CN108379520A - 一种治疗胃癌的药物及其制备方法 - Google Patents
一种治疗胃癌的药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗胃癌的药物及其制备方法,其主要是由神曲、延胡索、黄柏、紫草、马齿苋、苦参、半枝莲、虎杖、白花蛇舌草、瓦楞子、鸡内金、蛇蜕、党参、黄芪、地榆、石榴皮、升麻、败酱、鸡血藤、仙鹤草、白头翁、马钱子、赤芍、枸杞子、山药、芡实、郁金、甘草按一定重量配比制备而成,本发明药物具有健脾和胃、活血散瘀、清热解毒、滋阴降火、补中益气、燥湿消痰的功能,用于治疗胃癌见效快、疗效好,不复发。
Description
技术领域
本发明涉及一种治疗胃癌的药物及其制备方法,属中药领域。
技术背景
胃癌是起源于胃黏膜上皮的恶性肿瘤,胃癌可发生于胃的任何部位,其中半数以上发生于胃窦部,胃大弯、胃小弯及前后壁均可受累。中医则认为胃癌与肝胃不和、脾肾阳虚、瘀毒内阻、痰湿凝聚、气滞血瘀有关。由于西药治疗副作用大,因此人们对有效治疗胃癌的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗胃癌的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗胃癌的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明是选择神曲、延胡索、黄柏、紫草、马齿苋、苦参、半枝莲、虎杖、白花蛇舌草、瓦楞子、鸡内金、蛇蜕、党参、黄芪、地榆、石榴皮、升麻、败酱、鸡血藤、仙鹤草、白头翁、马钱子、赤芍、枸杞子、山药、芡实、郁金、甘草、佩兰、厚朴、太子参、海藻、槐花药物进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗胃癌。其中,选用神曲是因为其性味甘辛,温,入碑、胃经,有健脾和胃,消食调中的功能,治饮食停滞,胸痞腹胀,呕吐泻痢,产后瘀血腹痛,小儿腹大坚积。选用延胡索是因为其性味辛苦,温,入肝、胃经,有活血,散瘀,理气,止痛的功能,治心腹腰膝诸痛,月经不调,癥瘕,崩中,产后血晕,恶露不尽,跌打损伤。选用黄柏是因为其性味苦,寒,入肺、胃、肾经,有滋阴降火,润燥滑肠的功能,治烦热消渴,骨蒸劳热,肺热咳嗽,大便燥结,小便不利。选用紫草是因为其性味苦苦,寒,入心包络、肝经,有凉血,活血,清热解毒的功能,治温热斑疹,湿热黄疸,紫癜,吐、衄、尿血,淋浊,血痢,热结便秘,烧伤,湿疹,丹毒,痈疡。选用马齿苋是因为其性味酸,寒,入大肠、肝、脾经,有清热解毒,散血消肿的功能,治热痢脓血,热淋,血淋,带下,痈肿恶疮,丹毒,瘰疬。选用苦参是因为其性味苦,寒,入肝、肾、大肠、小肠经,有清热,燥湿,杀虫的功能,治热毒血痢,肠风下血,黄疸,赤白带下,小儿肺炎,疳积,急性扁桃体炎,痔漏,脱肛,皮肤瘙痒,阴疮湿痒,瘰疬,烫伤。选用半枝莲是因为其性味辛、苦,性寒。归肺经、肝经、肾经,有清热解毒、活血化瘀、利尿的功能,用于治疗晚期血吸虫病腹水、肝硬化腹水、毒蛇咬伤、疮疖痈肿。选用虎杖是因为其性味苦,平,有祛风,利湿,破瘀,通经的功能,治风湿筋骨疼痛,湿热黄疸,淋浊带下,妇女经闭,产后恶露不下,癥瘕积聚,痔漏下血,跌扑损伤,烫伤,恶疮癣疾。选用白花蛇舌草是因为其性味苦甘,寒,入心、肝、脾三经,有清热,利湿,解毒的功能,治肺热喘咳,扁桃体炎,咽喉炎,阑尾炎,痢疾,黄疸,盆腔炎,附件炎,痈肿疔疮,毒蛇咬伤。选用瓦楞子是因为其性味甘,咸,平,入肝、脾经,有化痰,软坚,散瘀,消积的功能,治痰积,胃痛,嘈杂,吐酸,癥瘕,瘰疬,牙疳。选用鸡内金是因为其性味甘,平,入脾、胃经,有消积滞,健脾胃的功能,治食积胀满,呕吐反胃,泻痢,疳积,消渴,遗溺,喉痹乳蛾,牙疳口疮。选用蛇蜕是因为其性平,味咸、甘,归肝经,有祛风、定惊、解毒、退翳的作用,用于治疗惊痫抽搐、目翳、风疹瘙痒、喉痹、口疮、耵耳、痈疽、疔毒、瘰疬、恶疮、烧烫伤。选用党参是因为其性味甘,平,入手、足太阴经气分,有补中益气,生津的功能,治脾胃虚弱,气血两亏,体倦无力,食少,口渴,久泻,脱肛。选用黄芪是因为其性味甘,微温,入肺、脾经,生用有益卫固表,利水消肿,托毒,生肌的功能,治自汗,盗汗,血痹,浮肿,痈疽不溃或溃久敛;炙用有补中益的功能,治内伤劳倦,脾虚泄泻,脱肛,气虚血脱,崩带及一切气衰血虚之症。选用地榆是因为其性味苦酸、寒。入肝、大肠经。凉血止血,清热解毒。治吐血,衄血,血痢,崩溃,肠风,痔漏,痈肿,湿疹,金疮,烧伤。选用石榴皮是因为其性味酸涩,温,有毒,入大肠、肾经,有涩肠,止血,驱虫的功能,治久泻,久痢,便血,脱肛,滑精,崩漏,带下,虫积腹痛,疥癣。选用升麻是因为其性味甘辛微苦,凉,入肺、脾、胃经,有升阳,发表,透疹,解毒的功能,治时气疫劳,头痛寒热,喉痛,口疮疤,斑疹不透,中气下陷,久泻久痢,脱肛,妇女崩带,子宫下坠,痈肿疮毒。选用败酱是因为其性味苦,平,入肝、胃、大肠经,有清热解毒,排脓破瘀的功能,治肠痈,下痢,赤白带下,产后瘀滞腹痛,目赤肿痛,痈肿疥癣。选用鸡血藤是因为其性味苦甘,温,入心、脾二经,有活血、舒筋的功能,治腰膝酸痛,麻木瘫痪,月经不调。选用仙鹤草是因为其性味苦辛,平,入肺、肝、脾经,有止血,健胃的功能,治咯血,吐血,尿血,便血,赤白痢疾,崩漏带下,劳伤脱力,痈肿,跌打、创伤出血。选用白头翁是因为其性味苦,寒,入大肠、肝、胃经,有清热凉血,解毒的功能,治热毒血痢,温疟寒热,鼻衄,血痔。选用马钱子是因为其性味苦,寒,有毒,有散血热,消肿,止痛的功能,治咽喉痹痛,痈疽肿毒,风痹疼痛,骨折,并治面神经麻痹,重症肌无力选用赤芍是因为其性味苦,微寒,归肝经,有清热凉血,散瘀止痛的功能,治温毒发狂,吐血衄血,目赤肿痛,肝郁胁痛,经闭痛经,癎瘕腹痛,跌扑损伤,痈肿疮疡。选用枸杞子是因为其性味甘,平,有滋肾,润肺,补肝,明目的功能,治肝肾阴亏,腰膝酸软,头晕目眩,目昏多泪,虚劳咳嗽,消渴,遗精。选用山药是因为其性味甘,平,入肺、脾、肾经,有健脾,补肺,固肾,益精的功能,治脾虚泄泻,久痢,虚劳咳嗽,消渴,遗精、带下,小便频数。选用芡实是因为其性味甘涩,平,入脾、肾经,有固肾涩精,补脾止泄,治遗精,淋浊,带下,小便不禁,大便泄泻。选用郁金是因为其性味辛苦,凉,入心、肺、肝经,有行气解随,凉血破瘀的功能,治胸腹胁肋诸痛,失心癫狂,热病神昏,吐血,衄血,尿血,血淋,妇女倒经,黄疸。选用甘草是因为其性味甘,平,入脾、胃、肺经,有和中缓急,润肺,解毒,调和诸药的功能,炙用,治脾胃虚弱,食少,腹痛便溏,劳倦发热,肺痿咳嗽,心悸,惊癎;生用,治咽喉肿痛,消化性溃疡,痈疽疮疡,解药毒及食物中毒。选用佩兰是因为其性味辛,平,入脾、胃经,有清暑,辟秽,化湿,调经的功能,治感受暑湿,寒热头痛,湿邪内蕴,脘痞不饥,口甘苔腻,月经不调。选用厚朴是因为其性味苦辛,温,入脾、胃、大肠经,有温中,下气,燥湿,消痰的功能,治胸腹痞满胀痛,反胃、呕吐,宿食不消,痰饮喘咳,寒湿泻痢。选用太子参是因为其性味甘苦,微温,入心、脾、肺三经,有补肺、健脾的功能,治肺虚咳嗽,脾虚食少,心悸目汗,精神疲乏。选用海藻是因为其性味苦咸,寒,入肺、脾、肾经,有软坚,消痰,利水,泄热的功能,治瘰疬,瘿瘤,积聚,水肿,脚气,睾丸肿痛。选用槐花是因为其性味苦,凉,入肝、大肠经,有清热,凉血,止血的功能,治肠风便血,痔血,尿血,血淋,崩漏,衄血,赤白痢下,风热目赤,痈疽疮毒,并用于预防中风。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
神曲10-20克、延胡索10-15克、黄柏10-15克、紫草10-20克、马齿苋10-20克、苦参10-15克、半枝莲5-15克、虎杖10-15克、白花蛇舌草10-20克、瓦楞子10-15克、鸡内金10-20克、蛇蜕5-10克、党参10-15克、黄芪5-15克、地榆5-15克、石榴皮10-15克、升麻5-15克、败酱10-20克、鸡血藤10-15克、仙鹤草10-20克、白头翁10-20克、马钱子2-4毫克、赤芍5-15克、枸杞子5-15克、山药10-15克、芡实5-15克、郁金10-15克、甘草5-15克、佩兰5-15克、厚朴10-15克、太子参5-15克、海藻10-15克、槐花5-15克。
优选为:
神曲15克、延胡索12克、黄柏12克、紫草15克、马齿苋15克、苦参12克、半枝莲10克、虎杖12克、白花蛇舌草15克、瓦楞子12克、鸡内金15克、蛇蜕8克、党参12克、黄芪10克、地榆10克、石榴皮12克、升麻10克、败酱15克、鸡血藤12克、仙鹤草15克、白头翁15克、马钱子3毫克、赤芍10克、枸杞子10克、山药12克、芡实10克、郁金12克、甘草10克、佩兰10克、厚朴12克、太子参10克、海藻12克、槐花10克。
本发明药物的制备方法如下
一、备料
1、神曲:取麸皮撒匀于热锅内,俟起烟,将神曲倒入,炒至黄色,取出,筛去麸皮,放凉;
2、延胡索:拣去杂质,用水浸泡,洗净,晒晾,润至内外湿度均匀,切片或打碎;
3、黄柏:拣去杂质,用水洗净,捞出,润透,切片或切丝,晒干;
4、紫草:洗净,润透,切片,晒干;
5、马齿苋:拣净杂质,除去残根,以水稍润,切段晒干;
6、苦参:拣净杂质,除去残茎,洗净泥土,用水浸泡,捞出,润透,切片,晒干;
7、半枝莲:春、夏季开花期采收,拔取全株,除去泥沙,晒干;
8、虎杖:采得后,细锉,晒干;
9、白花蛇舌草:取原药材,除去杂质,抢水洗净,稍晾,切段,干燥,筛去灰屑;
10、瓦楞子:洗净晒干,碾碎;
11、鸡内金:拣去杂质,漂净晒干;
12、蛇蜕:春末夏初或冬初采集,除去泥沙,干燥;
13、党参:洗净泥沙后润透去芦,切片或切段,晒干;
14、黄芪:拣净杂质,除去残留的根头和空心较大者,用水浸泡,捞出,润透后及时切片,晒干;
15、地榆:拣去杂质,用水洗净,稍浸泡,润透,切成厚片,晒干;
16、石榴皮:拣去杂质,去净残留的内瓤及子,洗净,切块,晒干;
17、升麻:拣去杂质,略泡洗净,捞出,润透,切片,晒干;
18、败酱:取原药材,除去杂质,用水喷淋,稍晾,切段,干燥;
19、鸡血藤:用水润透,切片,或蒸软后乘热切片,晒干;
20、仙鹤草:除去杂质残根,洗净,润透,切断,晒干;
21、白头翁:拣净杂质,洗净,润透后切片,晒干;
22、马钱子:取原药材,除去杂质;
23、赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑;
24、枸杞子:簸净杂质,摘去残留的梗和蒂;
25、山药:拣净杂质,用水浸泡至山药中心部软化为度,捞出稍晾,切片晒干或烘干;
26、芡实:先将麸皮放热锅内炒至烟起,再将净芡实倒入,拌炒至微黄色,取出,筛净麸皮,放凉;
27、郁金:用水浸泡,洗净,捞出晒晾,润透,切片,晒干;
28、甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透切片,晒干;
29、佩兰:拣净杂质,用水洗净,捞出,稍润后,除去残根,切段,晒干;
30、厚朴:用水浸泡捞出,润透后刮去粗皮,洗净,切丝,晾干;
31、太子参:摘除须根,晒干;
32、海藻:拣去杂质,用水略漂,稍晾,切段,晒干;
33、槐花:取原药材,除去梗、叶及杂质,筛去灰屑。
二、制备
1、将所述重量的神曲、延胡索、黄柏、紫草、马齿苋、苦参、半枝莲、虎杖、白花蛇舌草、瓦楞子、鸡内金、蛇蜕、党参、黄芪、地榆、石榴皮、升麻、败酱、鸡血藤、仙鹤草、白头翁、马钱子、赤芍、枸杞子、山药、芡实、郁金、甘草、佩兰、厚朴、太子参、海藻、槐花放入煎药容器内,加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
2、将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
3、将两次煎煮液混合搅拌均匀,分为4剂服用。
组方中神曲健脾和胃,消食调中,延胡索有活血,散瘀,理气,止痛的功能二者为君药;黄柏滋阴降火,润燥滑肠,紫草有凉血,活血,清热解毒的功能,与马齿苋、苦参、半枝莲、虎杖、白花蛇舌草、瓦楞子、鸡内金、蛇蜕为臣药,九味药共同发挥健脾和胃、活血散瘀、清热解毒、滋阴降火、润燥滑肠的作用,治疗胃癌效力全面,且以健脾和胃、活血散瘀、清热解毒、滋阴降火为主,可治本;党参有补中益气,生津的功能与黄芪、地榆、石榴皮、升麻、败酱、鸡血藤、仙鹤草、白头翁、马钱子为佐药;厚朴有温中,下气,燥湿,消痰的功能与余下诸药为使药,是治标。
本发明药物具有健脾和胃、活血散瘀、清热解毒、滋阴降火、补中益气、燥湿消痰的功能,用于治疗胃癌,疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治胃癌门诊患者共25例。
2、诊断标准
典型症状为:食欲下降、恶心厌食、消化不良、胃区疼痛、腹痛、贫血、水肿、发热等。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,15天为一个疗程,连续服用3个疗程。
4、疗效评定标准
显效:胃癌症状消失,恢复正常,随访一年无复发;
好转:患者食欲下降、恶心厌食、消化不良、胃区疼痛、腹痛、贫血、水肿、发热的现象减轻,胃癌症状明显好转,逐步恢复正常;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗胃癌患者25例,结果显效20例,显效率为72%,好转5例,好转率为20%,无效2例,总有效率为92%。
Claims (3)
1.一种治疗胃癌的药物,其特征在于:它是由下列重量范围内的原料药制成:
神曲10-20克、延胡索10-15克、黄柏10-15克、紫草10-20克、马齿苋10-20克、苦参10-15克、半枝莲5-15克、虎杖10-15克、白花蛇舌草10-20克、瓦楞子10-15克、鸡内金10-20克、蛇蜕5-10克、党参10-15克、黄芪5-15克、地榆5-15克、石榴皮10-15克、升麻5-15克、败酱10-20克、鸡血藤10-15克、仙鹤草10-20克、白头翁10-20克、马钱子2-4毫克、赤芍5-15克、枸杞子5-15克、山药10-15克、芡实5-15克、郁金10-15克、甘草5-15克、佩兰5-15克、厚朴10-15克、太子参5-15克、海藻10-15克、槐花5-15克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
