TW341574B - METHOD AND COMPOSITIONS FOR THE SYNTHESIS OF DIOXOLANE NUCLEOSIDES WITH β-CONFIGURATION the invention relates to methods and compositions for preparing biologically important nucleoside analogues containing 1,3-dioxolane sugar rings. - Google Patents
METHOD AND COMPOSITIONS FOR THE SYNTHESIS OF DIOXOLANE NUCLEOSIDES WITH β-CONFIGURATION the invention relates to methods and compositions for preparing biologically important nucleoside analogues containing 1,3-dioxolane sugar rings.Info
- Publication number
- TW341574B TW341574B TW085115392A TW85115392A TW341574B TW 341574 B TW341574 B TW 341574B TW 085115392 A TW085115392 A TW 085115392A TW 85115392 A TW85115392 A TW 85115392A TW 341574 B TW341574 B TW 341574B
- Authority
- TW
- Taiwan
- Prior art keywords
- compositions
- dioxolane
- synthesis
- configuration
- methods
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 230000015572 biosynthetic process Effects 0.000 title abstract 2
- 238000003786 synthesis reaction Methods 0.000 title abstract 2
- WNXJIVFYUVYPPR-UHFFFAOYSA-N 1,3-dioxolane Chemical compound C1COCO1 WNXJIVFYUVYPPR-UHFFFAOYSA-N 0.000 title 2
- 239000000203 mixture Substances 0.000 title 2
- 239000002777 nucleoside Substances 0.000 title 1
- 229940127073 nucleoside analogue Drugs 0.000 title 1
- KDCGOANMDULRCW-UHFFFAOYSA-N Purine Natural products N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 abstract 3
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical group C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 abstract 2
- YNWUIBSEOAWSHW-HIQWKFPQSA-N 5-[(e)-2-bromoethenyl]-1-[(2s,4s)-2-(hydroxymethyl)-1,3-dioxolan-4-yl]pyrimidine-2,4-dione Chemical compound O1[C@@H](CO)OC[C@H]1N1C(=O)NC(=O)C(\C=C\Br)=C1 YNWUIBSEOAWSHW-HIQWKFPQSA-N 0.000 abstract 1
- 230000001279 glycosylating effect Effects 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000000561 purinyl group Chemical group N1=C(N=C2N=CNC2=C1)* 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9525606.1A GB9525606D0 (en) | 1995-12-14 | 1995-12-14 | Method and compositions for the synthesis of dioxolane nucleosides with - configuration |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TW341574B true TW341574B (en) | 1998-10-01 |
Family
ID=10785435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW085115392A TW341574B (en) | 1995-12-14 | 1996-12-13 | METHOD AND COMPOSITIONS FOR THE SYNTHESIS OF DIOXOLANE NUCLEOSIDES WITH β-CONFIGURATION the invention relates to methods and compositions for preparing biologically important nucleoside analogues containing 1,3-dioxolane sugar rings. |
Country Status (27)
| Country | Link |
|---|---|
| US (4) | US5922867A (enExample) |
| EP (1) | EP0970074B1 (enExample) |
| JP (1) | JP3229990B2 (enExample) |
| KR (1) | KR100406159B1 (enExample) |
| CN (1) | CN1080263C (enExample) |
| AP (1) | AP879A (enExample) |
| AT (1) | ATE214699T1 (enExample) |
| AU (1) | AU706328B2 (enExample) |
| BR (1) | BR9612351A (enExample) |
| CA (1) | CA2237730C (enExample) |
| DE (1) | DE69620042T2 (enExample) |
| DK (1) | DK0970074T3 (enExample) |
| EA (1) | EA000844B1 (enExample) |
| ES (1) | ES2172697T3 (enExample) |
| GB (1) | GB9525606D0 (enExample) |
| HU (1) | HU224076B1 (enExample) |
| IL (3) | IL124663A (enExample) |
| IN (1) | IN187349B (enExample) |
| MX (1) | MX9804701A (enExample) |
| NO (1) | NO309901B1 (enExample) |
| NZ (1) | NZ323855A (enExample) |
| OA (1) | OA11094A (enExample) |
| PL (1) | PL188447B1 (enExample) |
| PT (1) | PT970074E (enExample) |
| TW (1) | TW341574B (enExample) |
| WO (1) | WO1997021706A1 (enExample) |
| ZA (1) | ZA9610544B (enExample) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001518899A (ja) | 1997-04-07 | 2001-10-16 | トライアングル ファーマシューティカルズ，インコーポレイティド | 他の抗ウイルス剤との組合せにおけるｍｋｃ−４４２の使用 |
| EP1104415B1 (en) | 1998-08-12 | 2004-11-10 | Gilead Sciences, Inc. | Method of manufacture of 1,3-oxathiolane nucleosides |
| US6979561B1 (en) * | 1998-10-09 | 2005-12-27 | Gilead Sciences, Inc. | Non-homogeneous systems for the resolution of enantiomeric mixtures |
| EA004767B1 (ru) | 1998-12-23 | 2004-08-26 | Шайре Байокем Инк. | Аналоги нуклеозида (варианты) и их применение, комбинация и способ лечения вирусных инфекций, фармацевтическая композиция |
| WO2000047759A1 (en) * | 1999-02-11 | 2000-08-17 | Shire Biochem Inc. | Stereoselective synthesis of nucleoside analogues |
| JP2003510271A (ja) * | 1999-09-24 | 2003-03-18 | シャイアー・バイオケム・インコーポレイテッド | ヌクレオシドアナログを使用したウィルス感染の処置または予防のための方法 |
| US6566365B1 (en) | 1999-11-04 | 2003-05-20 | Biochem Pharma Inc. | Method for the treatment of Flaviviridea viral infection using nucleoside analogues |
| KR100517163B1 (ko) * | 2000-02-10 | 2005-09-26 | 미쯔이카가쿠 가부시기가이샤 | 1-인산화 당유도체 아노머의 선택적인 제조방법 및뉴클레오사이드의 제조방법 |
| EP1265890B1 (en) * | 2000-02-11 | 2007-04-18 | Shire BioChem Inc. | Stereoselective synthesis of nucleoside analogues |
| WO2002051852A1 (fr) * | 2000-12-27 | 2002-07-04 | Mitsui Chemicals, Inc. | Procede de production d'un derive de saccharide non naturel |
| CN1503796B (zh) | 2001-03-01 | 2012-07-04 | 三角药品公司 | 顺-ftc的多晶型物及其它晶型 |
| AU2002329970A1 (en) * | 2001-09-04 | 2003-03-18 | Isis Pharmaceuticals, Inc. | Pyrrolo(2,3-d)pyrimidines for inhibiting rna-dependent rna viral polymerase |
| CA2465682A1 (en) * | 2001-11-02 | 2003-05-08 | Shire Biochem Inc. | Methods of treating leukemia |
| KR100978904B1 (ko) | 2001-12-14 | 2010-08-31 | 파마셋 인코포레이티드 | 바이러스 감염 치료용 ｎ4-아실사이토신 뉴클레오사이드 |
| ATE548366T1 (de) * | 2002-01-25 | 2012-03-15 | Shire Biochem Inc | Verfahren zur herstellung von dioxolan nukleosidanalogavorstufen |
| EP1534255B1 (en) | 2002-08-06 | 2011-01-19 | Pharmasset, Inc. | Processes for preparing 1,3-dioxolane nucleosides |
| ES2394304T3 (es) | 2002-10-15 | 2013-01-30 | Exxonmobil Chemical Patents, Inc. | Sistema de múltiples catalizadores para la polimerización de olefinas y polímeros producidos a partir de éstos |
| DE10335061B4 (de) | 2003-07-31 | 2005-11-17 | Wacker-Chemie Gmbh | Verfahren zur Herstellung von OH-geschützten [4-(2,6-damino-9H-purin-9-yl)-1,3-dioxolan-2-yl]methanol-Derivaten |
| WO2005074654A2 (en) * | 2004-02-03 | 2005-08-18 | Emory University | Methods to manufacture 1,3-dioxolane nucleosides |
| US7749531B2 (en) * | 2005-06-08 | 2010-07-06 | Indicator Systems International | Apparatus and method for detecting bacterial growth beneath a wound dressing |
| BRPI0813036A2 (pt) * | 2007-07-30 | 2017-10-24 | Rfs Pharma Llc | processo estereosseletivo para preparar derivados do nucleosídeo dioxolana de purina. |
| CN101862676B (zh) * | 2009-04-17 | 2012-01-25 | 中国石油化工股份有限公司 | 大孔径sba-15介孔材料-三氟甲磺酸铜复合催化剂、制备方法及应用 |
| CN103288806A (zh) * | 2013-07-02 | 2013-09-11 | 山东大学 | 一种曲沙他滨的合成方法 |
| WO2018022263A1 (en) | 2016-07-29 | 2018-02-01 | Exxonmobil Chemical Patents Inc. | Polymerization processes using high molecular weight polyhydric quenching agents |
| JP7337539B2 (ja) | 2018-06-21 | 2023-09-04 | メディヴィル・アクチエボラーグ | 白血病療法のための塩基修飾シチジンヌクレオチド |
| WO2019245444A1 (en) | 2018-06-21 | 2019-12-26 | Medivir Ab | Base-modified cytidine nucleotides for leukemia therapy |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5276151A (en) * | 1990-02-01 | 1994-01-04 | Emory University | Method of synthesis of 1,3-dioxolane nucleosides |
| NO932286L (no) * | 1992-06-22 | 1993-12-23 | Lilly Co Eli | Stereoselektiv anion-glykosyleringsprosess |
-
1995
- 1995-12-14 GB GBGB9525606.1A patent/GB9525606D0/en active Pending
-
1996
- 1996-12-13 EP EP96941539A patent/EP0970074B1/en not_active Expired - Lifetime
- 1996-12-13 US US08/849,722 patent/US5922867A/en not_active Expired - Lifetime
- 1996-12-13 PT PT96941539T patent/PT970074E/pt unknown
- 1996-12-13 AP APAP/P/1998/001252A patent/AP879A/en active
- 1996-12-13 EA EA199800555A patent/EA000844B1/ru not_active IP Right Cessation
- 1996-12-13 WO PCT/CA1996/000845 patent/WO1997021706A1/en not_active Ceased
- 1996-12-13 PL PL96327443A patent/PL188447B1/pl not_active IP Right Cessation
- 1996-12-13 AT AT96941539T patent/ATE214699T1/de not_active IP Right Cessation
- 1996-12-13 HU HU9901050A patent/HU224076B1/hu active IP Right Grant
- 1996-12-13 ZA ZA9610544A patent/ZA9610544B/xx unknown
- 1996-12-13 JP JP52157397A patent/JP3229990B2/ja not_active Expired - Lifetime
- 1996-12-13 AU AU10893/97A patent/AU706328B2/en not_active Expired
- 1996-12-13 BR BR9612351A patent/BR9612351A/pt not_active Application Discontinuation
- 1996-12-13 CN CN96199879A patent/CN1080263C/zh not_active Expired - Lifetime
- 1996-12-13 KR KR10-1998-0704473A patent/KR100406159B1/ko not_active Expired - Fee Related
- 1996-12-13 NZ NZ323855A patent/NZ323855A/xx unknown
- 1996-12-13 IL IL12466396A patent/IL124663A/en not_active IP Right Cessation
- 1996-12-13 DE DE69620042T patent/DE69620042T2/de not_active Expired - Lifetime
- 1996-12-13 ES ES96941539T patent/ES2172697T3/es not_active Expired - Lifetime
- 1996-12-13 TW TW085115392A patent/TW341574B/zh active
- 1996-12-13 DK DK96941539T patent/DK0970074T3/da active
- 1996-12-13 CA CA002237730A patent/CA2237730C/en not_active Expired - Lifetime
- 1996-12-13 IN IN2810DE1996 patent/IN187349B/en unknown
- 1996-12-13 IL IL14415596A patent/IL144155A/xx not_active IP Right Cessation
-
1998
- 1998-06-09 OA OA9800077A patent/OA11094A/en unknown
- 1998-06-11 MX MX9804701A patent/MX9804701A/es unknown
- 1998-06-12 NO NO982716A patent/NO309901B1/no unknown
-
1999
- 1999-02-17 US US09/251,431 patent/US6069250A/en not_active Expired - Lifetime
-
2001
- 2001-07-05 IL IL14415501A patent/IL144155A0/xx unknown
- 2001-11-16 US US09/987,845 patent/US20020058670A1/en not_active Abandoned
-
2002
- 2002-10-02 US US10/262,107 patent/US20030060476A1/en not_active Abandoned
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TW341574B (en) | METHOD AND COMPOSITIONS FOR THE SYNTHESIS OF DIOXOLANE NUCLEOSIDES WITH β-CONFIGURATION the invention relates to methods and compositions for preparing biologically important nucleoside analogues containing 1,3-dioxolane sugar rings. | |
| HU912253D0 (en) | Process for the production of purinyl-phosphonic acid derivatives | |
| BG100916A (en) | Process for the diastereoselective synthesis of nucleoside analogues | |
| TW366350B (en) | Processes for the diastereoselective synthesis of nucleosides | |
| BR9302434A (pt) | Processo para preparar um nucleosidio enriquecido com beta-anomero | |
| FI104176B1 (fi) | Menetelmä nukleosidien uusien antiviraalisten forfolipidijohdannaisten valmistamiseksi | |
| MX2007003085A (es) | Preparacion de 2'-fluoro-2'-alquilo sustituido u otras ribofuranosil pirimidinas y purinas opcionalmente sustituidas y sus derivados. | |
| EG20193A (en) | Process for preparing of 1,3- oxathiolane nucleoside analogues | |
| ATE140923T1 (de) | Verfahren zur herstellung von n4-acyl-5'-desoxy-5-fluorocytidinderivate | |
| DE3477791D1 (en) | Nucleoside process | |
| FI885094A7 (fi) | Menetelmä terapeuttisesti käyttökelpoisen 2',3'-dideoksi-3'-fluoripyrimidiini- tai -puriininukleosidin valmistamiseksi | |
| EP0330992A3 (en) | Novel cyclobutane derivatives, processes for their preparation and pharmaceutical compositions comprising them | |
| AU2003251936A1 (en) | Process for the preparation of 9-beta-anomeric nucleoside analogs | |
| EP0311694A4 (en) | Nucleoside derivatives and process for their preparation | |
| NO974512D0 (no) | Fremgangsmåte for syntese av nukleosid-analoger | |
| JPS6426594A (en) | Nucleotides and antitumor agent | |
| MX9604880A (es) | Procedimiento para la sintesis diasteroselectiva de analogos de nucleosido. | |
| GEP20002030B (en) | Diastereoselective Synthesis of Nucleosides | |
| JPS5634698A (en) | N6-acyl-3'-o(o-nitrobenzyl)adenosine-5'-monophosphate and its preparation | |
| CA2188306A1 (en) | Process for the diastereoselective synthesis of nucleoside analogues |