CN1072485C - 夫马菌醇及其衍生物用于制备抗肠道感染药物的用途 - Google Patents
夫马菌醇及其衍生物用于制备抗肠道感染药物的用途 Download PDFInfo
- Publication number
- CN1072485C CN1072485C CN96192923A CN96192923A CN1072485C CN 1072485 C CN1072485 C CN 1072485C CN 96192923 A CN96192923 A CN 96192923A CN 96192923 A CN96192923 A CN 96192923A CN 1072485 C CN1072485 C CN 1072485C
- Authority
- CN
- China
- Prior art keywords
- fumagillol
- purposes
- ester
- alkyl
- acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/336—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having three-membered rings, e.g. oxirane, fumagillin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/10—Anthelmintics
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Epoxy Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR95/03549 | 1995-03-27 | ||
| FR9503549 | 1995-03-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1179715A CN1179715A (zh) | 1998-04-22 |
| CN1072485C true CN1072485C (zh) | 2001-10-10 |
Family
ID=9477436
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN96192923A Expired - Lifetime CN1072485C (zh) | 1995-03-27 | 1996-03-26 | 夫马菌醇及其衍生物用于制备抗肠道感染药物的用途 |
Country Status (25)
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2216623C (en) * | 1995-03-27 | 2005-05-31 | Sanofi | Use of fumagillol and derivatives thereof for preparing medicaments against intestinal infections |
| EP0799616A1 (en) * | 1996-04-01 | 1997-10-08 | Takeda Chemical Industries, Ltd. | Oral composition comprising a fumagillol derivative |
| WO2000050084A1 (fr) * | 1999-02-26 | 2000-08-31 | Sanofi-Synthelabo | Formulation stable contenant de la fumagilline |
| JP3265394B1 (ja) * | 2001-03-14 | 2002-03-11 | 泰三 矢野 | アクリル系樹脂手袋 |
| DE10341887A1 (de) * | 2003-09-09 | 2005-03-31 | Leopold Kostal Gmbh & Co. Kg | Elektrisches Schaltermodul |
| FR2886855B1 (fr) * | 2005-06-08 | 2009-07-17 | Agronomique Inst Nat Rech | Utilisation de la fumagilline et de ses derives pour augmenter la biodisponibilite des lactones macrocyliques |
| CA2706914A1 (en) * | 2007-11-28 | 2009-06-11 | Mersana Therapeutics, Inc. | Biocompatible biodegradable fumagillin analog conjugates |
| CA2731020A1 (en) * | 2008-07-18 | 2010-01-21 | Zafgen, Inc. | Use of antiangiogenic fumagillins in the treatment of obesity |
| WO2010065877A2 (en) | 2008-12-04 | 2010-06-10 | Zafgen Corporation | Methods of treating an overweight or obese subject |
| WO2010065883A2 (en) | 2008-12-04 | 2010-06-10 | Zafgen Corporation | Method of treating an overweight or obese subject |
| WO2013055385A2 (en) | 2011-10-03 | 2013-04-18 | Zafgen Corporation | Methods of treating age related disorders |
| EP2486004B1 (en) | 2009-10-09 | 2017-05-03 | Zafgen, Inc. | Sulphone compounds for use in the treatment of obesity |
| EP2521719B1 (en) | 2010-01-08 | 2015-07-29 | Zafgen, Inc. | Fumagillol type compounds and methods of making and using same |
| WO2011085198A1 (en) | 2010-01-08 | 2011-07-14 | Zafgen Corporation | Metap-2 inhibitor for use in treating benign prostatic hypertrophy (bph) |
| WO2011127304A2 (en) | 2010-04-07 | 2011-10-13 | Zafgen Corporation | Methods of treating an overweight subject |
| CA2806221A1 (en) | 2010-07-22 | 2012-01-26 | Zafgen, Inc. | Tricyclic compounds and methods of making and using same |
| PH12013500934A1 (en) | 2010-11-09 | 2022-10-24 | Zafgen Inc | Crystalline solids of a metap-2 inhibitor and methods of making and using same |
| JP2013543899A (ja) | 2010-11-29 | 2013-12-09 | ザフゲン，インコーポレイテッド | ６−ｏ−（４−ジメチルアミノエトキシ）シンナモイルフマギロールの非連日投与を用いた肥満の治療 |
| EP2668169B1 (en) | 2011-01-26 | 2017-11-15 | Zafgen, Inc. | Tetrazole compounds and methods of making and using same |
| CN103534244B (zh) | 2011-03-08 | 2016-10-12 | 扎夫根股份有限公司 | 氧杂螺[2.5]辛烷衍生物及类似物 |
| MX343687B (es) | 2011-05-06 | 2016-11-16 | Zafgen Inc | Compuestos sulfonamida tricíclica y métodos para su fabricación y uso. |
| BR112013028666A2 (pt) | 2011-05-06 | 2017-08-08 | Zafgen Inc | compostos de pirazolo sulfonamida tricícilos e métodos para fazer e usar o mesmo |
| EP2705030B1 (en) | 2011-05-06 | 2016-07-27 | Zafgen, Inc. | Partially saturated tricyclic compounds and methods of making and using same |
| BR112014017673A8 (pt) | 2012-01-18 | 2017-07-11 | Zafgen Inc | Compostos de sulfonamida tricíclicos e métodos para fazer e usar os mesmos |
| WO2013109735A1 (en) | 2012-01-18 | 2013-07-25 | Zafgen, Inc. | Tricyclic sulfone compounds and methods of making and using same |
| EP2847176A1 (en) | 2012-05-07 | 2015-03-18 | Zafgen, Inc. | Polymorphic salt of the oxalate salt of 6 - o - ( 4 - dimethylaminoethoxy) cinnarnoyl fumagillol and methods of making and using same |
| EP2846792B1 (en) | 2012-05-08 | 2018-08-15 | Zafgen, Inc. | Treating hypothalamic obesity with metap2 inhibitors |
| CA2873574A1 (en) | 2012-05-09 | 2013-11-14 | Zafgen, Inc. | Fumagillol type compounds and methods of making and using same |
| US9868717B2 (en) | 2012-11-05 | 2018-01-16 | Zafgen, Inc. | Tricyclic sulphonamide compounds and methods of making and using same |
| AU2013337287B2 (en) | 2012-11-05 | 2017-03-23 | Zafgen, Inc. | Methods of treating liver diseases |
| US10174009B2 (en) | 2012-11-05 | 2019-01-08 | Zafgen, Inc. | Tricyclic sulphonamide compounds and methods of making and using same |
| MX362391B (es) | 2013-03-14 | 2019-01-15 | Zafgen Inc | Métodos de tratamiento de enfermedad renal y otros trastornos. |
| CN106432255A (zh) | 2015-08-11 | 2017-02-22 | 扎夫根公司 | 烟曲霉素醇螺环化合物和制备和使用其的方法 |
| AR105671A1 (es) | 2015-08-11 | 2017-10-25 | Zafgen Inc | Compuestos heterocíclicos de fumagillol y sus métodos de elaboración y uso |
| CN106591389B (zh) * | 2015-10-15 | 2019-10-11 | 中国科学院微生物研究所 | 一种利用烟曲霉菌生产烟曲霉素的方法 |
| CN105622593B (zh) * | 2016-02-25 | 2018-06-26 | 中国农业科学院蜜蜂研究所 | 一种烟曲霉素的提取方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2791530A (en) * | 1953-08-31 | 1957-05-07 | Abbott Lab | Stabilized fumagillin compositions |
| JPH0629278B2 (ja) * | 1985-06-26 | 1994-04-20 | 藤沢薬品工業株式会社 | オキサスピロオクタン化合物 |
| US5135920A (en) * | 1988-11-16 | 1992-08-04 | Takeda Chemical Industries, Ltd. | Angiostatic agents |
| JPH06504262A (ja) * | 1990-07-27 | 1994-05-19 | レブリゲン コーポレーション | 脈管形成性の病気の処置用の新規な方法と組成物 |
| US5328930A (en) * | 1993-03-01 | 1994-07-12 | Emory University | Treatment of microsporidial and acanthamoeba keratoconjunctivitis with topical fumagillin |
| CA2216623C (en) * | 1995-03-27 | 2005-05-31 | Sanofi | Use of fumagillol and derivatives thereof for preparing medicaments against intestinal infections |
| EP0799616A1 (en) * | 1996-04-01 | 1997-10-08 | Takeda Chemical Industries, Ltd. | Oral composition comprising a fumagillol derivative |
| CA2210600A1 (en) * | 1996-07-17 | 1998-01-17 | Takashi Houkan | Inhibitor of tumor metastasis or recurrence |
| AU3968597A (en) * | 1996-08-02 | 1998-02-25 | Children's Medical Center Corporation | Method of regulating the female reproductive system through angiogenesis inhibitors |
-
1996
- 1996-03-26 CA CA002216623A patent/CA2216623C/en not_active Expired - Lifetime
- 1996-03-26 CN CN96192923A patent/CN1072485C/zh not_active Expired - Lifetime
- 1996-03-26 EA EA199700267A patent/EA000150B1/ru not_active IP Right Cessation
- 1996-03-26 TR TR97/01048T patent/TR199701048T1/xx unknown
- 1996-03-26 PL PL96322470A patent/PL183378B1/pl unknown
- 1996-03-26 HU HU9801220A patent/HU224028B1/hu active IP Right Grant
- 1996-03-26 DE DE69600879T patent/DE69600879T2/de not_active Expired - Lifetime
- 1996-03-26 CZ CZ19973049A patent/CZ286821B6/cs not_active IP Right Cessation
- 1996-03-26 JP JP52900196A patent/JP3260378B2/ja not_active Expired - Lifetime
- 1996-03-26 AT AT96909200T patent/ATE172641T1/de active
- 1996-03-26 ES ES96909200T patent/ES2128846T3/es not_active Expired - Lifetime
- 1996-03-26 AP APAP/P/1997/001092A patent/AP646A/en active
- 1996-03-26 EP EP96909200A patent/EP0817626B1/fr not_active Expired - Lifetime
- 1996-03-26 DK DK96909200T patent/DK0817626T3/da active
- 1996-03-26 KR KR1019970706675A patent/KR100286920B1/ko not_active Expired - Lifetime
- 1996-03-26 AU AU52786/96A patent/AU706161B2/en not_active Expired
- 1996-03-26 NZ NZ304906A patent/NZ304906A/xx not_active IP Right Cessation
- 1996-03-26 US US08/913,360 patent/US5900431A/en not_active Expired - Lifetime
- 1996-03-26 UA UA97094765A patent/UA41446C2/uk unknown
- 1996-03-26 WO PCT/FR1996/000448 patent/WO1996030010A2/fr not_active Ceased
- 1996-03-26 SK SK1307-97A patent/SK283883B6/sk not_active IP Right Cessation
-
1997
- 1997-09-11 IS IS4557A patent/IS2048B/is unknown
- 1997-09-26 NO NO19974466A patent/NO315968B1/no not_active IP Right Cessation
- 1997-09-26 OA OA70088A patent/OA10515A/fr unknown
-
2006
- 2006-04-04 FR FR06C0014C patent/FR06C0014I2/fr active Active
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C53 | Correction of patent of invention or patent application | ||
| CB02 | Change of applicant information |
Applicant after: SANOFI-SYNTHELABO Applicant before: Sanofi |
|
| COR | Change of bibliographic data |
Free format text: CORRECT: APPLICANT; FROM: SANOFI CORP. TO: SANOFI SYNTHESIZING LABORATORY |
|
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C56 | Change in the name or address of the patentee |
Owner name: SANOFI. AVENTIS CO., LTD. Free format text: FORMER NAME OR ADDRESS: SANOFI SYNTHESIZING LABORATORY |
|
| CP01 | Change in the name or title of a patent holder |
Address after: Paris France Co-patentee after: ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS Patentee after: SANOFI-AVENTIS Address before: Paris France Co-patentee before: ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS Patentee before: SANOFI-SYNTHELABO |
|
| CX01 | Expiry of patent term |
Granted publication date: 20011010 |
|
| EXPY | Termination of patent right or utility model |