ATE176479T1 - Verfahren zur herstellung von mit beta-anomeren angereicherten 2-deoxy-2,2-difluor-d- ribofuranosyl-aryl-sulfonaten - Google Patents

Verfahren zur herstellung von mit beta-anomeren angereicherten 2-deoxy-2,2-difluor-d- ribofuranosyl-aryl-sulfonaten

Info

Publication number
ATE176479T1
ATE176479T1 AT93304816T AT93304816T ATE176479T1 AT E176479 T1 ATE176479 T1 AT E176479T1 AT 93304816 T AT93304816 T AT 93304816T AT 93304816 T AT93304816 T AT 93304816T AT E176479 T1 ATE176479 T1 AT E176479T1
Authority
AT
Austria
Prior art keywords
ribofuranosyl
deoxy
beta
aryl sulfonates
difluor
Prior art date
Application number
AT93304816T
Other languages
English (en)
Inventor
Ta-Sen Chou
Charles David Jones
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE176479T1 publication Critical patent/ATE176479T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT93304816T 1992-06-22 1993-06-21 Verfahren zur herstellung von mit beta-anomeren angereicherten 2-deoxy-2,2-difluor-d- ribofuranosyl-aryl-sulfonaten ATE176479T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/902,143 US5252756A (en) 1992-06-22 1992-06-22 Process for preparing beta-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl-arylsulfonates

Publications (1)

Publication Number Publication Date
ATE176479T1 true ATE176479T1 (de) 1999-02-15

Family

ID=25415363

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93304816T ATE176479T1 (de) 1992-06-22 1993-06-21 Verfahren zur herstellung von mit beta-anomeren angereicherten 2-deoxy-2,2-difluor-d- ribofuranosyl-aryl-sulfonaten

Country Status (9)

Country Link
US (1) US5252756A (de)
EP (1) EP0576228B1 (de)
JP (1) JPH0656864A (de)
AT (1) ATE176479T1 (de)
CA (1) CA2098885C (de)
DE (1) DE69323352T2 (de)
DK (1) DK0576228T3 (de)
ES (1) ES2127249T3 (de)
GR (1) GR3029572T3 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU214030B (en) * 1992-06-22 1997-12-29 Lilly Co Eli Process for preparing alpha-anomer enriched 1-halogen-2-deoxy-2,2-difluoro-d-ribofuranosyl derivatives
US7214791B2 (en) * 2004-07-01 2007-05-08 Shenzhen Hande Technology Co., Ltd. Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material
BRPI0513783A (pt) * 2004-07-29 2008-05-13 Hanmi Pharm Ind Co Ltd derivados 1-(alfa)-halo-2, 2-diflúor-2-desóxi-d-ribofuranose e processo para a sua preparação
AT502221A1 (de) * 2005-07-20 2007-02-15 Pharmacon Forschung & Beratung Gmbh Homogemcitabine, verfahren zu ihrer herstellung sowie deren verwendung
WO2007126139A1 (ja) * 2006-04-27 2007-11-08 Sumitomo Chemical Company, Limited エポキシ化合物の製造方法
KR100908363B1 (ko) * 2007-02-28 2009-07-20 한미약품 주식회사 트라이-Ｏ-아세틸-5-데옥시-β-Ｄ-라이보퓨라노즈의입체선택적 제조방법 및 이의 분리방법

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
DE3856527T2 (de) * 1987-08-28 2002-10-31 Eli Lilly And Co., Indianapolis Stereoselektives Verfahren zur Herstellung von geschützten 2',2'-difluorlactonen
US4965374A (en) * 1987-08-28 1990-10-23 Eli Lilly And Company Process for and intermediates of 2',2'-difluoronucleosides

Also Published As

Publication number Publication date
EP0576228A1 (de) 1993-12-29
DE69323352D1 (de) 1999-03-18
US5252756A (en) 1993-10-12
GR3029572T3 (en) 1999-06-30
ES2127249T3 (es) 1999-04-16
EP0576228B1 (de) 1999-02-03
DE69323352T2 (de) 1999-06-24
DK0576228T3 (da) 1999-09-20
JPH0656864A (ja) 1994-03-01
CA2098885A1 (en) 1993-12-23
CA2098885C (en) 2003-07-29

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Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee