CN107715021A - 一种治疗前列腺肥大的药物及其制备方法 - Google Patents
一种治疗前列腺肥大的药物及其制备方法 Download PDFInfo
- Publication number
- CN107715021A CN107715021A CN201711326754.6A CN201711326754A CN107715021A CN 107715021 A CN107715021 A CN 107715021A CN 201711326754 A CN201711326754 A CN 201711326754A CN 107715021 A CN107715021 A CN 107715021A
- Authority
- CN
- China
- Prior art keywords
- grams
- impurity
- picked
- dry
- radix
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000003814 drug Substances 0.000 title claims abstract description 45
- 210000002307 prostate Anatomy 0.000 title claims abstract description 17
- 206010020880 Hypertrophy Diseases 0.000 title claims abstract description 16
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- 235000002722 Dioscorea batatas Nutrition 0.000 claims abstract description 13
- 235000006536 Dioscorea esculenta Nutrition 0.000 claims abstract description 13
- 240000001811 Dioscorea oppositifolia Species 0.000 claims abstract description 13
- 235000003416 Dioscorea oppositifolia Nutrition 0.000 claims abstract description 13
- 235000013399 edible fruits Nutrition 0.000 claims abstract description 13
- 241000427159 Achyranthes Species 0.000 claims abstract description 12
- 244000020518 Carthamus tinctorius Species 0.000 claims abstract description 11
- 235000003255 Carthamus tinctorius Nutrition 0.000 claims abstract description 11
- 241000522254 Cassia Species 0.000 claims abstract description 11
- 241000218176 Corydalis Species 0.000 claims abstract description 11
- 244000111489 Gardenia augusta Species 0.000 claims abstract description 11
- 235000018958 Gardenia augusta Nutrition 0.000 claims abstract description 11
- 241000237502 Ostreidae Species 0.000 claims abstract description 11
- 244000197580 Poria cocos Species 0.000 claims abstract description 11
- 235000008599 Poria cocos Nutrition 0.000 claims abstract description 11
- 244000179560 Prunella vulgaris Species 0.000 claims abstract description 11
- 241000405414 Rehmannia Species 0.000 claims abstract description 11
- 240000004980 Rheum officinale Species 0.000 claims abstract description 11
- 235000008081 Rheum officinale Nutrition 0.000 claims abstract description 11
- 240000007164 Salvia officinalis Species 0.000 claims abstract description 11
- 235000008326 Trichosanthes anguina Nutrition 0.000 claims abstract description 11
- 244000078912 Trichosanthes cucumerina Species 0.000 claims abstract description 11
- 235000020636 oyster Nutrition 0.000 claims abstract description 11
- 235000005412 red sage Nutrition 0.000 claims abstract description 11
- 235000008113 selfheal Nutrition 0.000 claims abstract description 11
- 235000012222 talc Nutrition 0.000 claims abstract description 11
- 229910052623 talc Inorganic materials 0.000 claims abstract description 11
- 239000000454 talc Substances 0.000 claims abstract description 11
- 241000512259 Ascophyllum nodosum Species 0.000 claims abstract description 10
- 235000011034 Rubus glaucus Nutrition 0.000 claims abstract description 10
- 235000009122 Rubus idaeus Nutrition 0.000 claims abstract description 10
- 235000005187 Taraxacum officinale ssp. officinale Nutrition 0.000 claims abstract description 10
- 240000007651 Rubus glaucus Species 0.000 claims abstract description 9
- 240000001949 Taraxacum officinale Species 0.000 claims abstract description 3
- 239000012535 impurity Substances 0.000 claims description 52
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 26
- 229940079593 drug Drugs 0.000 claims description 24
- 241000227129 Aconitum Species 0.000 claims description 10
- 210000002216 heart Anatomy 0.000 claims description 10
- 241000245665 Taraxacum Species 0.000 claims description 7
- 241000196324 Embryophyta Species 0.000 claims description 2
- 241000605372 Fritillaria Species 0.000 claims description 2
- 240000007171 Imperata cylindrica Species 0.000 claims description 2
- 235000014676 Phragmites communis Nutrition 0.000 claims description 2
- 238000009835 boiling Methods 0.000 claims description 2
- 238000004140 cleaning Methods 0.000 claims description 2
- 238000001035 drying Methods 0.000 claims description 2
- 238000001914 filtration Methods 0.000 claims description 2
- 238000007654 immersion Methods 0.000 claims description 2
- 238000007873 sieving Methods 0.000 claims description 2
- 239000002689 soil Substances 0.000 claims description 2
- 239000007921 spray Substances 0.000 claims description 2
- 235000013547 stew Nutrition 0.000 claims description 2
- 244000235659 Rubus idaeus Species 0.000 claims 1
- 206010062717 Increased upper airway secretion Diseases 0.000 abstract description 15
- 208000026435 phlegm Diseases 0.000 abstract description 15
- 208000004880 Polyuria Diseases 0.000 abstract description 9
- 230000035619 diuresis Effects 0.000 abstract description 9
- 230000000694 effects Effects 0.000 abstract description 7
- 241000173529 Aconitum napellus Species 0.000 abstract 1
- 230000006870 function Effects 0.000 description 37
- 239000008280 blood Substances 0.000 description 30
- 210000004369 blood Anatomy 0.000 description 30
- 239000000796 flavoring agent Substances 0.000 description 24
- 235000019634 flavors Nutrition 0.000 description 24
- 210000004185 liver Anatomy 0.000 description 21
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 18
- 210000004072 lung Anatomy 0.000 description 18
- 210000000952 spleen Anatomy 0.000 description 15
- 210000003734 kidney Anatomy 0.000 description 14
- 210000002784 stomach Anatomy 0.000 description 14
- 208000002193 Pain Diseases 0.000 description 12
- 230000036407 pain Effects 0.000 description 12
- 210000001015 abdomen Anatomy 0.000 description 11
- 230000027939 micturition Effects 0.000 description 11
- 201000010099 disease Diseases 0.000 description 10
- 206010007247 Carbuncle Diseases 0.000 description 9
- 206010011224 Cough Diseases 0.000 description 8
- 206010044565 Tremor Diseases 0.000 description 8
- 210000000038 chest Anatomy 0.000 description 8
- 235000009508 confectionery Nutrition 0.000 description 8
- 208000035475 disorder Diseases 0.000 description 8
- 201000007227 lymph node tuberculosis Diseases 0.000 description 8
- 206010030113 Oedema Diseases 0.000 description 7
- 208000027418 Wounds and injury Diseases 0.000 description 7
- 235000019640 taste Nutrition 0.000 description 7
- 206010012735 Diarrhoea Diseases 0.000 description 6
- 206010018498 Goitre Diseases 0.000 description 6
- 206010028980 Neoplasm Diseases 0.000 description 6
- 230000006378 damage Effects 0.000 description 6
- 201000003872 goiter Diseases 0.000 description 6
- 201000000736 Amenorrhea Diseases 0.000 description 5
- 206010001928 Amenorrhoea Diseases 0.000 description 5
- 208000037093 Menstruation Disturbances Diseases 0.000 description 5
- 206010027339 Menstruation irregular Diseases 0.000 description 5
- 206010037660 Pyrexia Diseases 0.000 description 5
- 230000035508 accumulation Effects 0.000 description 5
- 238000009825 accumulation Methods 0.000 description 5
- 231100000540 amenorrhea Toxicity 0.000 description 5
- 230000000202 analgesic effect Effects 0.000 description 5
- 208000001848 dysentery Diseases 0.000 description 5
- 208000014674 injury Diseases 0.000 description 5
- 231100000614 poison Toxicity 0.000 description 5
- 230000001737 promoting effect Effects 0.000 description 5
- 208000006820 Arthralgia Diseases 0.000 description 4
- 206010018612 Gonorrhoea Diseases 0.000 description 4
- 206010023126 Jaundice Diseases 0.000 description 4
- 208000025865 Ulcer Diseases 0.000 description 4
