CN1067996C - 新型丙酸紫杉烯酯三水合物的制备方法 - Google Patents

新型丙酸紫杉烯酯三水合物的制备方法 Download PDF

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Publication number
CN1067996C
CN1067996C CN95193984A CN95193984A CN1067996C CN 1067996 C CN1067996 C CN 1067996C CN 95193984 A CN95193984 A CN 95193984A CN 95193984 A CN95193984 A CN 95193984A CN 1067996 C CN1067996 C CN 1067996C
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CN
China
Prior art keywords
beta
alpha
benzoyloxy
trihydroxy
epoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
CN95193984A
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English (en)
Chinese (zh)
Other versions
CN1151741A (zh
Inventor
J-R·奥斯林
J·多伟泽
E·福奎
B·迈达德
I·塔利皮德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis UK Holdings Ltd
Original Assignee
Rhone Poulenc Rorer SA
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9465183&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1067996(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Publication of CN1151741A publication Critical patent/CN1151741A/zh
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Publication of CN1067996C publication Critical patent/CN1067996C/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
CN95193984A 1994-07-08 1995-07-07 新型丙酸紫杉烯酯三水合物的制备方法 Expired - Lifetime CN1067996C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR94/08479 1994-07-08
FR9408479A FR2722191B1 (fr) 1994-07-08 1994-07-08 Procede de preparation du trihydrate du (2r,3s)-3-tertbutoxycarbonylamino-2-hydroxy-3-phenylpropionate de 4-acetoxy2alpha-benzoyloxy-5beta,20epoxy-1,7beta,10beta trihydroxy-9-oxo-tax-11-en-13alpha-yle

Publications (2)

Publication Number Publication Date
CN1151741A CN1151741A (zh) 1997-06-11
CN1067996C true CN1067996C (zh) 2001-07-04

Family

ID=9465183

Family Applications (1)

Application Number Title Priority Date Filing Date
CN95193984A Expired - Lifetime CN1067996C (zh) 1994-07-08 1995-07-07 新型丙酸紫杉烯酯三水合物的制备方法

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US (1) US6022985A (enExample)
EP (1) EP0770070B1 (enExample)
JP (1) JP3753155B2 (enExample)
KR (1) KR100391753B1 (enExample)
CN (1) CN1067996C (enExample)
AT (1) ATE171702T1 (enExample)
AU (1) AU706519B2 (enExample)
BR (1) BR9508789A (enExample)
CA (1) CA2193531C (enExample)
CO (1) CO4410189A1 (enExample)
CZ (1) CZ284695B6 (enExample)
DE (1) DE69505128T2 (enExample)
DK (1) DK0770070T3 (enExample)
DZ (1) DZ1905A1 (enExample)
ES (1) ES2121404T3 (enExample)
FI (1) FI119246B (enExample)
FR (1) FR2722191B1 (enExample)
GR (1) GR3027558T3 (enExample)
HU (1) HU220634B1 (enExample)
IL (1) IL114274A (enExample)
IN (1) IN183947B (enExample)
IS (1) IS2032B (enExample)
MA (1) MA23606A1 (enExample)
MX (1) MX9700173A (enExample)
MY (1) MY118481A (enExample)
NO (1) NO314500B1 (enExample)
NZ (1) NZ289455A (enExample)
PE (1) PE8697A1 (enExample)
PL (1) PL179876B1 (enExample)
RU (1) RU2126397C1 (enExample)
SI (1) SI0770070T1 (enExample)
SK (1) SK280520B6 (enExample)
TN (1) TNSN95071A1 (enExample)
TW (1) TW419473B (enExample)
UA (1) UA51624C2 (enExample)
UY (1) UY23991A1 (enExample)
WO (1) WO1996001815A1 (enExample)
ZA (1) ZA955646B (enExample)

