DE69620042D1 - Verfahren und zusammensetzungen zur synthese von dioxolan-nukleoside mit beta-struktur - Google Patents
Verfahren und zusammensetzungen zur synthese von dioxolan-nukleoside mit beta-strukturInfo
- Publication number
- DE69620042D1 DE69620042D1 DE69620042T DE69620042T DE69620042D1 DE 69620042 D1 DE69620042 D1 DE 69620042D1 DE 69620042 T DE69620042 T DE 69620042T DE 69620042 T DE69620042 T DE 69620042T DE 69620042 D1 DE69620042 D1 DE 69620042D1
- Authority
- DE
- Germany
- Prior art keywords
- synthesising
- dioxolan
- nucleosides
- compositions
- beta structure
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB9525606.1A GB9525606D0 (en) | 1995-12-14 | 1995-12-14 | Method and compositions for the synthesis of dioxolane nucleosides with - configuration |
| PCT/CA1996/000845 WO1997021706A1 (en) | 1995-12-14 | 1996-12-13 | METHOD AND COMPOSITIONS FOR THE SYNTHESIS OF DIOXOLANE NUCLEOSIDES WITH β-CONFIGURATION |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69620042D1 true DE69620042D1 (de) | 2002-04-25 |
| DE69620042T2 DE69620042T2 (de) | 2002-10-17 |
Family
ID=10785435
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69620042T Expired - Lifetime DE69620042T2 (de) | 1995-12-14 | 1996-12-13 | Verfahren und zusammensetzungen zur synthese von dioxolan-nukleoside mit beta-struktur |
Country Status (28)
| Country | Link |
|---|---|
| US (4) | US5922867A (de) |
| EP (1) | EP0970074B1 (de) |
| JP (1) | JP3229990B2 (de) |
| KR (1) | KR100406159B1 (de) |
| CN (1) | CN1080263C (de) |
| AP (1) | AP879A (de) |
| AT (1) | ATE214699T1 (de) |
| AU (1) | AU706328B2 (de) |
| BR (1) | BR9612351A (de) |
| CA (1) | CA2237730C (de) |
| DE (1) | DE69620042T2 (de) |
| DK (1) | DK0970074T3 (de) |
| EA (1) | EA000844B1 (de) |
| ES (1) | ES2172697T3 (de) |
| GB (1) | GB9525606D0 (de) |
| HK (1) | HK1017886A1 (de) |
| HU (1) | HU224076B1 (de) |
| IL (3) | IL124663A (de) |
| IN (1) | IN187349B (de) |
| MX (1) | MX9804701A (de) |
| NO (1) | NO309901B1 (de) |
| NZ (1) | NZ323855A (de) |
| OA (1) | OA11094A (de) |
| PL (1) | PL188447B1 (de) |
| PT (1) | PT970074E (de) |
| TW (1) | TW341574B (de) |
| WO (1) | WO1997021706A1 (de) |
| ZA (1) | ZA9610544B (de) |
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2001518899A (ja) | 1997-04-07 | 2001-10-16 | トライアングル ファーマシューティカルズ，インコーポレイティド | 他の抗ウイルス剤との組合せにおけるｍｋｃ−４４２の使用 |
| RU2439069C2 (ru) * | 1998-08-12 | 2012-01-10 | Гайлид Сайенсиз, Инк. | Способ получения 1,3-оксатиолановых нуклеозидов |
| US6979561B1 (en) | 1998-10-09 | 2005-12-27 | Gilead Sciences, Inc. | Non-homogeneous systems for the resolution of enantiomeric mixtures |
| JP2002533470A (ja) | 1998-12-23 | 2002-10-08 | シャイアー・バイオケム・インコーポレイテッド | 抗ウイルス性ヌクレオシド類似体 |
| JP2002538780A (ja) * | 1999-02-11 | 2002-11-19 | シェア バイオケム インコーポレーテッド | ヌクレオシド類似体の立体選択的合成 |
| EP1214074B1 (de) * | 1999-09-24 | 2004-06-16 | Shire Biochem Inc. | Dioxolan nukleosidanalogen zur behandlung und vorbeugung von viralen infektionen |
| CA2389745C (en) * | 1999-11-04 | 2010-03-23 | Shire Biochem Inc. | Method for the treatment or prevention of flaviviridae viral infection using nucleoside analogues |
| EP1178051B1 (de) * | 2000-02-10 | 2008-05-28 | Mitsui Chemicals, Inc. | Verfahren zur selektiven herstellung eines 1-phosphoryliertem zuckerderivativ-anomers und verfahren zur herstellung von nukleosiden |
| ATE360016T1 (de) * | 2000-02-11 | 2007-05-15 | Shire Biochem Inc | Ein stereoselektives verfahren zur herstellung von nukleosidanalogen |
| WO2002051852A1 (fr) * | 2000-12-27 | 2002-07-04 | Mitsui Chemicals, Inc. | Procede de production d'un derive de saccharide non naturel |
| CA2690137C (en) | 2001-03-01 | 2012-11-13 | Gilead Sciences, Inc. | Polymorphic and other crystalline forms of cis-ftc |
| AU2002329970A1 (en) * | 2001-09-04 | 2003-03-18 | Isis Pharmaceuticals, Inc. | Pyrrolo(2,3-d)pyrimidines for inhibiting rna-dependent rna viral polymerase |
| EP1441733A1 (de) * | 2001-11-02 | 2004-08-04 | Shire Biochem Inc. | Pharmazeutische zusammensetzung zur behandlung von leukemia, die dioxolan nukleosidanalogen enthält |
| BR0214944A (pt) | 2001-12-14 | 2005-06-07 | Pharmasset Ltd | Nucleosìdeos de n4-acilcitosina para o tratamento de infecções virais |