- 206010052428 Wound Diseases 0.000 description 4
- 230000017531 blood circulation Effects 0.000 description 4
- 238000011049 filling Methods 0.000 description 4
- 210000003127 knee Anatomy 0.000 description 4
- 208000004396 mastitis Diseases 0.000 description 4
- 231100000862 numbness Toxicity 0.000 description 4
- 238000010791 quenching Methods 0.000 description 4
- 208000024891 symptom Diseases 0.000 description 4
- 230000035922 thirst Effects 0.000 description 4
- 231100000397 ulcer Toxicity 0.000 description 4
- 210000003932 urinary bladder Anatomy 0.000 description 4
- 208000004998 Abdominal Pain Diseases 0.000 description 3
- 206010000087 Abdominal pain upper Diseases 0.000 description 3
- 206010010774 Constipation Diseases 0.000 description 3
- 208000032843 Hemorrhage Diseases 0.000 description 3
- 206010027514 Metrorrhagia Diseases 0.000 description 3
- 208000012287 Prolapse Diseases 0.000 description 3
- 206010046788 Uterine haemorrhage Diseases 0.000 description 3
- 230000000740 bleeding effect Effects 0.000 description 3
- 230000001276 controlling effect Effects 0.000 description 3
- 208000002173 dizziness Diseases 0.000 description 3
- 206010015037 epilepsy Diseases 0.000 description 3
- 201000001881 impotence Diseases 0.000 description 3
- 210000002429 large intestine Anatomy 0.000 description 3
- 210000000867 larynx Anatomy 0.000 description 3
- 206010033675 panniculitis Diseases 0.000 description 3
- 206010036067 polydipsia Diseases 0.000 description 3
- 210000000582 semen Anatomy 0.000 description 3
- 210000000697 sensory organ Anatomy 0.000 description 3
- 210000004304 subcutaneous tissue Anatomy 0.000 description 3
- 206010002383 Angina Pectoris Diseases 0.000 description 2
- 241000208365 Celastraceae Species 0.000 description 2
- 206010011878 Deafness Diseases 0.000 description 2
- 206010013911 Dysgeusia Diseases 0.000 description 2
- 208000008967 Enuresis Diseases 0.000 description 2
- 208000034507 Haematemesis Diseases 0.000 description 2
- 206010019233 Headaches Diseases 0.000 description 2
- 206010019909 Hernia Diseases 0.000 description 2
- 208000008454 Hyperhidrosis Diseases 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 206010036790 Productive cough Diseases 0.000 description 2
- 235000000336 Solanum dulcamara Nutrition 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 210000000436 anus Anatomy 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 235000019658 bitter taste Nutrition 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 201000006549 dyspepsia Diseases 0.000 description 2
- 208000001780 epistaxis Diseases 0.000 description 2
- 210000003414 extremity Anatomy 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 210000000232 gallbladder Anatomy 0.000 description 2
- 210000004907 gland Anatomy 0.000 description 2
- 231100000869 headache Toxicity 0.000 description 2
- 208000006750 hematuria Diseases 0.000 description 2
- 230000023597 hemostasis Effects 0.000 description 2
- 206010020718 hyperplasia Diseases 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000001939 inductive effect Effects 0.000 description 2
- 230000007794 irritation Effects 0.000 description 2
- 201000004792 malaria Diseases 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 239000002574 poison Substances 0.000 description 2
- 230000007096 poisonous effect Effects 0.000 description 2
- 238000010926 purge Methods 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 230000007958 sleep Effects 0.000 description 2
- 230000002269 spontaneous effect Effects 0.000 description 2
- 208000024794 sputum Diseases 0.000 description 2
- 210000003802 sputum Anatomy 0.000 description 2
- 238000005728 strengthening Methods 0.000 description 2
