CN106687460B - 小檗碱盐、熊去氧胆酸盐、相关复方及其制备方法和应用 - Google Patents

小檗碱盐、熊去氧胆酸盐、相关复方及其制备方法和应用 Download PDF

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CN106687460B
CN106687460B CN201580041177.9A CN201580041177A CN106687460B CN 106687460 B CN106687460 B CN 106687460B CN 201580041177 A CN201580041177 A CN 201580041177A CN 106687460 B CN106687460 B CN 106687460B
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acid
berberine
liver
diseases
disease
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CN106687460A (zh
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刘利平
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Shenzhen Hightide Biopharmaceutical Ltd
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Shenzhen Hightide Biopharmaceutical Ltd
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    • C07—ORGANIC CHEMISTRY
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    • C07D455/00—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
    • C07D455/03—Heterocyclic compounds containing quinolizine ring systems, e.g. emetine alkaloids, protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine containing quinolizine ring systems directly condensed with at least one six-membered carbocyclic ring, e.g. protoberberine; Alkylenedioxy derivatives of dibenzo [a, g] quinolizines, e.g. berberine
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    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
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    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
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  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Pain & Pain Management (AREA)
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  • Rheumatology (AREA)
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  • Transplantation (AREA)
  • Communicable Diseases (AREA)
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CN201580041177.9A 2014-07-29 2015-07-28 小檗碱盐、熊去氧胆酸盐、相关复方及其制备方法和应用 Active CN106687460B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910386683.1A CN110179792A (zh) 2014-07-29 2015-07-28 小檗碱盐、熊去氧胆酸盐、相关复方及其制备方法和应用

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201462030140P 2014-07-29 2014-07-29
US201462030147P 2014-07-29 2014-07-29
US62/030,140 2014-07-29
US62/030,147 2014-07-29
US201562128077P 2015-03-04 2015-03-04
US62/128,077 2015-03-04
PCT/CN2015/085350 WO2016015634A1 (en) 2014-07-29 2015-07-28 Berberine salts, ursodeoxycholic salts and combinations, methods of preparation and application thereof

Related Child Applications (1)

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CN201910386683.1A Division CN110179792A (zh) 2014-07-29 2015-07-28 小檗碱盐、熊去氧胆酸盐、相关复方及其制备方法和应用

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CN106687460A CN106687460A (zh) 2017-05-17
CN106687460B true CN106687460B (zh) 2019-05-17

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CN201580041177.9A Active CN106687460B (zh) 2014-07-29 2015-07-28 小檗碱盐、熊去氧胆酸盐、相关复方及其制备方法和应用

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US (4) US10301303B2 (https=)
EP (1) EP3174874B1 (https=)
JP (4) JP6917144B2 (https=)
KR (3) KR20230134598A (https=)
CN (2) CN110179792A (https=)
AU (2) AU2015296098B2 (https=)
BR (1) BR112017001623B1 (https=)
CA (3) CA3290585A1 (https=)
DK (1) DK3174874T3 (https=)
EA (1) EA032971B1 (https=)
ES (1) ES2835874T3 (https=)
IL (3) IL282156B (https=)
MX (3) MX373840B (https=)
NZ (1) NZ728488A (https=)
SG (1) SG11201700481YA (https=)
WO (1) WO2016015634A1 (https=)

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WO2015183794A1 (en) * 2014-05-27 2015-12-03 City Of Hope Tgr5 agonist complexes for treating diabetes and cancer
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IL282156B (en) * 2014-07-29 2022-07-01 Shenzhen Hightide Biopharmaceutical Ltd Berberine salts, ursodeoxycholic salts and combinations, methods of preparation and application thereof
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