CN106421430A - 一种治疗甲状腺功能亢进的药物及其制备方法 - Google Patents
一种治疗甲状腺功能亢进的药物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗甲状腺功能亢进的药物及其制备方法,其主要是由山茱萸、龙骨、知母、夏枯草、麦冬、太子参、墨旱莲、莲子、酸枣仁、玄参、独活、昆布、刺蒺藜、茺蔚子、马齿苋、忍冬藤、石斛、白芍、远志、葶苈子、浙贝母按一定重量配比制备而成,本发明药物具有补肝肾,清肝散结,养阴润肺,清心除烦,祛痰解郁,敛汗的功能,用于治疗甲状腺功能亢进见效快、疗效好,不复发。
Description
技术领域
本发明涉及一种治疗甲状腺功能亢进的药物及其制备方法,属中药领域。
背景技术
甲状腺功能亢进是由于甲状腺合成释放过多的甲状腺激素,造成机体代谢亢进和交感神经兴奋,引起心悸、出汗、进食和便次增多和体重减少的病症。中医则认为甲状腺功能亢进与肝肾阴虚,肝火旺盛,肝郁气滞,痰湿凝聚,气阴两虚有关。由于西药治疗副作用大,因此人们对有效治疗甲状腺功能亢进的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗甲状腺功能亢进的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗甲状腺功能亢进的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择山茱萸、龙骨、知母、夏枯草、麦冬、太子参、墨旱莲、莲子、酸枣仁、玄参、独活、昆布、刺蒺藜、茺蔚子、马齿苋、忍冬藤、石斛、白芍、桔梗、柴胡、牡丹皮、茯苓、决明子、大枣、桂枝、龙胆、远志、葶苈子、浙贝母、牡蛎、南沙参、黄药子进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗甲状腺功能亢进。其中选用山茱萸是因为其性味酸,微温,入肝、肾经,有补肝肾,涩精气,固虚脱的功能,治腰膝酸痛,眩晕,耳鸣,阳痿,遗精,小便频数,肝虚寒热,虚汗不止,心摇脉散。选用龙骨是因为其性味甘涩,平,入心、肝、肾、大肠经,有镇惊安神,敛汗固精,止血涩肠,生肌敛疮的功能,治惊癎癫狂,怔忡健忘,失眠多梦,自汗盗汗,遗精淋浊,吐衄便血,崩漏带下,泻痢脱肛,溃疡久不收口。选用知母是因为其性味苦,寒,入肺、胃、肾经,有滋阴降火,润燥滑肠的功能,治烦热消渴,骨蒸劳热,肺热咳嗽,大便燥结,小便不利。选用夏枯草是因为其性味苦辛,寒,入肝、胆经,有清肝,散结的功能,治瘰疬,瘿瘤,乳痈,乳癌,目珠夜痛,羞明流泪,头目眩晕,口眼歪斜,筋骨疼痛,肺结核,急性黄疸型传染性肝炎,血崩,带下。选用麦冬是因为其性味甘微苦,寒,入肺、胃、心经,有养阴润肺,清心除烦,益胃生津的功能,治肺燥干咳,吐血,咯血,肺痿,肺痈,虚劳烦热,清渴,热病津伤,咽干口燥,便秘。选用太子参是因为其性味甘苦,微温,入心、脾、肺三经,有补肺、健脾的功能,治肺虚咳嗽,脾虚食少,心悸目汗,精神疲乏。选用墨旱莲是因为其性味苦酸,凉,入肝、肾经,有凉血,止血,补肾,益阴的功能,治吐血,咳血,衄血,尿血,便血,血痢,刀伤出血,须发早白,白喉,淋浊,滞下,阴部湿痒。选用莲子是因为其性味甘涩,平,入心、脾、肾经,有养心,益肾,补脾,涩肠的功能,治夜寐多梦,遗精,淋浊,久痢,虚泻,妇人崩漏带下。选用酸枣仁是因为其性味甘,平,入心、脾、肝、胆经,有养肝,宁心,安神,敛汗的功能,治虚烦不眠,惊悸怔忡,烦渴,虚汗。选用玄参是因为其性味苦,咸,凉,入肺、肾经,有滋阴,降火,除烦,解毒的功能,治热病烦渴,发斑,骨蒸劳热,夜寐不宁,自汗盗汗,津伤便秘,吐血衄血,咽喉肿痛,痈肿,瘰疬。