- 238000007920 subcutaneous administration Methods 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 201000004647 tinea pedis Diseases 0.000 description 2
- 231100000820 toxicity test Toxicity 0.000 description 2
- 230000008736 traumatic injury Effects 0.000 description 2
- 210000002700 urine Anatomy 0.000 description 2
- 230000008673 vomiting Effects 0.000 description 2
- 206010000060 Abdominal distension Diseases 0.000 description 1
- 206010003011 Appendicitis Diseases 0.000 description 1
- 206010003694 Atrophy Diseases 0.000 description 1
- 206010004446 Benign prostatic hyperplasia Diseases 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 206010007027 Calculus urinary Diseases 0.000 description 1
- 208000017667 Chronic Disease Diseases 0.000 description 1
- 206010010741 Conjunctivitis Diseases 0.000 description 1
- 208000034656 Contusions Diseases 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 206010012218 Delirium Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010013935 Dysmenorrhoea Diseases 0.000 description 1
- 206010013954 Dysphoria Diseases 0.000 description 1
- 206010015958 Eye pain Diseases 0.000 description 1
- 206010016029 Face oedema Diseases 0.000 description 1
- 208000004929 Facial Paralysis Diseases 0.000 description 1
- 206010017553 Furuncle Diseases 0.000 description 1
- 208000007882 Gastritis Diseases 0.000 description 1
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 1
- 208000031361 Hiccup Diseases 0.000 description 1
- 206010021118 Hypotonia Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 206010024453 Ligament sprain Diseases 0.000 description 1
- 206010071289 Lower urinary tract symptoms Diseases 0.000 description 1
- 208000019693 Lung disease Diseases 0.000 description 1
- 206010027627 Miliaria Diseases 0.000 description 1
- 208000000112 Myalgia Diseases 0.000 description 1
- 206010059013 Nocturnal emission Diseases 0.000 description 1
- 241000233855 Orchidaceae Species 0.000 description 1
- 206010033557 Palpitations Diseases 0.000 description 1
- 208000001431 Psychomotor Agitation Diseases 0.000 description 1
- 206010057071 Rectal tenesmus Diseases 0.000 description 1
- 206010038743 Restlessness Diseases 0.000 description 1
- 241000593989 Scardinius erythrophthalmus Species 0.000 description 1
- 208000013738 Sleep Initiation and Maintenance disease Diseases 0.000 description 1
- 208000005392 Spasm Diseases 0.000 description 1
- 208000010040 Sprains and Strains Diseases 0.000 description 1
- 241001627955 Tetraodon lineatus Species 0.000 description 1
- 208000003443 Unconsciousness Diseases 0.000 description 1
- 208000000921 Urge Urinary Incontinence Diseases 0.000 description 1
- 208000036826 VIIth nerve paralysis Diseases 0.000 description 1
- 208000012886 Vertigo Diseases 0.000 description 1
- 206010047513 Vision blurred Diseases 0.000 description 1
- 201000004484 acute conjunctivitis Diseases 0.000 description 1
- 230000001154 acute effect Effects 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 208000007502 anemia Diseases 0.000 description 1
- 230000001147 anti-toxic effect Effects 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 208000006673 asthma Diseases 0.000 description 1
- 208000010668 atopic eczema Diseases 0.000 description 1
- 230000037444 atrophy Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 206010006451 bronchitis Diseases 0.000 description 1
- 208000034526 bruise Diseases 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 201000001352 cholecystitis Diseases 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 230000004087 circulation Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 230000008602 contraction Effects 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000001186 cumulative effect Effects 0.000 description 1
