DE69323352D1 - Verfahren zur Herstellung von mit Beta-Anomeren angereicherten 2-Deoxy-2,2-Difluor-D-Ribofuranosyl-Aryl-Sulfonaten - Google Patents

Verfahren zur Herstellung von mit Beta-Anomeren angereicherten 2-Deoxy-2,2-Difluor-D-Ribofuranosyl-Aryl-Sulfonaten

Info

Publication number
DE69323352D1
DE69323352D1 DE69323352T DE69323352T DE69323352D1 DE 69323352 D1 DE69323352 D1 DE 69323352D1 DE 69323352 T DE69323352 T DE 69323352T DE 69323352 T DE69323352 T DE 69323352T DE 69323352 D1 DE69323352 D1 DE 69323352D1
Authority
DE
Germany
Prior art keywords
ribofuranosyl
deoxy
difluoro
aryl sulfonates
enriched
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69323352T
Other languages
English (en)
Other versions
DE69323352T2 (de
Inventor
Ta-Sen Chou
Charles David Jones
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of DE69323352D1 publication Critical patent/DE69323352D1/de
Application granted granted Critical
Publication of DE69323352T2 publication Critical patent/DE69323352T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69323352T 1992-06-22 1993-06-21 Verfahren zur Herstellung von mit Beta-Anomeren angereicherten 2-Deoxy-2,2-Difluor-D-Ribofuranosyl-Aryl-Sulfonaten Expired - Fee Related DE69323352T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/902,143 US5252756A (en) 1992-06-22 1992-06-22 Process for preparing beta-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl-arylsulfonates

Publications (2)

Publication Number Publication Date
DE69323352D1 true DE69323352D1 (de) 1999-03-18
DE69323352T2 DE69323352T2 (de) 1999-06-24

Family

ID=25415363

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69323352T Expired - Fee Related DE69323352T2 (de) 1992-06-22 1993-06-21 Verfahren zur Herstellung von mit Beta-Anomeren angereicherten 2-Deoxy-2,2-Difluor-D-Ribofuranosyl-Aryl-Sulfonaten

Country Status (9)

Country Link
US (1) US5252756A (de)
EP (1) EP0576228B1 (de)
JP (1) JPH0656864A (de)
AT (1) ATE176479T1 (de)
CA (1) CA2098885C (de)
DE (1) DE69323352T2 (de)
DK (1) DK0576228T3 (de)
ES (1) ES2127249T3 (de)
GR (1) GR3029572T3 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69311000T2 (de) * 1992-06-22 1997-11-27 Lilly Co Eli Verfahren zur Herstellung von mit Alpha-Anomeren angereicherten 1-Halogen-2-Deoxy-2,2-Difluor-D-Ribofuranosyl-Derivaten
US7214791B2 (en) * 2004-07-01 2007-05-08 Shenzhen Hande Technology Co., Ltd. Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
EP1781678A4 (de) * 2004-07-29 2012-04-25 Hanmi Holdings Co Ltd 1-?-halogen-2,2-difluor-2-desoxy-d-ribofuranosederivate und verfahren zu deren herstellung
AT502221A1 (de) * 2005-07-20 2007-02-15 Pharmacon Forschung & Beratung Gmbh Homogemcitabine, verfahren zu ihrer herstellung sowie deren verwendung
WO2007126139A1 (ja) * 2006-04-27 2007-11-08 Sumitomo Chemical Company, Limited エポキシ化合物の製造方法
KR100908363B1 (ko) * 2007-02-28 2009-07-20 한미약품 주식회사 트라이-Ｏ-아세틸-5-데옥시-β-Ｄ-라이보퓨라노즈의입체선택적 제조방법 및 이의 분리방법

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
ATE202113T1 (de) * 1987-08-28 2001-06-15 Lilly Co Eli Verfahren zur herstellung von 2'-deoxy-2',2'- difluornukleosiden
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides

Also Published As

Publication number Publication date
CA2098885C (en) 2003-07-29
ATE176479T1 (de) 1999-02-15
US5252756A (en) 1993-10-12
GR3029572T3 (en) 1999-06-30
ES2127249T3 (es) 1999-04-16
DK0576228T3 (da) 1999-09-20
DE69323352T2 (de) 1999-06-24
EP0576228B1 (de) 1999-02-03
CA2098885A1 (en) 1993-12-23
JPH0656864A (ja) 1994-03-01
EP0576228A1 (de) 1993-12-29

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee