,入肝、脾经,有化痰,软坚,散瘀,消积的功能,治痰积,胃痛,嘈 杂,吐酸,癥瘕,瘰疬,牙疳。选用虎杖是因为其性味苦,平,有祛风,利湿,破瘀,通经的功能, 治风湿筋骨疼痛,湿热黄疸,淋浊带下,妇女经闭,产后恶露不下,癥瘕积聚,痔漏下血,跌扑 损伤,烫伤,恶疮癣疾。选用薏苡仁是因为其性味甘淡,凉,入脾、肺、肾经,有健脾,补肺,清 热,利湿的功能,治泄泻,湿痹,筋脉拘挛,屈伸不利,水肿,脚气,肺痿,肺痈,肠痈,淋浊,白 带。选用延胡索是因为其性味辛苦,温,入肝、胃经,有活血,散瘀,理气,止痛的功能,治心腹 腰膝诸痛,月经不调,癥瘕,崩中,产后血晕,恶露不尽,跌打损伤。选用大青叶是因为其性味 苦,寒,入肝、心、胃经,有清热,解毒,凉血,止血的功能,治温病热盛烦渴,流行性感冒,急性 传染性肝炎,菌痢,急性胃肠炎,急性肺炎,丹毒,吐血,衄血,黄疸,痢疾,喉痹,口疮,痈疽肿 毒。选用知母是因为其性味苦,寒,入肺、胃、肾经,有滋阴降火,润燥滑肠的功能,治烦热消 渴,骨蒸劳热,肺热咳嗽,大便燥结,小便不利。选用郁金是因为其性味辛苦,凉,入心、肺、肝 经,有行气解随,凉血破瘀的功能,治胸腹胁肋诸痛,失心癫狂,热病神昏,吐血,衄血,尿血, 血淋,妇女倒经,黄疸。选用牡蛎是因为其性味咸涩,凉,入肝、肾经,有敛阴,潜阳,止汗,涩 精的功能,治惊癎,眩晕,自汗,盗汗,遗精,淋浊,崩漏,带下,瘰疬,癭瘤。选用紫花地丁是因 为其性味苦、辛、寒,归心、肝经,有清热解毒,凉血消肿的功能,治疔疮肿毒,痈疽发背,丹 毒,毒蛇咬伤。选用败酱是因为其性味苦,平,入肝、胃、大肠经,有清热解毒,排脓破瘀的功 能,治肠痈,下痢,赤白带下,产后瘀滞腹痛,目赤肿痛,痈肿疥癣。选用玉米须是因为其性味 甘,平,有利尿,泄热,平肝,利胆的功能,治肾炎水肿,脚气,黄疸肝炎,高血压,胆囊炎,胆结 石,糖尿病,吐血衄血,鼻渊,乳痈。选用龙胆是因为其性味苦,寒,入肝、胆经,有泻肝实火, 除下焦湿热的功能,治肝经热盛,惊癎狂躁,乙型脑炎,头痛,目赤,咽痛,黄疸,热痢,痈肿疮 疡,阴囊肿痛,阴部湿痒。选用川楝子是因为其性味苦,寒,有毒,入肝、胃、小肠经,有降湿 热,清肝火,止痛,杀虫的功能,治热厥心痛,胁痛,疝痛,虫积腹痛。选用莱菔子是因为其性 味辛甘,平,入肺、胃经,有下气定喘,消食化痰的功能,治咳嗽痰喘,食积气滞,胸闷腹胀,下 痢后重。选用鸡内金是因为其性味甘,平,入脾、胃经,有治积滞,健脾胃的功能,治食积胀 满,呕吐反胃,泻痢,疳积,消渴,遗溺,喉痹乳蛾,牙疳口疮。选用乌药是因为其性味辛,温, 入脾、肺、肾、膀胱经,有顺气,开郁,散寒,止痛的功能,治气逆胸腹胀痛,宿食不满,反胃吐 食,寒疝,脚气,小便频数。选用牡丹皮是因为其性味辛苦,凉,入心、肝、肾经,有清热,凉血, 和血,消瘀的功能,治热入血分,发斑,惊癎,吐、衄、便血,骨蒸劳热,经闭,癥瘕,痈疡,扑损。 选用枳实是因为其性味苦,寒,入脾、胃经,有破气,散痞,泻痰,消积的功能,治胸腹胀痛,胸 痹,痞痛,痰癖,水肿,食积,便秘,胃下垂,子宫下垂,脱肛。选用青皮是因为其性味苦辛,微 温,入肝、胆经,有疏肝破气,散结消痰的功能,治胸胁胃脘疼痛,疝气,食积,乳肿,乳核,久 疟癖块。选用厚朴是因为其性味苦辛,温,入脾、胃、大肠经,有温中,下气,燥湿,消痰的功 能,治胸腹痞满胀痛,反胃、呕吐,宿食不消,痰饮喘咳,寒湿泻痢。选用陈皮是因为其性味 苦、辛,温,归肺、脾经,有理气健脾,燥湿化痰的功能,治胸脘胀满,食少吐泻,咳嗽痰多。选 用香橼是因为其性味辛苦酸,温,入肝、肺、脾经,有理气,舒郁,消痰,利膈的功能,治胃痛胀 满,痰饮咳嗽气壅,呕哕少食。选用火麻仁是因为其性味甘,平,入脾、胃、大肠经,有润燥,滑 肠,通淋,活血的功能,治肠燥便秘,消渴,热淋,风痹,痢疾,月经不调,疥疮,癣癫。选用海藻 是因为其性味苦咸,寒,入肺、脾、肾经,有软坚,消痰,利水,泄热的功能,治瘰疬,癭瘤,积 聚,水肿,脚气,睾丸肿痛。选用甘草是因为其性味甘平,入脾、胃、肺经,有和中缓急,润肺, 解毒,调和诸药的功能,炙用治脾胃虚弱,食少,腹痛便溏,劳倦发热,肺痿咳嗽,心悸,惊痈, 生用治咽喉肿痛,消化性溃疡,痈疽疮疡,解药毒及食物中毒。
具体实施方式 [0007] 本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重 量范围内都具有较好的疗效 茵陈蒿15-25克、黄芪15-20克、金钱草15-25克、生地黄10-20克、威灵仙5-15克、茯苓5-10克、瓦楞子10-20克、虎杖5-15克、薏苡仁10-15克、延胡索5-15克、大青叶5-15克、知母5-10克、郁金10-20克、牡蛎10-20克、紫花地丁10-15克、败酱5-15克、玉米须10-15克、龙胆5-10克、川楝子5-15克、莱菔子5-15克、鸡内金5-15克、乌药3-9克、牡丹皮10-20克、枳实5-15 克、青皮5-15克、厚朴10-15克、陈皮5-15克、香橼10-20克、火麻仁5-15克、海藻5-15克、甘草 10-20 克。
[0008] 优选为 茵陈蒿20克、黄芪18克、金钱草20克、生地黄15克、威灵仙10克、茯苓8克、瓦楞子15克、 虎杖10克、薏苡仁12克、延胡索10克、大青叶10克、知母8克、郁金15克、牡蛎15克、紫花地丁 12克、败酱10克、玉米须12克、龙胆8克、川楝子10克、莱菔子10克、鸡内金10克、乌药6克、牡 丹皮15克、枳实10克、青皮10克、厚朴12克、陈皮10克、香橼15克、火麻仁10克、海藻10克、甘 草15克。
[0009] 本发明药物的制备方法如下 一、备料 1、 茵陈蒿:过筛,拣去杂质,除去残根,碾碎,再过箩去净泥肩; 2、 黄芪:拣净杂质,除去残留的根头和空心较大者,用水浸泡,捞出,润透后及时切片, 晒干; 3、 金钱草:拣净杂质,筛去灰肩,晒干; 4、 生地黄:取原药材,除去杂质,洗净,稍润,切厚片,干燥,筛去碎肩; 5、 威灵仙:拣净杂质,除去残茎,用水浸泡,捞出润透,切段,晒干; 6、 茯苓:用水浸泡,洗净捞出,闷透后,切片,晒干; 7、 瓦楞子:洗净晒干,碾碎; 8、 虎杖:米得后,细挫,晒干; 9、 意该仁:取原药材,除去残留皮壳、杂质; 10、 延胡索:拣去杂质,用水浸泡,洗净,晒晾,润至内外湿度均匀,切片或打碎; 11、 大青叶:拣去杂质及枯叶,洗净,稍润,切段,晒干; 12、 知母:拣净杂质,用水撞洗,捞出,润软,切片晒干; 13、 郁金:用水浸泡,洗净,捞出晒晾,润透,切片,晒干; 14、 牡蛎:洗净,晒干,碾碎用; 15、 紫花地丁:取原药材,除去杂质,洗净,稍晾,切段,干燥; 16、 败酱:取原药材,除去杂质,用水喷淋,稍晾,切段,干燥; 17、 玉米须:取原药材,除去杂质,筛去灰肩; 18、 龙胆:拣去杂质,除去残茎,洗净,润透后切段,晒干; 19、 川楝子:拣去杂质,洗净,烘干,乳碎或劈成两半; 20、 莱菔子:簸去杂质,漂净泥土,捞出,晒干,用时捣碎; 21、 鸡内金:拣去杂质,漂净晒干; 22、 乌药:拣去杂质,分开大小条,用水泡透,根据季节注意换水,防止发臭,及时捞出切 片,筛去灰肩; 23、 牡丹皮:拣去杂质,除去木心,洗净,润透,切片,瞭干; 24、 枳实:拣净杂质,用水浸泡至八成透,捞出,润至内无硬心,切片,晾干; 25、 青皮:拣净杂质,用水浸泡,捞出,润透,切片,晒干; 26、 厚朴:用水浸泡捞出,润透后刮去粗皮,洗净,切丝,晾干; 27、 陈皮:取原药材,除去杂质及变黑的果皮,抢水洗净,润软,切丝,晒干或低温干燥, 筛去灰肩; 28、 香橼:取原药材,除去杂质,抢水洗净,稍润,切丝,低温干燥,筛去碎肩; 29、 火麻仁:拣去杂质及残留外壳,取净仁; 30、 海藻:拣去杂质,用水略漂,稍晾,切段,晒干; 31、 甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,凉干。
[0010] 二、制备 1、 将所述重量的茵陈蒿、黄芪、金钱草、生地黄、威灵仙、茯苓、瓦楞子、虎杖、薏苡仁、延 胡索、大青叶、知母、郁金、牡蛎、紫花地丁、败酱、玉米须、龙胆、川楝子、莱菔子、鸡内金、乌 药、牡丹皮、枳实、青皮、厚朴、陈皮、香橼、火麻仁、海藻、甘草放入煎药容器内,加水8倍量, 浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮 液倒入容器内; 2、 将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液; 3、 将两次煎煮液混合搅拌均匀,分为3剂服用。
[0011] 组方中茵陈蒿清热利湿,黄芪有益卫固表,利水消肿,托毒,生肌,补中益的功能二 者为君药;金钱草清热,利尿,镇咳,消肿,解毒,生地黄有清热凉血,养阴,生津的功能,与威 灵仙、茯苓、瓦楞子、虎杖、薏苡仁、延胡索、大青叶、知母、郁金、牡蛎、紫花地丁、败酱为臣 药,十六味药共同发挥清热利湿、益卫固表、补中益、解毒、养阴生津的作用,治疗慢性胆囊 炎效力全面,且以清热利湿、解毒、养阴生津为主,可治本;玉米须有利尿,泄热,平肝,利胆 的功能与龙胆、川楝子、莱菔子、鸡内金、乌药、牡丹皮、枳实、青皮、厚朴为佐药;陈皮有理气 健脾,燥湿化痰的功能与余下诸药为使药,是治标。
[0012] 本发明药物具有清热利湿、解毒、养阴生津、平肝利胆、理气健脾的功能,用于治疗 慢性胆囊炎,疗程短、见效快、治愈后不复发。
[0013] 以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发 明药物的动物毒性试验报告和临床疗效观察资料。
[0014] [试验例1]本发明药物的动物毒性试验报告: 取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验 组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给 药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良 毒副作用。
[0015] [试验例2]本发明药物的临床疗效观察 1、一般资料 收治慢性胆囊炎门诊患者共53例。
[0016] 2、诊断标准 典型症状为:长期出现右上腹隐痛、餐后上腹饱胀、嗳气等。
[0017] 3、治疗方法 选用上述药剂,给患者服用,每次服用1剂,每天早、中、晚各服1次,15天为一个疗程,连 续服用3个疗程。
[0018] 4、疗效评定标准 显效:慢性胆囊炎症状消失,恢复正常,痊愈; 好转:患者长期出现右上腹隐痛、餐后上腹饱胀、嗳气的现象减轻,慢性胆囊炎症状明 显好转,逐步恢复正常; 无效:达不到好转标准者。
[0019] 5、治疗结果(见下表)
Figure CN108815467AD00081
在上述治疗中,用本发明药物治疗慢性胆囊炎患者53例,结果显效43例,显效率为 81.13%,好转7例,好转率为13.21%,无效3例,总有效率为94.34%。

Claims (3)

1. 一种治疗慢性胆囊炎的药物,其特征在于:它是由下列重量范围内的原料药制成: 茵陈蒿15-25克、黄芪15-20克、金钱草15-25克、生地黄10-20克、威灵仙5-15克、茯苓5- 10克、瓦楞子10-20克、虎杖5-15克、薏苡仁10-15克、延胡索5-15克、大青叶5-15克、知母5-10克、郁金10-20克、牡蛎10-20克、紫花地丁10-15克、败酱5-15克、玉米须10-15克、龙胆5-10克、川楝子5-15克、莱菔子5-15克、鸡内金5-15克、乌药3-9克、牡丹皮10-20克、枳实5-15 克、青皮5-15克、厚朴10-15克、陈皮5-15克、香橼10-20克、火麻仁5-15克、海藻5-15克、甘草 10-20 克。