神曲15克、延胡索12克、黄柏12克、紫草15克、马齿苋15克、苦参12克、半枝莲10克、虎杖12克、白花蛇舌草15克、瓦楞子12克、鸡内金15克、蛇蜕8克、党参12克、黄芪10克、地榆10克、石榴皮12克、升麻10克、败酱15克、鸡血藤12克、仙鹤草15克、白头翁15克、马钱子3毫克、赤芍10克、枸杞子10克、山药12克、芡实10克、郁金12克、甘草10克、佩兰10克、厚朴12克、太子参10克、海藻12克、槐花10克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)神曲:取麸皮撒匀于热锅内,俟起烟,将神曲倒入,炒至黄色,取出,筛去麸皮,放凉;
(2)延胡索:拣去杂质,用水浸泡,洗净,晒晾,润至内外湿度均匀,切片或打碎;
(3)黄柏:拣去杂质,用水洗净,捞出,润透,切片或切丝,晒干;
(4)紫草:洗净,润透,切片,晒干;
(5)马齿苋:拣净杂质,除去残根,以水稍润,切段晒干;
(6)苦参:拣净杂质,除去残茎,洗净泥土,用水浸泡,捞出,润透,切片,晒干;
(7)半枝莲:春、夏季开花期采收,拔取全株,除去泥沙,晒干;
(8)虎杖:采得后,细锉,晒干;
(9)白花蛇舌草:取原药材,除去杂质,抢水洗净,稍晾,切段,干燥,筛去灰屑;
(10)瓦楞子:洗净晒干,碾碎;
(11)鸡内金:拣去杂质,漂净晒干;
(12)蛇蜕:春末夏初或冬初采集,除去泥沙,干燥;
(13)党参:洗净泥沙后润透去芦,切片或切段,晒干;
(14)黄芪:拣净杂质,除去残留的根头和空心较大者,用水浸泡,捞出,润透后及时切片,晒干;
(15)地榆:拣去杂质,用水洗净,稍浸泡,润透,切成厚片,晒干;
(16)石榴皮:拣去杂质,去净残留的内瓤及子,洗净,切块,晒干;
(17)升麻:拣去杂质,略泡洗净,捞出,润透,切片,晒干;
(18)败酱:取原药材,除去杂质,用水喷淋,稍晾,切段,干燥;
(19)鸡血藤:用水润透,切片,或蒸软后乘热切片,晒干;
(20)仙鹤草:除去杂质残根,洗净,润透,切断,晒干;
(21)白头翁:拣净杂质,洗净,润透后切片,晒干;
(22)马钱子:取原药材,除去杂质;
(23)赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑;
(24)枸杞子:簸净杂质,摘去残留的梗和蒂;
(25)山药:拣净杂质,用水浸泡至山药中心部软化为度,捞出稍晾,切片晒干或烘干;
(26)芡实:先将麸皮放热锅内炒至烟起,再将净芡实倒入,拌炒至微黄色,取出,筛净麸皮,放凉;
(27)郁金:用水浸泡,洗净,捞出晒晾,润透,切片,晒干;
(28)甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透切片,晒干;
(29)佩兰:拣净杂质,用水洗净,捞出,稍润后,除去残根,切段,晒干;
(30)厚朴:用水浸泡捞出,润透后刮去粗皮,洗净,切丝,晾干;
(31)太子参:摘除须根,晒干;
(32)海藻:拣去杂质,用水略漂,稍晾,切段,晒干;
(33)槐花:取原药材,除去梗、叶及杂质,筛去灰屑;
(二)制备
(1)将所述重量的神曲、延胡索、黄柏、紫草、马齿苋、苦参、半枝莲、虎杖、白花蛇舌草、瓦楞子、鸡内金、蛇蜕、党参、黄芪、地榆、石榴皮、升麻、败酱、鸡血藤、仙鹤草、白头翁、马钱子、赤芍、枸杞子、山药、芡实、郁金、甘草、佩兰、厚朴、太子参、海藻、槐花放入煎药容器内,加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合搅拌均匀,分为4剂服用。
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