CN104383334A - 一种清除肠道毒素的药物及其制备方法 - Google Patents

一种清除肠道毒素的药物及其制备方法 Download PDF

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CN104383334A
CN104383334A CN201410703760.9A CN201410703760A CN104383334A CN 104383334 A CN104383334 A CN 104383334A CN 201410703760 A CN201410703760 A CN 201410703760A CN 104383334 A CN104383334 A CN 104383334A
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薛学明
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薛学明
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Abstract

本发明公开了一种清除肠道毒素的药物及其制备方法,其主要是由木瓜、玉米须、芝麻叶、杨树叶、茜草、稀莶草、茯苓、火麻仁、郁李仁、石膏、知母、白芷、防风、羌活按一定重量配比制备而成,本发明药物具有清热解毒、润燥滑肠、下气利水的功能,用于清除肠道毒素见效快、疗效好、无副作用。

Description

一种清除肠道毒素的药物及其制备方法
技术领域
[0001] 本发明涉及一种清除肠道毒素的药物及其制备方法,属中药领域。
背景技术
[0002] 肠道是人体的排毒器官,担负了人体大部分的排毒任务。肠道本身充满褶皱,是人 体大部分毒素与代谢物集中的大本营。然而,现代人因饮食过于精细、饮食不规律、饮食质 量安全等问题,造成肠道中很容易暗藏毒素,使本来最大的排毒器官反而成为了藏污纳垢 的大本营。肠道毒素也被形象的誉为:万病之源。肠道毒素不但引发疾病,也是引发肥胖的 元凶之一。因此及时清除肠道毒素对人体健康至关重要。目前由于西药无法有效清除肠道 毒素,且存有副作用,因此人们对可以快速有效进行肠道排毒的中药药物存在极大的需求, 至今为止,还没有发现关于本发明的有关报道。
发明内容
[0003] 本发明人依据中医理论的研究和临床试验的反复验证,终于找到了有效清除肠道 毒素的药物,从而完成了本发明。
[0004] 本发明的目的就是提供一种更有效的清除肠道毒素的中药组合药物。
[0005] 本发明的另一目的就是提供了该中药组合药物的制备方法。
[0006] 本发明药物是选择木瓜、玉米须、芝麻叶、杨树叶、茜草、稀莶草、茯苓、火麻仁、郁 李仁、石膏、知母、白龙、防风、宪活、蜂蜜、饴糖、当归、何首乌、白巧、虹蝴、橘皮、积实、木香、 扁豆、旋复花、丹参、莱菔子、鸡内金药物进行组合制备的,将这些药物组合使得各药物功效 产生协同作用,从而能够有效进行排毒。选用木瓜是因为其性味酸,温,入肝、脾经,有平肝 和胃,去湿舒筋的功能,治吐泻转筋,湿痹,脚气,水肿,痢疾。选用玉米须是因为其性味甘, 平,有利尿,泄热,平肝,利胆的功能,治肾炎水肿,脚气,黄疸肝炎,高血压,胆囊炎,胆结石, 糖尿病,吐血衄血,鼻渊,乳痈。选用芝麻叶是因为其性平,味苦,具有滋养肝、胃、润燥滑肠 的功能,治肝、肾虚,头晕眩,病后脱发,大便秘结。杨树叶为落叶乔木杨树的叶片,叶常宽 阔,花雌雄异株,柔荑花序,苞片边缘常有剪碎状裂片,无花被,有清除肠道的功能。选用茜 草是因为其性味苦,寒,有凉血止血,祛瘀通经的功能,治吐血,衄血,崩漏,外伤出血,瘀阻 经闭,关节痹痛,跌扑肿痛。选用稀莶草是因为其性味辛苦寒,归肝、肾经,有怯风湿,利关 节,解毒的功能,治风湿痹痛,筋骨无力,腰膝酸软,四肢麻痹,半身不遂,风疹湿疮。选用茯 苓是因为其性味甘淡,平,入心、脾、肺经,有渗湿利水,益脾和胃,宁心安神的功能,治小便 不利,水肿胀满,痰饮咳逆,呕唆,泄泻,遗精,淋池,惊t季,健忘。选用火麻仁是因为其性味 甘,平,入脾、胃、大肠经,有润燥,滑肠,通淋,活血的功能,治肠燥便秘,消渴,热淋,风痹,痢 疾,月经不调,疥疮,癣癫。选用郁李仁是因为其性味辛苦甘,平,入脾、大小肠经,有润燥, 滑肠,下气,利水的功能,治大肠气滞,燥涩不通,小便不利,大腹水肿,四肢浮肿,脚气。选 用石膏是因为其性味辛甘,寒,入肺、胃经,生用有解肌清热,除烦止渴的功能,治热病壮热 不退,心烦神昏,谵语发狂,口渴咽干,肺热喘急,中暑自汗,胃火头痛、牙痛,热毒壅盛,发斑 发疹,口舌生疮,煅敷生肌敛疮,外治痈疽疮疡,溃不收回,汤火烫伤。选用知母是因为其性 味苦,寒,入肺、胃、肾经,有滋阴降火,润燥滑肠的功能,治烦热消渴,骨蒸劳热,肺热咳嗽, 大便燥结,小便不利。选用白芷是因为其性味辛,温,入肺、脾、胃经,有祛风,燥湿,消肿,止 痛的功能,治头痛,眉棱骨痛,齿痛,鼻渊,寒湿腹痛,肠风痔漏,赤白带下,痈疽疮疡,皮肤燥 痒,疥癣。选用防风是因为其性味辛甘,温,入膀胱、肺、脾经,有发表,祛风,胜湿,止痛的功 能,治外感风寒,头痛,目眩,项强,风寒湿痹,骨节酸痛,四肢挛急,破伤风。选用羌活是因为 其性味辛苦,温,入膀胱、肾经,有散表寒,祛风湿,利关节的功能,治感冒风寒,头痛无汗,风 寒湿痹,项强筋急,骨节酸疼,风水浮肿,痈疽疮毒。选用蜂蜜是因为其性味甘,平,入肺、脾、 大肠经,有补中,润燥,止痛,解毒的功能,治肺燥咳嗽,肠燥便秘,胃脘疼痛,鼻渊,口疮,汤 火烫伤,解乌头毒。选用饴糖是因为其性味甘,温,入脾、胃、肺经,有缓中,补虚,生津,润燥 的功能,治劳倦伤脾,里急腹痛,肺燥咳嗽,吐血,口渴,咽痛,便秘。选用当归是因为其性味 甘辛,温,入心、肝、脾经,有补血和血,调经止痛,润燥滑肠的功能,治月经不调,经闭腹痛, 癥瘕结聚,崩漏,血虚头痛,眩晕,痿痹,肠燥难便,赤痢后重,痈疽疮疡,金疮,跌扑损伤。选 用何首乌是因为其性味苦甘涩,微温,入肝、肾经,有补肝,益肾,养血,祛风的功能,治肝肾 阴亏,发须早白,血虚头晕,腰膝软弱,筋骨酸痛,遗精,崩带,久疟,久痢,慢性肝炎,痈肿,瘰 疬,肠风,痔疾。选用白芍是因为其性味苦酸,凉,入肝、脾经,有养血柔肝,缓中止痛,敛阴收 汗的功能,治胸腹胁肋疼痛,泻痢腹痛,自汗盗汗,阴虚发热,月经不调,崩漏,带下。选用蚯 蚓是因为其性味咸,寒,入肝、脾、肺经,有清热,平肝,止喘,通络的功能,治高热狂躁,惊风 抽搐,风热头痛,目赤,中风半身不遂,喘息,喉痹,关节疼痛,齿衄,小便不通,瘰疬,痄腮,疮 疡。选用橘皮是因为其性味辛苦,温,入脾、肺经,有理气,调中,燥湿,化痰的功能,治胸腹胀 满,不思饮食,呕吐哕逆,咳嗽痰多。选用枳实是因为其性味苦,寒,入脾、胃经,有破气,散 痞,泻痰,消积的功能,治胸腹胀痛,胸痹,痞痛,痰癖,水肿,食积,便秘,胃下垂,子宫下垂, 脱肛。选用木香是因为其性味辛苦,温,入肺、肝、脾经,有行气止痛,温中和胃的功能,治中 寒气滞,胸腹胀痛,呕吐,泄泻,下痢里急后重,寒疝。选用扁豆是因为其性味甘,平,入脾、胃 经,有健脾和中,消暑化湿的功能,治暑湿吐泻,脾虚呕逆,食少久泄,水停消渴,赤白带下, 小儿疳积。