CN106397388A - 一种粗品环酯纯化制备高纯度环酯的工艺 - Google Patents
一种粗品环酯纯化制备高纯度环酯的工艺 Download PDFInfo
- Publication number
- CN106397388A CN106397388A CN201610807374.3A CN201610807374A CN106397388A CN 106397388 A CN106397388 A CN 106397388A CN 201610807374 A CN201610807374 A CN 201610807374A CN 106397388 A CN106397388 A CN 106397388A
- Authority
- CN
- China
- Prior art keywords
- cyclic ester
- lactide
- crude product
- purity
- water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000012043 crude product Substances 0.000 title claims abstract description 86
- 238000000034 method Methods 0.000 title claims abstract description 77
- -1 cyclic ester Chemical class 0.000 title claims abstract description 72
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 46
- 239000000047 product Substances 0.000 claims abstract description 17
- 238000001035 drying Methods 0.000 claims abstract description 9
- 239000007788 liquid Substances 0.000 claims description 25
- 238000000746 purification Methods 0.000 claims description 24
- RKDVKSZUMVYZHH-UHFFFAOYSA-N 1,4-dioxane-2,5-dione Chemical compound O=C1COC(=O)CO1 RKDVKSZUMVYZHH-UHFFFAOYSA-N 0.000 claims description 21
- 238000000926 separation method Methods 0.000 claims description 21
- 238000005406 washing Methods 0.000 claims description 17
- 239000007787 solid Substances 0.000 claims description 15
- JJTUDXZGHPGLLC-UHFFFAOYSA-N lactide Chemical compound CC1OC(=O)C(C)OC1=O JJTUDXZGHPGLLC-UHFFFAOYSA-N 0.000 claims description 12
- 238000001291 vacuum drying Methods 0.000 claims description 11
- 239000008367 deionised water Substances 0.000 claims description 9
- 229910021641 deionized water Inorganic materials 0.000 claims description 9
- 238000002360 preparation method Methods 0.000 claims description 9
- 239000012153 distilled water Substances 0.000 claims description 8
- 239000002245 particle Substances 0.000 claims description 8
- 238000003756 stirring Methods 0.000 claims description 8
- 239000003960 organic solvent Substances 0.000 abstract description 5
- 239000002699 waste material Substances 0.000 abstract description 2
- 238000010924 continuous production Methods 0.000 abstract 1
- 239000003599 detergent Substances 0.000 abstract 1
- 238000011112 process operation Methods 0.000 abstract 1
- 239000002912 waste gas Substances 0.000 abstract 1
- 239000002351 wastewater Substances 0.000 abstract 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 16
- 239000000178 monomer Substances 0.000 description 15
- 238000004458 analytical method Methods 0.000 description 14
- 238000007151 ring opening polymerisation reaction Methods 0.000 description 13
- JJTUDXZGHPGLLC-ZXZARUISSA-N (3r,6s)-3,6-dimethyl-1,4-dioxane-2,5-dione Chemical compound C[C@H]1OC(=O)[C@H](C)OC1=O JJTUDXZGHPGLLC-ZXZARUISSA-N 0.000 description 11
- 229920000642 polymer Polymers 0.000 description 11
- 239000000539 dimer Substances 0.000 description 10
- 239000002994 raw material Substances 0.000 description 9
- 238000009826 distribution Methods 0.000 description 8
- 239000004310 lactic acid Substances 0.000 description 8
- 235000014655 lactic acid Nutrition 0.000 description 8
- 239000003795 chemical substances by application Substances 0.000 description 7
- 238000005516 engineering process Methods 0.000 description 7
- 230000000977 initiatory effect Effects 0.000 description 7
- 239000000463 material Substances 0.000 description 7
- 229920001432 poly(L-lactide) Polymers 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 6
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 6
- ZRALSGWEFCBTJO-UHFFFAOYSA-N anhydrous guanidine Natural products NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 description 6
