HUT64358A - A stereoselective glycosyling procedure - Google Patents

A stereoselective glycosyling procedure

Info

Publication number
HUT64358A
HUT64358A HU9301822A HU9301822A HUT64358A HU T64358 A HUT64358 A HU T64358A HU 9301822 A HU9301822 A HU 9301822A HU 9301822 A HU9301822 A HU 9301822A HU T64358 A HUT64358 A HU T64358A
Authority
HU
Hungary
Prior art keywords
stereoselective
glycosyling
procedure
anomer
fluorocarbohydrate
Prior art date
Application number
HU9301822A
Other languages
English (en)
Other versions
HU9301822D0 (en
Inventor
Ta-Sen Chou
Charles David Jones
Laurie Michelle Poteet
Cora Sue Grossman
Larry Wayne Hertel
Richard Elmer Holmes
Thomas Edward Mabry
Douglas Patton Kjell
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27583678&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HUT64358(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US07/902,312 external-priority patent/US5371210A/en
Priority claimed from US08/044,345 external-priority patent/US5594124A/en
Priority claimed from US08/044,996 external-priority patent/US5821357A/en
Priority claimed from US08/044,343 external-priority patent/US5401838A/en
Priority claimed from US08/044,312 external-priority patent/US5426183A/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of HU9301822D0 publication Critical patent/HU9301822D0/hu
Publication of HUT64358A publication Critical patent/HUT64358A/hu

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
HU9301822A 1992-06-22 1993-06-21 A stereoselective glycosyling procedure HUT64358A (en)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
US90215092A 1992-06-22 1992-06-22
US90230292A 1992-06-22 1992-06-22
US90231392A 1992-06-22 1992-06-22
US90211292A 1992-06-22 1992-06-22
US90213592A 1992-06-22 1992-06-22
US07/902,312 US5371210A (en) 1992-06-22 1992-06-22 Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US4431593A 1993-04-07 1993-04-07
US4430993A 1993-04-07 1993-04-07
US08/044,345 US5594124A (en) 1992-06-22 1993-04-07 Stereoselective glycosylation process for preparing 2'-Deoxy-2',2'-difluoropyrimidine nucleosides and 2'-deoxy-2'-fluoropyrimidine nucleosides and intermediates thereof
US08/044,996 US5821357A (en) 1992-06-22 1993-04-07 Stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoropurine and triazole nucleosides
US08/044,343 US5401838A (en) 1992-06-22 1993-04-07 Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US08/044,312 US5426183A (en) 1992-06-22 1993-04-07 Catalytic stereoselective glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides

Publications (2)

Publication Number Publication Date
HU9301822D0 HU9301822D0 (en) 1993-09-28
HUT64358A true HUT64358A (en) 1993-12-28

Family

ID=27583678

Family Applications (2)

Application Number Title Priority Date Filing Date
HU0201196A HU223837B1 (hu) 1992-06-22 1993-06-21 Sztereoszelektív glikozilezési eljárás
HU9301822A HUT64358A (en) 1992-06-22 1993-06-21 A stereoselective glycosyling procedure

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HU0201196A HU223837B1 (hu) 1992-06-22 1993-06-21 Sztereoszelektív glikozilezési eljárás

Country Status (20)

Country Link
EP (1) EP0577303B1 (hu)
JP (1) JP3313191B2 (hu)
KR (1) KR100252452B1 (hu)
AT (1) ATE158799T1 (hu)
BR (1) BR9302434A (hu)
CA (1) CA2098881C (hu)
CY (1) CY2067A (hu)
DE (1) DE69314239C5 (hu)
DK (1) DK0577303T3 (hu)
ES (1) ES2107624T3 (hu)
FI (1) FI108643B (hu)
GR (1) GR3025689T3 (hu)
HU (2) HU223837B1 (hu)
IL (1) IL106071A (hu)
MX (1) MX9303707A (hu)
MY (1) MY115775A (hu)
NO (1) NO180235B3 (hu)
NZ (1) NZ247939A (hu)
PL (1) PL172348B1 (hu)
UA (1) UA41261C2 (hu)