选用旋复花是因为其性味咸,温,入肺、肝、胃经,有消痰,下气,软坚,行水的功 能,治胸中痰结,胁下胀满,咳喘,呃逆,唾如胶漆,心下痞硬,噫气不除,大腹水肿。选用丹参 是因为其性味苦,微温,入心、肝经,有活血去瘀,安神宁心,排脓,止痛的功能,治心绞痛,月 经不调,痛经,以闭,血崩带下,癥瘕,积聚,瘀血腹痛,骨节疼痛,惊悸不眠,恶疮肿毒。选用 莱菔子是因为其性味辛甘,平,入肺、胃经,有下气定喘,消食化痰的功能,治咳嗽痰喘,食积 气滞,胸闷腹胀,下痢后重。选用鸡内金是因为其性味甘,平,入脾、胃经,有治积滞,健脾胃 的功能,治食积胀满,呕吐反胃,泻痢,疳积,消渴,遗溺,喉痹乳蛾,牙疳口疮。
[0007]具体实施方式 本发明组分的药物用量也是发明人经过大量摸索总结得出的,各组分的用量在下述重 量范围内都具有较好的疗效: 木瓜10_15g、玉米须8_18g、芝麻叶6_15g、杨树叶8_15g、茜草10_15g、稀莶草12_15g、 茯苓10-15g、火麻仁8-15g、郁李仁6-15g、石膏8-15g、知母10-15g、白芷10-15g、防风 8_15g、羌活6-15g、蜂蜜10-15g、饴糖10-15g、当归8-15g、何首乌8-15g、白芍10-15g、蚯蚓 8_14g、橘皮10-15g、枳实10-15g、木香8-15g、扁豆8-15g、旋复花5-10g、丹参6-10g、莱菔 子6-10g、鸡内金4-10g优选为: 木瓜15g、玉米须15g、芝麻叶15g、杨树叶15g、茜草15g、稀莶草15g、茯苓15g、火麻仁 15g、郁李仁15g、石膏15g、知母15g、白芷15g、防风15g、羌活15g、蜂蜜15g、饴糖15g、当归 15g、何首乌15g、白巧15g、te蝴15g、橘皮15g、积实15g、木香15g、扁豆15g、旋复花10g、丹 参l〇g、莱菔子l〇g、鸡内金l〇g 本发明药物的制备方法如下 一、备料 1、 木瓜:清水洗净,稍浸泡,闷润至透,置蒸笼内蒸熟,趁热切片,日晒夜露,以由红转紫 黑色为止; 2、 玉米须:取原药材,除去杂质,筛去灰屑; 3、 芝麻叶:除去杂质,洗净,晒干; 4、 杨树叶:除去杂质,洗净,晒干; 5、 茜草:除去杂质,洗净,润透,切厚片或段,干燥,筛去碎屑; 6、 稀莶草:取药材,除去杂质,洗净,稍晾、切段、晒干; 7、 茯苓:用水浸泡,洗净,捞出,闷透后,切片,晒干; 8、 火麻仁:拣去杂质及残留外壳,取净仁; 9、 郁李仁:筛去泥屑,淘净,拣净杂质和碎壳,晒干,用时捣碎; 10、 生石膏:去净杂石,洗净泥土,打碎成小块; 11、 知母:拣净杂质,用水撞洗,捞出,润软,切片晒干; 12、 白芷:拣净杂质,用水洗净,浸泡,捞出润透,略晒至外皮无滑腻感时,再闷润后,切 片干燥; 13、 防风:除去残茎,用水浸泡,捞出,润透切片,晒干; 14、 羌活:拣去杂质,洗净,润透,切片,晾干; 15、 蜂蜜:取纯净的蜂蜜,用文火熬炼,过滤去沫; 16、 饴糖:按量提取; 17、 当归:拣去杂质,洗净,闷润,稍晾,切片晒干; 18、 何首乌:拣去杂质,洗净,用水泡至八成透,捞出,润至内外湿度均匀,切片或切成方 块,晒干; 19、 白芍:拣去杂质,分开大小个,用水浸泡至八成透,捞出,晒晾,切片,干燥; 20、 蚯蚓:拣去杂质,用水漂净,及时捞出,晒干,切段; 21、 橘皮:刷去泥土,拣净杂质,喷淋清水,闷润后切丝或切片,晾干; 22、 枳实:拣净杂质,用水浸泡至八成透,捞出,润至内无硬心,切片,晾干; 23、 木香:将原生药放清水内洗净,捞出,闷润12 - 24小时使软,切片,晒干; 24、 扁豆:拣净杂质,置沸水中稍煮,至种皮鼓起、松软为度,捞出,浸入冷水中,脱去皮, 晒干; 25、 旋复花:拣净杂质,除去梗叶,筛去泥土; 26、 丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干; 27、 莱菔子:簸去杂质,漂净泥土,捞出,晒干,用时捣碎; 28、鸡内金:拣去杂质,漂净晒干。