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SE510650C2 (sv) * 1997-05-30 1999-06-14 Astra Ab Ny förening
FR2794771B1 (fr) 1999-06-11 2001-08-10 Aventis Pharma Sa Adenovirus recombinants codant pour le transporteur specifique de l'iode (nis)
US6266619B1 (en) * 1999-07-20 2001-07-24 Halliburton Energy Services, Inc. System and method for real time reservoir management
US6853921B2 (en) 1999-07-20 2005-02-08 Halliburton Energy Services, Inc. System and method for real time reservoir management
GB9920548D0 (en) * 1999-08-31 1999-11-03 Rhone Poulenc Rorer Sa Treatment of hepatocellular carcinoma
US6891050B2 (en) * 2001-08-10 2005-05-10 Dabur India Limited Process for the preparation of taxanes such as paclitaxel, docetaxel and structurally similar analogs
US6881852B2 (en) * 2002-02-05 2005-04-19 Dabur India Limited Process of purification of paclitaxel and docetaxel
US7247738B2 (en) * 2002-05-07 2007-07-24 Dabur India Limited Method of preparation of anticancer taxanes using 3-[(substituted-2-trialkylsilyl) ethoxycarbonyl]-5-oxazolidine carboxylic acids
US6900342B2 (en) * 2002-05-10 2005-05-31 Dabur India Limited Anticancer taxanes such as paclitaxel, docetaxel and their structural analogs, and a method for the preparation thereof
US6838569B2 (en) * 2002-12-16 2005-01-04 Dabur India Limited Process for preparation of paclitaxel trihydrate and docetaxel trihydrate
US7584165B2 (en) * 2003-01-30 2009-09-01 Landmark Graphics Corporation Support apparatus, method and system for real time operations and maintenance
US8703982B2 (en) 2003-03-17 2014-04-22 Phyton Holdings Llc Purification of taxanes
CN1268619C (zh) * 2003-05-08 2006-08-09 上海迪赛诺化学制药有限公司 多烯紫杉醇三水化合物的制备方法
FR2859996B1 (fr) * 2003-09-19 2006-02-03 Aventis Pharma Sa Solvat acetonique du dimethoxy docetaxel et son procede de preparation
DE602004020506D1 (de) 2003-12-12 2009-05-20 Quiral Quimica Do Brasil Verfahren zur herstellung von wasserfreien und hydratisierten pharmazeutischen wirkstoffen (apis); aus diesen hergestellte stabile pharmazeutische zusammensetzungen und anwendungen für diese zusammensetzungen
US7142986B2 (en) * 2005-02-01 2006-11-28 Smith International, Inc. System for optimizing drilling in real time
CN100420681C (zh) * 2005-04-29 2008-09-24 上海奥锐特国际贸易有限公司 多烯紫杉醇三水物的制备方法
CA2880727C (en) 2005-08-31 2019-05-07 Neil P. Desai Compositions comprising poorly water soluble pharmaceutical agents and antimicrobial agents
KR101643416B1 (ko) 2005-08-31 2016-07-27 아브락시스 바이오사이언스, 엘엘씨 증가된 안정성을 가진 수 난용성 약물의 조성물 및 제조방법
TW200730518A (en) * 2005-10-12 2007-08-16 Sicor Inc Crystalline forms of docetaxel and processes for their preparation
KR100995390B1 (ko) 2006-01-02 2010-11-19 주식회사 삼양제넥스 무정형, 무수결정형 또는 수화 결정형 도세탁셀의 제조방법
CN101371164A (zh) * 2006-01-20 2009-02-18 界标制图有限公司 动态生产系统管理
JP2009533330A (ja) * 2006-03-21 2009-09-17 ドクター レディズ ラボラトリーズ リミテッド ドセタキセルの多形体およびプロセス
US7662980B2 (en) * 2006-10-20 2010-02-16 Scinopharm Singapore Pte Ltd. Crystalline forms of docetaxel and process for preparation thereof
KR100868116B1 (ko) * 2007-04-09 2008-11-10 한미약품 주식회사 도세탁셀·모노프로필렌글라이콜 내포화합물 및 이의제조방법
KR100878455B1 (ko) 2007-04-10 2009-01-13 한미약품 주식회사 안정한 무수결정형 도세탁셀 및 이의 제조방법
WO2009006590A2 (en) * 2007-07-04 2009-01-08 Dr. Reddy's Laboratories Ltd. Docetaxel process and polymorphs
DK2080764T3 (da) 2008-01-18 2012-09-24 Indena Spa Faste former af ortataxel
EP2080763A1 (en) * 2008-01-18 2009-07-22 INDENA S.p.A. Crystalline form I of ortataxel
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
US8686165B2 (en) * 2009-11-04 2014-04-01 Emcure Pharmaceuticals Limited Process for preparation of taxane derivatives
SG185389A1 (en) 2010-05-03 2012-12-28 Teikoku Pharma Usa Inc Non-aqueous taxane pro-emulsion formulations and methods of making and using the same
WO2012160568A1 (en) * 2011-05-23 2012-11-29 Shilpa Medicare Limited Process for preparing docetaxel trihydrate polymorph
LT2753355T (lt) 2011-09-08 2019-01-25 New York University Onkolitinis herpes simplex virusas ir jo terapinis panaudojimas
US9745631B2 (en) 2011-12-20 2017-08-29 Dana-Farber Cancer Institute, Inc. Methods for diagnosing and treating oncogenic kras-associated cancer
US9913822B2 (en) 2012-04-04 2018-03-13 Halozyme, Inc. Combination therapy with an anti-hyaluronan agent and therapeutic agent
WO2013177426A2 (en) 2012-05-24 2013-11-28 Dana-Farber Cancer Institute, Inc. Targeting the glutamine to pyruvate pathway for treatment of oncogenic kras-associated cancer
US20150285802A1 (en) 2012-07-18 2015-10-08 Dana-Farber Cancer Institute, Inc. Methods for treating, preventing and predicting risk of developing breast cancer
JO3685B1 (ar) 2012-10-01 2020-08-27 Teikoku Pharma Usa Inc صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها
WO2014149871A1 (en) 2013-03-14 2014-09-25 Icahn School Of Medicine At Mount Sinai Autologous tumor lysate-loaded dendritic cell vaccine for treatment of liver cancer
WO2015050844A1 (en) 2013-10-01 2015-04-09 Dana-Farber Cancer Institute, Inc. Methods of treating cancer with atovaquone-related compounds
US10350264B2 (en) 2014-03-27 2019-07-16 Dana-Farber Cancer Institute, Inc. Compositions and methods for modulating NCOA4-mediated autophagic targeting of ferritin
MA39818A (fr) 2014-03-30 2017-02-08 Benevir Biopharm Inc Virus oncolytiques « armés » comprenant un inhibiteur de tap exogène et leurs utilisations thérapeutiques
EP3307330B1 (en) 2015-06-15 2021-03-10 New York University Method of treatment using oncolytic viruses
US20190351031A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20

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Publication number Priority date Publication date Assignee Title
EP0253738A1 (fr) * 1986-07-17 1988-01-20 Rhone-Poulenc Sante Dérivés du taxol, leur préparation et les compositions pharmaceutiques qui les contiennent

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US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides

Patent Citations (1)

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EP0253738A1 (fr) * 1986-07-17 1988-01-20 Rhone-Poulenc Sante Dérivés du taxol, leur préparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
GR3027558T3 (en) 1998-11-30
CO4410189A1 (es) 1997-01-09
MA23606A1 (fr) 1996-04-01
DZ1905A1 (fr) 2002-02-17
HU220634B1 (hu) 2002-03-28
SK697A3 (en) 1997-06-04
US6022985A (en) 2000-02-08
KR100391753B1 (ko) 2004-02-11
UA51624C2 (uk) 2002-12-16
FR2722191A1 (fr) 1996-01-12
MY118481A (en) 2004-11-30
AU706519B2 (en) 1999-06-17
PE8697A1 (es) 1997-03-26
PL318195A1 (en) 1997-05-26
UY23991A1 (es) 1995-09-20
WO1996001815A1 (fr) 1996-01-25
ATE171702T1 (de) 1998-10-15
ES2121404T3 (es) 1998-11-16
NO314500B1 (no) 2003-03-31
CN1151741A (zh) 1997-06-11
FI970069A0 (fi) 1997-01-07
EP0770070A1 (fr) 1997-05-02
ZA955646B (en) 1996-02-21
IS2032B (is) 2005-08-15
IL114274A (en) 1999-04-11
JPH10502627A (ja) 1998-03-10
RU2126397C1 (ru) 1999-02-20
NO970007L (no) 1997-01-02
CZ284695B6 (cs) 1999-02-17
BR9508789A (pt) 1997-10-21
AU2930595A (en) 1996-02-09
CA2193531C (fr) 2006-12-05
FI119246B (fi) 2008-09-15
NO970007D0 (no) 1997-01-02
TW419473B (en) 2001-01-21
HU9700041D0 (en) 1997-02-28
NZ289455A (en) 1997-12-19
DE69505128T2 (de) 1999-04-01
IN183947B (enExample) 2000-05-20
TNSN95071A1 (fr) 1996-02-06
IS4411A (is) 1997-01-07
SI0770070T1 (en) 1998-12-31
KR970704721A (ko) 1997-09-06
CZ3597A3 (en) 1997-04-16
FI970069L (fi) 1997-01-07
DE69505128D1 (de) 1998-11-05
IL114274A0 (en) 1995-10-31
SK280520B6 (sk) 2000-03-13
MX9700173A (es) 1997-04-30
HUT76833A (en) 1997-11-28
EP0770070B1 (fr) 1998-09-30
FR2722191B1 (fr) 1996-08-23
DK0770070T3 (da) 1999-03-01
JP3753155B2 (ja) 2006-03-08
CA2193531A1 (fr) 1996-01-25
PL179876B1 (pl) 2000-11-30

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