选用独活是因为其性味辛苦,温,入肾、膀胱经,有祛风,胜湿,散寒,止痛的功能,治风寒湿痹,腰漆酸痛,手脚挛痛,慢性气管炎,头痛,齿痛。选用昆布是因为其性味咸,寒,入胃经,有软坚,行水的功能,治瘰疬,瘿瘤,噎膈,水肿,睾丸肿痛,带下。选用刺蒺藜是因为其性味苦辛,温,入肝、肺经,有散风,明目,下气,行血的功能,治头痛,身痒,目赤肿翳,胸满,咳逆,癥瘕,乳难,痈疽,瘰疬。选用茺蔚子是因为其性味甘辛,凉,入心胞、肝经,有活血调经,疏风清热的功能,治妇女月经不调,崩中带下,产后瘀血作痛,肝热头痛,目赤肿痛,或生翳膜。选用马齿苋是因为其性味酸,寒,入大肠、肝、脾经,有清热解毒,散血消肿的功能,治热痢脓血,热淋,血淋,带下,痈肿恶疮,丹毒,瘰疬。选用忍冬藤是因为其性味甘,寒,入心、肺经,有清热,解毒,通络的功能,治温病发热,热毒血痢,传染性肝炎,痈肿疮毒,筋骨疼痛。选用石斛是因为其性味甘淡微咸,寒,入有、肺、肾经,有生津益胃,清热养阴的功能,治热病伤津,口干烦喝,病后虚热,阴伤目暗。选用白芍是因为其性味苦酸,凉,入肝、脾经,有养血柔肝,缓中止痛,敛阴收汗的功能,治胸腹胁肋疼痛,泻痢腹痛,自汗盗汗,阴虚发热,月经不调,崩漏,带下。选用桔梗是因为其性味苦辛,平,入肺、胃经,有开宣肺气,祛痰排脓的功能,治外感咳嗽,咽喉肿痛,肺痈吐脓,胸满胁痛,痢疾腹痛。选用柴胡是因为其性味苦,凉,入肝、胆经,有和解表里,疏肝,升阳的功能,治寒热往来,胸满胁痛,口苦耳聋,头痛目眩,疟疾,下利脱肛,月经不调,子宫下垂。选用牡丹皮是因为其性味辛苦,凉,入心、肝、肾经,有清热,凉血,和血,消瘀的功能,治热入血分,发斑,惊癎,吐、衄、便血,骨蒸劳热,经闭,癥瘕,痈疡,扑损。选用茯苓是因为其性味甘淡,平,入心、脾、肺经,有渗湿利水,益脾和胃,宁心安神的功能,治小便不利,水肿胀满,痰饮咳逆,呕哕,泄泻,遗精,淋浊,惊悸,健忘。选用决明子是因为其性味苦甘,凉,入肝、肾经,有清肝,明目,利水,通便的功能,治风热赤眼,青盲,雀目,高血压,肝炎,肝硬化腹化,习惯性便秘。选用大枣是因为其性味甘,温,入脾、胃经,有补脾和胃,益气生津,调营卫,解药毒的功能,治胃虚食少,脾弱便溏,气血津液不足,营卫不和,心悸怔忡,妇人脏躁。选用桂枝是因为其性味辛甘,温,入膀胱、心、肺经,有发汗解肌,温经通脉的功能,治风寒表证,肩背肢节酸疼,胸痹痰饮,经闭癥瘕。选用龙胆是因为其性味苦,寒,入肝、胆经,有泻肝实火,除下焦湿热的功能,治肝经热盛,惊癎狂躁,乙型脑炎,头痛,目赤,咽痛,黄疸,热痢,痈肿疮疡,阴囊肿痛,阴部湿痒。选用远志是因为其性味苦辛,温,入心、肾经,有安神益智,祛痰,解郁的功能,治惊悸,健忘,梦遗,失眠,咳嗽多痰,痈疽疮肿。选用葶苈子是因为其性味辛,苦,大寒,归肺、膀胱经,有泻肺平喘,利水消肿的功能,治痰涎壅肺,咳喘痰多,胸胁胀满,胸腹水肿,小便不利及肺源性心脏病水肿。选用浙贝母是因为其性味苦,微寒,归肺、心经,有清热散结,化痰止咳的功能,治风热犯肺,痰火咳嗽,肺痈,乳痈,瘰疬,疮毒,心胸郁闷。选用牡蛎是因为其性味咸涩,凉,入肝、肾经,有敛阴,潜阳,止汗,涩精,化痰,软坚的功能,治惊癎,眩晕,自汗,盗汗,遗精,淋浊,崩漏,带下,瘰疬,瘿瘤。选用南沙参是因为其性味甘微苦,凉,入肺、肝经,有养阴清肺,祛痰止咳的功能,治肺热燥咳,虚痨久咳,阴伤咽干喉痛。选用黄药子是因为其性味苦平,入少手阴、足厥阴经,有凉血,降火,消瘿,解毒的功能,治吐血,衄血,喉痹,瘿气,疮痈瘰疬。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
