CN106511897A - 一种治疗前列腺肥大的药物及其制备方法 - Google Patents

一种治疗前列腺肥大的药物及其制备方法 Download PDF

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CN106511897A
CN106511897A CN201611106963.5A CN201611106963A CN106511897A CN 106511897 A CN106511897 A CN 106511897A CN 201611106963 A CN201611106963 A CN 201611106963A CN 106511897 A CN106511897 A CN 106511897A
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冉兆斌
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Abstract

本发明公开了一种治疗前列腺肥大的药物及其制备方法,其主要是由黄芪、当归、枸杞子、柴胡、川贝母、川牛膝、党参、丹参、菟丝子、泽泻、牡蛎、甘草、石菖蒲、香附、莪术、瓜蒌、肉桂、知母等按一定重量配比制备而成,本发明药物具有利水消肿,托毒生肌,滋阴降火的功能,用于治疗前列腺肥大见效快,疗效好,无副作用。

Description

一种治疗前列腺肥大的药物及其制备方法
技术领域
本发明涉及一种治疗前列腺肥大的药物及其制备方法,属中药领域。
背景技术
前列腺肥大(BPH),又称良性前列腺增生症,多发生于50岁以上的老年人。是一种前列腺明显增大而影响老年男性健康的常见病。现代医学认为前列腺肥大与内分泌系统有关,是前列腺内层尿道腺和尿道下腺上皮细胞及基质增生,腺泡囊性扩张,结缔组织及平滑肌节样增生所致。由于前列腺恰好位于膀胱出口处,围绕着尿道的特殊位置,一旦发生增生,便会从四面八方压迫尿道,使膀胱内的尿液排出受阻,引起泌尿系统的一系列病变,进而也可以危害到性健康。
由于西药无法有效快速治疗前列腺肥大,因此人们对有效治疗前列腺肥大的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗前列腺肥大的药物,从而完成了本发明。
本发明的目的就是提供一种更有效的治疗前列腺肥大的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择黄芪、当归、枸杞子、柴胡、川贝母、川牛膝、党参、丹参、菟丝子、泽泻、牡蛎、甘草、石菖蒲、香附、莪术、瓜蒌、肉桂、知母、茯苓、赤芍、桃仁、山茱萸、木通、车前草、冬葵子、瞿麦、滑石、海藻、升麻、黄柏、甘草原料药进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗前列腺肥大。其中选用黄芪是因为其性味甘,微温,入肺、脾经,生用有益卫固表,利水消肿,托毒,生肌的功能,治自汗,盗汗,血痹,浮肿,痈疽不溃或溃久敛;炙用有补中益气的功能,治内伤劳倦,脾虚泄泻,脱肛,气虚血脱,崩带及一切气衰血虚之症。选用当归是因为其性味甘辛,温,入心、肝、脾经,有补血和血,调经止痛,润燥滑肠的功能,治月经不调,经闭腹痛,癥瘕结聚,崩漏,血虚头痛,眩晕,痿痹,肠燥难便,赤痢后重,痈疽疮疡,金疮,跌扑损伤。选用枸杞子是因为其性味甘,平,有滋肾,润肺,补肝,明目的功能,治肝肾阴亏,腰膝酸软,头晕目眩,目昏多泪,虚劳咳嗽,消渴,遗精。选用柴胡是因为其性味苦,凉,入肝、胆经,有和解表里,疏肝,升阳的功能,治寒热往来,胸满胁痛,口苦耳聋,头痛目眩,疟疾,下利脱肛,月经不调,子宫下垂。选用川贝母是因为其性味苦甘,凉,入肺经,有润肺散结,止嗽化痰的功能,治虚劳咳嗽,吐痰咯血,心胸郁结,肺痿,肺痈,瘿瘤,瘰疬,喉痹,乳痈。选用川牛膝是因为其性味平,味苦微苦,无毒,入肝、肾二经,有祛风,利湿,通经,活血的功能,治风湿腰膝疼痛,脚痿筋挛,血淋,尿血,妇女经闭,癥瘕。选用党参是因为其性味甘,平,入手、足太阴经气分,有补中益气,生津的功能,治脾胃虚弱,气血两亏,体倦无力,食少,口渴,久泻,脱肛。选用丹参是因为其性味苦,微温,入心、肝经,有活血去瘀,安神宁心,排脓,止痛的功能,治心绞痛,月经不调,痛经,以闭,血崩带下,癥瘕,积聚,瘀血腹痛,骨节疼痛,惊悸不眠,恶疮肿毒。选用菟丝子是因为其性味辛甘,平,入肝、肾经,有补肝肾,益精髓,明目的功能,治腰膝酸痛,遗精,消渴,尿有余沥,目暗。选用泽泻是因为其性味甘,寒,入膀胱经,有利水,渗湿,泄热的功能,治小便不利,水肿肛满,呕吐,泻痢,痰饮,脚气,淋病,尿血。选用牡蛎是因为其性味咸涩,凉,入肝、肾经,有敛阴,潜阳,止汗,涩精,化痰,软坚的功能,治惊癎,眩晕,自汗,盗汗,遗精,淋浊,崩漏,带下,瘰疬,瘿瘤。选用石菖蒲是因为其性味辛苦,微温,入心、肝、脾经,有开窍,豁痰,理气,活血,散风,去湿的功能,治癫癎,痰厥,热病神昏,健忘,气闭耳聋,心胸烦闷,胃痛,腹痛,风寒湿痹,痈疽肿毒,跌打损伤。选用香附是因为其性味辛微苦干,平,入肝、三焦经,有理气解郁,止痛调经的功能,治肝胃不和,气郁不舒,胸腹胁肋胀痛,痰饮痞满,月经不调,崩漏带下。选用莪术是因为其性味辛、苦、温。归肝、脾经。行气破血,消积止痛。用于癥瘕痞块,瘀血经闭,食积胀痛,跌打肿痛,早期宫颈癌。选用瓜蒌子是因为其性味甘,寒,归肺、胃、大肠经,有润肺化痰,滑肠通便的功能,治燥咳痰黏,肠燥便秘。选用肉桂是因为其性味辛甘,热,入肾、脾、膀胱经,有补元阳,暖脾胃,除积冷,通血脉的功能,治命门火衰,肢冷脉微,亡阳虚脱,腹痛泄泻,寒疝奔豚,腰膝冷痛,经闭癥瘕,阴疽,流注,及虚阳浮越,上热下寒。选用知母是因为其性味苦,寒,入肺、胃、肾经,有滋阴降火,润燥滑肠的功能,治烦热消渴,骨蒸劳热,肺热咳嗽,大便燥结,小便不利。选用茯苓是因为其性味甘淡,平,入心、脾、肺经,有渗湿利水,益脾和胃,宁心安神的功能,治小便不利水肿胀痛,痰饮咳逆,呕哕,泄泻,遗精,淋浊,惊悸,健忘。选用赤芍是因为其性味苦,微寒,归肝经,有清热凉血,散瘀止痛的功能,治温毒发狂,吐血衄血,目赤肿痛,肝郁胁痛,经闭痛经,癎瘕腹痛,跌扑损伤,痈肿疮疡。选用桃仁是因为其性味苦甘,平,入心、肝、大肠经,有破血行瘀,润燥滑经的功能,治经闭,癥瘕,热病蓄血,血痹,疟疾,跌打损伤,瘀血肿痛,血燥便秘。选用山茱萸是因为其性味酸,微温,入肝、肾经,有补肝肾,涩精气,固虚脱的功能,治腰膝酸痛,眩晕,耳鸣,阳痿,遗精,小便频数,肝虚寒热,虚汗不止,心摇脉散。选用木通是因为其性味苦,凉,入心、小肠、膀胱经,有泻火行水,通利血脉的功能,治小便赤涩,淋浊,水肿,胸中烦热,喉痹咽痛,遍身拘痛,妇女经闭,乳汁不通。选用车前草是因为其性味甘,寒,入肝、脾二经,有利水,清热,明目,祛痰的功能,治小便不通,淋浊,带下,尿血,黄疸,水肿,热痢,泄泻,鼻衄,目赤肿痛,喉痹乳蛾,咳嗽,皮肤溃疡。选用冬葵子是因为其性味甘,寒。入大小肠、膀胱经。利水,滑肠,下乳。治二便不通,淋病,水肿,妇女乳汁不行,乳房肿痛。选用瞿麦是因为其性味苦,寒,入心、肾、小肠、膀胱经,有清热利水,破血通经的功能,治小便不通,淋病,水肿,经闭,痈肿,目赤障翳,浸淫疮毒。选用滑石是因为其性味甘、淡,寒,归膀胱、肺、胃经,有利尿通淋,清热解毒,祛湿解暑的功能,治热痢、淋病,尿热涩痛,暑湿烦渴,湿热水泻,外治湿疹,湿疮,痱子。选用海藻是因为其性味苦咸,寒,入肺、脾、肾经,有软坚,消痰,利水,泄热的功能,治瘰疬,瘿瘤,积聚,水肿,脚气,睾丸肿痛。