- DDRJAANPRJIHGJ-UHFFFAOYSA-N creatinine Chemical compound CN1CC(=O)NC1=N DDRJAANPRJIHGJ-UHFFFAOYSA-N 0.000 description 6
- 230000007062 hydrolysis Effects 0.000 description 6
- 238000006460 hydrolysis reaction Methods 0.000 description 6
- 229910052751 metal Inorganic materials 0.000 description 6
- 239000002184 metal Substances 0.000 description 6
- 239000000203 mixture Substances 0.000 description 6
- 238000006384 oligomerization reaction Methods 0.000 description 6
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 description 5
- 239000002253 acid Substances 0.000 description 5
- 239000006227 byproduct Substances 0.000 description 5
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 description 5
- 239000012535 impurity Substances 0.000 description 5
- JVTAAEKCZFNVCJ-UWTATZPHSA-N D-lactic acid Chemical compound C[C@@H](O)C(O)=O JVTAAEKCZFNVCJ-UWTATZPHSA-N 0.000 description 4
- 230000003197 catalytic effect Effects 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 239000002904 solvent Substances 0.000 description 4
- ODIGIKRIUKFKHP-UHFFFAOYSA-N (n-propan-2-yloxycarbonylanilino) acetate Chemical compound CC(C)OC(=O)N(OC(C)=O)C1=CC=CC=C1 ODIGIKRIUKFKHP-UHFFFAOYSA-N 0.000 description 3
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 3
- 150000004703 alkoxides Chemical class 0.000 description 3
- 239000007864 aqueous solution Substances 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 239000000470 constituent Substances 0.000 description 3
- 229940109239 creatinine Drugs 0.000 description 3
- 229920006237 degradable polymer Polymers 0.000 description 3
- 230000018044 dehydration Effects 0.000 description 3
- 238000006297 dehydration reaction Methods 0.000 description 3
- 238000005265 energy consumption Methods 0.000 description 3
- 229910052749 magnesium Inorganic materials 0.000 description 3
- 239000011777 magnesium Substances 0.000 description 3
- 150000002739 metals Chemical class 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 238000003860 storage Methods 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 229910052718 tin Inorganic materials 0.000 description 3
- 239000011135 tin Substances 0.000 description 3
- 229910052725 zinc Inorganic materials 0.000 description 3
- 239000011701 zinc Substances 0.000 description 3
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 2
- 239000003054 catalyst Substances 0.000 description 2
- 150000002148 esters Chemical class 0.000 description 2
- 125000004836 hexamethylene group Chemical group [H]C([H])([*:2])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[*:1] 0.000 description 2
- 230000003287 optical effect Effects 0.000 description 2
- 238000006116 polymerization reaction Methods 0.000 description 2
- 238000011084 recovery Methods 0.000 description 2
- 238000000638 solvent extraction Methods 0.000 description 2
- 241000370738 Chlorion Species 0.000 description 1
- 229930182843 D-Lactic acid Natural products 0.000 description 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 1
- 229920000954 Polyglycolide Polymers 0.000 description 1
- 229920001273 Polyhydroxy acid Polymers 0.000 description 1
- 239000004372 Polyvinyl alcohol Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 229920002988 biodegradable polymer Polymers 0.000 description 1
- 239000004621 biodegradable polymer Substances 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 210000000481 breast Anatomy 0.000 description 1
- 238000006555 catalytic reaction Methods 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 238000002242 deionisation method Methods 0.000 description 1
