JP2017505337A - Ｉｒａｋ４阻害剤としてのインダゾール化合物 - Google Patents

Ｉｒａｋ４阻害剤としてのインダゾール化合物 Download PDF

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JP2017505337A
JP2017505337A JP2016563277A JP2016563277A JP2017505337A JP 2017505337 A JP2017505337 A JP 2017505337A JP 2016563277 A JP2016563277 A JP 2016563277A JP 2016563277 A JP2016563277 A JP 2016563277A JP 2017505337 A JP2017505337 A JP 2017505337A
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mmol
methyl
indazol
give
compound
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JP2017505337A5 (enExample
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ラオ グムマディ，ヴェンカテシュワル
ラオ グムマディ，ヴェンカテシュワル
サマジダール，スサンタ
グプタ，アジャイ
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アウリジーン ディスカバリー テクノロジーズ リミテッド
アウリジーン ディスカバリー テクノロジーズ リミテッド
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Application filed by アウリジーン ディスカバリー テクノロジーズ リミテッド, アウリジーン ディスカバリー テクノロジーズ リミテッド filed Critical アウリジーン ディスカバリー テクノロジーズ リミテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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  • Diabetes (AREA)
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  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
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  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Neurology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2016563277A 2014-01-10 2015-01-07 Ｉｒａｋ４阻害剤としてのインダゾール化合物 Ceased JP2017505337A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
IN146/CHE/2014 2014-01-10
IN146CH2014 2014-01-10
IN3018CH2014 2014-06-20
IN3018/CHE/2014 2014-06-20
PCT/IB2015/050119 WO2015104662A1 (en) 2014-01-10 2015-01-07 Indazole compounds as irak4 inhibitors

Publications (2)

Publication Number Publication Date
JP2017505337A true JP2017505337A (ja) 2017-02-16
JP2017505337A5 JP2017505337A5 (enExample) 2018-02-15

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JP2016563277A Ceased JP2017505337A (ja) 2014-01-10 2015-01-07 Ｉｒａｋ４阻害剤としてのインダゾール化合物

Country Status (16)

Country Link
US (1) US10160753B2 (enExample)
EP (1) EP3092226B1 (enExample)
JP (1) JP2017505337A (enExample)
KR (1) KR20160115933A (enExample)
CN (1) CN106458982A (enExample)
AU (1) AU2015205348A1 (enExample)
BR (1) BR112016015983A2 (enExample)
CA (1) CA2935880A1 (enExample)
CU (1) CU20160109A7 (enExample)
EA (1) EA201691401A1 (enExample)
HK (1) HK1231480A1 (enExample)
IL (1) IL246555A0 (enExample)
MX (1) MX2016009011A (enExample)
PH (1) PH12016501338A1 (enExample)
SG (1) SG11201605408RA (enExample)
WO (1) WO2015104662A1 (enExample)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2022540464A (ja) * 2019-07-10 2022-09-15 メッドシャイン ディスカバリー インコーポレイテッド Ｉｒａｋ４及びｂｔｋマルチターゲット阻害剤としてのオキサゾール化合物
JP2024500247A (ja) * 2020-12-25 2024-01-05 メッドシャイン ディスカバリー インコーポレイテッド アミドオキサゾール系化合物
JP2025501618A (ja) * 2021-12-23 2025-01-22 ハンチョウ ポリメド バイオファーマシューティカルズ インコーポレイテッド ５員縮合６員化合物、製造方法、医薬組成物、及び応用

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HRP20181795T1 (hr) 2014-01-13 2019-01-25 Aurigene Discovery Technologies Limited Biciklički heterociklilni derivati kao inhibitori irak4
US20180228907A1 (en) 2014-04-14 2018-08-16 Arvinas, Inc. Cereblon ligands and bifunctional compounds comprising the same
EA201692418A1 (ru) * 2014-06-20 2017-04-28 Ауриджен Дискавери Текнолоджиз Лимитед Замещенные индазольные соединения в качестве irak4 ингибиторов
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WO2016096709A1 (en) 2014-12-16 2016-06-23 Eudendron S.R.L. Heterocyclic derivatives modulating activity of certain protein kinases
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CA2984259C (en) 2015-04-30 2024-02-13 Bayer Pharma Aktiengesellschaft Combinations of inhibitors of irak4 with inhibitors of btk
HK1249509A1 (zh) * 2015-07-15 2018-11-02 Aurigene Discovery Technologies Limited 作为irak-4抑制剂的吲唑及氮杂吲唑化合物
DK3331879T3 (da) * 2015-08-04 2020-08-10 Rigel Pharmaceuticals Inc Benzazolforbindelser og fremgangsmåder til fremstilling og anvendelse af forbindelserne
JP6868011B2 (ja) * 2015-09-11 2021-05-12 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング ピラゾリル置換ヘテロアリール及び医薬としてのその使用
WO2017108744A1 (de) * 2015-12-22 2017-06-29 Bayer Pharma Aktiengesellschaft Neue substituierte indazole, verfahren zu ihrer herstellung, pharmazeutische präparate die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln
US10435396B2 (en) 2016-03-03 2019-10-08 Bayer Pharma Aktiegesellschaft 2-substituted indazoles, methods for producing same, pharmaceutical preparations that contain same, and use of same to produce drugs
EA038035B1 (ru) 2016-04-29 2021-06-25 Байер Фарма Акциенгезельшафт Синтез индазолов
MX385470B (es) * 2016-04-29 2025-03-18 Bayer Pharma AG Formas cristalinas de n-[2-(3-hidroxi-3-metilbutil)-6-(2-hidroxipropan-2-il)-2h-indazol-5-il]-6-(trifluorometil)-piridin-2-carboxamida.
WO2017207385A1 (de) 2016-05-31 2017-12-07 Bayer Pharma Aktiengesellschaft Substituierte 3-methylindazole, verfahren zu ihrer herstellung, pharmazeutische präparate, die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln
AU2017272505B9 (en) * 2016-06-01 2021-10-28 Bayer Pharma Aktiengesellschaft Substituted indazoles useful for treatment and prevention of allergic and/or inflammatory diseases in animals
WO2017207386A1 (de) * 2016-06-01 2017-12-07 Bayer Pharma Aktiengesellschaft Verwendung von 2-substituierten indazolen zur behandlung und prophylaxe von autoimmunerkrankungen
US11254667B2 (en) 2016-08-17 2022-02-22 Children's Hospital Medical Center Substituted imidazo[1,2-A]pyridines as IRAK 1/4 and flt3 inhibitors
US11542261B2 (en) 2016-08-17 2023-01-03 Children's Hospital Medical Center Substituted Imidazo[1,2-a]-pyridines as IRAK 1/4 and FLT3 inhibitors
US20180072718A1 (en) 2016-09-09 2018-03-15 Incyte Corporation Pyrazolopyridine compounds and uses thereof
MA46191A (fr) 2016-09-09 2021-04-21 Incyte Corp Dérivés de pyrazolopyridine comme modulateurs de hpk1 et leurs utilisations pour le traitement du cancer
WO2018049191A1 (en) 2016-09-09 2018-03-15 Incyte Corporation Pyrazolopyridone derivatives as hpk1 modulators and uses thereof for the treatment of cancer
TW201811799A (zh) 2016-09-09 2018-04-01 美商英塞特公司 吡唑并嘧啶化合物及其用途
US20180228786A1 (en) 2017-02-15 2018-08-16 Incyte Corporation Pyrazolopyridine compounds and uses thereof
JOP20180011A1 (ar) 2017-02-16 2019-01-30 Gilead Sciences Inc مشتقات بيرولو [1، 2-b]بيريدازين
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US10722495B2 (en) 2017-09-08 2020-07-28 Incyte Corporation Cyanoindazole compounds and uses thereof
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EP3694331B1 (en) 2017-10-11 2022-11-16 Merck Sharp & Dohme LLC Indazolyl-spiro[2.3]hexane-carbonitrile derivatives as lrrk2 inhibitors, pharmaceutical compositions, and uses thereof
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