| EP1467990B1 (de) * | 2002-01-25 | 2012-03-07 | Shire BioChem Inc. | Verfahren zur herstellung von dioxolan nukleosidanalogavorstufen |
| MXPA05001451A (es) | 2002-08-06 | 2005-09-30 | Pharmasset Ltd | Procesos para preparar nucleosidos de 1,3-dioxolano. |
| EP2261292B1 (de) | 2002-10-15 | 2014-07-23 | ExxonMobil Chemical Patents Inc. | Polyolefin-Klebstoffzusammensetzungen |
| DE10335061B4 (de) | 2003-07-31 | 2005-11-17 | Wacker-Chemie Gmbh | Verfahren zur Herstellung von OH-geschützten [4-(2,6-damino-9H-purin-9-yl)-1,3-dioxolan-2-yl]methanol-Derivaten |
| US7785839B2 (en) | 2004-02-03 | 2010-08-31 | Emory University | Methods to manufacture 1,3-dioxolane nucleosides |
| US7749531B2 (en) * | 2005-06-08 | 2010-07-06 | Indicator Systems International | Apparatus and method for detecting bacterial growth beneath a wound dressing |
| BRPI0813036A2 (pt) * | 2007-07-30 | 2017-10-24 | Rfs Pharma Llc | processo estereosseletivo para preparar derivados do nucleosídeo dioxolana de purina. |
| CN101862676B (zh) * | 2009-04-17 | 2012-01-25 | 中国石油化工股份有限公司 | 大孔径sba-15介孔材料-三氟甲磺酸铜复合催化剂、制备方法及应用 |
| CN103288806A (zh) * | 2013-07-02 | 2013-09-11 | 山东大学 | 一种曲沙他滨的合成方法 |
| WO2018022263A1 (en) | 2016-07-29 | 2018-02-01 | Exxonmobil Chemical Patents Inc. | Polymerization processes using high molecular weight polyhydric quenching agents |
| WO2019245444A1 (en) | 2018-06-21 | 2019-12-26 | Medivir Ab | Base-modified cytidine nucleotides for leukemia therapy |
| JP7337539B2 (ja) * | 2018-06-21 | 2023-09-04 | メディヴィル・アクチエボラーグ | 白血病療法のための塩基修飾シチジンヌクレオチド |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5276151A (en) * | 1990-02-01 | 1994-01-04 | Emory University | Method of synthesis of 1,3-dioxolane nucleosides |
| FI932871A (fi) * | 1992-06-22 | 1993-12-23 | Lilly Co Eli | Stereoselektiv anjonglykosylationsprocess |
-
1995
- 1995-12-14 GB GBGB9525606.1A patent/GB9525606D0/en active Pending
-
1996
- 1996-12-13 AT AT96941539T patent/ATE214699T1/de not_active IP Right Cessation
- 1996-12-13 JP JP52157397A patent/JP3229990B2/ja not_active Expired - Lifetime
- 1996-12-13 PT PT96941539T patent/PT970074E/pt unknown
- 1996-12-13 KR KR10-1998-0704473A patent/KR100406159B1/ko not_active IP Right Cessation
- 1996-12-13 DK DK96941539T patent/DK0970074T3/da active
- 1996-12-13 WO PCT/CA1996/000845 patent/WO1997021706A1/en active IP Right Grant
- 1996-12-13 US US08/849,722 patent/US5922867A/en not_active Expired - Lifetime
- 1996-12-13 HU HU9901050A patent/HU224076B1/hu active IP Right Grant
- 1996-12-13 EP EP96941539A patent/EP0970074B1/de not_active Expired - Lifetime
- 1996-12-13 IL IL12466396A patent/IL124663A/en not_active IP Right Cessation
- 1996-12-13 PL PL96327443A patent/PL188447B1/pl not_active IP Right Cessation
- 1996-12-13 EA EA199800555A patent/EA000844B1/ru not_active IP Right Cessation
- 1996-12-13 CA CA002237730A patent/CA2237730C/en not_active Expired - Lifetime
- 1996-12-13 TW TW085115392A patent/TW341574B/zh active
- 1996-12-13 DE DE69620042T patent/DE69620042T2/de not_active Expired - Lifetime
- 1996-12-13 NZ NZ323855A patent/NZ323855A/xx unknown
- 1996-12-13 ES ES96941539T patent/ES2172697T3/es not_active Expired - Lifetime
- 1996-12-13 AU AU10893/97A patent/AU706328B2/en not_active Expired
- 1996-12-13 IL IL14415596A patent/IL144155A/xx not_active IP Right Cessation
- 1996-12-13 BR BR9612351A patent/BR9612351A/pt not_active Application Discontinuation
- 1996-12-13 CN CN96199879A patent/CN1080263C/zh not_active Expired - Lifetime
- 1996-12-13 AP APAP/P/1998/001252A patent/AP879A/en active
- 1996-12-13 IN IN2810DE1996 patent/IN187349B/en unknown
- 1996-12-13 ZA ZA9610544A patent/ZA9610544B/xx unknown
-
1998
- 1998-06-09 OA OA9800077A patent/OA11094A/en unknown
- 1998-06-11 MX MX9804701A patent/MX9804701A/es unknown
- 1998-06-12 NO NO982716A patent/NO309901B1/no unknown
-
1999
- 1999-02-17 US US09/251,431 patent/US6069250A/en not_active Expired - Lifetime
- 1999-05-17 HK HK99102184A patent/HK1017886A1/xx not_active IP Right Cessation
-
2001
- 2001-07-05 IL IL14415501A patent/IL144155A0/xx unknown
- 2001-11-16 US US09/987,845 patent/US20020058670A1/en not_active Abandoned
-
2002
- 2002-10-02 US US10/262,107 patent/US20030060476A1/en not_active Abandoned
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |