TW224101B - - Google Patents
Info
- Publication number
- TW224101B TW224101B TW082104989A TW82104989A TW224101B TW 224101 B TW224101 B TW 224101B TW 082104989 A TW082104989 A TW 082104989A TW 82104989 A TW82104989 A TW 82104989A TW 224101 B TW224101 B TW 224101B
- Authority
- TW
- Taiwan
- Prior art keywords
- anomer
- beta
- ribofuranosyl sulfonate
- sulfonate
- ribofuranosyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H11/00—Compounds containing saccharide radicals esterified by inorganic acids; Metal salts thereof
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/902,305 US5256798A (en) | 1992-06-22 | 1992-06-22 | Process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates |
Publications (1)
Publication Number | Publication Date |
---|---|
TW224101B true TW224101B (zh) | 1994-05-21 |
Family
ID=25415655
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
TW082104989A TW224101B (zh) | 1992-06-22 | 1993-06-22 |
Country Status (14)
Country | Link |
---|---|
US (1) | US5256798A (zh) |
EP (1) | EP0577302B1 (zh) |
JP (1) | JP3379993B2 (zh) |
AT (1) | ATE155476T1 (zh) |
BR (1) | BR9302429A (zh) |
CA (1) | CA2098882C (zh) |
DE (1) | DE69312176T2 (zh) |
DK (1) | DK0577302T3 (zh) |
ES (1) | ES2105114T3 (zh) |
GR (1) | GR3024975T3 (zh) |
HU (1) | HU216832B (zh) |
IL (1) | IL106077A (zh) |
MX (1) | MX9303712A (zh) |
TW (1) | TW224101B (zh) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR940000475A (ko) * | 1992-06-22 | 1994-01-03 | 리로이 휘테커 | 알파-아노머가 풍부한 1-할로-2-데옥시-2, 2-디플루오로-d-리보푸라노실 유도체의 제조방법 |
UA41261C2 (uk) * | 1992-06-22 | 2001-09-17 | Елі Ліллі Енд Компані | Спосіб одержання збагачених бета-аномером нуклеозидів |
US5424416A (en) * | 1993-08-25 | 1995-06-13 | Eli Lilly And Company | Process for preparation of 2-deoxy-2,2-difluoro-D-ribofuranosyl-3,5-hydroxy protected-1-alkyl and aryl sulfonates and their use in preparation of 2',2'-difluoro-2'-deoxy nucleosides |
US7214791B2 (en) * | 2004-07-01 | 2007-05-08 | Shenzhen Hande Technology Co., Ltd. | Method for preparation of 2′-deoxy-2′, 2′-difluoro-β-cytidine or pharmaceutically acceptable salts thereof by using 1,6-anhydro-β-d-glucose as raw material |
CN101023094B (zh) | 2004-07-21 | 2011-05-18 | 法莫赛特股份有限公司 | 烷基取代的2-脱氧-2-氟代-d-呋喃核糖基嘧啶和嘌呤及其衍生物的制备 |
PT3109244T (pt) * | 2004-09-14 | 2019-06-04 | Gilead Pharmasset Llc | ¿preparação de ribofuranosil pirimidinas e purinas 2¿-fluoro-2¿-alquil substituídas ou outras opcionalmente substituídas e os seus derivados |
BRPI0520050A2 (pt) * | 2005-03-04 | 2009-11-17 | Dabur Pharma Ltd | composto, processo para a preparação de um composto e processo de glicosilação estereoseletiva para a preparação de mais de 99% de anÈmero b enriquecido de hidrocloreto de gencitabina |
AU2011202539B2 (en) * | 2005-06-03 | 2012-07-05 | Scinopharm Taiwan, Ltd. | Process of making an alpha-anomer enriched 2-deoxy-2,2-difluoro-d-ribofuranosyl sulfonate and use thereof for making a beta nucleoside |
CN101203525B (zh) * | 2005-06-03 | 2012-06-13 | 台湾神隆股份有限公司 | 制备α-端基异构体富集的2-脱氧-2,2-二氟-D-呋喃核糖基磺酸酯的方法及其制备β核苷的应用 |
AT502221A1 (de) * | 2005-07-20 | 2007-02-15 | Pharmacon Forschung & Beratung Gmbh | Homogemcitabine, verfahren zu ihrer herstellung sowie deren verwendung |
JP2009526782A (ja) * | 2006-02-07 | 2009-07-23 | ケマジス・リミテッド | ゲムシタビンおよび関連中間体の製造方法 |
US20070249823A1 (en) * | 2006-04-20 | 2007-10-25 | Chemagis Ltd. | Process for preparing gemcitabine and associated intermediates |
US7964580B2 (en) | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
CN101024667B (zh) * | 2007-03-30 | 2011-01-26 | 湖北益泰药业有限公司 | 盐酸吉西他宾的合成方法 |
US20080262215A1 (en) * | 2007-04-23 | 2008-10-23 | Chemagis Ltd. | Gemcitabine production process |
US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
JP5793084B2 (ja) | 2008-12-23 | 2015-10-14 | ギリアド ファーマセット エルエルシー | プリンヌクレオシドの合成 |
US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
TWI598358B (zh) | 2009-05-20 | 2017-09-11 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
CN102858790A (zh) | 2010-03-31 | 2013-01-02 | 吉利德制药有限责任公司 | 核苷氨基磷酸酯 |
US8563530B2 (en) | 2010-03-31 | 2013-10-22 | Gilead Pharmassel LLC | Purine nucleoside phosphoramidate |
PT3042910T (pt) | 2010-11-30 | 2019-04-16 | Gilead Pharmasset Llc | 2'-espiro-nucleósidos para utilização na terapia da hepatite c |
US8889159B2 (en) | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
CN102603838B (zh) * | 2012-02-14 | 2015-02-18 | 江苏八巨药业有限公司 | 一种制备吉西他滨盐酸盐的方法 |
MX2016002185A (es) | 2013-08-27 | 2016-06-06 | Gilead Pharmasset Llc | Formulacion combinada de dos compuestos antivirales. |
CN103692332B (zh) * | 2013-12-31 | 2015-12-09 | 景宁畲族自治县通用机械配件厂(普通合伙) | 全自动抛光除油机 |
CN107793334A (zh) * | 2017-09-27 | 2018-03-13 | 九江善水科技股份有限公司 | 芳基磺酸铵盐化合物、其制备方法及应用 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4526988A (en) * | 1983-03-10 | 1985-07-02 | Eli Lilly And Company | Difluoro antivirals and intermediate therefor |
US4965374A (en) * | 1987-08-28 | 1990-10-23 | Eli Lilly And Company | Process for and intermediates of 2',2'-difluoronucleosides |
ES2176279T3 (es) * | 1987-08-28 | 2002-12-01 | Lilly Co Eli | Procedimiento estereoselectivo para preparar 2`-2`-difluorolactonen protegidos. |
-
1992
- 1992-06-22 US US07/902,305 patent/US5256798A/en not_active Expired - Lifetime
-
1993
- 1993-06-21 DE DE69312176T patent/DE69312176T2/de not_active Expired - Lifetime
- 1993-06-21 JP JP14916193A patent/JP3379993B2/ja not_active Expired - Fee Related
- 1993-06-21 ES ES93304814T patent/ES2105114T3/es not_active Expired - Lifetime
- 1993-06-21 CA CA002098882A patent/CA2098882C/en not_active Expired - Lifetime
- 1993-06-21 AT AT93304814T patent/ATE155476T1/de not_active IP Right Cessation
- 1993-06-21 DK DK93304814.2T patent/DK0577302T3/da active
- 1993-06-21 IL IL10607793A patent/IL106077A/en not_active IP Right Cessation
- 1993-06-21 MX MX9303712A patent/MX9303712A/es not_active IP Right Cessation
- 1993-06-21 EP EP93304814A patent/EP0577302B1/en not_active Expired - Lifetime
- 1993-06-21 BR BR9302429A patent/BR9302429A/pt not_active Application Discontinuation
- 1993-06-21 HU HU9301825A patent/HU216832B/hu not_active IP Right Cessation
- 1993-06-22 TW TW082104989A patent/TW224101B/zh active
-
1997
- 1997-10-09 GR GR970402617T patent/GR3024975T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
CA2098882C (en) | 2004-05-04 |
CA2098882A1 (en) | 1993-12-23 |
HU9301825D0 (en) | 1993-09-28 |
EP0577302A1 (en) | 1994-01-05 |
GR3024975T3 (en) | 1998-01-30 |
ES2105114T3 (es) | 1997-10-16 |
JPH0656865A (ja) | 1994-03-01 |
IL106077A (en) | 1998-07-15 |
MX9303712A (es) | 1994-05-31 |
HUT65207A (en) | 1994-05-02 |
US5256798A (en) | 1993-10-26 |
HU216832B (hu) | 1999-09-28 |
BR9302429A (pt) | 1994-01-11 |
DK0577302T3 (da) | 1997-10-06 |
JP3379993B2 (ja) | 2003-02-24 |
EP0577302B1 (en) | 1997-07-16 |
DE69312176T2 (de) | 1997-12-11 |
ATE155476T1 (de) | 1997-08-15 |
IL106077A0 (en) | 1993-10-20 |
DE69312176D1 (de) | 1997-08-21 |
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