CN1067996C - 新型丙酸紫杉烯酯三水合物的制备方法 - Google Patents

新型丙酸紫杉烯酯三水合物的制备方法 Download PDF

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Publication number
CN1067996C
CN1067996C CN95193984A CN95193984A CN1067996C CN 1067996 C CN1067996 C CN 1067996C CN 95193984 A CN95193984 A CN 95193984A CN 95193984 A CN95193984 A CN 95193984A CN 1067996 C CN1067996 C CN 1067996C
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CN
China
Prior art keywords
beta
alpha
benzoyloxy
trihydroxy
epoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
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CN95193984A
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English (en)
Chinese (zh)
Other versions
CN1151741A (zh
Inventor
J-R·奥斯林
J·多伟泽
E·福奎
B·迈达德
I·塔利皮德
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis UK Holdings Ltd
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Rhone Poulenc Rorer SA
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9465183&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CN1067996(C) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Rhone Poulenc Rorer SA filed Critical Rhone Poulenc Rorer SA
Publication of CN1151741A publication Critical patent/CN1151741A/zh
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Publication of CN1067996C publication Critical patent/CN1067996C/zh
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
CN95193984A 1994-07-08 1995-07-07 新型丙酸紫杉烯酯三水合物的制备方法 Expired - Lifetime CN1067996C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR94/08479 1994-07-08
FR9408479A FR2722191B1 (fr) 1994-07-08 1994-07-08 Procede de preparation du trihydrate du (2r,3s)-3-tertbutoxycarbonylamino-2-hydroxy-3-phenylpropionate de 4-acetoxy2alpha-benzoyloxy-5beta,20epoxy-1,7beta,10beta trihydroxy-9-oxo-tax-11-en-13alpha-yle

Publications (2)

Publication Number Publication Date
CN1151741A CN1151741A (zh) 1997-06-11
CN1067996C true CN1067996C (zh) 2001-07-04

Family

ID=9465183

Family Applications (1)

Application Number Title Priority Date Filing Date
CN95193984A Expired - Lifetime CN1067996C (zh) 1994-07-08 1995-07-07 新型丙酸紫杉烯酯三水合物的制备方法

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US (1) US6022985A (enExample)
EP (1) EP0770070B1 (enExample)
JP (1) JP3753155B2 (enExample)
KR (1) KR100391753B1 (enExample)
CN (1) CN1067996C (enExample)
AT (1) ATE171702T1 (enExample)
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BR (1) BR9508789A (enExample)
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FR (1) FR2722191B1 (enExample)
GR (1) GR3027558T3 (enExample)
HU (1) HU220634B1 (enExample)
IL (1) IL114274A (enExample)
IN (1) IN183947B (enExample)
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UY (1) UY23991A1 (enExample)
WO (1) WO1996001815A1 (enExample)
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SE510650C2 (sv) * 1997-05-30 1999-06-14 Astra Ab Ny förening
FR2794771B1 (fr) 1999-06-11 2001-08-10 Aventis Pharma Sa Adenovirus recombinants codant pour le transporteur specifique de l'iode (nis)
US6853921B2 (en) 1999-07-20 2005-02-08 Halliburton Energy Services, Inc. System and method for real time reservoir management
US6266619B1 (en) * 1999-07-20 2001-07-24 Halliburton Energy Services, Inc. System and method for real time reservoir management
GB9920548D0 (en) * 1999-08-31 1999-11-03 Rhone Poulenc Rorer Sa Treatment of hepatocellular carcinoma
US6891050B2 (en) * 2001-08-10 2005-05-10 Dabur India Limited Process for the preparation of taxanes such as paclitaxel, docetaxel and structurally similar analogs
US6881852B2 (en) * 2002-02-05 2005-04-19 Dabur India Limited Process of purification of paclitaxel and docetaxel
US7247738B2 (en) * 2002-05-07 2007-07-24 Dabur India Limited Method of preparation of anticancer taxanes using 3-[(substituted-2-trialkylsilyl) ethoxycarbonyl]-5-oxazolidine carboxylic acids
US6900342B2 (en) * 2002-05-10 2005-05-31 Dabur India Limited Anticancer taxanes such as paclitaxel, docetaxel and their structural analogs, and a method for the preparation thereof
US6838569B2 (en) * 2002-12-16 2005-01-04 Dabur India Limited Process for preparation of paclitaxel trihydrate and docetaxel trihydrate
US7584165B2 (en) * 2003-01-30 2009-09-01 Landmark Graphics Corporation Support apparatus, method and system for real time operations and maintenance
US8703982B2 (en) * 2003-03-17 2014-04-22 Phyton Holdings Llc Purification of taxanes
CN1268619C (zh) * 2003-05-08 2006-08-09 上海迪赛诺化学制药有限公司 多烯紫杉醇三水化合物的制备方法
FR2859996B1 (fr) * 2003-09-19 2006-02-03 Aventis Pharma Sa Solvat acetonique du dimethoxy docetaxel et son procede de preparation
EP1947094A3 (en) 2003-12-12 2009-02-18 Quiral Quimica Do Brasil Process for the preparation of taxane derivatives
US7142986B2 (en) * 2005-02-01 2006-11-28 Smith International, Inc. System for optimizing drilling in real time
CN100420681C (zh) * 2005-04-29 2008-09-24 上海奥锐特国际贸易有限公司 多烯紫杉醇三水物的制备方法
US8034765B2 (en) * 2005-08-31 2011-10-11 Abraxis Bioscience, Llc Compositions and methods for preparation of poorly water soluble drugs with increased stability
HUE042678T2 (hu) * 2005-08-31 2019-07-29 Abraxis Bioscience Llc Vízben rosszul oldódó gyógyszerhatóanyagok és antimikrobiális szerek
JP2008523111A (ja) * 2005-10-12 2008-07-03 シコール インコーポレイティド ドセタキセルの結晶形及びそれらの調製方法
KR100995390B1 (ko) 2006-01-02 2010-11-19 주식회사 삼양제넥스 무정형, 무수결정형 또는 수화 결정형 도세탁셀의 제조방법
CN101371164A (zh) * 2006-01-20 2009-02-18 界标制图有限公司 动态生产系统管理
WO2007109654A2 (en) * 2006-03-21 2007-09-27 Dr. Reddy's Laboratories Ltd. Docetaxel polymorphs and processes
CA2667416C (en) * 2006-10-20 2013-12-17 Scinopharm Singapore Pte, Ltd. Process for making crystalline anhydrous docetaxel
KR100868116B1 (ko) 2007-04-09 2008-11-10 한미약품 주식회사 도세탁셀·모노프로필렌글라이콜 내포화합물 및 이의제조방법
KR100878455B1 (ko) * 2007-04-10 2009-01-13 한미약품 주식회사 안정한 무수결정형 도세탁셀 및 이의 제조방법
EP2173732A4 (en) * 2007-07-04 2011-09-07 Reddys Lab Ltd Dr PROCESSES FOR THE PREPARATION OF DOCETAXEL AND POLYMORPHIC
ES2389518T3 (es) * 2008-01-18 2012-10-26 Indena S.P.A. Formas sólidas de ortataxel
EP2080763A1 (en) * 2008-01-18 2009-07-22 INDENA S.p.A. Crystalline form I of ortataxel
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
US8686165B2 (en) * 2009-11-04 2014-04-01 Emcure Pharmaceuticals Limited Process for preparation of taxane derivatives
SG10201503234SA (en) 2010-05-03 2015-06-29 Teikoku Pharma Usa Inc Non-Aqueous Taxane Pro-Emulsion Formulations and Methods of Making and Using the Same
WO2012160568A1 (en) * 2011-05-23 2012-11-29 Shilpa Medicare Limited Process for preparing docetaxel trihydrate polymorph
RS58146B1 (sr) 2011-09-08 2019-02-28 Univ New York Onkolitički herpes simpleks virus i njegova terapeutska upotreba
US9745631B2 (en) 2011-12-20 2017-08-29 Dana-Farber Cancer Institute, Inc. Methods for diagnosing and treating oncogenic kras-associated cancer
CN104411324A (zh) 2012-04-04 2015-03-11 哈洛齐梅公司 使用抗透明质酸剂和肿瘤靶向紫杉烷的组合疗法
CA2874521A1 (en) 2012-05-24 2013-11-28 Dana-Farber Cancer Institute, Inc. Targeting the glutamine to pyruvate pathway for treatment of oncogenic kras-associated cancer
WO2014014518A1 (en) 2012-07-18 2014-01-23 Dana-Farber Cancer Institute, Inc. Methods for treating, preventing and predicting risk of developing breast cancer
JO3685B1 (ar) 2012-10-01 2020-08-27 Teikoku Pharma Usa Inc صيغ التشتيت الجسيمي للتاكسين غير المائي وطرق استخدامها
US10238723B2 (en) 2013-03-14 2019-03-26 Icahn School Of Medicine At Mount Sinai Autologous tumor lysate-loaded dendritic cell vaccine for treatment of liver cancer
US10130590B2 (en) 2013-10-01 2018-11-20 Dana-Farber Cancer Institute, Inc. Methods of treating cancer with atovaquone-related compounds
US10350264B2 (en) 2014-03-27 2019-07-16 Dana-Farber Cancer Institute, Inc. Compositions and methods for modulating NCOA4-mediated autophagic targeting of ferritin
MA39818A (fr) 2014-03-30 2017-02-08 Benevir Biopharm Inc Virus oncolytiques « armés » comprenant un inhibiteur de tap exogène et leurs utilisations thérapeutiques
EP3307330B1 (en) 2015-06-15 2021-03-10 New York University Method of treatment using oncolytic viruses
US20190351031A1 (en) 2018-05-16 2019-11-21 Halozyme, Inc. Methods of selecting subjects for combination cancer therapy with a polymer-conjugated soluble ph20

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0253738A1 (fr) * 1986-07-17 1988-01-20 Rhone-Poulenc Sante Dérivés du taxol, leur préparation et les compositions pharmaceutiques qui les contiennent

Family Cites Families (1)

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US5229526A (en) * 1991-09-23 1993-07-20 Florida State University Metal alkoxides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0253738A1 (fr) * 1986-07-17 1988-01-20 Rhone-Poulenc Sante Dérivés du taxol, leur préparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
NZ289455A (en) 1997-12-19
BR9508789A (pt) 1997-10-21
FR2722191B1 (fr) 1996-08-23
HUT76833A (en) 1997-11-28
US6022985A (en) 2000-02-08
JP3753155B2 (ja) 2006-03-08
IL114274A (en) 1999-04-11
WO1996001815A1 (fr) 1996-01-25
IS4411A (is) 1997-01-07
PL318195A1 (en) 1997-05-26
PE8697A1 (es) 1997-03-26
DK0770070T3 (da) 1999-03-01
AU2930595A (en) 1996-02-09
CZ3597A3 (en) 1997-04-16
KR100391753B1 (ko) 2004-02-11
AU706519B2 (en) 1999-06-17
UA51624C2 (uk) 2002-12-16
ES2121404T3 (es) 1998-11-16
MY118481A (en) 2004-11-30
SK697A3 (en) 1997-06-04
NO970007D0 (no) 1997-01-02
MA23606A1 (fr) 1996-04-01
NO314500B1 (no) 2003-03-31
IN183947B (enExample) 2000-05-20
IS2032B (is) 2005-08-15
HU220634B1 (hu) 2002-03-28
KR970704721A (ko) 1997-09-06
ZA955646B (en) 1996-02-21
DE69505128D1 (de) 1998-11-05
FI970069L (fi) 1997-01-07
CO4410189A1 (es) 1997-01-09
TW419473B (en) 2001-01-21
PL179876B1 (pl) 2000-11-30
HU9700041D0 (en) 1997-02-28
EP0770070A1 (fr) 1997-05-02
RU2126397C1 (ru) 1999-02-20
GR3027558T3 (en) 1998-11-30
UY23991A1 (es) 1995-09-20
DZ1905A1 (fr) 2002-02-17
CA2193531C (fr) 2006-12-05
MX9700173A (es) 1997-04-30
NO970007L (no) 1997-01-02
FR2722191A1 (fr) 1996-01-12
FI970069A0 (fi) 1997-01-07
EP0770070B1 (fr) 1998-09-30
CA2193531A1 (fr) 1996-01-25
CN1151741A (zh) 1997-06-11
FI119246B (fi) 2008-09-15
IL114274A0 (en) 1995-10-31
JPH10502627A (ja) 1998-03-10
SK280520B6 (sk) 2000-03-13
CZ284695B6 (cs) 1999-02-17
DE69505128T2 (de) 1999-04-01
ATE171702T1 (de) 1998-10-15
TNSN95071A1 (fr) 1996-02-06
SI0770070T1 (en) 1998-12-31

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