CN108291230B - 用于使rna稳定的3’utr序列 - Google Patents

用于使rna稳定的3’utr序列 Download PDF

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CN108291230B
CN108291230B CN201680058612.3A CN201680058612A CN108291230B CN 108291230 B CN108291230 B CN 108291230B CN 201680058612 A CN201680058612 A CN 201680058612A CN 108291230 B CN108291230 B CN 108291230B
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nucleic acid
acid sequence
sequence
rna
untranslated region
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CN108291230A (zh
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亚历山德拉·奥兰迪尼冯尼森
斯特凡妮·费塞尔
布丽塔·瓦拉扎
蒂姆·拜塞特
安德烈亚斯·库恩
乌尔·沙欣
马尔科·亚历山大·波莱加诺夫
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Translationale Onkologie An Der Universitatsmedizin Der Johannes Gutenberg-Univers
Debiotech SA
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Translationale Onkologie An Der Universitatsmedizin Der Johannes Gutenberg-Univers
Debiotech SA
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CN201680058612.3A 2015-10-07 2016-10-05 用于使rna稳定的3’utr序列 Active CN108291230B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/EP2015/073180 WO2017059902A1 (en) 2015-10-07 2015-10-07 3' utr sequences for stabilization of rna
EPPCT/EP2015/073180 2015-10-07
PCT/EP2016/073814 WO2017060314A2 (en) 2015-10-07 2016-10-05 3' utr sequences for stabilization of rna

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Publication Number Publication Date
CN108291230A CN108291230A (zh) 2018-07-17
CN108291230B true CN108291230B (zh) 2022-12-20

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EP (3) EP3337902B1 (https=)
JP (6) JP7084302B2 (https=)
KR (4) KR102848891B1 (https=)
CN (1) CN108291230B (https=)
AU (3) AU2016335029B2 (https=)
BR (2) BR112018003486B1 (https=)
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WO2017059902A1 (en) 2015-10-07 2017-04-13 Biontech Rna Pharmaceuticals Gmbh 3' utr sequences for stabilization of rna
WO2018013525A1 (en) 2016-07-11 2018-01-18 Translate Bio Ma, Inc. Nucleic acid conjugates and uses thereof
KR102718353B1 (ko) * 2016-10-17 2024-10-15 얀센 파마슈티칼즈, 인코포레이티드 재조합 바이러스 레플리콘 시스템 및 그의 용도
CA3072960A1 (en) * 2017-08-15 2019-02-21 Intellia Therapeutics, Inc. Stabilized nucleic acids encoding messenger ribonucleic acid (mrna)
WO2019140102A1 (en) 2018-01-10 2019-07-18 Translate Bio Ma, Inc. Compositions and methods for facilitating delivery of synthetic nucleic acids to cells
US20210113606A1 (en) 2018-02-12 2021-04-22 Biontech Rna Pharmaceuticals Gmbh Treatment using cytokine encoding rna
EP3788155A1 (en) * 2018-05-01 2021-03-10 Wake Forest University Health Sciences Lentiviral-based vectors and related systems and methods for eukaryotic gene editing
MX2021000801A (es) 2018-07-24 2021-04-12 BioNTech SE Agonistas de il2.
AU2020208193A1 (en) * 2019-01-14 2021-07-29 BioNTech SE Methods of treating cancer with a PD-1 axis binding antagonist and an RNA vaccine
EP4414033A3 (en) 2019-02-08 2024-10-30 Biontech Cell & Gene Therapies Gmbh Treatment involving car-engineered t cells and cytokines
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