BR9302434A - Processo para preparar um nucleosidio enriquecido com beta-anomero - Google Patents

Processo para preparar um nucleosidio enriquecido com beta-anomero

Info

Publication number
BR9302434A
BR9302434A BR9302434A BR9302434A BR9302434A BR 9302434 A BR9302434 A BR 9302434A BR 9302434 A BR9302434 A BR 9302434A BR 9302434 A BR9302434 A BR 9302434A BR 9302434 A BR9302434 A BR 9302434A
Authority
BR
Brazil
Prior art keywords
anomer
beta
prepare
enriched nucleoside
enriched
Prior art date
Application number
BR9302434A
Other languages
English (en)
Inventor
Douglas Patton Kjell
Ta-Sen Chou
Cora Sue Grossman
Larry Wayne Hertel
Richard Elmer Holmes
Charles David Jones
Thomas Edward Mabry
Laurie Michelle Poteet
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27583678&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR9302434(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US07/902,312 external-priority patent/US5371210A/en
Priority claimed from US08/044,345 external-priority patent/US5594124A/en
Priority claimed from US08/044,312 external-priority patent/US5426183A/en
Priority claimed from US08/044,996 external-priority patent/US5821357A/en
Priority claimed from US08/044,343 external-priority patent/US5401838A/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BR9302434A publication Critical patent/BR9302434A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
BR9302434A 1992-06-22 1993-06-21 Processo para preparar um nucleosidio enriquecido com beta-anomero BR9302434A (pt)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US90211292A 1992-06-22 1992-06-22
US90231392A 1992-06-22 1992-06-22
US90215092A 1992-06-22 1992-06-22
US90213592A 1992-06-22 1992-06-22
US90230292A 1992-06-22 1992-06-22
US07/902,312 US5371210A (en) 1992-06-22 1992-06-22 Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US4430993A 1993-04-07 1993-04-07
US4431593A 1993-04-07 1993-04-07
US08/044,345 US5594124A (en) 1992-06-22 1993-04-07 Stereoselective glycosylation process for preparing 2'-Deoxy-2',2'-difluoropyrimidine nucleosides and 2'-deoxy-2'-fluoropyrimidine nucleosides and intermediates thereof
US08/044,312 US5426183A (en) 1992-06-22 1993-04-07 Catalytic stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US08/044,996 US5821357A (en) 1992-06-22 1993-04-07 Stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoropurine and triazole nucleosides
US08/044,343 US5401838A (en) 1992-06-22 1993-04-07 Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides

Publications (1)

Publication Number Publication Date
BR9302434A true BR9302434A (pt) 1994-02-16

Family

ID=27583678

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9302434A BR9302434A (pt) 1992-06-22 1993-06-21 Processo para preparar um nucleosidio enriquecido com beta-anomero

Country Status (20)