- 208000013219 diaphoresis Diseases 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 238000002651 drug therapy Methods 0.000 description 1
- 206010013990 dysuria Diseases 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000004438 eyesight Effects 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 210000003608 fece Anatomy 0.000 description 1
- 208000017561 flaccidity Diseases 0.000 description 1
- 238000007667 floating Methods 0.000 description 1
- 230000004907 flux Effects 0.000 description 1
- 208000003512 furunculosis Diseases 0.000 description 1
- 238000003304 gavage Methods 0.000 description 1
- 208000001786 gonorrhea Diseases 0.000 description 1
- 210000003128 head Anatomy 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 208000006454 hepatitis Diseases 0.000 description 1
- 231100000283 hepatitis Toxicity 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 206010022437 insomnia Diseases 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 238000002386 leaching Methods 0.000 description 1
- 230000003902 lesion Effects 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 230000009245 menopause Effects 0.000 description 1
- 230000002175 menstrual effect Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 201000004169 miliaria rubra Diseases 0.000 description 1
- 210000003205 muscle Anatomy 0.000 description 1
- 230000036565 night sweats Effects 0.000 description 1
- 206010029410 night sweats Diseases 0.000 description 1
- 230000000414 obstructive effect Effects 0.000 description 1
- 201000005111 ocular hyperemia Diseases 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 210000002826 placenta Anatomy 0.000 description 1
- 230000001855 preneoplastic effect Effects 0.000 description 1
- 208000008128 pulmonary tuberculosis Diseases 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 230000001624 sedative effect Effects 0.000 description 1
- 230000035807 sensation Effects 0.000 description 1
- 235000019615 sensations Nutrition 0.000 description 1
- 230000035939 shock Effects 0.000 description 1
- 230000035900 sweating Effects 0.000 description 1
- 206010042772 syncope Diseases 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 208000012271 tenesmus Diseases 0.000 description 1
- 206010044008 tonsillitis Diseases 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 230000002936 tranquilizing effect Effects 0.000 description 1
- 206010046494 urge incontinence Diseases 0.000 description 1
- 210000001635 urinary tract Anatomy 0.000 description 1
- 208000019206 urinary tract infection Diseases 0.000 description 1
- 208000008281 urolithiasis Diseases 0.000 description 1
- 210000004291 uterus Anatomy 0.000 description 1
- 231100000889 vertigo Toxicity 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/233—Bupleurum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/06—Aluminium, calcium or magnesium; Compounds thereof, e.g. clay
- A61K33/12—Magnesium silicate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/56—Materials from animals other than mammals
- A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/02—Algae
- A61K36/03—Phaeophycota or phaeophyta (brown algae), e.g. Fucus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
- A61K36/07—Basidiomycota, e.g. Cryptococcus
- A61K36/076—Poria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/21—Amaranthaceae (Amaranth family), e.g. pigweed, rockwort or globe amaranth
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/232—Angelica
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/42—Cucurbitaceae (Cucumber family)
- A61K36/428—Trichosanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/536—Prunella or Brunella (selfheal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/66—Papaveraceae (Poppy family), e.g. bloodroot
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/714—Aconitum (monkshood)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/74—Rubiaceae (Madder family)
- A61K36/744—Gardenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/752—Citrus, e.g. lime, orange or lemon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/804—Rehmannia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/80—Scrophulariaceae (Figwort family)
- A61K36/808—Scrophularia (figwort)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/894—Dioscoreaceae (Yam family)
- A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8964—Anemarrhena
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8966—Fritillaria, e.g. checker lily or mission bells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/902—Sparganiaceae (Bur-reed family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biotechnology (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Inorganic Chemistry (AREA)
- Marine Sciences & Fisheries (AREA)
- Zoology (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
本发明公开了一种治疗前列腺肥大的药物及其制备方法,其是由柴胡、丹参、赤芍、当归、牡蛎、玄参、川贝母、夏枯草、海藻、昆布、海浮石、泽兰、蒲公英、瓜蒌、知母、附子、肉桂、山药、熟地黄、牡丹皮、茯苓、牛膝、覆盆子、白茅根、滑石、栀子、红花、枳壳、大黄、延胡索、三棱、苍术按一定重量配比制备而成,本发明药物具有软坚消痰,利水泄热,清热解毒,利尿散结,滋阴降火的功能,用于治疗前列腺肥大见效快、疗效好,不复发。
Description
技术领域
本发明涉及一种治疗前列腺肥大的药物及其制备方法,属中药领域。
背景技术
前列腺肥大是中老年男性常见疾病之一,随全球人口老年化发病日渐增多。前列腺肥大的发病率随年龄递增,但有增生病变时不一定有临床症状。城镇发病率高于乡村,而且种族差异也影响增生程度。由于西药治疗副作用大,因此人们对有效治疗前列腺肥大的中药药物存在极大的需求,至今为止,还没有发现关于本发明的有关报道。
发明内容
本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效治疗前列腺肥大的药物,从而完成了本发明。
本发明的目的就是提供一种有效治疗前列腺肥大的中药组合药物。
本发明的另一目的就是提供了该中药组合药物的制备方法。
本发明药物是选择柴胡、丹参、赤芍、当归、牡蛎、玄参、川贝母、夏枯草、海藻、昆布、海浮石、泽兰、蒲公英、瓜蒌、知母、附子、肉桂、山药、熟地黄、牡丹皮、茯苓、牛膝、覆盆子、白茅根、滑石、栀子、红花、枳壳、大黄、延胡索、三棱、苍术进行组合制备的,将这些药物组合使得各药物功效产生协同作用,从而能够有效治疗前列腺肥大。其中选用柴胡是因为其性味苦,凉,入肝、胆经,有和解表里,疏肝,升阳的功能,治寒热往来,胸满胁痛,口苦耳聋,头痛目眩,疟疾,下利脱肛,月经不调,子宫下垂。选用丹参是因为其性味苦,微温,入心、肝经,有活血去瘀,安神宁心,排脓,止痛的功能,治心绞痛,月经不调,痛经,以闭,血崩带下,癥瘕,积聚,瘀血腹痛,骨节疼痛,惊悸不眠,恶疮肿毒。选用赤芍是因为其性味苦,微寒,归肝经,有清热凉血,散瘀止痛的功能,治温毒发狂,吐血衄血,目赤肿痛,肝郁胁痛,经闭痛经,癎瘕腹痛,跌扑损伤,痈肿疮疡。选用当归是因为其性味甘辛,温,入心、肝、脾经,有补血和血,调经止痛,润燥滑肠的功能,治月经不调,经闭腹痛,癥瘕结聚,崩漏,血虚头痛,眩晕,痿痹,肠燥难便,赤痢后重,痈疽疮疡,金疮,跌扑损伤。选用牡蛎是因为其性味咸涩,凉,入肝、肾经,有敛阴,潜阳,止汗,涩精,化痰,软坚的功能,治惊癎,眩晕,自汗,盗汗,遗精,淋浊,崩漏,带下,瘰疬,瘿瘤。选用玄参是因为其性味苦咸,凉,入肺、肾经,有滋阴,降火,除烦,解毒的功能,治热病烦渴,发斑,骨蒸劳热,夜寐不宁,自汗盗汗,津伤便秘,吐血衄血,咽喉肿痛,痈肿,瘰疬。选用川贝母是因为其性味苦甘,凉,入肺经,有润肺散结,止嗽化痰的功能,治虚劳咳嗽,吐痰咯血,心胸郁结,肺痿,肺痈,瘿瘤,瘰疬,喉痹,乳痈。选用夏枯草是因为其性味苦辛,寒,入肝、胆经,有清肝,散结的功能,治瘰疬,瘿瘤,乳痈,乳癌,目珠夜痛,羞明流泪,头目眩晕,口眼歪斜,筋骨疼痛,肺结核,急性黄疸型传染性肝炎,血崩,带下。选用海藻是因为其性味苦咸,寒,入肺、脾、肾经,有软坚,消痰,利水,泄热的功能,治瘰疬,瘿瘤,积聚,水肿,脚气,睾丸肿痛。选用昆布是因为其性味咸,寒,入胃经,有软坚,行水的功能,治瘰疬,瘿瘤,噎膈,水肿,睾丸肿痛,带下。选用海浮石是因为其性味咸寒,入肺、胃经,有清肺火,化老痰,软坚,通淋的功能,治痰热喘嗽,老痰积块,瘿瘤,瘰疬,疝气,疮肿,目翳。选用泽兰是因为其性味苦辛,微温,入肝、脾经,有活血,行水的功能,治经闭,癥瘕,产后瘀滞腹痛,身面浮肿,跌扑损伤,金疮,痈肿。选用蒲公英是因为其性味苦甘,寒,入肝、胃经,有清热解毒,利尿散结的功能,治急性乳腺炎,淋巴腺炎,瘰疬,疔毒疮肿,急性结膜炎,感冒发热,急性扁桃体炎,急性支气管炎,胃炎,肝炎,胆囊炎,尿路感染。选用瓜蒌是因为其性味甘、微苦,寒,归肺、胃、大肠经,有清热涤痰,宽胸散结,润燥滑肠的功能,治肺热咳嗽,痰浊黄稠,胸痹心痛,结胸痞满,乳痈,肠痈,大便秘结。选用知母是因为其性味苦,寒,入肺、胃、肾经,有滋阴降火,润燥滑肠的功能,治烦热消渴,骨蒸劳热,肺热咳嗽,大便燥结,小便不利。选用附子是因为其性味辛甘,热,有毒,入心、脾、肾经,有回阳补火,散寒除湿的功能,治阴盛络阳,大汗亡阳,吐利厥逆,心腹冷痛,脾泄冷痢,脚气水肿,小儿慢惊,风寒湿痹,踒躄拘挛,阴疽疮漏及一切沉寒痼冷之疾。选用肉桂是因为其性味辛甘,热,入肾、脾、膀胱经,有补元阳,暖脾胃,除积冷,通血脉的功能,治命门火衰,肢冷脉微,亡阳虚脱,腹痛泄泻,寒疝奔豚,腰膝冷痛,经闭癥瘕,阴疽,流注,及虚阳浮越,上热下寒。选用山药是因为其性味甘,平,入肺、脾、肾经,有健脾,补肺,固肾,益精的功能,治脾虚泄泻,久痢,虚劳咳嗽,消渴,遗精、带下,小便频数。选用熟地黄是因为其性味甘,微温,入肝、肾经,有滋阴,补血的功能,治阴虚血少,腰膝痿弱,劳嗽骨蒸,遗精,崩漏,月经不调,消渴,溲数,耳聋,目昏。选用牡丹皮是因为其性味辛苦,凉,入心、肝、肾经,有清热,凉血,和血,消瘀的功能,治热入血分,发斑,惊癎,吐、衄、便血,骨蒸劳热,经闭,癥瘕,痈疡,扑损。选用茯苓是因为其性味甘淡,平,入心、脾、肺经,有渗湿利水,益脾和胃,宁心安神的功能,治小便不利水肿胀痛,痰饮咳逆,呕哕,泄泻,遗精,淋浊,惊悸,健忘。选用牛膝是因为其性味甘苦酸,平,入肝、肾经,生用散瘀血,消痈肿的功能,治淋病,尿血,经闭,癥瘕,难产,胞衣不下,产后瘀血腹痛,喉痹,痈肿,跌打损伤,熟用补肝肾,强筋骨,治腰膝骨痛,四肢拘挛,痿痹。选用覆盆子是因为其性味甘,酸,平,入肝、肾二经,有补肝肾,缩小便,助阳,固精,明目的功能,治阳痿,遗精,溲数,遗溺,虚劳,目暗。选用白茅根是因为其性味甘、寒,入肺、胃、小肠经,有凉血,止血,清热,利尿的功能,治热病烦渴,吐血,衄血,肺热喘急,胃热哕逆,淋病,小便不利,水肿,黄疸。选用滑石是因为其性味甘、淡,寒,归膀胱、肺、胃经,有利尿通淋,清热解毒,祛湿解暑的功能,治热淋、石淋,尿热涩痛,暑湿烦渴,湿热水泻,外治湿疹,湿疮,痱子。选用栀子是因为其性味苦,寒,入心、肝、肺、胃经,有清热,泻火,凉血的功能,治热病虚烦不眠,黄疸,淋病,消渴,目赤,咽痛,吐血,衄血,血痢,尿血,热毒疮疡,扭伤肿痛。选用红花是因为其性味辛,温,入心、肝经,有活血通经,去瘀止痛的功能,治经闭,癥瘕,难产,死胎,产后恶露不行,瘀血作痛,痈肿,跌扑损伤。选用枳壳是因为其性味苦辛,凉,入肺、脾、大肠经,有破气,行痰,消积的功能,治胸膈痰滞,胸痞,胁胀,食积,噫气,呕逆,下痢后重,脱肛,子宫脱垂。选用大黄是因为其性味苦、寒,入胃、大肠、肝径,有泻热毒,破积滞,行瘀血的功能,治实热便秘,谵语发狂,食积痞满,痢疾初起,里急后重,瘀停经闭,癥瘕积聚,时行热疫,暴眼赤痛,吐血,衄血,阳黄,水肿,淋浊,溲赤,痈疡肿毒,疔疮,汤火伤。选用延胡索是因为其性味辛苦,温,入肝、胃经,有活血,散瘀,理气,止痛的功能,治心腹腰膝诸痛,月经不调,癥瘕,崩中,产后血晕,恶露不尽,跌打损伤。选用三棱是因为其性味苦辛,平,入肝、脾经,有破血,行气,消积,止痛的功能,治癥瘕积聚,气血凝带,心腹疼痛,胁下胀疼,经闭,产后瘀血腹痛,跌打损伤,疮肿坚硬。选用苍术是因为其性味辛苦,温,入脾、胃经,有健脾,燥湿,解郁,辟秽的功能,治湿盛困脾,倦怠嗜卧,脘痞腹胀,食欲不振,呕吐,泄泻,痢疾,疟疾,痰饮,水肿,时气感冒,风寒湿痹,足痿,夜盲。
具体实施方式
本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重量范围内都具有较好的疗效
柴胡5-15克,丹参10-20克,赤芍10-20克,当归10-20克,牡蛎25-35克,玄参10-20克,川贝母3-5克,夏枯草10-20克,海藻10-20克,昆布10-20克,海浮石10-20克,泽兰10-20克,蒲公英15-25克,瓜蒌25-35克,知母10-14克,附子5-15克,肉桂4-8克,山药10-14克,熟地黄10-20克,牡丹皮5-15克,茯苓5-15克,牛膝4-8克,覆盆子10-20克,白茅根15-25克,滑石10-14克,栀子5-15克,红花5-15克,枳壳5-15克,大黄5-15克,延胡索10-20克,三棱5-15克,苍术5-15克。
优选为
柴胡10克,丹参15克,赤芍15克,当归15克,牡蛎30克,玄参15克,川贝母3克,夏枯草15克,海藻15克,昆布15克,海浮石15克,泽兰15克,蒲公英20克,瓜蒌30克,知母12克,附子10克,肉桂6克,山药12克,熟地黄15克,牡丹皮10克,茯苓10克,牛膝6克,覆盆子15克,白茅根20克,滑石12克,栀子10克,红花10克,枳壳10克,大黄10克,延胡索15克,三棱10克,苍术10克。
本发明药物的制备方法如下
一、备料
1、柴胡:拣去杂质,除去残茎,洗净泥沙,捞出,润透后及时切片,随即晒干;
2、丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干;
3、赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑;
4、当归:拣去杂质,洗净,闷润,稍晾至内外湿度适宜时,切片晒干;
5、牡蛎:洗净,晒干,打碎用;
6、玄参:拣净杂质,除去芦头,洗净润透,切片,晾干;
7、川贝母:拣去杂质,用水稍泡,捞出,闷润,剥去心,晒干;
8、夏枯草:取原药材,除去枝梗、叶片及杂质,筛去灰屑;
9、海藻:拣去杂质,用水略漂,稍晾,切段,晒干;
10、昆布:拣去杂质,用水漂净,切成宽丝,晾干;
11、海浮石:洗净晒干,打碎;
12、泽兰:拣去杂质,除去残根,喷水稍润,切段晒干;
13、蒲公英:拣去杂质,洗净泥土,切段,晒干;
14、瓜蒌:取原药材,除去杂质及果柄,洗净,压扁,切丝或小块,干燥;
15、知母:拣净杂质,用水撞洗,捞出,润软,切片晒干;
16、附子:用水浸泡,捞出,切片,晾干;
17、肉桂:拣净杂质,刮去粗皮,用时打碎,或刮去粗皮,用温开水浸润片刻,切片,晾干;
18、山药:拣净杂质,用水浸泡至山药中心部软化为度,捞出稍晾,切片晒干或烘干;
19、熟地黄:取原药材,蒸至表面乌黑色,取出,晒至八成干时,切片,干燥;
20、牡丹皮:拣去杂质,除去木心,洗净,润透,切片,晾干;
21、茯苓:用水浸泡,洗净捞出,闷透后,切片,晒干;
22、牛膝:拣去杂质,洗净,润软,去芦,切段,晒干;
23、覆盆子:筛去灰屑,拣净杂质,去柄;
24、白茅根:拣净杂质,洗净,微润,切段,晒干,簸净碎屑;
25、滑石:取原药材,除去杂质,洗净,干燥;
26、栀子:筛去灰屑,拣去杂质,碾碎过筛或剪去两端;
27、红花:拣净杂质,除去茎叶、蒂头,晒干;
28、枳壳:除去瓤、核,冼净,稍浸,捞出,润软,以手能捏对折为度,切片,晾干;
29、大黄:拣净杂质,大小分档,焖润至内外湿度均匀,切片或切成小块、晒干;
30、延胡索:拣去杂质,用水浸泡,洗净,晒晾,润至内外湿度均匀,切片或打碎;
31、三棱:拣净杂质,用水浸泡,捞出润透,切片,晒干;
32、苍术:拣去杂质,用水泡至七、八成透,捞出,润透后切片,晒干。
二、制备
1、将所述重量的柴胡、丹参、赤芍、当归、牡蛎、玄参、川贝母、夏枯草、海藻、昆布、海浮石、泽兰、蒲公英、瓜蒌、知母、附子、肉桂、山药、熟地黄、牡丹皮、茯苓、牛膝、覆盆子、白茅根、滑石、栀子、红花、枳壳、大黄、延胡索、三棱、苍术放入煎药容器内,加水6倍量,浸泡120分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
2、将过滤的药渣加水4倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
3、将两次煎煮液混合搅拌均匀,分为2剂服用。
组方中海藻有软坚,消痰,利水,泄热的功能为君药;蒲公英有清热解毒,利尿散结的功能;知母有滋阴降火,润燥滑肠的功能,二者为臣药,三味药共同发挥软坚消痰,利水泄热,清热解毒,利尿散结,滋阴降火的作用,治疗前列腺肥大效力全面,且以软坚消痰,清热解毒,利尿散结为主可治本,牡丹皮有清热,凉血,和血,消瘀的功能为佐药,牛膝有散瘀血,消痈肿的功能为使药,与下余诸药是治标。
本发明药物具有软坚消痰,利水泄热,清热解毒,利尿散结,滋阴降火的功能,用于治疗前列腺肥大,疗程短、见效快、治愈后不复发。
以下通过试验例来进一步阐述本发明所述药物的有益效果,这些试验例包括本发明药物的动物毒性试验报告和临床疗效观察资料。
[试验例1]本发明药物的动物毒性试验报告:
取家兔30只,雌雄兼用,体重2.0—2.5kg,分两组,每组15只,其中一组为超剂量试验组,另一组为正常量试验组。超常量组为20ml/kg,正常量为10ml/kg,给药方式为灌胃法给药,每天两次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物无不良毒副作用。
[试验例2]本发明药物的临床疗效观察
1、一般资料
收治前列腺肥大门诊患者共55例。
2、诊断标准
症状主要表现为两组症状,一类是膀胱刺激症状;另一类是因增生前列腺阻塞尿路产生的梗阻性症状。膀胱刺激症状:尿频、尿急、夜尿增多及急迫性尿失禁。尿频是前列腺增生的早期信号,尤其夜尿次数增多更有临床意义。该病有三个主要特征:前列腺体积增大;膀胱出口阻塞;有排尿困难、尿频、 尿急等下尿路症状。
3、治疗方法
选用上述药剂,给患者服用,每次服用1剂,每天早、晚各服1次,15天为一个疗程,连续服用3个疗程。
4、疗效评定标准
显效:前列腺肥大症状消失,体质恢复正常,痊愈;
好转:尿频、尿急、尿液增多减少,前列腺肥大症状明显好转,体质逐步恢复正常;
无效:达不到好转标准者。
5、治疗结果(见下表)
在上述治疗中,用本发明药物治疗前列腺肥大患者55例,结果显效46例,显效率为83.6%,好转6例,好转率为10.9%,无效3例,总有效率为94.5%。
Claims (3)
1.一种治疗前列腺肥大的药物,其特征在于:它是由下列重量范围内的原料药制成:
柴胡5-15克,丹参10-20克,赤芍10-20克,当归10-20克,牡蛎25-35克,玄参10-20克,川贝母3-5克,夏枯草10-20克,海藻10-20克,昆布10-20克,海浮石10-20克,泽兰10-20克,蒲公英15-25克,瓜蒌25-35克,知母10-14克,附子5-15克,肉桂4-8克,山药10-14克,熟地黄10-20克,牡丹皮5-15克,茯苓5-15克,牛膝4-8克,覆盆子10-20克,白茅根15-25克,滑石10-14克,栀子5-15克,红花5-15克,枳壳5-15克,大黄5-15克,延胡索10-20克,三棱5-15克,苍术5-15克。
2.根据权利要求1所述的药物,其中各原料药的用量为:
柴胡10克,丹参15克,赤芍15克,当归15克,牡蛎30克,玄参15克,川贝母3克,夏枯草15克,海藻15克,昆布15克,海浮石15克,泽兰15克,蒲公英20克,瓜蒌30克,知母12克,附子10克,肉桂6克,山药12克,熟地黄15克,牡丹皮10克,茯苓10克,牛膝6克,覆盆子15克,白茅根20克,滑石12克,栀子10克,红花10克,枳壳10克,大黄10克,延胡索15克,三棱10克,苍术10克。
3.根据权利要求1或2所述药物的制备方法,它包括下列步骤:
(一)备料