山茱萸5-15克,龙骨10-20克,知母10-20克,夏枯草15-25克,麦冬10-15克,太子参10-20克,墨旱莲10-20克,莲子5-15克,酸枣仁10-20克,玄参10-15克,独活10-20克,昆布10-20克,刺蒺藜10-20克,茺蔚子10-15克,马齿苋10-20克,忍冬藤10-20克,石斛5-15克,白芍5-15克,桔梗10-20克,柴胡5-15克,牡丹皮10-20克,茯苓10-20克,决明子5-15克,大枣5-15克,桂枝10-15克,龙胆10-20克,远志5-15克,葶苈子5-15克,浙贝母10-15克,牡蛎10-20克,南沙参10-20克,黄药子10-20克。
优选为:
山茱萸10克,龙骨15克,知母15克,夏枯草20克,麦冬12克,太子参15克,墨旱莲15克,莲子10克,酸枣仁15克,玄参12克,独活15克,昆布15克,刺蒺藜15克,茺蔚子12克,马齿苋15克,忍冬藤15克,石斛10克,白芍10克,桔梗15克,柴胡10克,牡丹皮15克,茯苓15克,决明子10克,大枣10克,桂枝12克,龙胆15克,远志10克,葶苈子10克,浙贝母12克,牡蛎15克,南沙参15克,黄药子15克。
本发明药物的制备方法如下
一、备料
1、山茱萸:洗净,除去果核及杂质,晒干;
2、龙骨:刷净泥土,打碎;
3、知母:拣净杂质,用水撞洗,捞出,润软,切片晒干;
4、夏枯草:取原药材,除去枝梗、叶片及杂质,筛去灰屑;
5、麦冬:拣净杂质,用水浸泡,捞出,润透后抽去心,再洗净晒干;
6、太子参:摘除须根,晒干;
7、墨旱莲:拣净杂质,除去残根,洗净闷透,切段晒干;
8、莲子:拣尽杂质,或砸碎、去皮、去心;
9、酸枣仁:原药放入竹箩内,沉入清水缸中,使仁浮在水面,壳沉水底,将枣仁捞出,晒干;
10、玄参:拣净杂质,除去芦头,洗净润透,切片,晾干;
11、独活:拣去杂质,分开大小个,洗净,润透后切片,干燥;
12、昆布:拣去杂质,用水漂净,切成宽丝,晾干;
13、刺蒺藜:漂去泥沙,除净残留的硬刺;
14、茺蔚子:果实成熟时割取全株,晒干,打下果实,拣去枝叶,筛净杂质;
15、马齿苋:拣净杂质,除去残根,以水稍润,切段晒干;
16、忍冬藤:拣去杂质,用水浸泡,润透,切片,晒干;
17、石斛:取干燥的石斛,用水泡至八成透,闷润,除去残根及黑枝,切段,撞去薄膜,晒干;
18、白芍:拣去杂质,分开大小个,用水浸泡至八成透,捞出,晒晾,润至内外湿度均匀,切片,干燥;
19、桔梗:拣净杂质,除去芦头,洗净捞出,润透后切片,晒干;
20、柴胡:拣去杂质,除去残茎,洗净泥沙,捞出,润透后及时切片,随即晒干;
21、牡丹皮:拣去杂质,除去木心,洗净,润透,切片,晾干;
22、茯苓:用水浸泡,洗净,捞出,闷透后,切片,晒干;
23、决明子:取净决明子,置锅内炒至微有香气,取出,放凉;
24、大枣:拣净杂质,晒干;
25、桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去屑;
26、龙胆:拣去杂质,除去残茎,洗净,润透后切段,晒干;
27、远志:拣去杂质,切段,筛去灰屑;
28、葶苈子:拣净杂质,筛去灰屑;
29、浙贝母:除去杂质,大小分档,洗净,润透,切片,干燥,街去碎屑,或打碎;
30、牡蛎:洗净,晒干,碾碎;
31、南沙参:拣净杂质,去芦,用水洗净,略润,切片,筛净晒干;
32、黄药子:拣净杂质,剪去须毛,洗净,润透后切成小块,晒干。
二、制备
1、将炮制后的山茱萸、龙骨、知母、夏枯草、麦冬、太子参、墨旱莲、莲子、酸枣仁、玄参、独活、昆布、刺蒺藜、茺蔚子、马齿苋、忍冬藤、石斛、白芍、桔梗、柴胡、牡丹皮、茯苓、决明子、大枣、桂枝、龙胆、远志、葶苈子、浙贝母、牡蛎、南沙参、黄药子放入煎药容器内,第一次加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
2、将过滤的药渣加6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
3、将两次煎煮液混合搅拌均匀,分为4剂服用。
