ES2127249T3 - Procedimiento para preparar 2-desoxi-2,2-difluoro-d-ribofuranosil-arilsulfonatos enriquecidos en el anomero beta. - Google Patents

Procedimiento para preparar 2-desoxi-2,2-difluoro-d-ribofuranosil-arilsulfonatos enriquecidos en el anomero beta.

Info

Publication number
ES2127249T3
ES2127249T3 ES93304816T ES93304816T ES2127249T3 ES 2127249 T3 ES2127249 T3 ES 2127249T3 ES 93304816 T ES93304816 T ES 93304816T ES 93304816 T ES93304816 T ES 93304816T ES 2127249 T3 ES2127249 T3 ES 2127249T3
Authority
ES
Spain
Prior art keywords
difluoro
arilsulfonatos
ribofuranosil
desoxi
enriched
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES93304816T
Other languages
English (en)
Inventor
Ta-Sen Chou
Charles David Jones
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Application granted granted Critical
Publication of ES2127249T3 publication Critical patent/ES2127249T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

UN PROCESO ESTEREOSELECTIVO PARA LA PREPARACION DE 2-DESOXI-2,2-DIFLUORO-DRIBOFURANOSIL-ARILSULFONATOS ENRIQUECIDOS CON BETA-ANOMEROS O DE ARILSULFONATOS SUSTITUIDOS QUE CONSISTE EN HACER REACCIONAR UN LACTOL CON UN DEPURADOR DE ACIDO Y UN REACTIVO DE SULFONACION EN UN SOLVENTE INERTE.
ES93304816T 1992-06-22 1993-06-21 Procedimiento para preparar 2-desoxi-2,2-difluoro-d-ribofuranosil-arilsulfonatos enriquecidos en el anomero beta. Expired - Lifetime ES2127249T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/902,143 US5252756A (en) 1992-06-22 1992-06-22 Process for preparing beta-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl-arylsulfonates

Publications (1)

Publication Number Publication Date
ES2127249T3 true ES2127249T3 (es) 1999-04-16

Family

ID=25415363

Family Applications (1)

Application Number Title Priority Date Filing Date
ES93304816T Expired - Lifetime ES2127249T3 (es) 1992-06-22 1993-06-21 Procedimiento para preparar 2-desoxi-2,2-difluoro-d-ribofuranosil-arilsulfonatos enriquecidos en el anomero beta.

Country Status (9)

Country Link
US (1) US5252756A (es)
EP (1) EP0576228B1 (es)
JP (1) JPH0656864A (es)
AT (1) ATE176479T1 (es)
CA (1) CA2098885C (es)
DE (1) DE69323352T2 (es)
DK (1) DK0576228T3 (es)
ES (1) ES2127249T3 (es)
GR (1) GR3029572T3 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX9303713A (es) * 1992-06-22 1994-05-31 Lilly Co Eli Proceso estereoselectivo para preparar un derivadoribofuranosilo enriquecido con alfa anomero.
US7214791B2 (en) * 2004-07-01 2007-05-08 Shenzhen Hande Technology Co., Ltd. Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
WO2006011713A1 (en) * 2004-07-29 2006-02-02 Hanmi Pharm. Co., Ltd. 1-α-HALO-2,2-DIFLUORO-2-DEOXY-D-RIBOFURANOSE DERIVATIVES AND PROCESS FOR THE PREPARATION THEREOF
AT502221A1 (de) * 2005-07-20 2007-02-15 Pharmacon Forschung & Beratung Gmbh Homogemcitabine, verfahren zu ihrer herstellung sowie deren verwendung
EP2017270A4 (en) * 2006-04-27 2009-04-29 Sumitomo Chemical Co METHOD FOR PRODUCING AN EPOXY COMPOUND
KR100908363B1 (ko) 2007-02-28 2009-07-20 한미약품 주식회사 트라이-Ｏ-아세틸-5-데옥시-β-Ｄ-라이보퓨라노즈의입체선택적 제조방법 및 이의 분리방법

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides
EP0688783B1 (en) * 1987-08-28 2001-06-13 Eli Lilly And Company Method for preparing 2'-deoxy-2',2'-difluornucleosides

Also Published As

Publication number Publication date
GR3029572T3 (en) 1999-06-30
DK0576228T3 (da) 1999-09-20
EP0576228A1 (en) 1993-12-29
DE69323352T2 (de) 1999-06-24
CA2098885C (en) 2003-07-29
ATE176479T1 (de) 1999-02-15
US5252756A (en) 1993-10-12
JPH0656864A (ja) 1994-03-01
DE69323352D1 (de) 1999-03-18
EP0576228B1 (en) 1999-02-03
CA2098885A1 (en) 1993-12-23

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