选用升麻是因为其性味甘辛微苦,凉,入肺、脾、胃经,有升阳,发表,透疹,解毒的功能,治时气疫劳,头痛寒热,喉痛,口疮疤,斑疹不透,中气下陷,久泻久痢,脱肛,妇女崩带,子宫下坠,痈肿疮毒。选用黄柏是因为其性味苦,寒,入肾、膀胱经,有清热,燥湿,泻火,解毒的功能,治热痢,泄泻,消渴,黄疸,痿躄,梦遗,淋浊,痔疮,便血,赤白带下,骨蒸劳热,目赤肿痛,口舌生疮,疮疡肿毒。选用甘草是因为其性味甘平,入脾、胃、肺经,有和中缓急,润肺,解毒,调和诸药的功能,炙用治脾胃虚弱,食少,腹痛便溏,劳倦发热,肺痿咳嗽,心悸,惊痈,生用治咽喉肿痛,消化性溃疡,痈疽疮疡,解药毒及食物中毒。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效:
黄芪15-25克,当归5-15克,枸杞子5-15克,柴胡5-15克,川贝母5-15克,川牛膝5-15克,党参10-20克,丹参10-20克,菟丝子5-15克,泽泻5-15克,牡蛎10-20克,甘草4-6克,石菖蒲4-6克,香附8-10克,莪术8-10克,瓜蒌10-15克,肉桂3-7克,知母5-15克,茯苓5-15克,赤芍5-15克,桃仁5-15克,山茱萸5-15克, 木通5-15克,车前草5-15克,冬葵子10-15克,瞿麦5-15克,滑石5-15克,海藻5-15克,升麻5-10克,黄柏7-11克,甘草4-6克。
优选为:
黄芪20克,当归10克,枸杞子10克,柴胡10克,川贝母10克,川牛膝10克,党参15克,丹参15克,菟丝子10克,泽泻10克,牡蛎15克,甘草5克,石菖蒲5克,香附9克,莪术9克,瓜蒌12克,肉桂5克,知母10克,茯苓10克,赤芍10克,桃仁10克,山茱萸10克, 木通10克,车前草10克,冬葵子12克,瞿麦10克,滑石10克,海藻10克,升麻8克,黄柏9克,甘草5克。
本发明药物的制备方法如下
一、备料
1、黄芪:拣净杂质,除去残留的根头和空心较大的根,用水浸泡,捞出,润透后及时切片,晒干;
2、当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
3、枸杞子:簸净杂质,摘去残留的梗和蒂;
4、柴胡:拣去杂质,除去残茎,洗净泥沙,捞出,润透后及时切片,晒干;
5、川贝母:拣去杂质,用水稍泡,捞出,闷润,剥去心,晒干;
6、川牛膝:拣去杂质,晾干;
7、党参:洗净泥沙后润透去芦,切片或切段,晒干;
8、丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干;
9、菟丝子:过箩去净杂质,洗净,晒干;
10、泽泻:拣去杂质,大小分档,用水浸泡至八成透,捞出,晒凉,闷润至内外湿度均匀,切片,晒干;
11、牡蛎:洗净,晒干,打碎用;
12、石菖蒲:拣去杂质,洗净,稍浸泡,润透,切片,晒干;
13、香附:拣去杂质,碾成碎粒,簸去细毛及细末;
14、莪术:取原药材,除去杂质,大小分档,洗净,略浸泡,取出,润透,切薄片,干燥,筛去碎屑;
15、瓜蒌子:取原药材,除去干瘪种子、杂质,用时捣碎;
16、肉桂:拣净杂质,刮去粗皮,用时打碎,或刮去粗皮,用温开水浸润片刻,切片,晾干;
17、知母:拣净杂质,用水撞洗,捞出,润软,切片晒干;
18、茯苓:用水浸泡,洗净捞出,闷透后,切片,晒干;
19、赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑;
20、桃仁:除去硬壳杂质,置沸水锅中煮至外皮微皱,捞出,浸入凉水中,搓去种皮,晒干,簸净;
21、山茱萸:洗净,除去果核及杂质,晒干;
22、木通:用水稍浸泡,闷润至透,切片,晒干;
23、车前草:去尽泥土,晒干;
24、冬葵子:拣去杂质,筛去泥屑;
25、瞿麦:拣净杂质,除去残根,洗净,焖润,切段,晒干;
26、滑石:取原药材,除去杂质,洗净,干燥;
