CN1080263C - 合成β－构型二氧戊环核苷的方法及中间体 - Google Patents

合成β－构型二氧戊环核苷的方法及中间体 Download PDF

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Publication number
CN1080263C
CN1080263C CN96199879A CN96199879A CN1080263C CN 1080263 C CN1080263 C CN 1080263C CN 96199879 A CN96199879 A CN 96199879A CN 96199879 A CN96199879 A CN 96199879A CN 1080263 C CN1080263 C CN 1080263C
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CN
China
Prior art keywords
formula
alkyl
hydrogen
group
iodine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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CN96199879A
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English (en)
Chinese (zh)
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CN1208414A (zh
Inventor
T·曼索尔
A·斯姆波伊尔
K·贝德纳斯基
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Shire Canada Inc
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Biochem Pharma Inc
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Publication of CN1208414A publication Critical patent/CN1208414A/zh
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Publication of CN1080263C publication Critical patent/CN1080263C/zh
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Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
CN96199879A 1995-12-14 1996-12-13 合成β－构型二氧戊环核苷的方法及中间体 Expired - Lifetime CN1080263C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9525606.1A GB9525606D0 (en) 1995-12-14 1995-12-14 Method and compositions for the synthesis of dioxolane nucleosides with › - configuration
GB9525606.1 1995-12-14

Publications (2)

Publication Number Publication Date
CN1208414A CN1208414A (zh) 1999-02-17
CN1080263C true CN1080263C (zh) 2002-03-06

Family

ID=10785435

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96199879A Expired - Lifetime CN1080263C (zh) 1995-12-14 1996-12-13 合成β－构型二氧戊环核苷的方法及中间体

Country Status (27)

Country Link
US (4) US5922867A (enExample)
EP (1) EP0970074B1 (enExample)
JP (1) JP3229990B2 (enExample)
KR (1) KR100406159B1 (enExample)
CN (1) CN1080263C (enExample)
AP (1) AP879A (enExample)
AT (1) ATE214699T1 (enExample)
AU (1) AU706328B2 (enExample)
BR (1) BR9612351A (enExample)
CA (1) CA2237730C (enExample)
DE (1) DE69620042T2 (enExample)
DK (1) DK0970074T3 (enExample)
EA (1) EA000844B1 (enExample)
ES (1) ES2172697T3 (enExample)
GB (1) GB9525606D0 (enExample)
HU (1) HU224076B1 (enExample)
IL (3) IL124663A (enExample)
IN (1) IN187349B (enExample)
MX (1) MX9804701A (enExample)
NO (1) NO309901B1 (enExample)
NZ (1) NZ323855A (enExample)
OA (1) OA11094A (enExample)
PL (1) PL188447B1 (enExample)
PT (1) PT970074E (enExample)
TW (1) TW341574B (enExample)
WO (1) WO1997021706A1 (enExample)
ZA (1) ZA9610544B (enExample)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
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JP2001518899A (ja) 1997-04-07 2001-10-16 トライアングル ファーマシューティカルズ，インコーポレイティド 他の抗ウイルス剤との組合せにおけるｍｋｃ−４４２の使用
EP1104415B1 (en) 1998-08-12 2004-11-10 Gilead Sciences, Inc. Method of manufacture of 1,3-oxathiolane nucleosides
US6979561B1 (en) * 1998-10-09 2005-12-27 Gilead Sciences, Inc. Non-homogeneous systems for the resolution of enantiomeric mixtures
EA004767B1 (ru) 1998-12-23 2004-08-26 Шайре Байокем Инк. Аналоги нуклеозида (варианты) и их применение, комбинация и способ лечения вирусных инфекций, фармацевтическая композиция
WO2000047759A1 (en) * 1999-02-11 2000-08-17 Shire Biochem Inc. Stereoselective synthesis of nucleoside analogues
JP2003510271A (ja) * 1999-09-24 2003-03-18 シャイアー・バイオケム・インコーポレイテッド ヌクレオシドアナログを使用したウィルス感染の処置または予防のための方法
US6566365B1 (en) 1999-11-04 2003-05-20 Biochem Pharma Inc. Method for the treatment of Flaviviridea viral infection using nucleoside analogues
KR100517163B1 (ko) * 2000-02-10 2005-09-26 미쯔이카가쿠 가부시기가이샤 1-인산화 당유도체 아노머의 선택적인 제조방법 및뉴클레오사이드의 제조방법
EP1265890B1 (en) * 2000-02-11 2007-04-18 Shire BioChem Inc. Stereoselective synthesis of nucleoside analogues
WO2002051852A1 (fr) * 2000-12-27 2002-07-04 Mitsui Chemicals, Inc. Procede de production d'un derive de saccharide non naturel
CN1503796B (zh) 2001-03-01 2012-07-04 三角药品公司 顺-ftc的多晶型物及其它晶型
AU2002329970A1 (en) * 2001-09-04 2003-03-18 Isis Pharmaceuticals, Inc. Pyrrolo(2,3-d)pyrimidines for inhibiting rna-dependent rna viral polymerase
CA2465682A1 (en) * 2001-11-02 2003-05-08 Shire Biochem Inc. Methods of treating leukemia
KR100978904B1 (ko) 2001-12-14 2010-08-31 파마셋 인코포레이티드 바이러스 감염 치료용 ｎ4-아실사이토신 뉴클레오사이드
ATE548366T1 (de) * 2002-01-25 2012-03-15 Shire Biochem Inc Verfahren zur herstellung von dioxolan nukleosidanalogavorstufen
EP1534255B1 (en) 2002-08-06 2011-01-19 Pharmasset, Inc. Processes for preparing 1,3-dioxolane nucleosides
ES2394304T3 (es) 2002-10-15 2013-01-30 Exxonmobil Chemical Patents, Inc. Sistema de múltiples catalizadores para la polimerización de olefinas y polímeros producidos a partir de éstos
DE10335061B4 (de) 2003-07-31 2005-11-17 Wacker-Chemie Gmbh Verfahren zur Herstellung von OH-geschützten [4-(2,6-damino-9H-purin-9-yl)-1,3-dioxolan-2-yl]methanol-Derivaten
WO2005074654A2 (en) * 2004-02-03 2005-08-18 Emory University Methods to manufacture 1,3-dioxolane nucleosides
US7749531B2 (en) * 2005-06-08 2010-07-06 Indicator Systems International Apparatus and method for detecting bacterial growth beneath a wound dressing
BRPI0813036A2 (pt) * 2007-07-30 2017-10-24 Rfs Pharma Llc processo estereosseletivo para preparar derivados do nucleosídeo dioxolana de purina.
CN101862676B (zh) * 2009-04-17 2012-01-25 中国石油化工股份有限公司 大孔径sba-15介孔材料-三氟甲磺酸铜复合催化剂、制备方法及应用
CN103288806A (zh) * 2013-07-02 2013-09-11 山东大学 一种曲沙他滨的合成方法
WO2018022263A1 (en) 2016-07-29 2018-02-01 Exxonmobil Chemical Patents Inc. Polymerization processes using high molecular weight polyhydric quenching agents
JP7337539B2 (ja) 2018-06-21 2023-09-04 メディヴィル・アクチエボラーグ 白血病療法のための塩基修飾シチジンヌクレオチド
WO2019245444A1 (en) 2018-06-21 2019-12-26 Medivir Ab Base-modified cytidine nucleotides for leukemia therapy

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992014729A1 (en) * 1991-02-22 1992-09-03 Emory University Antiviral 1,3-dioxolane nucleosides and synthesis thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NO932286L (no) * 1992-06-22 1993-12-23 Lilly Co Eli Stereoselektiv anion-glykosyleringsprosess

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992014729A1 (en) * 1991-02-22 1992-09-03 Emory University Antiviral 1,3-dioxolane nucleosides and synthesis thereof

Also Published As

Publication number Publication date
TW341574B (en) 1998-10-01
ES2172697T3 (es) 2002-10-01
CN1208414A (zh) 1999-02-17
DE69620042T2 (de) 2002-10-17
IL144155A (en) 2003-07-06
EA000844B1 (ru) 2000-06-26
AP879A (en) 2000-10-02
CA2237730A1 (en) 1997-06-19
EP0970074A1 (en) 2000-01-12
ZA9610544B (en) 1997-07-29
HUP9901050A3 (en) 2001-05-28
PL327443A1 (en) 1998-12-07
DK0970074T3 (da) 2002-07-15
NZ323855A (en) 1999-11-29
US20030060476A1 (en) 2003-03-27
US6069250A (en) 2000-05-30
KR100406159B1 (ko) 2004-11-16
GB9525606D0 (en) 1996-02-14
AU706328B2 (en) 1999-06-17
NO982716D0 (no) 1998-06-12
IL144155A0 (en) 2002-05-23
NO982716L (no) 1998-06-12
US20020058670A1 (en) 2002-05-16
WO1997021706A1 (en) 1997-06-19
HK1017886A1 (en) 1999-12-03
DE69620042D1 (de) 2002-04-25
CA2237730C (en) 2001-12-04
AU1089397A (en) 1997-07-03
EA199800555A1 (ru) 1999-02-25
EP0970074B1 (en) 2002-03-20
ATE214699T1 (de) 2002-04-15
HU224076B1 (hu) 2005-05-30
MX9804701A (es) 1998-10-31
BR9612351A (pt) 1999-07-13
JP2000501714A (ja) 2000-02-15
AP9801252A0 (en) 1998-06-30
OA11094A (en) 2003-03-13
NO309901B1 (no) 2001-04-17
US5922867A (en) 1999-07-13
PT970074E (pt) 2002-09-30
IL124663A (en) 2001-10-31
IN187349B (enExample) 2002-03-30
KR19990072141A (ko) 1999-09-27
PL188447B1 (pl) 2005-02-28
IL124663A0 (en) 1998-12-06
HUP9901050A2 (hu) 2001-04-28
JP3229990B2 (ja) 2001-11-19

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