BR9612351A - Processo para a síntese de nucleosídeos dioxolana com configuração b- - Google Patents
Processo para a síntese de nucleosídeos dioxolana com configuração b-Info
- Publication number
- BR9612351A BR9612351A BR9612351A BR9612351A BR9612351A BR 9612351 A BR9612351 A BR 9612351A BR 9612351 A BR9612351 A BR 9612351A BR 9612351 A BR9612351 A BR 9612351A BR 9612351 A BR9612351 A BR 9612351A
- Authority
- BR
- Brazil
- Prior art keywords
- synthesis
- configuration
- dioxolane nucleosides
- nucleosides
- dioxolane
- Prior art date
Links
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 239000002777 nucleoside Substances 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9525606.1A GB9525606D0 (en) | 1995-12-14 | 1995-12-14 | Method and compositions for the synthesis of dioxolane nucleosides with - configuration |
| PCT/CA1996/000845 WO1997021706A1 (en) | 1995-12-14 | 1996-12-13 | METHOD AND COMPOSITIONS FOR THE SYNTHESIS OF DIOXOLANE NUCLEOSIDES WITH β-CONFIGURATION |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR9612351A true BR9612351A (pt) | 1999-07-13 |
Family
ID=10785435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR9612351A BR9612351A (pt) | 1995-12-14 | 1996-12-13 | Processo para a síntese de nucleosídeos dioxolana com configuração b- |
Country Status (27)
| Country | Link |
|---|---|
| US (4) | US5922867A (enExample) |
| EP (1) | EP0970074B1 (enExample) |
| JP (1) | JP3229990B2 (enExample) |
| KR (1) | KR100406159B1 (enExample) |
| CN (1) | CN1080263C (enExample) |
| AP (1) | AP879A (enExample) |
| AT (1) | ATE214699T1 (enExample) |
| AU (1) | AU706328B2 (enExample) |
| BR (1) | BR9612351A (enExample) |
| CA (1) | CA2237730C (enExample) |
| DE (1) | DE69620042T2 (enExample) |
| DK (1) | DK0970074T3 (enExample) |
| EA (1) | EA000844B1 (enExample) |
| ES (1) | ES2172697T3 (enExample) |
| GB (1) | GB9525606D0 (enExample) |
| HU (1) | HU224076B1 (enExample) |
| IL (3) | IL144155A (enExample) |
| IN (1) | IN187349B (enExample) |
| MX (1) | MX9804701A (enExample) |
| NO (1) | NO309901B1 (enExample) |
| NZ (1) | NZ323855A (enExample) |
| OA (1) | OA11094A (enExample) |
| PL (1) | PL188447B1 (enExample) |
| PT (1) | PT970074E (enExample) |
| TW (1) | TW341574B (enExample) |
| WO (1) | WO1997021706A1 (enExample) |
| ZA (1) | ZA9610544B (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2285577A1 (en) | 1997-04-07 | 1998-10-15 | Triangle Pharmaceuticals, Inc. | Compositions containing mkc-442 in combination with other antiviral agents |
| CA2340214C (en) | 1998-08-12 | 2007-10-30 | Triangle Pharmaceuticals, Inc. | Method of manufacture of 1,3-oxathiolane nucleosides |
| US6979561B1 (en) * | 1998-10-09 | 2005-12-27 | Gilead Sciences, Inc. | Non-homogeneous systems for the resolution of enantiomeric mixtures |
| IL143867A0 (en) | 1998-12-23 | 2002-04-21 | Shire Biochem Inc | Antiviral nucleoside analogues |
| AU2653200A (en) * | 1999-02-11 | 2000-08-29 | Biochem Pharma Inc. | Stereoselective synthesis of nucleoside analogues |
| WO2001022950A2 (en) * | 1999-09-24 | 2001-04-05 | Shire Biochem Inc. | Diosolane nucleoside analogs for the treatment or prevention of viral infection |
| CA2389745C (en) * | 1999-11-04 | 2010-03-23 | Shire Biochem Inc. | Method for the treatment or prevention of flaviviridae viral infection using nucleoside analogues |
| BR0104461A (pt) * | 2000-02-10 | 2002-08-06 | Mitsui Chemicals Inc | Processo seletivo para produzir um anÈmero a partir de um derivado de sacarìdeo 1-fosforilado e processo para produzir um nucleosìdeo |
| WO2001058894A1 (en) * | 2000-02-11 | 2001-08-16 | Shire Biochem Inc. | Stereoselective synthesis of nucleoside analogues |
| WO2002051852A1 (fr) * | 2000-12-27 | 2002-07-04 | Mitsui Chemicals, Inc. | Procede de production d'un derive de saccharide non naturel |
| ATE383355T1 (de) * | 2001-03-01 | 2008-01-15 | Abbott Lab | Polymorph und andere kristallinische formen von zusammen-ftc |
| AU2002329970A1 (en) * | 2001-09-04 | 2003-03-18 | Isis Pharmaceuticals, Inc. | Pyrrolo(2,3-d)pyrimidines for inhibiting rna-dependent rna viral polymerase |
| CA2465682A1 (en) * | 2001-11-02 | 2003-05-08 | Shire Biochem Inc. | Methods of treating leukemia |
| BR0214944A (pt) * | 2001-12-14 | 2005-06-07 | Pharmasset Ltd | Nucleosìdeos de n4-acilcitosina para o tratamento de infecções virais |
| EP1467990B1 (en) * | 2002-01-25 | 2012-03-07 | Shire BioChem Inc. | Process for producing dioxolane nucleoside analogue precursors |
| MXPA05001451A (es) | 2002-08-06 | 2005-09-30 | Pharmasset Ltd | Procesos para preparar nucleosidos de 1,3-dioxolano. |
| WO2005108442A1 (en) | 2002-10-15 | 2005-11-17 | Exxonmobil Chemical Patents Inc. | Polyolefin adhesive compositions and articles made therefrom |
| DE10335061B4 (de) * | 2003-07-31 | 2005-11-17 | Wacker-Chemie Gmbh | Verfahren zur Herstellung von OH-geschützten [4-(2,6-damino-9H-purin-9-yl)-1,3-dioxolan-2-yl]methanol-Derivaten |
| KR101157468B1 (ko) | 2004-02-03 | 2012-07-06 | 에모리 유니버시티 | 1,3-디옥솔란 뉴클레오시드 제조방법 |
| US7749531B2 (en) * | 2005-06-08 | 2010-07-06 | Indicator Systems International | Apparatus and method for detecting bacterial growth beneath a wound dressing |
| BRPI0813036A2 (pt) * | 2007-07-30 | 2017-10-24 | Rfs Pharma Llc | processo estereosseletivo para preparar derivados do nucleosídeo dioxolana de purina. |
| CN101862676B (zh) * | 2009-04-17 | 2012-01-25 | 中国石油化工股份有限公司 | 大孔径sba-15介孔材料-三氟甲磺酸铜复合催化剂、制备方法及应用 |
| CN103288806A (zh) * | 2013-07-02 | 2013-09-11 | 山东大学 | 一种曲沙他滨的合成方法 |
| WO2018022263A1 (en) | 2016-07-29 | 2018-02-01 | Exxonmobil Chemical Patents Inc. | Polymerization processes using high molecular weight polyhydric quenching agents |
| WO2019245444A1 (en) | 2018-06-21 | 2019-12-26 | Medivir Ab | Base-modified cytidine nucleotides for leukemia therapy |
| JP7337539B2 (ja) * | 2018-06-21 | 2023-09-04 | メディヴィル・アクチエボラーグ | 白血病療法のための塩基修飾シチジンヌクレオチド |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5276151A (en) * | 1990-02-01 | 1994-01-04 | Emory University | Method of synthesis of 1,3-dioxolane nucleosides |
| BR9302431A (pt) * | 1992-06-22 | 1994-01-11 | Lilly Co Eli | Processo de glicosilacao de anion estereosseletivo |
-
1995
- 1995-12-14 GB GBGB9525606.1A patent/GB9525606D0/en active Pending
-
1996
- 1996-12-13 ES ES96941539T patent/ES2172697T3/es not_active Expired - Lifetime
- 1996-12-13 TW TW085115392A patent/TW341574B/zh active
- 1996-12-13 PT PT96941539T patent/PT970074E/pt unknown
- 1996-12-13 CN CN96199879A patent/CN1080263C/zh not_active Expired - Lifetime
- 1996-12-13 NZ NZ323855A patent/NZ323855A/xx unknown
- 1996-12-13 HU HU9901050A patent/HU224076B1/hu active IP Right Grant
- 1996-12-13 WO PCT/CA1996/000845 patent/WO1997021706A1/en not_active Ceased
- 1996-12-13 AT AT96941539T patent/ATE214699T1/de not_active IP Right Cessation
- 1996-12-13 US US08/849,722 patent/US5922867A/en not_active Expired - Lifetime
- 1996-12-13 BR BR9612351A patent/BR9612351A/pt not_active Application Discontinuation
- 1996-12-13 CA CA002237730A patent/CA2237730C/en not_active Expired - Lifetime
- 1996-12-13 EP EP96941539A patent/EP0970074B1/en not_active Expired - Lifetime
- 1996-12-13 ZA ZA9610544A patent/ZA9610544B/xx unknown
- 1996-12-13 PL PL96327443A patent/PL188447B1/pl not_active IP Right Cessation
- 1996-12-13 JP JP52157397A patent/JP3229990B2/ja not_active Expired - Lifetime
- 1996-12-13 KR KR10-1998-0704473A patent/KR100406159B1/ko not_active Expired - Fee Related
- 1996-12-13 AU AU10893/97A patent/AU706328B2/en not_active Expired
- 1996-12-13 IL IL14415596A patent/IL144155A/xx not_active IP Right Cessation
- 1996-12-13 AP APAP/P/1998/001252A patent/AP879A/en active
- 1996-12-13 IN IN2810DE1996 patent/IN187349B/en unknown
- 1996-12-13 IL IL12466396A patent/IL124663A/en not_active IP Right Cessation
- 1996-12-13 DK DK96941539T patent/DK0970074T3/da active
- 1996-12-13 DE DE69620042T patent/DE69620042T2/de not_active Expired - Lifetime
- 1996-12-13 EA EA199800555A patent/EA000844B1/ru not_active IP Right Cessation
-
1998
- 1998-06-09 OA OA9800077A patent/OA11094A/en unknown
- 1998-06-11 MX MX9804701A patent/MX9804701A/es unknown
- 1998-06-12 NO NO982716A patent/NO309901B1/no unknown
-
1999
- 1999-02-17 US US09/251,431 patent/US6069250A/en not_active Expired - Lifetime
-
2001
- 2001-07-05 IL IL14415501A patent/IL144155A0/xx unknown
- 2001-11-16 US US09/987,845 patent/US20020058670A1/en not_active Abandoned
-
2002
- 2002-10-02 US US10/262,107 patent/US20030060476A1/en not_active Abandoned
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EG | Technical examination (opinion): publication of technical examination (opinion) | ||
| FC | Decision: refusal |