27、海藻:拣去杂质,用水略漂,稍晾,切段,晒干;
28、升麻:拣去杂质,略泡洗净,捞出,润透,切片,晒干;
29、黄柏:拣去杂质,用水洗净,捞出,润透,切片或切丝,晒干;
30、甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,晾干。
二、制备
1、将炮制后的黄芪、当归、枸杞子、柴胡、川贝母、川牛膝、党参、丹参、菟丝子、泽泻、牡蛎、甘草、石菖蒲、香附、莪术、瓜蒌、肉桂、知母、茯苓、赤芍、桃仁、山茱萸、木通、车前草、冬葵子、瞿麦、滑石、海藻、升麻、黄柏、甘草药物放入煎药容器中,第一次加水8倍量,浸泡60分钟后,武火煎煮沸腾,再用文火煎煮30分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
2、将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟过滤,将第二次煎煮液倒入容器内;
3、将两次煎煮液混合搅拌均匀,即得混合药液,分成4剂服用。
组方中肉桂有补元阳,暖脾胃,除积冷,通血脉功能为君药;泽泻利水,渗湿,泄热,黄芪益卫固表,利水消肿,托毒,生肌二者为臣药,三味药共同发挥利水渗湿,消肿托毒的作用,治疗前列腺肥大效力全面,且以利水渗湿为主,可治本;莪术行气破血,消积止痛为佐药;知母有滋阴降火,润燥滑肠为使药,与下余诸药是治标。
本发明药物具有利水消肿,托毒生肌,滋阴降火的功能,用于治疗前列腺肥大,疗程短、见效快、治愈后不复发、无毒副作用。
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治前列腺肥大门诊患者共40例。
2、诊断标准
临床上,前列腺肥大表现为:尿频尿急, 排尿困难,尿失禁,急性尿潴留,血尿,由于经常用力排尿所引起如疝、痔、脱肛、下肢静脉曲张、肺气肿等合并症。 晚期由于肾功亏损、衰竭引起之氮质血症、酸中毒、高血压、食欲不佳、贫血消瘦、以至心衰、脑血管病症状等,均可见有。 经检查发现 :(1)患者皆为高龄男性,一般在50岁以上。(2)查体时可于下腹部查见膨大之膀胱。(3)肛指检查时,可触知前列腺肿大高起,中央沟消失或两侧增宽。于肥大腺体之上缘,常可触及胀大之膀胱。(4)尚可查见有疝、痔、脱肛等合并症之体征。
3、治疗方法
选用上述药剂,给患者服用,一日2次,每次服用1剂,每天早、晚各服1次,7天为一个疗程,连续服用3-4个疗程。
4、疗效评定标准
显效:前列腺肥大症状消失,痊愈,体质恢复正常;
好转:前列腺肥大症状明显好转,尿频尿急症状已消除,体质逐步恢复;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗前列腺肥大患者40例,结果显效38例,显效率为95%,好转1例,好转率为2.5%,无效1例,总有效率为97.5%。

Claims (3)

1.一种治疗前列腺肥大的药物,其特征在于:它是由下列用量范围内的原料药制成:
黄芪15-25克,当归5-15克,枸杞子5-15克,柴胡5-15克,川贝母5-15克,川牛膝5-15克,党参10-20克,丹参10-20克,菟丝子5-15克,泽泻5-15克,牡蛎10-20克,甘草4-6克,石菖蒲4-6克,香附8-10克,莪术8-10克,瓜蒌10-15克,肉桂3-7克,知母5-15克,茯苓5-15克,赤芍5-15克,桃仁5-15克,山茱萸5-15克, 木通5-15克,车前草5-15克,冬葵子10-15克,瞿麦5-15克,滑石5-15克,海藻5-15克,升麻5-10克,黄柏7-11克,甘草4-6克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
黄芪20克,当归10克,枸杞子10克,柴胡10克,川贝母10克,川牛膝10克,党参15克,丹参15克,菟丝子10克,泽泻10克,牡蛎15克,甘草5克,石菖蒲5克,香附9克,莪术9克,瓜蒌12克,肉桂5克,知母10克,茯苓10克,赤芍10克,桃仁10克,山茱萸10克, 木通10克,车前草10克,冬葵子12克,瞿麦10克,滑石10克,海藻10克,升麻8克,黄柏9克,甘草5克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)黄芪:拣净杂质,除去残留的根头和空心较大的根,用水浸泡,捞出,润透后及时切片,晒干;
(2)当归:拣去杂质,洗净,闷润,稍晾,切片晒干;
(3)枸杞子:簸净杂质,摘去残留的梗和蒂;
(4)柴胡:拣去杂质,除去残茎,洗净泥沙,捞出,润透后及时切片,晒干;
(5)川贝母:拣去杂质,用水稍泡,捞出,闷润,剥去心,晒干;
(6)川牛膝:拣去杂质,晾干;
(7)党参:洗净泥沙后润透去芦,切片或切段,晒干;
(8)丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干;
(9)菟丝子:过箩去净杂质,洗净,晒干;
(10)泽泻:拣去杂质,大小分档,用水浸泡至八成透,捞出,晒凉,闷润至内外湿度均匀,切片,晒干;
(11)牡蛎:洗净,晒干,打碎用;
(12)石菖蒲:拣去杂质,洗净,稍浸泡,润透,切片,晒干;
(13)香附:拣去杂质,碾成碎粒,簸去细毛及细末;
(14)莪术:取原药材,除去杂质,大小分档,洗净,略浸泡,取出,润透,切薄片,干燥,筛去碎屑;
(15)瓜蒌子:取原药材,除去干瘪种子、杂质,用时捣碎;
(16)肉桂:拣净杂质,刮去粗皮,用时打碎,或刮去粗皮,用温开水浸润片刻,切片,晾干;
(17)知母:拣净杂质,用水撞洗,捞出,润软,切片晒干;
(18)茯苓:用水浸泡,洗净捞出,闷透后,切片,晒干;
(19)赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑;
(20)桃仁:除去硬壳杂质,置沸水锅中煮至外皮微皱,捞出,浸入凉水中,搓去种皮,晒干,簸净;
(21)山茱萸:洗净,除去果核及杂质,晒干;
(22)木通:用水稍浸泡,闷润至透,切片,晒干;
(23)车前草:去尽泥土,晒干;
(24)冬葵子:拣去杂质,筛去泥屑;
(25)瞿麦:拣净杂质,除去残根,洗净,焖润,切段,晒干;
(26)滑石:取原药材,除去杂质,洗净,干燥;
(27)海藻:拣去杂质,用水略漂,稍晾,切段,晒干;
(28)升麻:拣去杂质,略泡洗净,捞出,润透,切片,晒干;
(29)黄柏:拣去杂质,用水洗净,捞出,润透,切片或切丝,晒干;
(30)甘草:拣去杂质,洗净,用水浸泡至八成透时,捞出,润透,切片,晾干;
(二)制备
(1)将炮制后的黄芪、当归、枸杞子、柴胡、川贝母、川牛膝、党参、丹参、菟丝子、泽泻、牡蛎、甘草、石菖蒲、香附、莪术、瓜蒌、肉桂、知母、茯苓、赤芍、桃仁、山茱萸、木通、车前草、冬葵子、瞿麦、滑石、海藻、升麻、黄柏、甘草药物放入煎药容器中,第一次加水8倍量,浸泡60分钟后,武火煎煮沸腾,再用文火煎煮30分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水6倍量,武火煮沸,再用文火煎煮20分钟过滤,将第二次煎煮液倒入容器内;
(3)将两次煎煮液混合搅拌均匀,即得混合药液,分成4剂服用。
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CN107715021A (zh) * 2017-12-13 2018-02-23 阜阳市平衡医疗保健器械有限公司 一种治疗前列腺肥大的药物及其制备方法

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