CN1066147C - 嘌呤衍生物及其制备方法 - Google Patents

嘌呤衍生物及其制备方法 Download PDF

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Publication number
CN1066147C
CN1066147C CN96198457.0A CN96198457A CN1066147C CN 1066147 C CN1066147 C CN 1066147C CN 96198457 A CN96198457 A CN 96198457A CN 1066147 C CN1066147 C CN 1066147C
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CN
China
Prior art keywords
amino
carbamoyl
phenyl
ethyl
hydroxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN96198457.0A
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English (en)
Chinese (zh)
Other versions
CN1202896A (zh
Inventor
J·齐默曼
H－G·凯普拉洛
P·伊姆巴克
P·福里特
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Novartis AG
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Novartis AG
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Publication of CN1202896A publication Critical patent/CN1202896A/zh
Application granted granted Critical
Publication of CN1066147C publication Critical patent/CN1066147C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN96198457.0A 1995-11-01 1996-10-22 嘌呤衍生物及其制备方法 Expired - Fee Related CN1066147C (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
CH309495 1995-11-01
CH3094/95 1995-11-01
CH3094/1995 1995-11-01
CH2213/1996 1996-09-10
CH221396 1996-09-10
CH2213/96 1996-09-10
PCT/EP1996/004573 WO1997016452A1 (en) 1995-11-01 1996-10-22 Purine derivatives and processes for their preparation

Publications (2)

Publication Number Publication Date
CN1202896A CN1202896A (zh) 1998-12-23
CN1066147C true CN1066147C (zh) 2001-05-23

Family

ID=25689809

Family Applications (1)

Application Number Title Priority Date Filing Date
CN96198457.0A Expired - Fee Related CN1066147C (zh) 1995-11-01 1996-10-22 嘌呤衍生物及其制备方法

Country Status (13)

Country Link
US (1) US7091346B1 (https=)
EP (1) EP0874846B1 (https=)
JP (2) JP4004066B2 (https=)
CN (1) CN1066147C (https=)
AR (1) AR004134A1 (https=)
AT (1) ATE236161T1 (https=)
AU (1) AU7296896A (https=)
BR (1) BR9611157A (https=)
CA (1) CA2234609C (https=)
DE (1) DE69627195T2 (https=)
ES (1) ES2196181T3 (https=)
PT (1) PT874846E (https=)
WO (1) WO1997016452A1 (https=)

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US6573044B1 (en) 1997-08-07 2003-06-03 The Regents Of The University Of California Methods of using chemical libraries to search for new kinase inhibitors
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UA66840C2 (uk) * 1998-02-26 2004-06-15 Авентіс Фармасьютікалз Інк. 6,9-дизаміщені 2-[транс-(4-аміноциклогексил)аміно]пурини, фармацевтична композиція та способи лікування проліферативного розладу, попередження апоптозу нервових клітин, захисту нервових клітин від руйнування
US6479487B1 (en) 1998-02-26 2002-11-12 Aventis Pharmaceuticals Inc. 6, 9-disubstituted 2-[trans-(4-aminocyclohexyl)amino] purines
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FR2818642B1 (fr) 2000-12-26 2005-07-15 Hoechst Marion Roussel Inc Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilistion
PE20030008A1 (es) 2001-06-19 2003-01-22 Bristol Myers Squibb Co Inhibidores duales de pde 7 y pde 4
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US7223766B2 (en) 2003-03-28 2007-05-29 Scios, Inc. Bi-cyclic pyrimidine inhibitors of TGFβ
US7439246B2 (en) 2004-06-28 2008-10-21 Bristol-Myers Squibb Company Fused heterocyclic kinase inhibitors
US7173031B2 (en) * 2004-06-28 2007-02-06 Bristol-Myers Squibb Company Pyrrolotriazine kinase inhibitors
WO2007070872A1 (en) 2005-12-15 2007-06-21 Rigel Pharmaceuticals, Inc. Kinase inhibitors and their uses
NZ577197A (en) 2006-12-08 2011-02-25 Irm Llc Pyrimidine compounds especially 4-phenylamino-2-arylamino-pyrimidine derivatives and compositions as protein kinase inhibitors
EA017405B9 (ru) * 2006-12-08 2014-05-30 АйАрЭм ЭлЭлСи Соединения и композиции в качестве ингибиторов протеинкиназы
EP2144911A2 (en) 2007-03-28 2010-01-20 NeuroSearch AS Purinyl derivatives and their use as potassium channel modulators
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US8268838B2 (en) 2008-09-26 2012-09-18 Neurosearch A/S Substituted purinyl-pyrazole derivatives and their use as potassium channel modulators
AU2012225232B2 (en) 2011-03-09 2016-05-12 Richard G. Pestell Prostate cancer cell lines, gene signatures and uses thereof
US9382239B2 (en) 2011-11-17 2016-07-05 Dana-Farber Cancer Institute, Inc. Inhibitors of c-Jun-N-terminal kinase (JNK)
JP6518585B2 (ja) 2012-05-14 2019-05-22 リチャード ジー． ペステル がんの治療のためのｃｃｒ５の修飾薬の使用
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KR101652010B1 (ko) * 2013-03-27 2016-08-29 재단법인 아산사회복지재단 p34의 발현 억제제 또는 활성 억제제를 유효성분으로 포함하는 암의 치료 또는 전이 억제용 조성물
EP3057956B1 (en) 2013-10-18 2021-05-05 Dana-Farber Cancer Institute, Inc. Polycyclic inhibitors of cyclin-dependent kinase 7 (cdk7)
CN108064274A (zh) 2014-07-30 2018-05-22 耶达研究及发展有限公司 用于培养多能干细胞的培养基
JP6854762B2 (ja) 2014-12-23 2021-04-07 ダナ−ファーバー キャンサー インスティテュート， インコーポレイテッド サイクリン依存性キナーゼ７（ｃｄｋ７）の阻害剤
USRE50776E1 (en) 2015-03-27 2026-02-03 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinases
AU2016319125B2 (en) 2015-09-09 2021-04-08 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinases
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EP3810132A4 (en) 2018-06-25 2022-06-22 Dana-Farber Cancer Institute, Inc. TAIRE FAMILY KINASE INHIBITORS AND RELATED USES
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CN120289460A (zh) * 2024-01-09 2025-07-11 中国科学院合肥物质科学研究院 含有嘌呤环的化合物及其用途

Citations (1)

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Publication number Priority date Publication date Assignee Title
EP0212535A1 (de) * 1985-08-17 1987-03-04 Roche Diagnostics GmbH N6-Disubstituierte Purinderivate, Verfahren zu deren Herstellung sowie diese Verbindungen enthaltende Arzneimittel

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US6107300A (en) 1996-03-27 2000-08-22 Dupont Pharmaceuticals Arylamino fused pyrimidines
US5866702A (en) * 1996-08-02 1999-02-02 Cv Therapeutics, Incorporation Purine inhibitors of cyclin dependent kinase 2
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GB9903762D0 (en) * 1999-02-18 1999-04-14 Novartis Ag Organic compounds
EP1578722A4 (en) * 2001-10-12 2006-09-06 Irm Llc KINASEINHIBITOR SCAFFOLD AND METHOD FOR THE PRODUCTION THEREOF
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Patent Citations (1)

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Also Published As

Publication number Publication date
DE69627195T2 (de) 2004-01-29
WO1997016452A1 (en) 1997-05-09
JP2007231023A (ja) 2007-09-13
CA2234609C (en) 2006-11-28
ES2196181T3 (es) 2003-12-16
ATE236161T1 (de) 2003-04-15
HK1016580A1 (en) 1999-11-05
CA2234609A1 (en) 1997-05-09
AU7296896A (en) 1997-05-22
AR004134A1 (es) 1998-09-30
DE69627195D1 (de) 2003-05-08
EP0874846B1 (en) 2003-04-02
US7091346B1 (en) 2006-08-15
BR9611157A (pt) 1999-03-30
PT874846E (pt) 2003-08-29
CN1202896A (zh) 1998-12-23
JP4004066B2 (ja) 2007-11-07
JPH11514336A (ja) 1999-12-07
EP0874846A1 (en) 1998-11-04

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Granted publication date: 20010523

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