组方中山茱萸有补肝肾,涩精气,固虚脱,治肝虚寒热,虚汗不止的功能为君药;夏枯草清肝,散结;麦冬有养阴润肺,清心除烦,益胃生津的功能,二者为臣药,三味药共同发挥补肝肾,涩精气,固虚脱,清肝,散结,养阴润肺,清心除烦,益胃生津的作用,治疗甲状腺功能亢进效力全面,且以补肝肾,清肝散结,养阴润肺,清心除烦为主可治本,酸枣仁有养肝,宁心,安神,敛汗的功能为佐药,远志有安神益智,祛痰,解郁的功能为使药,与余下诸药是治标。
本发明药物具有补肝肾,清肝散结,养阴润肺,清心除烦,祛痰解郁,敛汗的功能,用于治疗甲状腺功能亢进,疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治甲状腺功能亢进门诊患者共32例。
2、诊断标准
典型症状为胃肠活动增强,出现便次增多;虽然进食增多,但氧化反应增强,机体能量消耗增多,患者表现体重减少;产热增多表现怕热出汗,个别患者出现低热;甲状腺激素增多刺激交感神经兴奋,临床表现心悸、心动过速,失眠,对周围事物敏感,情绪波动,食欲亢进,眼球突出,手舌颤抖,甚至焦虑等症状。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,10天为一个疗程,连续服用2个疗程。
4、疗效评定标准
显效:甲状腺功能亢进症状消失,体质恢复正常,痊愈;
好转:患者心悸,失眠,情绪波动,食欲亢进的症状减轻,甲状腺功能亢进症状明显好转,体质逐步恢复;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗甲状腺功能亢进患者32例,结果显效25例,显效率为78.12%,好转5例,好转率为15.62%,无效2例,总有效率为93.74%。
Claims (3)
1.一种治疗甲状腺功能亢进的药物,其特征在于:它是由下列重量范围内的原料药制成:
山茱萸5-15克,龙骨10-20克,知母10-20克,夏枯草15-25克,麦冬10-15克,太子参10-20克,墨旱莲10-20克,莲子5-15克,酸枣仁10-20克,玄参10-15克,独活10-20克,昆布10-20克,刺蒺藜10-20克,茺蔚子10-15克,马齿苋10-20克,忍冬藤10-20克,石斛5-15克,白芍5-15克,桔梗10-20克,柴胡5-15克,牡丹皮10-20克,茯苓10-20克,决明子5-15克,大枣5-15克,桂枝10-15克,龙胆10-20克,远志5-15克,葶苈子5-15克,浙贝母10-15克,牡蛎10-20克,南沙参10-20克,黄药子10-20克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
山茱萸10克,龙骨15克,知母15克,夏枯草20克,麦冬12克,太子参15克,墨旱莲15克,莲子10克,酸枣仁15克,玄参12克,独活15克,昆布15克,刺蒺藜15克,茺蔚子12克,马齿苋15克,忍冬藤15克,石斛10克,白芍10克,桔梗15克,柴胡10克,牡丹皮15克,茯苓15克,决明子10克,大枣10克,桂枝12克,龙胆15克,远志10克,葶苈子10克,浙贝母12克,牡蛎15克,南沙参15克,黄药子15克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)山茱萸:洗净,除去果核及杂质,晒干;
(2)龙骨:刷净泥土,打碎;
(3)知母:拣净杂质,用水撞洗,捞出,润软,切片晒干;
(4)夏枯草:取原药材,除去枝梗、叶片及杂质,筛去灰屑;
(5)麦冬:拣净杂质,用水浸泡,捞出,润透后抽去心,再洗净晒干;
(6)太子参:摘除须根,晒干;
(7)墨旱莲:拣净杂质,除去残根,洗净闷透,切段晒干;
(8)莲子:拣尽杂质,或砸碎、去皮、去心;
(9)酸枣仁:原药放入竹箩内,沉入清水缸中,使仁浮在水面,壳沉水底,将枣仁捞出,晒干;