Families Citing this family (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5606048A (en) * 1992-06-22 1997-02-25 Eli Lilly And Company Stereoselective glycosylation process for preparing 2'-Deoxy-2', 2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5424416A (en) * 1993-08-25 1995-06-13 Eli Lilly And Company Process for preparation of 2-deoxy-2,2-difluoro-D-ribofuranosyl-3,5-hydroxy protected-1-alkyl and aryl sulfonates and their use in preparation of 2',2'-difluoro-2'-deoxy nucleosides
US5637688A (en) * 1994-12-13 1997-06-10 Eli Lilly And Company Process for preparing 1-(2'-deoxy-2'-difluoro-d-ribofuranosyl)-4-aminopyrimidin-2-one hydrochloride
US5559222A (en) * 1995-02-03 1996-09-24 Eli Lilly And Company Preparation of 1-(2'-deoxy-2',2'-difluoro-D-ribo-pentofuranosyl)-cytosine from 2-deoxy-2,2-difluoro-β-D-ribo-pentopyranose
AU1289697A (en) 1995-12-13 1997-07-03 Eli Lilly And Company Alpha, alpha-difluoro-beta-hydroxy thiol esters and their synthesis
US6326507B1 (en) 1998-06-19 2001-12-04 Trustees Of Dartmouth College Therapeutic compounds and methods of use
JP4555536B2 (ja) 2000-02-18 2010-10-06 サザン・リサーチ・インスティテュート ２−クロロ−９−（２−デオキシ−２−フルオロ−β−Ｄ−アラビノフラノシル）−９Ｈ−プリン−６−アミンの合成方法
US7435755B2 (en) 2000-11-28 2008-10-14 The Trustees Of Dartmouth College CDDO-compounds and combination therapies thereof
ES2306783T3 (es) * 2001-08-02 2008-11-16 Ilex Oncology, Inc. Procedimiento para preparar nucleosidos purinicos.
US7176237B2 (en) 2002-01-15 2007-02-13 The Trustees Of Dartmouth College Tricyclic-bis-enone derivatives and methods of use thereof
US6884880B2 (en) * 2002-08-21 2005-04-26 Ash Stevens, Inc. Process for the preparation of 9-β-anomeric nucleoside analogs
US7265096B2 (en) 2002-11-04 2007-09-04 Xenoport, Inc. Gemcitabine prodrugs, pharmaceutical compositions and uses thereof
US8148505B2 (en) 2003-05-22 2012-04-03 Japan Science And Technology Agency Method of α-selective glycosylation
WO2006070985A1 (en) 2004-12-30 2006-07-06 Hanmi Pharm. Co., Ltd. METHOD FOR THE PREPARATION OF 2#-DEOXY-2#,2#-DIFLUOROCYTIDINE
KR20070112774A (ko) * 2005-03-04 2007-11-27 다브르 파마 리미티드 베타―아노머가 많은２１데옥시，２１，２１－디플루오로－ｄ－리보푸라노실뉴클레오시드의 제조를 위한 중간체 및 제조 방법
US7572898B2 (en) * 2005-06-03 2009-08-11 Scinopharm Taiwan, Ltd. Process of making an alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonate and use thereof for making a beta nucleoside
CN100391966C (zh) * 2005-06-17 2008-06-04 华东师范大学 一种2’-脱氧-2’，2’-二氟-胞苷合成的方法
US8921340B2 (en) 2006-11-17 2014-12-30 Trustees Of Dartmouth College Methods for using synthetic triterpenoids in the treatment of bone or cartilage diseases or conditions
US8299046B2 (en) 2006-11-17 2012-10-30 Trustees Of Dartmouth College Synthetic triterpenoids and tricyclic-bis-enones for use in stimulating bone and cartilage growth
WO2008064133A1 (en) 2006-11-17 2008-05-29 Trustees Of Dartmouth College Synthesis and biological activities of new tricyclic-bis-enones (tbes)
US20080262215A1 (en) * 2007-04-23 2008-10-23 Chemagis Ltd. Gemcitabine production process
CN100475832C (zh) 2007-05-31 2009-04-08 南京卡文迪许生物工程技术有限公司 一种新颖的高立体选择性合成吉西他滨工艺及中间体
EP2048151A1 (en) * 2007-10-10 2009-04-15 Cilag AG Method for producing nucleosides by direct glycosylation of the nucleoside base
EP2050757A1 (en) * 2007-10-10 2009-04-22 Cilag AG Method of producing 2' -deoxy-5-azacytidine (Decitabine)
HUE043175T2 (hu) 2008-01-11 2019-08-28 Reata Pharmaceuticals Inc Szintetikus triterpenoidok és alkalmazásuk betegség kezelésében
CN104250280A (zh) 2008-04-18 2014-12-31 里亚塔医药公司 抗氧化剂炎症调节剂:c-17同系化齐墩果酸衍生物
ES2703274T3 (es) 2008-04-18 2019-03-07 Reata Pharmaceuticals Inc Moduladores de la inflamación antioxidantes: derivados del ácido oleanólico con modificaciones amino y otras en C-17
MX339476B (es) 2008-04-18 2016-05-27 Reata Pharmaceuticals Inc Compuestos que incluyen un nucleo farmaceutico antiinflamatorio y sus metodos de uso.
US8071632B2 (en) 2008-04-18 2011-12-06 Reata Pharmaceuticals, Inc. Antioxidant inflammation modulators: novel derivatives of oleanolic acid
KR101713140B1 (ko) 2008-04-18 2017-03-08 리타 파마슈티컬스 잉크. Ｃ-환에서 포화된 산화방지성 염증 조절제 올레아놀산 유도체
NZ700073A (en) 2012-04-04 2016-08-26 Halozyme Inc Combination therapy with an anti - hyaluronan agent and a tumor - targeted taxane
US8921419B2 (en) 2012-05-08 2014-12-30 Trustees Of Dartmouth College Triterpenoids and compositions containing the same
CN105229020B (zh) * 2013-03-15 2018-09-25 表观遗传学药业有限责任公司 氟化嘧啶类似物及其使用方法
CA3061621A1 (en) 2017-04-26 2018-11-01 Thomas I. Kalman Multitargeted nucleoside derivatives
US20190351031A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1295998C (en) * 1985-07-29 1992-02-18 Sai P. Sunkara Nucleosides and their use as antineoplastic agents
DE3856477T2 (de) * 1987-08-28 2001-11-08 Eli Lilly And Co., Indianapolis Verfahren zur Herstellung von 2'-deoxy-2',2'-difluornukleosiden
JPH0217199A (ja) * 1988-07-05 1990-01-22 Japan Tobacco Inc ２’−デオキシ−β−アデノシンの製造方法
GB8816345D0 (en) * 1988-07-08 1988-08-10 Hoffmann La Roche Purine derivatives
HU906976D0 (en) * 1989-11-13 1991-05-28 Bristol Myers Squibb Co Process for producing 2', 3'-didesoxy-2'-fluoarabinonucleoside analogues
WO1991015498A2 (en) * 1990-04-04 1991-10-17 Nycomed Imaging As Nucleoside derivatives
US5817799A (en) * 1990-07-23 1998-10-06 The United States Of America As Represented By The Department Of Health And Human Services 2'-Fluorofuranosyl derivatives and methods for preparing 2'-fluoropyrimidine and 2'-fluoropurine nucleosides
US5371210A (en) * 1992-06-22 1994-12-06 Eli Lilly And Company Stereoselective fusion glycosylation process for preparing 2'-deoxy-2',2'-difluoronucleosides and 2'-deoxy-2'-fluoronucleosides
US5256798A (en) * 1992-06-22 1993-10-26 Eli Lilly And Company Process for preparing alpha-anomer enriched 2-deoxy-2,2-difluoro-D-ribofuranosyl sulfonates

