BR9302429A - Processo para a preparacao de um sulfonato de riboturanosila enriquecido do anomero alfa - Google Patents

Processo para a preparacao de um sulfonato de riboturanosila enriquecido do anomero alfa

Info

Publication number
BR9302429A
BR9302429A BR9302429A BR9302429A BR9302429A BR 9302429 A BR9302429 A BR 9302429A BR 9302429 A BR9302429 A BR 9302429A BR 9302429 A BR9302429 A BR 9302429A BR 9302429 A BR9302429 A BR 9302429A
Authority
BR
Brazil
Prior art keywords
enriched
riboturanosil
sulphonate
preparation
anomer
Prior art date
Application number
BR9302429A
Other languages
English (en)
Inventor
Ta-Sen Chou
Charles David Jones
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of BR9302429A publication Critical patent/BR9302429A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
BR9302429A 1992-06-22 1993-06-21 Processo para a preparacao de um sulfonato de riboturanosila enriquecido do anomero alfa BR9302429A (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/902,305 US5256798A (en) 1992-06-22 1992-06-22 Process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates

Publications (1)

Publication Number Publication Date
BR9302429A true BR9302429A (pt) 1994-01-11

Family

ID=25415655

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9302429A BR9302429A (pt) 1992-06-22 1993-06-21 Processo para a preparacao de um sulfonato de riboturanosila enriquecido do anomero alfa

Country Status (14)

Country Link
US (1) US5256798A (pt)
EP (1) EP0577302B1 (pt)
JP (1) JP3379993B2 (pt)
AT (1) ATE155476T1 (pt)
BR (1) BR9302429A (pt)
CA (1) CA2098882C (pt)
DE (1) DE69312176T2 (pt)
DK (1) DK0577302T3 (pt)
ES (1) ES2105114T3 (pt)
GR (1) GR3024975T3 (pt)
HU (1) HU216832B (pt)
IL (1) IL106077A (pt)
MX (1) MX9303712A (pt)
TW (1) TW224101B (pt)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA41261C2 (uk) * 1992-06-22 2001-09-17 Елі Ліллі Енд Компані Спосіб одержання збагачених бета-аномером нуклеозидів
CA2098887C (en) * 1992-06-22 2003-10-28 Ta-Sen Chou Process for preparing alpha-anomer enriched 1-halo-2-deoxy-2,2-difluoro-d-ribofuranosyl derivatives
US5424416A (en) * 1993-08-25 1995-06-13 Eli Lilly And Company Process for preparation of 2-deoxy-2,2-difluoro-D-ribofuranosyl-3,5-hydroxy protected-1-alkyl and aryl sulfonates and their use in preparation of 2',2'-difluoro-2'-deoxy nucleosides
US7214791B2 (en) * 2004-07-01 2007-05-08 Shenzhen Hande Technology Co., Ltd. Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
CN101023094B (zh) 2004-07-21 2011-05-18 法莫赛特股份有限公司 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备
NZ554442A (en) * 2004-09-14 2011-05-27 Pharmasset Inc Preparation of 2'fluoro-2'-alkyl-substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives
KR20070112774A (ko) * 2005-03-04 2007-11-27 다브르 파마 리미티드 베타―아노머가 많은２１데옥시，２１，２１－디플루오로－ｄ－리보푸라노실뉴클레오시드의 제조를 위한 중간체 및 제조 방법
AU2011202539B2 (en) * 2005-06-03 2012-07-05 Scinopharm Taiwan, Ltd. Process of making an alpha-anomer enriched 2-deoxy-2,2-difluoro-d-ribofuranosyl sulfonate and use thereof for making a beta nucleoside
AU2006255706B2 (en) * 2005-06-03 2011-06-23 Scinopharm Taiwan, Ltd. Process of making an alpha-anomer enriched 2-deoxy-2,2-difluoro-d-ribofuranosyl sulfonate and use thereof for making a beta nucleoside
AT502221A1 (de) * 2005-07-20 2007-02-15 Pharmacon Forschung & Beratung Gmbh Homogemcitabine, verfahren zu ihrer herstellung sowie deren verwendung
JP2009526782A (ja) * 2006-02-07 2009-07-23 ケマジス・リミテッド ゲムシタビンおよび関連中間体の製造方法
US20070249823A1 (en) * 2006-04-20 2007-10-25 Chemagis Ltd. Process for preparing gemcitabine and associated intermediates
CN101024667B (zh) * 2007-03-30 2011-01-26 湖北益泰药业有限公司 盐酸吉西他宾的合成方法
US7964580B2 (en) 2007-03-30 2011-06-21 Pharmasset, Inc. Nucleoside phosphoramidate prodrugs
US20080262215A1 (en) * 2007-04-23 2008-10-23 Chemagis Ltd. Gemcitabine production process
US8173621B2 (en) 2008-06-11 2012-05-08 Gilead Pharmasset Llc Nucleoside cyclicphosphates
EP2671888A1 (en) 2008-12-23 2013-12-11 Gilead Pharmasset LLC 3',5'-cyclic nucleoside phosphate analogues
US8618076B2 (en) 2009-05-20 2013-12-31 Gilead Pharmasset Llc Nucleoside phosphoramidates
TWI583692B (zh) * 2009-05-20 2017-05-21 基利法瑪席特有限責任公司 核苷磷醯胺
EP2552931B1 (en) 2010-03-31 2014-07-23 Gilead Pharmasset LLC Stereoselective synthesis of phosphorus containing actives
PL3290428T3 (pl) 2010-03-31 2022-02-07 Gilead Pharmasset Llc Tabletka zawierająca krystaliczny (S)-2-(((S)-(((2R,3R,4R,5R)-5-(2,4-diokso-3,4-dihydropirymidyn-1(2H)-ylo)-4-fluoro-3-hydroksy-4-metylotetrahydrofuran-2-ylo)metoksy)(fenoksy)fosforylo)amino)propanian izopropylu
US8841275B2 (en) 2010-11-30 2014-09-23 Gilead Pharmasset Llc 2′-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections
US8889159B2 (en) 2011-11-29 2014-11-18 Gilead Pharmasset Llc Compositions and methods for treating hepatitis C virus
CN102603838B (zh) * 2012-02-14 2015-02-18 江苏八巨药业有限公司 一种制备吉西他滨盐酸盐的方法
PT3038601T (pt) 2013-08-27 2020-06-30 Gilead Pharmasset Llc Formulação combinada de dois compostos antivirais
CN103692332B (zh) * 2013-12-31 2015-12-09 景宁畲族自治县通用机械配件厂（普通合伙） 全自动抛光除油机
CN107793334A (zh) * 2017-09-27 2018-03-13 九江善水科技股份有限公司 芳基磺酸铵盐化合物、其制备方法及应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
DE3856527T2 (de) * 1987-08-28 2002-10-31 Lilly Co Eli Stereoselektives Verfahren zur Herstellung von geschützten 2',2'-difluorlactonen