[0008]二、制备 1、将所述重量的木瓜、玉米须、芝麻叶、杨树叶、茜草、稀莶草、茯苓、火麻仁、郁李仁、石 膏、知母、白芷、防风、羌活、蜂蜜、当归、何首乌、白芍、蚯蚓、橘皮、枳实、木香、扁豆、旋复花、 丹参、莱菔子、鸡内金加水煎煮两次,第一次加水6倍量,武火煎煮沸腾10分钟,再用文火煎 煮25分钟,过滤得第一次煎煮液。
[0009] 2、将第一次过滤后的药渣加水4倍量,武火煎煮沸腾,再用文火煎煮20分钟,过滤 得第二次煎煮液。
[0010] 3、合并两次煎煮液,武火煮沸,再用文火煎煮10分钟,加入烊化的饴糖,即得药 液,分为二剂服用。
[0011] 本发明选用茜草为君药,知母、蚯蚓为臣,火麻仁为佐,丹参为使,将上述药物与方 中诸药组合,制成排除肠道毒素的药物。
[0012] 本发明药物具有清热解毒、润燥滑肠、下气利水的功能,用于清除肠道毒素见效 快、疗效好,无副作用。以下通过试验例来进一步阐述本发明药物的有益效果,这些试验包 括本发明药物的动物毒性试验和临床疗效观察试验。
[0013][试验例1]本发明药物的动物毒性试验 取西德兔30只,雌雄兼用,体重2. 0-2. 5kg,分两组,每组15只,其中一组为超剂量试验 组,另一组为正常量试验组。超剂量试验组为25ml/kg,正常量为10ml/kg,给药方式为灌胃 法给药,每天二次,连服7天,每天观察给药反应,结果表明二组家兔活动、饮食正常,药物 无不良毒副作用。
[试验例2]本发明药物的临床疗效观察 1、一般资料 收治门诊患者共45例。
[0014] 2、诊断标准 肠道毒素累积的表现包括: 1)经常打嗝、腹胀、食欲差、吃饭没味道。
[0015] 2)大便不好:腹泻次数多、便秘时间长、大便不规律、不成形、大便硬结、恶臭、颜色 黑。
[0016] 3)气色差、面色晦暗、皮肤粗糙、毛孔扩张、痤疮等。
[0017] 4) 口臭、体味重、屁多屁臭。
[0018] 5)精力下降、易疲劳、头晕脑胀、健忘。
[0019] 3、治疗方法 选用上述药剂,给患者服用,每日一剂,连续服用14天。
[0020] 4、疗效评定标准 显效:患者的肠道毒素症状消失,因肠道毒素导致的非健康化情况痊愈,身体状况恢复 正常。
[0021] 好转:患者的肠道毒素症状减轻,体质恢复,食欲增加,精神状态逐步恢复正常。
[0022] 无效:达不到好转标准者。
[0023]5、治疗结果(见下表):
Figure CN104383334AD00081
在上述治疗中,用本发明药物进行肠道毒素排除的患者45例,结果显效36例,显效率 为80%,好转8例,好转率为17. 78%,无效1例,总有效率为97. 78%。

Claims (3)

1. 一种清除肠道毒素的药物,其特征在于:它是由下列重量范围内的原料药制成:木 瓜l〇-15g、玉米须8_18g、芝麻叶6_15g、杨树叶8_15g、茜草10_15g、稀莶草12_15g、获茶 10-15g、火麻仁8-15g、郁李仁6-15g、石膏8-15g、知母10-15g、白芷10-15g、防风8-15g、羌 活6-15g、蜂蜜10-15g、饴糖10-15g、当归8-15g、何首乌8-15g、白芍10-15g、蚯蚓8-14g、橘 皮10-15g、枳实10-15g、木香8-15g、扁豆8-15g、旋复花5-10g、丹参6-10g、莱菔子6-10g、 鸡内金4-10g。