Also Published As

Publication number Publication date
MX9303707A (es) 1994-06-30
HU223837B1 (hu) 2005-02-28
FI108643B (fi) 2002-02-28
DE69314239C5 (de) 2012-11-29
NO180235B (no) 1996-12-02
KR100252452B1 (en) 2000-04-15
JPH06157570A (ja) 1994-06-03
DE69314239T2 (de) 1998-02-19
NO180235B3 (no) 2007-10-01
CA2098881A1 (en) 1993-12-23
IL106071A (en) 2006-08-20
GR3025689T3 (en) 1998-03-31
KR940005658A (ko) 1994-03-22
NO932288A (no) 1993-12-23
NZ247939A (en) 1996-02-27
CA2098881C (en) 2005-06-07
DE69314239D1 (de) 1997-11-06
EP0577303B1 (en) 1997-10-01
ES2107624T3 (es) 1997-12-01
FI932869L (fi) 1993-12-23
NO180235C (no) 1997-03-12
DK0577303T3 (da) 1997-10-27
EP0577303A1 (en) 1994-01-05
BR9302434A (pt) 1994-02-16
IL106071A0 (en) 1993-10-20
PL299415A1 (en) 1994-03-07
ATE158799T1 (de) 1997-10-15
HU9301822D0 (en) 1993-09-28
FI932869A0 (fi) 1993-06-21
PL172348B1 (pl) 1997-09-30
CY2067A (en) 1993-06-21
NO932288D0 (no) 1993-06-21
HU0201196D0 (hu) 2002-06-29
MY115775A (en) 2003-09-30
JP3313191B2 (ja) 2002-08-12
UA41261C2 (uk) 2001-09-17

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