CA2188306A1 - Process for the diastereoselective synthesis of nucleoside analogues - Google Patents

Process for the diastereoselective synthesis of nucleoside analogues

Info

Publication number
CA2188306A1
CA2188306A1 CA002188306A CA2188306A CA2188306A1 CA 2188306 A1 CA2188306 A1 CA 2188306A1 CA 002188306 A CA002188306 A CA 002188306A CA 2188306 A CA2188306 A CA 2188306A CA 2188306 A1 CA2188306 A1 CA 2188306A1
Authority
CA
Canada
Prior art keywords
nucleoside analogues
diastereoselective synthesis
diastereoselective
synthesis
nucleoside
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002188306A
Other languages
French (fr)
Other versions
CA2188306C (en
Inventor
Malcolm Leithead Hill
Andrew Jonathan Whitehead
Roy Hornby
Peter Hallett
Michael David Goodyear
P. Owen Dwyer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glaxo Group Ltd
Original Assignee
Malcolm Leithead Hill
Andrew Jonathan Whitehead
Roy Hornby
Peter Hallett
Michael David Goodyear
P. Owen Dwyer
Glaxo Group Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB9408091A external-priority patent/GB9408091D0/en
Priority claimed from GB9408112A external-priority patent/GB9408112D0/en
Priority claimed from GB9408103A external-priority patent/GB9408103D0/en
Application filed by Malcolm Leithead Hill, Andrew Jonathan Whitehead, Roy Hornby, Peter Hallett, Michael David Goodyear, P. Owen Dwyer, Glaxo Group Limited filed Critical Malcolm Leithead Hill
Priority claimed from PCT/EP1995/001503 external-priority patent/WO1995029174A1/en
Publication of CA2188306A1 publication Critical patent/CA2188306A1/en
Application granted granted Critical
Publication of CA2188306C publication Critical patent/CA2188306C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D327/00—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms
    • C07D327/02—Heterocyclic compounds containing rings having oxygen and sulfur atoms as the only ring hetero atoms one oxygen atom and one sulfur atom
    • C07D327/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

A diastereoselective process for the preparation of compounds of formula (I), wherein W is S, S=O, SO2, or O; X is S, S=O, SO2, or O; R1 is hydrogen or acyl, and R2 is a purine or pyrimidine base or an analogue or derivative thereof, is described.
CA002188306A 1994-04-23 1995-04-21 Process for the diastereoselective synthesis of nucleoside analogues Expired - Lifetime CA2188306C (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB9408091A GB9408091D0 (en) 1994-04-23 1994-04-23 Process
GB9408112.2 1994-04-23
GB9408112A GB9408112D0 (en) 1994-04-23 1994-04-23 Process
GB9408103A GB9408103D0 (en) 1994-04-23 1994-04-23 Chemical compounds
GB9408103.1 1994-04-23
GB9408091.8 1994-04-23
PCT/EP1995/001503 WO1995029174A1 (en) 1994-04-23 1995-04-21 Process for the diastereoselective synthesis of nucleoside analogues

Publications (2)

Publication Number Publication Date
CA2188306A1 true CA2188306A1 (en) 1995-11-02
CA2188306C CA2188306C (en) 2007-07-03

Family

ID=38247232

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002188306A Expired - Lifetime CA2188306C (en) 1994-04-23 1995-04-21 Process for the diastereoselective synthesis of nucleoside analogues

Country Status (1)

Country Link
CA (1) CA2188306C (en)

Also Published As

Publication number Publication date
CA2188306C (en) 2007-07-03

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Legal Events

Date Code Title Description
EEER Examination request
MKEX Expiry

Effective date: 20150421