Country Link
EP (1) EP0577303B1 (pt)
JP (1) JP3313191B2 (pt)
KR (1) KR100252452B1 (pt)
AT (1) ATE158799T1 (pt)
BR (1) BR9302434A (pt)
CA (1) CA2098881C (pt)
CY (1) CY2067A (pt)
DE (1) DE69314239C5 (pt)
DK (1) DK0577303T3 (pt)
ES (1) ES2107624T3 (pt)
FI (1) FI108643B (pt)
GR (1) GR3025689T3 (pt)
HU (2) HU223837B1 (pt)
IL (1) IL106071A (pt)
MX (1) MX9303707A (pt)
MY (1) MY115775A (pt)
NO (1) NO180235B3 (pt)
NZ (1) NZ247939A (pt)
PL (1) PL172348B1 (pt)
UA (1) UA41261C2 (pt)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5606048A (en) * 1992-06-22 1997-02-25 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-Deoxy-2', 2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5424416A (en) * 1993-08-25 1995-06-13 Eli Lilly And Company Process for preparation of 2-deoxy-2,2-difluoro-D-ribofuranosyl-3,5-hydroxy protected-1-alkyl and aryl sulfonates and their use in preparation of 2',2'-difluoro-2'-deoxy nucleosides
US5637688A (en) * 1994-12-13 1997-06-10 Eli Lilly And Company Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride
US5559222A (en) * 1995-02-03 1996-09-24 Eli Lilly And Company Preparation of 1-(2'-deoxy-2',2'-difluoro-D-ribo-pentofuranosyl)-cytosine from 2-deoxy-2,2-difluoro-β-D-ribo-pentopyranose
AU1289697A (en) 1995-12-13 1997-07-03 Eli Lilly And Company Alpha, alpha-difluoro-beta-hydroxy thiol esters and their synthesis
US6326507B1 (en) 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
US6949640B2 (en) 2000-02-18 2005-09-27 Southern Research Institute Method for synthesizing 2-chloro-9-(2-fluoro-β-D-arabinofuranosyl)-9H-purin-6-amine
US7435755B2 (en) 2000-11-28 2008-10-14 The Trustees Of Dartmouth College CDDO-compounds and combination therapies thereof
JP4593917B2 (ja) * 2001-08-02 2010-12-08 アイレックス オンコロジー， インコーポレイテッド プリンヌクレオシドを調製する方法
CA2472581C (en) 2002-01-15 2012-06-26 Trustees Of Dartmouth College Tricyclic-bis-enone derivatives and methods of use thereof
US6884880B2 (en) * 2002-08-21 2005-04-26 Ash Stevens, Inc. Process for the preparation of 9-β-anomeric nucleoside analogs
WO2004041203A2 (en) 2002-11-04 2004-05-21 Xenoport, Inc. Gemcitabine prodrugs, pharmaceutical compositions and uses thereof
EP1626053B1 (en) 2003-05-22 2011-07-06 Japan Science and Technology Agency Method of alpha-selective glycosylation
WO2006070985A1 (en) 2004-12-30 2006-07-06 Hanmi Pharm. Co., Ltd. METHOD FOR THE PREPARATION OF 2#-DEOXY-2#,2#-DIFLUOROCYTIDINE
MX2007010316A (es) * 2005-03-04 2008-02-19 Dabur Pharma Ltd Intermediario de 21-desoxi, 21,21-difluoro-d-ribofuranosil nucleosidos enriquecidos en (-anomero y proceso para prepararlo.
CN101203525B (zh) * 2005-06-03 2012-06-13 台湾神隆股份有限公司 制备α-端基异构体富集的2-脱氧-2,2-二氟-D-呋喃核糖基磺酸酯的方法及其制备β核苷的应用
CN100391966C (zh) * 2005-06-17 2008-06-04 华东师范大学 一种2’-脱氧-2’，2’-二氟-胞苷合成的方法
US8921340B2 (en) 2006-11-17 2014-12-30 Trustees Of Dartmouth College Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions
EP2094651A1 (en) 2006-11-17 2009-09-02 Trustees Of Dartmouth College Synthesis and biological activities of new tricyclic-bis-enones (tbes)
US8299046B2 (en) 2006-11-17 2012-10-30 Trustees Of Dartmouth College Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
US20080262215A1 (en) * 2007-04-23 2008-10-23 Chemagis Ltd. Gemcitabine production process
CN100475832C (zh) 2007-05-31 2009-04-08 南京卡文迪许生物工程技术有限公司 一种新颖的高立体选择性合成吉西他滨工艺及中间体
EP2050757A1 (en) * 2007-10-10 2009-04-22 Cilag AG Method of producing 2' -deoxy-5-azacytidine (Decitabine)
EP2048151A1 (en) * 2007-10-10 2009-04-15 Cilag AG Method for producing nucleosides by direct glycosylation of the nucleoside base
MX356760B (es) 2008-01-11 2018-06-12 Dartmouth College Triterpenoides sinteticos y metodos de uso en el tratamiento de enfermedad.
WO2009129545A1 (en) 2008-04-18 2009-10-22 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: oleanolic acid derivatives with saturation in the c-ring
ME02751B (me) 2008-04-18 2018-01-20 Reata Pharmaceuticals Inc Antioksidansni modulatori upale: c-17 homologisani derivati oleanolinske kiseline
TWI453023B (zh) 2008-04-18 2014-09-21 Reata Pharmaceuticals Inc 抗氧化發炎調節劑：在ｃ－１７處具有胺基及其他修飾之齊墩果酸衍生物
MX339476B (es) 2008-04-18 2016-05-27 Reata Pharmaceuticals Inc Compuestos que incluyen un nucleo farmaceutico antiinflamatorio y sus metodos de uso.
US8071632B2 (en) 2008-04-18 2011-12-06 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: novel derivatives of oleanolic acid
AU2013243873B2 (en) 2012-04-04 2016-08-25 Halozyme, Inc. Combination therapy with an anti - hyaluronan agent and a tumor - targeted taxane
US8921419B2 (en) 2012-05-08 2014-12-30 Trustees Of Dartmouth College Triterpenoids and compositions containing the same
JP6431520B2 (ja) * 2013-03-15 2018-11-28 エピジェネティクス・ファーマ・エルエルシー フッ化ピリミジン類縁体及びその使用方法
JP7173613B2 (ja) 2017-04-26 2022-11-16 カールマン，トーマス，アイ． 多標的ヌクレオシド誘導体
US20190351031A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1295998C (en) * 1985-07-29 1992-02-18 Sai P. Sunkara Nucleosides and their use as antineoplastic agents
ATE217009T1 (de) * 1987-08-28 2002-05-15 Lilly Co Eli Stereoselektives verfahren zur herstellung von geschützten 2',2'-difluorlactonen
JPH0217199A (ja) * 1988-07-05 1990-01-22 Japan Tobacco Inc ２’−デオキシ−β−アデノシンの製造方法
GB8816345D0 (en) * 1988-07-08 1988-08-10 Hoffmann La Roche Purine derivatives
HU906976D0 (en) * 1989-11-13 1991-05-28 Bristol Myers Squibb Co Process for producing 2', 3'-didesoxy-2'-fluoarabinonucleoside analogues
EP0523110A1 (en) * 1990-04-04 1993-01-20 Nycomed Imaging As Nucleoside derivatives
US5817799A (en) * 1990-07-23 1998-10-06 The United States Of America As Represented By The Department Of Health And Human Services 2'-Fluorofuranosyl derivatives and methods for preparing 2'-fluoropyrimidine and 2'-fluoropurine nucleosides
US5371210A (en) * 1992-06-22 1994-12-06 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5256798A (en) * 1992-06-22 1993-10-26 Eli Lilly And Company Process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates

Also Published As

Publication number Publication date
NZ247939A (en) 1996-02-27
HUT64358A (en) 1993-12-28
JPH06157570A (ja) 1994-06-03
EP0577303A1 (en) 1994-01-05
KR100252452B1 (en) 2000-04-15
NO180235B3 (no) 2007-10-01
FI932869A0 (fi) 1993-06-21
NO180235B (no) 1996-12-02
IL106071A0 (en) 1993-10-20
DE69314239C5 (de) 2012-11-29
ATE158799T1 (de) 1997-10-15
JP3313191B2 (ja) 2002-08-12
IL106071A (en) 2006-08-20
EP0577303B1 (en) 1997-10-01
UA41261C2 (uk) 2001-09-17
PL299415A1 (en) 1994-03-07
CA2098881C (en) 2005-06-07
PL172348B1 (pl) 1997-09-30
HU0201196D0 (pt) 2002-06-29
DE69314239D1 (de) 1997-11-06
CY2067A (en) 1993-06-21
GR3025689T3 (en) 1998-03-31
ES2107624T3 (es) 1997-12-01
NO932288D0 (no) 1993-06-21
NO932288A (no) 1993-12-23
FI108643B (fi) 2002-02-28
CA2098881A1 (en) 1993-12-23
KR940005658A (ko) 1994-03-22
HU9301822D0 (en) 1993-09-28
DK0577303T3 (da) 1997-10-27
DE69314239T2 (de) 1998-02-19
FI932869A (fi) 1993-12-23
HU223837B1 (hu) 2005-02-28
MX9303707A (es) 1994-06-30
MY115775A (en) 2003-09-30
NO180235C (no) 1997-03-12