(10)玄参:拣净杂质,除去芦头,洗净润透,切片,晾干;
(11)独活:拣去杂质,分开大小个,洗净,润透后切片,干燥;
(12)昆布:拣去杂质,用水漂净,切成宽丝,晾干;
(13)刺蒺藜:漂去泥沙,除净残留的硬刺;
(14)茺蔚子:果实成熟时割取全株,晒干,打下果实,拣去枝叶,筛净杂质;
(15)马齿苋:拣净杂质,除去残根,以水稍润,切段晒干;
(16)忍冬藤:拣去杂质,用水浸泡,润透,切片,晒干;
(17)石斛:取干燥的石斛,用水泡至八成透,闷润,除去残根及黑枝,切段,撞去薄膜,晒干;
(18)白芍:拣去杂质,分开大小个,用水浸泡至八成透,捞出,晒晾,润至内外湿度均匀,切片,干燥;
(19)桔梗:拣净杂质,除去芦头,洗净捞出,润透后切片,晒干;
(20)柴胡:拣去杂质,除去残茎,洗净泥沙,捞出,润透后及时切片,随即晒干;
(21)牡丹皮:拣去杂质,除去木心,洗净,润透,切片,晾干;
(22)茯苓:用水浸泡,洗净,捞出,闷透后,切片,晒干;
(23)决明子:取净决明子,置锅内炒至微有香气,取出,放凉;
(24)大枣:拣净杂质,晒干;
(25)桂枝:用水稍浸泡,捞出,闷润至透,切片,晾干,筛去屑;
(26)龙胆:拣去杂质,除去残茎,洗净,润透后切段,晒干;
(27)远志:拣去杂质,切段,筛去灰屑;
(28)葶苈子:拣净杂质,筛去灰屑;
(29)浙贝母:除去杂质,大小分档,洗净,润透,切片,干燥,街去碎屑,或打碎;
牡蛎:洗净,晒干,碾碎;
南沙参:拣净杂质,去芦,用水洗净,略润,切片,筛净晒干;
黄药子:拣净杂质,剪去须毛,洗净,润透后切成小块,晒干;
(二)制备
(1)将炮制后的山茱萸、龙骨、知母、夏枯草、麦冬、太子参、墨旱莲、莲子、酸枣仁、玄参、独活、昆布、刺蒺藜、茺蔚子、马齿苋、忍冬藤、石斛、白芍、桔梗、柴胡、牡丹皮、茯苓、决明子、大枣、桂枝、龙胆、远志、葶苈子、浙贝母、牡蛎、南沙参、黄药子放入煎药容器内,加水8倍量,浸泡100分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合搅拌均匀,分为4剂服用。
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CN106798894A (zh) * | 2017-03-13 | 2017-06-06 | 董新芳 | 一种治疗甲状腺机能亢进的药物及其制备方法 |
KR20200113993A (ko) * | 2019-03-27 | 2020-10-07 | 김형준 | 갑상선 호르몬 레벨 정상화에 효과적인 한약 조성물 |
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CN102228644A (zh) * | 2011-06-30 | 2011-11-02 | 张永红 | 一种治疗甲状腺肿大的药物及其制备方法 |
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CN106798894A (zh) * | 2017-03-13 | 2017-06-06 | 董新芳 | 一种治疗甲状腺机能亢进的药物及其制备方法 |
KR20200113993A (ko) * | 2019-03-27 | 2020-10-07 | 김형준 | 갑상선 호르몬 레벨 정상화에 효과적인 한약 조성물 |
KR102232064B1 (ko) | 2019-03-27 | 2021-03-25 | 김형준 | 갑상선 호르몬 레벨 정상화에 효과적인 한약 조성물 |
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