CN113227079A - 一种作为irak抑制剂的化合物 - Google Patents

一种作为irak抑制剂的化合物 Download PDF

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CN113227079A
CN113227079A CN201980085817.4A CN201980085817A CN113227079A CN 113227079 A CN113227079 A CN 113227079A CN 201980085817 A CN201980085817 A CN 201980085817A CN 113227079 A CN113227079 A CN 113227079A
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CN113227079B (zh
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冯焱
野国中
李世强
胡治隆
王朝东
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Shanghai Meiyue Biotech Development Co Ltd
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Abstract

本发明涉及一种作为IRAK抑制剂的化合物。具体地，本发明提供一种化合物、或其顺反异构体、光学异构体或其外消旋体、或其药学上可接受的盐、或其前药、或其氘代衍生物、或其水合物、或其溶剂合物，所述化合物具有如下式I结构。本发明所述的化合物对IRAK具有有效的抑制作用，从而对与IRAK相关的疾病具有治疗作用。(I)

Description

PCT国内申请，说明书已公开。

Claims (10)

  1. PCT国内申请，权利要求书已公开。
CN201980085817.4A 2018-12-25 2019-12-25 一种作为irak抑制剂的化合物 Active CN113227079B (zh)

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CN201811593893X 2018-12-25
CN201811593893 2018-12-25
PCT/CN2019/128347 WO2020135513A1 (zh) 2018-12-25 2019-12-25 一种作为irak抑制剂的化合物

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Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111499612B (zh) * 2019-01-30 2022-12-30 上海美悦生物科技发展有限公司 一种作为irak抑制剂的化合物及其制备方法和用途
CN111560012B (zh) * 2019-02-14 2023-06-23 上海美悦生物科技发展有限公司 一种作为irak抑制剂的化合物
CN111793064B (zh) * 2019-04-02 2023-06-23 上海美悦生物科技发展有限公司 一种作为irak抑制剂的化合物及其制备方法和用途
WO2021007477A1 (en) 2019-07-11 2021-01-14 E-Scape Bio, Inc. Indazoles and azaindazoles as lrrk2 inhibitors
TWI832010B (zh) * 2019-09-24 2024-02-11 大陸商上海美悦生物科技發展有限公司 Irak抑制劑及其製備方法和用途
PE20231066A1 (es) 2020-02-07 2023-07-17 Gasherbrum Bio Inc Agonistas heterociclicos de glp-1
US20240182443A1 (en) * 2021-03-19 2024-06-06 Shanghai Meiyue Biotech Development Co., Ltd. Polymorphic forms of compound and preparation method therefor and application thereof
CN113278017B (zh) * 2021-05-27 2023-03-28 上海应用技术大学 取代吲唑类化合物、制备方法、应用和包含其的组合物
CN114605328A (zh) * 2022-03-23 2022-06-10 汉瑞药业(荆门)有限公司 一种6-氯-2-甲基-2h-吲唑-5-胺的制备方法
CN115181066B (zh) * 2022-06-14 2023-07-14 浙江宏元药业股份有限公司 一种6-氯-2-甲基-2h-吲唑-5-胺的合成方法
CN115108992B (zh) * 2022-06-29 2024-05-31 浙江手心制药有限公司 6-氯-2-甲基-2h-吲唑-5-胺的制备方法
CN115252609B (zh) * 2022-08-01 2023-05-26 上海美悦生物科技发展有限公司 一种irak4抑制剂的组合物及其制备方法、用途
CN115677587A (zh) * 2022-11-01 2023-02-03 爱斯特（成都）生物制药股份有限公司 一种制备6-氯-5-硝基-1氢-吲唑的方法
CN116023332A (zh) * 2022-12-23 2023-04-28 上海药坦药物研究开发有限公司 一种6-氯-2-甲基-2h-吲唑-5-胺的合成方法

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WO2017108744A1 (de) * 2015-12-22 2017-06-29 Bayer Pharma Aktiengesellschaft Neue substituierte indazole, verfahren zu ihrer herstellung, pharmazeutische präparate die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln
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WO2016174183A1 (en) * 2015-04-30 2016-11-03 Bayer Pharma Aktiengesellschaft Combinations of inhibitors of irak4 with inhibitors of btk

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CN106170486A (zh) * 2013-12-19 2016-11-30 拜耳医药股份有限公司 新吲唑甲酰胺、其制备方法、包含其的药物制剂及其用于制备药物的用途
CN106458982A (zh) * 2014-01-10 2017-02-22 奥列基因发现技术有限公司 作为irak4抑制剂的吲唑化合物
CN107406416A (zh) * 2014-11-26 2017-11-28 拜耳医药股份有限公司 新型取代的吲唑、其制备方法、包含其的药物制剂及其用于制备药物的用途
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WO2017108744A1 (de) * 2015-12-22 2017-06-29 Bayer Pharma Aktiengesellschaft Neue substituierte indazole, verfahren zu ihrer herstellung, pharmazeutische präparate die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln
WO2017148902A1 (de) * 2016-03-03 2017-09-08 Bayer Pharma Aktiengesellschaft Neue 2-substituierte indazole, verfahren zu ihrer herstellung, pharmazeutische präparate die diese enthalten, sowie deren verwendung zur herstellung von arzneimitteln

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WO2020135513A1 (zh) 2020-07-02
US20220204473A1 (en) 2022-06-30
EP3889150A4 (en) 2022-02-23
EP3889150A1 (en) 2021-10-06

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