2. 根据权利要求1所述的药物,其中各原料药的用量为:木瓜15g、玉米须15g、芝麻 叶15g、杨树叶15g、茜草15g、稀莶草15g、获考:15g、火麻仁15g、郁李仁15g、石膏15g、知母 15g、白]E 15g、防风15g、芜;活15g、蜂蜜15g、饴糖15g、当归15g、何首乌15g、白巧15g、虫丘虫引 15g、橘皮15g、积实15g、木香15g、扁豆15g、旋复花10g、丹参10g、莱菔子10g、鸡内金10g。
3. 根据权利要求1或2所述清除肠道毒素药物的制备方法,其特征在于,它包括下列步 骤: (一)备料 (1) 木瓜:清水洗净,稍浸泡,闷润至透,置蒸笼内蒸熟,趁热切片,日晒夜露,以由红转 紫黑色为止; (2) 玉米须:取原药材,除去杂质,筛去灰屑; (3) 芝麻叶:除去杂质,洗净,晒干; (4) 杨树叶:除去杂质,洗净,晒干; (5) 茜草:除去杂质,洗净,润透,切厚片或段,干燥,筛去碎屑; (6) 稀莶草:取药材,除去杂质,洗净,稍晾、切段、晒干; (7) 茯苓:用水浸泡,洗净,捞出,闷透后,切片,晒干; (8) 火麻仁:拣去杂质及残留外壳,取净仁; (9) 郁李仁:筛去泥屑,淘净,拣净杂质和碎壳,晒干,用时捣碎; (10) 生石膏:去净杂石,洗净泥土,打碎成小块; (11) 知母:拣净杂质,用水撞洗,捞出,润软,切片晒干; (12) 白芷:拣净杂质,用水洗净,浸泡,捞出润透,略晒至外皮无滑腻感时,再闷润后,切 片干燥; (13) 防风:除去残茎,用水浸泡,捞出,润透切片,晒干; (14) 羌活:拣去杂质,洗净,润透,切片,晾干; (15) 蜂蜜:取纯净的蜂蜜,用文火熬炼,过滤去沫; (16) 饴糖:按量提取; (17) 当归:拣去杂质,洗净,闷润,稍晾,切片晒干; (18) 何首乌:拣去杂质,洗净,用水泡至八成透,捞出,润至内外湿度均匀,切片或切成 方块,晒干; (19) 白芍:拣去杂质,分开大小个,用水浸泡至八成透,捞出,晒晾,切片,干燥; (20) 蚯蚓:拣去杂质,用水漂净,及时捞出,晒干,切段; (21) 橘皮:刷去泥土,拣净杂质,喷淋清水,闷润后切丝或切片,晾干; (22) 枳实:拣净杂质,用水浸泡至八成透,捞出,润至内无硬心,切片,晾干; (23) 木香:将原生药放清水内洗净,捞出,闷润12 - 24小时使软,切片,晒干; (24) 扁豆:拣净杂质,置沸水中稍煮,至种皮鼓起、松软为度,捞出,浸入冷水中,脱去 皮,晒干; (25) 旋复花:拣净杂质,除去梗叶,筛去泥土; (26) 丹参:拣净杂质,除去根茎,洗净,捞出,润透后切片,晾干; (27 )莱菔子:簸去杂质,漂净泥土,捞出,晒干,用时捣碎; (28)鸡内金:拣去杂质,漂净晒干; (二)制备 (1) 将所述重量的木瓜、玉米须、芝麻叶、杨树叶、茜草、稀莶草、茯苓、火麻仁、郁李仁、 石膏、知母、白芷、防风、羌活、蜂蜜、当归、何首乌、白芍、蚯蚓、橘皮、枳实、木香、扁豆、旋复 花、丹参、莱菔子、鸡内金加水煎煮两次,第一次加水6倍量,武火煎煮沸腾10分钟,再用文 火煎煮25分钟,过滤得第一次煎煮液, (2) 将第一次过滤后的药渣加水4倍量,武火煎煮沸腾,再用文火煎煮20分钟,过滤得 第二次煎煮液, (3) 合并两次煎煮液,武火煮沸,再用文火煎煮10分钟,加入烊化的饴糖,即得药液。
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