ZA9610544B - Method and compositions for the synthesis of dioxolane nucleosides with beta-configuration - Google Patents

Method and compositions for the synthesis of dioxolane nucleosides with beta-configuration

Info

Publication number
ZA9610544B
ZA9610544B ZA9610544A ZA9610544A ZA9610544B ZA 9610544 B ZA9610544 B ZA 9610544B ZA 9610544 A ZA9610544 A ZA 9610544A ZA 9610544 A ZA9610544 A ZA 9610544A ZA 9610544 B ZA9610544 B ZA 9610544B
Authority
ZA
South Africa
Prior art keywords
beta
synthesis
compositions
configuration
dioxolane nucleosides
Prior art date
Application number
ZA9610544A
Other languages
English (en)
Inventor
Tarek Mansour
Alex Cimpoia
Krzystof Bednarski
Original Assignee
Iaf Biochem Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Iaf Biochem Int filed Critical Iaf Biochem Int
Publication of ZA9610544B publication Critical patent/ZA9610544B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA9610544A 1995-12-14 1996-12-13 Method and compositions for the synthesis of dioxolane nucleosides with beta-configuration ZA9610544B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9525606.1A GB9525606D0 (en) 1995-12-14 1995-12-14 Method and compositions for the synthesis of dioxolane nucleosides with › - configuration

Publications (1)

Publication Number Publication Date
ZA9610544B true ZA9610544B (en) 1997-07-29

Family

ID=10785435

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9610544A ZA9610544B (en) 1995-12-14 1996-12-13 Method and compositions for the synthesis of dioxolane nucleosides with beta-configuration

Country Status (28)

Country Link
US (4) US5922867A (de)
EP (1) EP0970074B1 (de)
JP (1) JP3229990B2 (de)
KR (1) KR100406159B1 (de)
CN (1) CN1080263C (de)
AP (1) AP879A (de)
AT (1) ATE214699T1 (de)
AU (1) AU706328B2 (de)
BR (1) BR9612351A (de)
CA (1) CA2237730C (de)
DE (1) DE69620042T2 (de)
DK (1) DK0970074T3 (de)
EA (1) EA000844B1 (de)
ES (1) ES2172697T3 (de)
GB (1) GB9525606D0 (de)
HK (1) HK1017886A1 (de)
HU (1) HU224076B1 (de)
IL (3) IL124663A (de)
IN (1) IN187349B (de)
MX (1) MX9804701A (de)
NO (1) NO309901B1 (de)
NZ (1) NZ323855A (de)
OA (1) OA11094A (de)
PL (1) PL188447B1 (de)
PT (1) PT970074E (de)
TW (1) TW341574B (de)
WO (1) WO1997021706A1 (de)
ZA (1) ZA9610544B (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6410546B1 (en) 1997-04-07 2002-06-25 Triangle Pharmaceuticals, Inc. Use of MKC-442 in combination with other antiviral agents
JP4249393B2 (ja) 1998-08-12 2009-04-02 トライアングル・ファーマシューティカルズ，インコーポレイテッド １，３−オキサチオランヌクレオチドの製造方法
US6979561B1 (en) 1998-10-09 2005-12-27 Gilead Sciences, Inc. Non-homogeneous systems for the resolution of enantiomeric mixtures
CA2355712C (en) 1998-12-23 2009-03-17 Shire Biochem Inc. Antiviral nucleoside analogues
JP2002538780A (ja) * 1999-02-11 2002-11-19 シェア バイオケム インコーポレーテッド ヌクレオシド類似体の立体選択的合成
AU777869B2 (en) * 1999-09-24 2004-11-04 Shire Canada Inc. Method for the treatment or prevention of viral infection using nucleoside analogues
US6566365B1 (en) 1999-11-04 2003-05-20 Biochem Pharma Inc. Method for the treatment of Flaviviridea viral infection using nucleoside analogues
BR0104461A (pt) * 2000-02-10 2002-08-06 Mitsui Chemicals Inc Processo seletivo para produzir um anÈmero a partir de um derivado de sacarìdeo 1-fosforilado e processo para produzir um nucleosìdeo
JP2003522769A (ja) * 2000-02-11 2003-07-29 シェア バイオケム インコーポレーテッド ヌクレオシド類似体の立体選択的合成
WO2002051852A1 (fr) * 2000-12-27 2002-07-04 Mitsui Chemicals, Inc. Procede de production d'un derive de saccharide non naturel
CN102911166B (zh) * 2001-03-01 2016-08-17 基利得科学公司 顺-ftc的多晶型物及其它晶型
WO2003020222A2 (en) * 2001-09-04 2003-03-13 Merck & Co., Inc. PYRROLO[2,3-d]PYRIMIDINES FOR INHIBITING RNA-DEPENDENT RNA VIRAL POLYMERASE
JP2005512984A (ja) * 2001-11-02 2005-05-12 シャイアー バイオケム インコーポレイテッド ジオキソランヌクレオシド類似体を含む白血病の治療のための医薬組成物
KR100978904B1 (ko) * 2001-12-14 2010-08-31 파마셋 인코포레이티드 바이러스 감염 치료용 ｎ4-아실사이토신 뉴클레오사이드
AU2003236757B2 (en) 2002-01-25 2009-12-03 Takeda Pharmaceutical Company Limited Process for producing dioxolane nucleoside analogues
ATE496054T1 (de) 2002-08-06 2011-02-15 Pharmasset Inc Verfahren zur herstellung von 1,3-dioxolan- nucleosiden
CA2499951C (en) 2002-10-15 2013-05-28 Peijun Jiang Multiple catalyst system for olefin polymerization and polymers produced therefrom
DE10335061B4 (de) 2003-07-31 2005-11-17 Wacker-Chemie Gmbh Verfahren zur Herstellung von OH-geschützten [4-(2,6-damino-9H-purin-9-yl)-1,3-dioxolan-2-yl]methanol-Derivaten
WO2005074654A2 (en) * 2004-02-03 2005-08-18 Emory University Methods to manufacture 1,3-dioxolane nucleosides
US7749531B2 (en) * 2005-06-08 2010-07-06 Indicator Systems International Apparatus and method for detecting bacterial growth beneath a wound dressing
BRPI0813036A2 (pt) * 2007-07-30 2017-10-24 Rfs Pharma Llc processo estereosseletivo para preparar derivados do nucleosídeo dioxolana de purina.
CN101862676B (zh) * 2009-04-17 2012-01-25 中国石油化工股份有限公司 大孔径sba-15介孔材料-三氟甲磺酸铜复合催化剂、制备方法及应用
CN103288806A (zh) * 2013-07-02 2013-09-11 山东大学 一种曲沙他滨的合成方法
WO2018022263A1 (en) 2016-07-29 2018-02-01 Exxonmobil Chemical Patents Inc. Polymerization processes using high molecular weight polyhydric quenching agents
WO2019245444A1 (en) 2018-06-21 2019-12-26 Medivir Ab Base-modified cytidine nucleotides for leukemia therapy
JP7337539B2 (ja) * 2018-06-21 2023-09-04 メディヴィル・アクチエボラーグ 白血病療法のための塩基修飾シチジンヌクレオチド

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5276151A (en) * 1990-02-01 1994-01-04 Emory University Method of synthesis of 1,3-dioxolane nucleosides
PL299413A1 (en) * 1992-06-22 1994-03-07 Lilly Co Eli Stereoselective glycozilation process effected by means o anions