Similar Documents

Publication Publication Date Title
BR9302434A (pt) Processo para preparar um nucleosidio enriquecido com beta-anomero
MX9305301A (es) Proceso para incrementar la producccion de nucleosido de beta anomero.
TW341574B (en) METHOD AND COMPOSITIONS FOR THE SYNTHESIS OF DIOXOLANE NUCLEOSIDES WITH β-CONFIGURATION the invention relates to methods and compositions for preparing biologically important nucleoside analogues containing 1,3-dioxolane sugar rings.
CY2154B1 (en) Novel process for producing N4-acyl-5'-deoxy-5-fluorocytidine derivatives
BR9302429A (pt) Processo para a preparacao de um sulfonato de riboturanosila enriquecido do anomero alfa
NO932286L (no) Stereoselektiv anion-glykosyleringsprosess
DE3477791D1 (en) Nucleoside process
DE3671896D1 (de) Herstellung von cytosin-nukleosiden.
DE3065146D1 (en) Process for the preparation of 5'-deoxy-5-fluoro uridine and intermediates in this process
IL106073A0 (en) 2'-deoxy-2',2'-difluoro(2,6,8-substituted)purine nucleosides having anti-viral and anti-cancer activity and intermediates
BR8704363A (pt) Processo para deposicao controlada de metal em uma matriz composicao de no minimo duas matrizes separadas
ES2094623T3 (es) Procedimiento estereoselectivo para la preparacion de 2-desoxi-2,2-difluoro-d-ribofuranosil-3,5-hidroxi protegido-1-alquil y aril-sulfonatos intermedios enriquecidos en el anomero beta.
BR9304843A (pt) Cultura biologicamente pura do microorganismo de streptomyces avermitilis, processo para produzir pelo menos um composto de avermectina e avermectina assim produzida, processo para produzir ivermectina e ivermectina assim produzida.
RU93046709A (ru) Способ получения нуклеозидов
RU93046506A (ru) Способ получения нуклеозидов
HK1009451A1 (en) Process for the synthesis of nucleoside analogues
IL102144A0 (en) Process for producing 2'-deoxy-2',2'-difluoro nucleosides
IT9040121A0 (it) Cabina di bagnatura per piastrelle da smaltare, dotata di vasca depuratrice di ricircolo

Legal Events

Date Code Title Description
EE Request for examination
EG Technical examination (opinion): publication of technical examination (opinion)
FC Decision: refusal
CKFC Appeal: appeal against refusal
B07B Technical examination (opinion): publication cancelled [chapter 7.2 patent gazette]
B09T Decision of refusal: decision cancelled [chapter 9.2.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]
B15W Others matters related to applications: legal action concerning application

Free format text: INPI-52400.003713/05 ORIGEM: JUIZ FEDERAL DA 39A VARA DO RIO DE JANEIRO MANDADO DE INTIMACAO AUTOR: ELI LILLY AND COMPANY REU: INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL - INPI.

B15N Others concerning applications: notification of judicial decision

Free format text: INPI-52400.003713/05 39A VARA FEDERAL DO RIO DE JANEIRO PROC. NO2005.51.01.506948-1 NO MANDADO: 0039.000812-4/2005 MANDADO DE INTIMACAO AUTOR: ELI LILLY AND COMPANY REU: INSTITUTO NACIONAL DA PROPRIEDADE INDUSTRIAL - INPI DECISAO: FAZER PUBLICAR NA REVISTA DA PROPRIEDADE INDUSTRIAL, IMEDIATAMENTE, QUE O REFERIDO PROCESSO ADMINISTRATIVO ENCONTRA-SE "SUB JUDICE", MANTENDO-O SOBRESTADO ATE ULTERIOR DECISAO DESTE MM. JUIZO.

B11Z Dismissal: petition dismissal - article 216, par 2 of industrial property law

Free format text: REFERENCIA: PETICAO INPI/RJ 020080025023 DE 20.02.2008, DE ACORDO COM O ART. 216 2O DA LPI.

B15N Others concerning applications: notification of judicial decision

Free format text: INPI-52400.00430401 1A SECAO ESPECIALIZADA DO TRF2 PROCESSO NO: 2007.02.01.009600-2 ACAO RESCISORIA AUTOR: INSTITUTO NACIONAL DE PROPRIEDADE INDUSTRIAL - LTDA REU: ELY LILLY AND COMPANY ACORDAO: ANTE O EXPOSTO, JULGO PROCEDENTE O PEDIDO RESCINDENS, COM FULCRO NO ARTIGO 485, INCISO V, DO CODIGO DE PROCESSO CIVIL, PARA RESCINDIR O ACORDAO LAVRADO NOS AUTOS DO PROCESSO NO 2001.51.01.531698-3 E, PROFERINDO NOVO JULGAMENTO, JULGO PROCEDENTE O PEDIDO RESCISORIUM, PARA NEGAR PROVIMENTO A APELACAO CIVEL INTERPOSTA PELA EMPRESA RE, MANTENDO A SENTENCA DE PRIMEIRO GRAU QUE JULGOU IMPROCEDENTE O PEDIDO DE ANULACAO DO ATO ADMINISTRATIVO DO INPI QUE IMPORTOU NO INDEFERIMENTO DO PEDIDO DE PATENTE PI