Also Published As

Publication number Publication date
CA2098882A1 (en) 1993-12-23
HU216832B (hu) 1999-09-28
US5256798A (en) 1993-10-26
IL106077A (en) 1998-07-15
EP0577302A1 (en) 1994-01-05
JP3379993B2 (ja) 2003-02-24
ES2105114T3 (es) 1997-10-16
DE69312176T2 (de) 1997-12-11
IL106077A0 (en) 1993-10-20
ATE155476T1 (de) 1997-08-15
JPH0656865A (ja) 1994-03-01
HU9301825D0 (en) 1993-09-28
TW224101B (pt) 1994-05-21
HUT65207A (en) 1994-05-02
DE69312176D1 (de) 1997-08-21
CA2098882C (en) 2004-05-04
DK0577302T3 (da) 1997-10-06
MX9303712A (es) 1994-05-31
EP0577302B1 (en) 1997-07-16
GR3024975T3 (en) 1998-01-30

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Publication Publication Date Title
BR9302429A (pt) Processo para a preparacao de um sulfonato de riboturanosila enriquecido do anomero alfa
ES2090880T3 (es) Procedimiento para anomerizacion de nucleosidos.
BR9302428A (pt) Processo estereosseletivo a baixa temperatura para preparar um derivado enriquecido de riboturanosila alfa-anomero e o derivado obitdo
MX9303708A (es) Proceso de glucosilacion anionica estereoselectiva para preparar 2'-desoxifluoro-beta nucleosidos.
CA2098888A1 (en) Process for separating 2-deoxy-2,2-difluoro-d-ribofuranosyl alkylsulfonate anomers
ES2094623T3 (es) Procedimiento estereoselectivo para la preparacion de 2-desoxi-2,2-difluoro-d-ribofuranosil-3,5-hidroxi protegido-1-alquil y aril-sulfonatos intermedios enriquecidos en el anomero beta.
ES2127249T3 (es) Procedimiento para preparar 2-desoxi-2,2-difluoro-d-ribofuranosil-arilsulfonatos enriquecidos en el anomero beta.
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Legal Events

Date Code Title Description
EE Request for examination
EG Technical examination (opinion): publication of technical examination (opinion)
FC Decision: refusal
CKFC Appeal: appeal against refusal