(1)柴胡:拣去杂质,除去残茎,洗净泥沙,捞出,润透后及时切片,随即晒干;
(2)丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干;
(3)赤芍:取原药材,除去杂质,大小分档,洗净,润透,切薄片,干燥,筛去碎屑;
(4)当归:拣去杂质,洗净,闷润,稍晾至内外湿度适宜时,切片晒干;
(5)牡蛎:洗净,晒干,打碎用;
(6)玄参:拣净杂质,除去芦头,洗净润透,切片,晾干;
(7)川贝母:拣去杂质,用水稍泡,捞出,闷润,剥去心,晒干;
(8)夏枯草:取原药材,除去枝梗、叶片及杂质,筛去灰屑;
(9)海藻:拣去杂质,用水略漂,稍晾,切段,晒干;
(10)昆布:拣去杂质,用水漂净,切成宽丝,晾干;
(11)海浮石:洗净晒干,打碎;
(12)泽兰:拣去杂质,除去残根,喷水稍润,切段晒干;
(13)蒲公英:拣去杂质,洗净泥土,切段,晒干;
(14)瓜蒌:取原药材,除去杂质及果柄,洗净,压扁,切丝或小块,干燥;
(15)知母:拣净杂质,用水撞洗,捞出,润软,切片晒干;
(16)附子:用水浸泡,捞出,切片,晾干;
(17)肉桂:拣净杂质,刮去粗皮,用时打碎,或刮去粗皮,用温开水浸润片刻,切片,晾干;
(18)山药:拣净杂质,用水浸泡至山药中心部软化为度,捞出稍晾,切片晒干或烘干;
(19)熟地黄:取原药材,蒸至表面乌黑色,取出,晒至八成干时,切片,干燥;
(20)牡丹皮:拣去杂质,除去木心,洗净,润透,切片,晾干;
(21)茯苓:用水浸泡,洗净捞出,闷透后,切片,晒干;
(22)牛膝:拣去杂质,洗净,润软,去芦,切段,晒干;
(23)覆盆子:筛去灰屑,拣净杂质,去柄;
(24)白茅根:拣净杂质,洗净,微润,切段,晒干,簸净碎屑;
(25)滑石:取原药材,除去杂质,洗净,干燥;
(26)栀子:筛去灰屑,拣去杂质,碾碎过筛或剪去两端;
(27)红花:拣净杂质,除去茎叶、蒂头,晒干;
(28)枳壳:除去瓤、核,冼净,稍浸,捞出,润软,以手能捏对折为度,切片,晾干;
(29)大黄:拣净杂质,大小分档,焖润至内外湿度均匀,切片或切成小块、晒干;
(30)延胡索:拣去杂质,用水浸泡,洗净,晒晾,润至内外湿度均匀,切片或打碎;
(31)三棱:拣净杂质,用水浸泡,捞出润透,切片,晒干;
(32)苍术:拣去杂质,用水泡至七、八成透,捞出,润透后切片,晒干;
(二)制备
(1)将所述重量的柴胡、丹参、赤芍、当归、牡蛎、玄参、川贝母、夏枯草、海藻、昆布、海浮石、泽兰、蒲公英、瓜蒌、知母、附子、肉桂、山药、熟地黄、牡丹皮、茯苓、牛膝、覆盆子、白茅根、滑石、栀子、红花、枳壳、大黄、延胡索、三棱、苍术放入煎药容器内,加水6倍量,浸泡120分钟后,武火煎煮沸腾,再用文火煎煮20分钟,过滤得第一次煎煮液,将第一次煎煮液倒入容器内;
(2)将过滤的药渣加水4倍量,武火煮沸,再用文火煎煮20分钟,过滤得第二次煎煮液;
(3)将两次煎煮液混合搅拌均匀,分为2剂服用。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201711326754.6A CN107715021A (zh) | 2017-12-13 | 2017-12-13 | 一种治疗前列腺肥大的药物及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201711326754.6A CN107715021A (zh) | 2017-12-13 | 2017-12-13 | 一种治疗前列腺肥大的药物及其制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN107715021A true CN107715021A (zh) | 2018-02-23 |
Family
ID=61220315
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201711326754.6A Withdrawn CN107715021A (zh) | 2017-12-13 | 2017-12-13 | 一种治疗前列腺肥大的药物及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN107715021A (zh) |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105641528A (zh) * | 2016-02-23 | 2016-06-08 | 陈军 | 一种前列腺脐疗膏药贴 |
CN106511897A (zh) * | 2016-12-06 | 2017-03-22 | 冉兆斌 | 一种治疗前列腺肥大的药物及其制备方法 |
CN106822554A (zh) * | 2017-04-04 | 2017-06-13 | 李少伦 | 一种治疗前列腺炎的药物及其制备方法 |
-
2017
- 2017-12-13 CN CN201711326754.6A patent/CN107715021A/zh not_active Withdrawn
Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN105641528A (zh) * | 2016-02-23 | 2016-06-08 | 陈军 | 一种前列腺脐疗膏药贴 |
CN106511897A (zh) * | 2016-12-06 | 2017-03-22 | 冉兆斌 | 一种治疗前列腺肥大的药物及其制备方法 |
CN106822554A (zh) * | 2017-04-04 | 2017-06-13 | 李少伦 | 一种治疗前列腺炎的药物及其制备方法 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103638314A (zh) | 一种治疗甲状腺腺瘤的药物及其制备方法 | |
CN103751682B (zh) | 一种治疗肺热咳嗽的药物及其制备方法 | |
CN102805843B (zh) | 一种治疗胃痛的药物及其制备方法 | |
CN104352758A (zh) | 一种治疗高血压的药物及其制备方法 | |
CN106924476A (zh) | 一种治疗视网膜中央静脉阻塞的药物及其制备方法 | |
CN106421430A (zh) | 一种治疗甲状腺功能亢进的药物及其制备方法 | |
CN103638464B (zh) | 一种治疗慢性肝炎的药物及其制备方法 | |
CN107715021A (zh) | 一种治疗前列腺肥大的药物及其制备方法 | |
CN104056224A (zh) | 一种治疗习惯性流产的药物及其制备方法 | |
CN103638345A (zh) | 一种治疗肺气虚的药物及其制备方法 | |
CN108524888A (zh) | 一种治疗失眠的药物及其制备方法 | |
CN106924694A (zh) | 一种治疗习惯性便秘的药物及其制备方法 | |
CN107625933A (zh) | 一种治疗神经衰弱的药物及其制备方法 | |
CN106729118A (zh) | 一种治疗肾盂肾炎的药物及其制备方法 | |
CN106860824A (zh) | 一种治疗习惯性便秘的药物及其制备方法 | |
CN105213946A (zh) | 一种治疗便秘的药物及其制备方法 | |
CN104383334A (zh) | 一种清除肠道毒素的药物及其制备方法 | |
CN108355094A (zh) | 一种治疗肾癌的药物及其制备方法 | |
CN103690911A (zh) | 一种治疗产后发热的药物及其制备方法 | |
CN106924661A (zh) | 一种治疗结核性胸膜炎的药物及其制备方法 | |
CN108339090A (zh) | 一种治疗乳腺癌的药物及其制备方法 | |
CN108785570A (zh) | 一种治疗梅尼埃病的药物及其制备方法 | |
CN108524867A (zh) | 一种治疗肝癌的药物及其制备方法 | |
CN108785567A (zh) | 一种治疗骨关节结核的药物及其制备方法 | |
CN107823530A (zh) | 一种治疗遗精的药物及其制备方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
WW01 | Invention patent application withdrawn after publication | ||
WW01 | Invention patent application withdrawn after publication |
Application publication date: 20180223 |