CN107075516A - 经修饰的双链rna试剂 - Google Patents

经修饰的双链rna试剂 Download PDF

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Publication number
CN107075516A
CN107075516A CN201580056832.8A CN201580056832A CN107075516A CN 107075516 A CN107075516 A CN 107075516A CN 201580056832 A CN201580056832 A CN 201580056832A CN 107075516 A CN107075516 A CN 107075516A
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ome
nucleotides
dsrna
antisense strand
sense strand
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CN201580056832.8A
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Chinese (zh)
Inventor
M·迈尔
D·福斯特
S·米尔斯泰恩
S·库奇曼奇
V·贾达夫
K·拉杰夫
M·玛诺哈兰
R·帕马
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Alnylam Pharmaceuticals Inc
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Alnylam Pharmaceuticals Inc
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Priority to CN202410668845.1A priority Critical patent/CN118652888A/zh
Priority to CN202111550874.0A priority patent/CN114181942B/zh
Publication of CN107075516A publication Critical patent/CN107075516A/zh
Pending legal-status Critical Current

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CN201580056832.8A 2014-08-20 2015-08-14 经修饰的双链rna试剂 Pending CN107075516A (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202410668845.1A CN118652888A (zh) 2014-08-20 2015-08-14 经修饰的双链rna试剂
CN202111550874.0A CN114181942B (zh) 2014-08-20 2015-08-14 经修饰的双链rna试剂

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201462039507P 2014-08-20 2014-08-20
US62/039,507 2014-08-20
US201462083744P 2014-11-24 2014-11-24
US62/083,744 2014-11-24
US201462093919P 2014-12-18 2014-12-18
US62/093,919 2014-12-18
PCT/US2015/045407 WO2016028649A1 (en) 2014-08-20 2015-08-14 Modified double-stranded rna agents

Related Child Applications (2)

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CN202410668845.1A Division CN118652888A (zh) 2014-08-20 2015-08-14 经修饰的双链rna试剂
CN202111550874.0A Division CN114181942B (zh) 2014-08-20 2015-08-14 经修饰的双链rna试剂

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CN107075516A true CN107075516A (zh) 2017-08-18

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CN201580056832.8A Pending CN107075516A (zh) 2014-08-20 2015-08-14 经修饰的双链rna试剂
CN202111550874.0A Active CN114181942B (zh) 2014-08-20 2015-08-14 经修饰的双链rna试剂
CN202410668845.1A Pending CN118652888A (zh) 2014-08-20 2015-08-14 经修饰的双链rna试剂

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CN202111550874.0A Active CN114181942B (zh) 2014-08-20 2015-08-14 经修饰的双链rna试剂
CN202410668845.1A Pending CN118652888A (zh) 2014-08-20 2015-08-14 经修饰的双链rna试剂

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US (11) US10233448B2 (enExample)
EP (4) EP3812462A1 (enExample)
JP (5) JP7289610B2 (enExample)
KR (3) KR102494171B1 (enExample)
CN (3) CN107075516A (enExample)
CA (1) CA2958758A1 (enExample)
EA (1) EA201790420A1 (enExample)
IL (3) IL316808A (enExample)
MX (3) MX2017002144A (enExample)
NZ (1) NZ730296A (enExample)
SG (3) SG10201913791QA (enExample)
WO (1) WO2016028649A1 (enExample)

Cited By (32)

* Cited by examiner, † Cited by third party
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CN110944675A (zh) * 2017-12-01 2020-03-31 苏州瑞博生物技术有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
CN110945130A (zh) * 2017-12-01 2020-03-31 苏州瑞博生物技术有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
CN110945131A (zh) * 2017-12-01 2020-03-31 苏州瑞博生物技术有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
CN110945132A (zh) * 2017-12-01 2020-03-31 苏州瑞博生物技术有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
CN110997919A (zh) * 2017-12-01 2020-04-10 苏州瑞博生物技术有限公司 双链寡核苷酸、含双链寡核苷酸的组合物与缀合物及制备方法和用途
CN110997917A (zh) * 2017-12-01 2020-04-10 苏州瑞博生物技术有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
CN111050807A (zh) * 2017-12-01 2020-04-21 苏州瑞博生物技术有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
CN111378657A (zh) * 2018-12-28 2020-07-07 苏州瑞博生物技术有限公司 抑制COL1A1基因表达的siRNA、含有该siRNA的药物组合物及其用途
CN111378659A (zh) * 2018-12-29 2020-07-07 苏州瑞博生物技术有限公司 抑制stat3基因表达的核酸、含有该核酸的药物组合物及其用途
CN111378658A (zh) * 2018-12-28 2020-07-07 苏州瑞博生物技术有限公司 抑制TIMP-1基因表达的siRNA、含有该siRNA的药物组合物及其用途
CN111378655A (zh) * 2018-12-28 2020-07-07 苏州瑞博生物技术有限公司 抑制CTGF基因表达的siRNA、含有该siRNA的药物组合物及其用途
CN111655297A (zh) * 2018-09-30 2020-09-11 苏州瑞博生物技术有限公司 一种siRNA缀合物及其制备方法和用途
CN111655849A (zh) * 2018-08-21 2020-09-11 苏州瑞博生物技术有限公司 一种核酸、含有该核酸的药物组合物和缀合物及其用途
CN111973619A (zh) * 2019-05-23 2020-11-24 苏州瑞博生物技术股份有限公司 核酸、含有该核酸的药物组合物与siRNA缀合物及制备方法和用途
CN112007040A (zh) * 2019-05-31 2020-12-01 苏州瑞博生物技术股份有限公司 用于治疗乙型病毒性肝炎的联合用药物
CN112423794A (zh) * 2018-12-28 2021-02-26 苏州瑞博生物技术股份有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
CN112424354A (zh) * 2017-04-05 2021-02-26 赛伦斯治疗有限责任公司 在反义链的5’末端具有乙烯基膦酸酯的siRNA
CN112423795A (zh) * 2018-12-28 2021-02-26 苏州瑞博生物技术股份有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
CN112876534A (zh) * 2019-11-29 2021-06-01 苏州瑞博生物技术股份有限公司 肝靶向化合物及缀合物
CN113227376A (zh) * 2019-05-22 2021-08-06 苏州瑞博生物技术股份有限公司 核酸、药物组合物与缀合物及制备方法和用途
CN113286888A (zh) * 2019-05-22 2021-08-20 苏州瑞博生物技术股份有限公司 核酸、药物组合物与缀合物及制备方法和用途
CN113330117A (zh) * 2019-01-18 2021-08-31 苏州瑞博生物技术股份有限公司 一种核酸、含有该核酸的组合物与缀合物及制备方法和用途
CN113795280A (zh) * 2019-05-24 2021-12-14 苏州瑞博生物技术股份有限公司 核酸、药物组合物与缀合物及制备方法和用途
CN113891939A (zh) * 2019-05-24 2022-01-04 苏州瑞博生物技术股份有限公司 核酸、药物组合物与缀合物及制备方法和用途
CN114685585A (zh) * 2020-12-31 2022-07-01 苏州瑞博生物技术股份有限公司 核苷酸序列、双链寡核苷酸、药物组合物与缀合物及制备方法和用途
CN114945669A (zh) * 2019-11-06 2022-08-26 阿尔尼拉姆医药品有限公司 肝外递送
US11633482B2 (en) 2017-12-29 2023-04-25 Suzhou Ribo Life Science Co., Ltd. Conjugates and preparation and use thereof
WO2023109932A1 (zh) * 2021-12-16 2023-06-22 上海拓界生物医药科技有限公司 一种dsRNA、其制备方法及应用
CN116333013A (zh) * 2020-09-30 2023-06-27 纳肽得(青岛)生物医药有限公司 一种靶向配体
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