MX2016009011A - Compuestos de indazol como inhibidores de cinasa-4 asociada al receptor de interleucina-1 (irak4). - Google Patents

Compuestos de indazol como inhibidores de cinasa-4 asociada al receptor de interleucina-1 (irak4).

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Publication number
MX2016009011A
MX2016009011A MX2016009011A MX2016009011A MX2016009011A MX 2016009011 A MX2016009011 A MX 2016009011A MX 2016009011 A MX2016009011 A MX 2016009011A MX 2016009011 A MX2016009011 A MX 2016009011A MX 2016009011 A MX2016009011 A MX 2016009011A
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MX
Mexico
Prior art keywords
irak4 inhibitors
diseases
formula
pharmaceutically acceptable
indazole compounds
Prior art date
Application number
MX2016009011A
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English (en)
Inventor
Rao Gummadi Venkateshwar
Gupta Ajay
Samajdar Susanta
Original Assignee
Aurigene Discovery Tech Ltd
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52462359&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2016009011(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Aurigene Discovery Tech Ltd filed Critical Aurigene Discovery Tech Ltd
Publication of MX2016009011A publication Critical patent/MX2016009011A/es

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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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Abstract

La presente invención proporciona un compuesto de indazol de la fórmula (I), el cual es útil terapéuticamente como inhibidor de cinasa, particularmente inhibidor de IRAK4, en donde Z1, Z2, R1, R2, R3, "m" y "n" tienen los significados proporcionados en la especificación y sales o estereoisomeros farmacéuticamente aceptable del mismo que son útiles en el tratamiento y prevención de enfermedades o trastornos, en particular, su uso en enfermedades o trastornos mediados por una enzima cinasa, particularmente la enzima IRAK4. La presente invención también proporciona una composición farmacéutica que comprende por lo menos uno de los compuestos de la fórmula (I) junto con un portador, diluyente o excipiente farmacéuticamente aceptable para el mismo.
MX2016009011A 2014-01-10 2015-01-07 Compuestos de indazol como inhibidores de cinasa-4 asociada al receptor de interleucina-1 (irak4). MX2016009011A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN146CH2014 2014-01-10
IN3018CH2014 2014-06-20
PCT/IB2015/050119 WO2015104662A1 (en) 2014-01-10 2015-01-07 Indazole compounds as irak4 inhibitors

Publications (1)

Publication Number Publication Date
MX2016009011A true MX2016009011A (es) 2017-01-23

Family

ID=52462359

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2016009011A MX2016009011A (es) 2014-01-10 2015-01-07 Compuestos de indazol como inhibidores de cinasa-4 asociada al receptor de interleucina-1 (irak4).

Country Status (16)

Country Link
US (1) US10160753B2 (es)
EP (1) EP3092226B1 (es)
JP (1) JP2017505337A (es)
KR (1) KR20160115933A (es)
CN (1) CN106458982A (es)
AU (1) AU2015205348A1 (es)
BR (1) BR112016015983A2 (es)
CA (1) CA2935880A1 (es)
CU (1) CU20160109A7 (es)
EA (1) EA201691401A1 (es)
HK (1) HK1231480A1 (es)
IL (1) IL246555A0 (es)
MX (1) MX2016009011A (es)
PH (1) PH12016501338A1 (es)
SG (1) SG11201605408RA (es)
WO (1) WO2015104662A1 (es)

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