2. 根据权利要求1所述的药物,其中各原料药的用量为: 茵陈蒿20克、黄芪18克、金钱草20克、生地黄15克、威灵仙10克、茯苓8克、瓦楞子15克、 虎杖10克、薏苡仁12克、延胡索10克、大青叶10克、知母8克、郁金15克、牡蛎15克、紫花地丁 12克、败酱10克、玉米须12克、龙胆8克、川楝子10克、莱菔子10克、鸡内金10克、乌药6克、牡 丹皮15克、枳实10克、青皮10克、厚朴12克、陈皮10克、香橼15克、火麻仁10克、海藻10克、甘 草15克。
3. 根据权利要求1或2所述药物的制备方法,它包括下列步骤: (一)备料 (1) 茵陈蒿:过筛,拣去杂质,除去残根,碾碎,再过箩去净泥肩; (2) 黄芪:拣净杂质,除去残留的根头和空心较大者,用水浸泡,捞出,润透后及时切片, 晒干; (3) 金钱草:拣净杂质,筛去灰肩,晒干; (4) 生地黄:取原药材,除去杂质,洗净,稍润,切厚片,干燥,筛去碎肩; (5) 威灵仙:拣净杂质,除去残茎,用水浸泡,捞出润透,切段,晒干; ⑹茯苓:用水浸泡,洗净捞出,闷透后,切片,晒干; (7)瓦楞子:洗净晒干,碾碎; ⑻虎杖:采得后,细锉,晒干; (9) 意该仁:取原药材,除去残留皮壳、杂质; (10) 延胡索:拣去杂质,用水浸泡,洗净,晒晾,润至内外湿度均匀,切片或打碎; (11) 大青叶:拣去杂质及枯叶,洗净,稍润,切段,晒干; (12) 知母:拣净杂质,用水撞洗,捞出,润软,切片晒干; (13) 郁金:用水浸泡,洗净,携出晒晾,润透,切片,晒干; (14) 牡蛎:洗净,晒干,碾碎用; (15) 紫花地丁:取原药材,除去杂质,洗净,稍晾,切段,干燥; (16) 败酱:取原药材,除去杂质,用水喷淋,稍晾,切段,干燥; (17) 玉米须:取原药材,除去杂质,筛去灰肩; (18) 龙胆:拣去杂质,除去残茎,洗净,润透后切段,晒干; (19) 川楝子:拣去杂质,洗净,烘干,乳碎或劈成两半; (20) 莱菔子:簸去杂质,漂净泥土,捞出,晒干,用时捣碎; (21) 鸡内金:拣去杂质,漂净晒干; (22) 乌药:拣去杂质,分开大小条,用水泡透,根据季节注意换水,防止发臭,及时捞出 切片,筛去灰肩; (23) 牡丹皮:拣去杂质,除去木心,洗净,润透,切片,瞭干; (24) 枳实:拣净杂质,用水浸泡至八成透,捞出,润至内无硬心,切片,晾干; (25) 青皮:拣净杂质,用水浸泡,捞出,润透,切片,晒干; (26) 厚朴:用水浸泡捞出,润透后刮去粗皮,洗净,切丝,晾干; (27) 陈皮:取原药材,除去杂质及变黑的果皮,抢水洗净,润软,切丝,晒干或低温干燥, 筛去灰肩; (28) 香橼:取原药材,除去杂质,抢水洗净,稍润,切丝,低温干燥,筛去碎肩; (29) 火麻仁:拣去杂质及残留外壳,取净仁; (30) 海藻:拣去杂质,用水略漂,稍晾,切段,晒干; (31) 甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,凉干; (二)制备 (1) 将所述重量的茵陈蒿、黄芪、金钱草、生地黄、威灵仙、茯苓、瓦楞子、虎杖、薏苡仁、 延胡索、大青叶、知母、郁金、牡蛎、紫花地丁、败酱、玉米须、龙胆、川楝子、莱菔子、鸡内金、 乌药、牡丹皮、枳实、青皮、厚朴、陈皮、香橼、火麻仁、海藻、甘草放入煎药容器内,加水8倍 量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次 煎煮液倒入容器内; (2) 将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液; (3) 将两次煎煮液混合搅拌均匀,分为3剂服用。
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