Also Published As

Publication number Publication date
PT970074E (pt) 2002-09-30
CA2237730A1 (en) 1997-06-19
MX9804701A (es) 1998-10-31
DK0970074T3 (da) 2002-07-15
AP9801252A0 (en) 1998-06-30
EA000844B1 (ru) 2000-06-26
DE69620042D1 (de) 2002-04-25
IL144155A (en) 2003-07-06
EP0970074A1 (de) 2000-01-12
CN1208414A (zh) 1999-02-17
GB9525606D0 (en) 1996-02-14
NZ323855A (en) 1999-11-29
AU1089397A (en) 1997-07-03
HUP9901050A3 (en) 2001-05-28
DE69620042T2 (de) 2002-10-17
IL124663A0 (en) 1998-12-06
IL124663A (en) 2001-10-31
AU706328B2 (en) 1999-06-17
AP879A (en) 2000-10-02
NO982716L (no) 1998-06-12
BR9612351A (pt) 1999-07-13
PL188447B1 (pl) 2005-02-28
CN1080263C (zh) 2002-03-06
US6069250A (en) 2000-05-30
ATE214699T1 (de) 2002-04-15
US20020058670A1 (en) 2002-05-16
EA199800555A1 (ru) 1999-02-25
JP3229990B2 (ja) 2001-11-19
JP2000501714A (ja) 2000-02-15
HU224076B1 (hu) 2005-05-30
TW341574B (en) 1998-10-01
CA2237730C (en) 2001-12-04
NO309901B1 (no) 2001-04-17
KR100406159B1 (ko) 2004-11-16
KR19990072141A (ko) 1999-09-27
HUP9901050A2 (hu) 2001-04-28
IN187349B (de) 2002-03-30
HK1017886A1 (en) 1999-12-03
WO1997021706A1 (en) 1997-06-19
NO982716D0 (no) 1998-06-12
PL327443A1 (en) 1998-12-07
US20030060476A1 (en) 2003-03-27
EP0970074B1 (de) 2002-03-20
ES2172697T3 (es) 2002-10-01
US5922867A (en) 1999-07-13
IL144155A0 (en) 2002-05-23
OA11094A (en) 2003-03-13

Similar Documents

Publication Publication Date Title
IL124663A0 (en) Method and compositions for the synthesis of dioxolane nucleosides with beta-configuration
AU2447195A (en) Process for the diastereoselective synthesis of nucleoside analogues
AU5529596A (en) Methods and compositions related to stereolithography
EP0747882A3 (de) Veränderte Grundfrequenzverzögerung bei Verlust von Datenrahmen
AU4237896A (en) Method and intermediates for the synthesis of korupensamines
EP0481038A4 (en) Saccharide compositions, methods and apparatus for their synthesis
HUP9603377A3 (en) Crystalline maltitol composition and method for preparing the same
GB2272904B (en) Solvent based enzymatic synthesis
EP0861817A4 (de) Gaserzeugende zusammensetzung
PL316985A1 (en) Derivatives of adenosine
AU4980097A (en) Efficient synthesis of nucleosides
AU7706191A (en) Synthesis of nucleotide and nucleoside derivatives
IL118238A0 (en) Synthesis of benzoquinolinones
SI0817784T1 (en) Process for the synthesis of nucleoside analogues
GB9319985D0 (en) Method of making nucleosides
HU9501956D0 (en) Antiviral compositions and process for producing them
ZA953235B (en) Process for the diastereoselective synthesis of nucleoside analogues
SI0757684T1 (en) Process for the diastereoselective synthesis of nucleoside analogues
GB9526161D0 (en) Substituted dioxolane nucleoside analogues useful in the treatment of cancer
RU1833505C (ru) Cпocoб пoлучehия 2-tpet-буtил-4-metилфehoлa
AU6905394A (en) Method of reducing hcn in synthesis gas
AU131679S (en) Shield clock
ZA934244B (en) Explosive composition and method for producing the same
GB9411032D0 (en) Synthesis of substituted diaminophthalimides and analogues
EP0868189A4 (de) Antineoplastische verfahren und mittel unter verwendung von (+)-fotemustin