CN106458982A - 作为irak4抑制剂的吲唑化合物 - Google Patents

作为irak4抑制剂的吲唑化合物 Download PDF

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Publication number
CN106458982A
CN106458982A CN201580012991.8A CN201580012991A CN106458982A CN 106458982 A CN106458982 A CN 106458982A CN 201580012991 A CN201580012991 A CN 201580012991A CN 106458982 A CN106458982 A CN 106458982A
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Prior art keywords
indazol
methyl
oxazole
piperidin
carboxamide
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Pending
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CN201580012991.8A
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Chinese (zh)
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V.R.贡马迪
S.萨马达
A.古普塔
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Oleg Gene Discovery Technology Co Ltd
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Oleg Gene Discovery Technology Co Ltd
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Application filed by Oleg Gene Discovery Technology Co Ltd filed Critical Oleg Gene Discovery Technology Co Ltd
Publication of CN106458982A publication Critical patent/CN106458982A/zh
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CN201580012991.8A 2014-01-10 2015-01-07 作为irak4抑制剂的吲唑化合物 Pending CN106458982A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IN146CH2014 2014-01-10
IN146/CHE/2014 2014-01-10
IN3018CH2014 2014-06-20
IN3018/CHE/2014 2014-06-20
PCT/IB2015/050119 WO2015104662A1 (en) 2014-01-10 2015-01-07 Indazole compounds as irak4 inhibitors

Publications (1)

Publication Number Publication Date
CN106458982A true CN106458982A (zh) 2017-02-22

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CN201580012991.8A Pending CN106458982A (zh) 2014-01-10 2015-01-07 作为irak4抑制剂的吲唑化合物

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US (1) US10160753B2 (enExample)
EP (1) EP3092226B1 (enExample)
JP (1) JP2017505337A (enExample)
KR (1) KR20160115933A (enExample)
CN (1) CN106458982A (enExample)
AU (1) AU2015205348A1 (enExample)
BR (1) BR112016015983A2 (enExample)
CA (1) CA2935880A1 (enExample)
CU (1) CU20160109A7 (enExample)
EA (1) EA201691401A1 (enExample)
HK (1) HK1231480A1 (enExample)
IL (1) IL246555A0 (enExample)
MX (1) MX2016009011A (enExample)
PH (1) PH12016501338A1 (enExample)
SG (1) SG11201605408RA (enExample)
WO (1) WO2015104662A1 (enExample)

Cited By (13)

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Publication number Priority date Publication date Assignee Title
CN109152771A (zh) * 2016-06-01 2019-01-04 拜耳医药股份有限公司 2-取代的吲唑用于治疗和预防自身免疫疾病的用途
WO2020035019A1 (zh) * 2018-08-17 2020-02-20 浙江海正药业股份有限公司 吲唑胺类衍生物及其制备方法和其在医药上的用途
CN111225911A (zh) * 2017-10-31 2020-06-02 库里斯公司 用于治疗血液病的化合物和组合物
WO2020259626A1 (zh) * 2019-06-26 2020-12-30 南京明德新药研发有限公司 作为irak4抑制剂的咪唑并吡啶类化合物
WO2021004533A1 (zh) * 2019-07-10 2021-01-14 南京明德新药研发有限公司 作为irak4和btk多靶点抑制剂的噁唑类化合物
CN112480101A (zh) * 2019-09-12 2021-03-12 中国科学院上海药物研究所 一类irak4激酶抑制剂及其制备和应用
CN112898269A (zh) * 2016-04-29 2021-06-04 拜耳医药股份有限公司 化合物的结晶形式
CN113227079A (zh) * 2018-12-25 2021-08-06 上海美悦生物科技发展有限公司 一种作为irak抑制剂的化合物
CN113677678A (zh) * 2019-03-29 2021-11-19 加拉帕戈斯股份有限公司 用于治疗炎性障碍的新化合物及其药物组合物
WO2022135338A1 (zh) * 2020-12-25 2022-06-30 南京明德新药研发有限公司 酰胺噁唑类化合物
CN115181066A (zh) * 2022-06-14 2022-10-14 浙江宏元药业股份有限公司 一种6-氯-2-甲基-2h-吲唑-5-胺的合成方法
CN115785064A (zh) * 2021-11-19 2023-03-14 成都奥睿药业有限公司 三取代吡啶衍生物的制备及作为芳香烃受体调节物的应用
WO2023116866A1 (zh) * 2021-12-23 2023-06-29 杭州多域生物技术有限公司 一种五元并六元化合物、制备方法、药物组合物和应用

Families Citing this family (64)

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GB201311891D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compound
GB201311888D0 (en) 2013-07-03 2013-08-14 Glaxosmithkline Ip Dev Ltd Novel compounds
KR20160115933A (ko) 2014-01-10 2016-10-06 오리진 디스커버리 테크놀로지스 리미티드 Irak4 억제제로서의 인다졸 화합물
HRP20181795T1 (hr) 2014-01-13 2019-01-25 Aurigene Discovery Technologies Limited Biciklički heterociklilni derivati kao inhibitori irak4
US20180228907A1 (en) 2014-04-14 2018-08-16 Arvinas, Inc. Cereblon ligands and bifunctional compounds comprising the same
EP3157521A4 (en) * 2014-06-20 2018-02-14 Aurigene Discovery Technologies Limited Substituted indazole compounds as irak4 inhibitors
JO3705B1 (ar) 2014-11-26 2021-01-31 Bayer Pharma AG إندازولات مستبدلة جديدة، عمليات لتحضيرها، مستحضرات دوائية تحتوي عليها واستخدامها في إنتاج أدوية
EP3233840B1 (en) 2014-12-16 2018-11-21 Eudendron S.r.l. Heterocyclic derivatives modulating activity of certain protein kinases
EP3195865A1 (de) 2016-01-25 2017-07-26 Bayer Pharma Aktiengesellschaft Kombinationen von irak4 inhibitoren und btk inhibitoren
UY36660A (es) 2015-04-30 2016-11-30 Bayer Pharma AG Combinaciones de inhibidores de irak4
EA201890307A1 (ru) * 2015-07-15 2018-10-31 Ориджин Дискавери Текнолоджиз Лимитед Индазольные и азаиндазольные соединения как ингибиторы irak-4
US10065946B2 (en) 2015-08-04 2018-09-04 Rigel Pharmaceuticals, Inc. Benzazole compounds and methods for making and using the compounds
HUE046920T2 (hu) * 2015-09-11 2020-03-30 Boehringer Ingelheim Int Pirazolil-szubsztituált heteroarilszármazékok és gyógyszerként történõ alkalmazásuk
WO2017108744A1 (de) * 2015-12-22 2017-06-29 Bayer Pharma Aktiengesellschaft Neue substituierte indazole, verfahren zu ihrer herstellung, pharmazeutische präparate die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln
US10435396B2 (en) 2016-03-03 2019-10-08 Bayer Pharma Aktiegesellschaft 2-substituted indazoles, methods for producing same, pharmaceutical preparations that contain same, and use of same to produce drugs
PL3448848T3 (pl) * 2016-04-29 2024-03-11 Bayer Pharma Aktiengesellschaft Postać polimorficzna N-{6-(2-hydroksypropan-2-ylo)-2-[2-(metylosulfonylo)etylo]-2H-indazol-5-ilo}-6-(trifluorometylo)pirydyno-2-karboksyamidu
WO2017207385A1 (de) 2016-05-31 2017-12-07 Bayer Pharma Aktiengesellschaft Substituierte 3-methylindazole, verfahren zu ihrer herstellung, pharmazeutische präparate, die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln
AU2017272505B9 (en) 2016-06-01 2021-10-28 Bayer Pharma Aktiengesellschaft Substituted indazoles useful for treatment and prevention of allergic and/or inflammatory diseases in animals
US11254667B2 (en) 2016-08-17 2022-02-22 Children's Hospital Medical Center Substituted imidazo[1,2-A]pyridines as IRAK 1/4 and flt3 inhibitors
US11542261B2 (en) 2016-08-17 2023-01-03 Children's Hospital Medical Center Substituted Imidazo[1,2-a]-pyridines as IRAK 1/4 and FLT3 inhibitors
UA125650C2 (uk) 2016-09-09 2022-05-11 Інсайт Корпорейшн Регулятори нрk1 на основі похідних піразолопіридину та їх застосування для лікування раку
US10280164B2 (en) 2016-09-09 2019-05-07 Incyte Corporation Pyrazolopyridone compounds and uses thereof
AR109595A1 (es) 2016-09-09 2018-12-26 Incyte Corp Compuestos de pirazolopirimidina y usos de estos como inhibidores de hpk1
WO2018049214A1 (en) 2016-09-09 2018-03-15 Incyte Corporation Pyrazolopyridine derivatives as hpk1 modulators and uses thereof for the treatment of cancer
US20180228786A1 (en) 2017-02-15 2018-08-16 Incyte Corporation Pyrazolopyridine compounds and uses thereof
JOP20180011A1 (ar) 2017-02-16 2019-01-30 Gilead Sciences Inc مشتقات بيرولو [1، 2-b]بيريدازين
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