- 238000010931 ester hydrolysis Methods 0.000 description 1
- 239000002360 explosive Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 230000003301 hydrolyzing effect Effects 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 238000011031 large-scale manufacturing process Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000006068 polycondensation reaction Methods 0.000 description 1
- 239000004633 polyglycolic acid Substances 0.000 description 1
- 239000004626 polylactic acid Substances 0.000 description 1
- 235000019422 polyvinyl alcohol Nutrition 0.000 description 1
- 229920002451 polyvinyl alcohol Polymers 0.000 description 1
- 230000006340 racemization Effects 0.000 description 1
- 238000001953 recrystallisation Methods 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 235000011121 sodium hydroxide Nutrition 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 239000008399 tap water Substances 0.000 description 1
- 235000020679 tap water Nutrition 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/10—1,4-Dioxanes; Hydrogenated 1,4-dioxanes
- C07D319/12—1,4-Dioxanes; Hydrogenated 1,4-dioxanes not condensed with other rings
Abstract
Description
粗品L-丙交酯主要组分 | 组分质量含量(wt%) |
L-丙交酯 | ≥90.0 |
D-丙交酯 | ≤1.0 |
meso-丙交酯 | ≤1.0 |
乳酸单体、二聚体及多聚体 | ≤10.0 |
水 | ≤5.0 |
粗品D-丙交酯主要组分 | 组分质量含量(wt%) |
D-丙交酯 | ≥90.0 |
L-丙交酯 | ≤1.0 |
meso-丙交酯 | ≤1.0 |
乳酸单体、二聚体及多聚体 | ≤10.0 |
水 | ≤5.0 |
粗品乙交酯主要组分 | 组分质量含量(wt%) |
乙交酯 | ≥90.0 |
乙醇酸单体、二聚体及多聚体 | ≤10.0 |
水 | ≤5.0 |
主要组分 | 纯化前(wt%) | 纯化后(wt%) |
L-丙交酯 | 95.3 | 99.8 |
D-丙交酯 | 0.5 | 未检出 |
meso-丙交酯 | 1.5 | 0.2 |
乳酸单体、二聚体及多聚体 | 1.6 | 未检出 |
水 | 1.1 | 未检出 |
主要组分 | 纯化前(wt%) | 纯化后(wt%) |
L-丙交酯 | 95.3 | 99.5 |
D-丙交酯 | 0.5 | 未检出 |
meso-丙交酯 | 1.5 | 0.5 |
乳酸单体、二聚体及多聚体 | 1.6 | 未检出 |
水 | 1.1 | 未检出 |
主要组分 | 纯化前(wt%) | 纯化后(wt%) |
L-丙交酯 | 98.6 | 99.9 |
D-丙交酯 | 0.1 | 未检出 |
meso-丙交酯 | 0.2 | 0.1 |
乳酸单体、二聚体及多聚体 | 0.9 | 未检出 |
水 | 0.2 | 未检出 |
主要组分 | 纯化前(wt%) | 纯化后(wt%) |
L-丙交酯 | 99.5 | 100.0 |
D-丙交酯 | 未检出 | 未检出 |
meso-丙交酯 | 0.2 | 未检出 |
乳酸单体、二聚体及多聚体 | 0.3 | 未检出 |
水 | 未检出 | 未检出 |
主要组分 | 纯化前(wt%) | 纯化后(wt%) |
L-丙交酯 | 97.1 | 99.8 |
D-丙交酯 | 0.2 | 未检出 |
meso-丙交酯 | 0.3 | 0.2 |
乳酸单体、二聚体及多聚体 | 1.8 | 未检出 |
水 | 0.6 | 未检出 |
主要组分 | 纯化前(wt%) | 纯化后(wt%) |
L-丙交酯 | 0.6 | 未检出 |
D-丙交酯 | 95.6 | 99.8 |
meso-丙交酯 | 1.8 | 0.2 |
乳酸单体、二聚体及多聚体 | 1.4 | 未检出 |
水 | 0.6 | 未检出 |
主要组分 | 纯化前(wt%) | 纯化后(wt%) |
乙交酯 | 96.0 | 100.0 |
乙醇酸单体、二聚体及多聚体 | 2.5 | 未检出 |
水 | 1.5 | 未检出 |
Claims (4)
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610807374.3A CN106397388B (zh) | 2016-09-07 | 2016-09-07 | 一种粗品环酯纯化制备高纯度环酯的工艺 |
PCT/CN2017/100464 WO2018045938A1 (zh) | 2016-09-07 | 2017-09-05 | 一种粗品环酯纯化方法 |
JP2019533269A JP2019529531A (ja) | 2016-09-07 | 2017-09-05 | 粗環状エステルの精製方法 |
US16/251,047 US10570111B2 (en) | 2016-09-07 | 2019-01-17 | Method of purifying cyclic ester |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN201610807374.3A CN106397388B (zh) | 2016-09-07 | 2016-09-07 | 一种粗品环酯纯化制备高纯度环酯的工艺 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN106397388A true CN106397388A (zh) | 2017-02-15 |
CN106397388B CN106397388B (zh) | 2019-02-01 |
Family
ID=57999329
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN201610807374.3A Active CN106397388B (zh) | 2016-09-07 | 2016-09-07 | 一种粗品环酯纯化制备高纯度环酯的工艺 |
Country Status (4)
Country | Link |
---|---|
US (1) | US10570111B2 (zh) |
JP (1) | JP2019529531A (zh) |
CN (1) | CN106397388B (zh) |
WO (1) | WO2018045938A1 (zh) |
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018045938A1 (zh) * | 2016-09-07 | 2018-03-15 | 南京大学 | 一种粗品环酯纯化方法 |
WO2019057032A1 (zh) * | 2017-09-21 | 2019-03-28 | 南京大学 | 一种生产乙、丙交酯副产聚合物残渣再利用的工艺方法 |
CN114014835A (zh) * | 2021-12-09 | 2022-02-08 | 内蒙古久泰新材料有限公司 | 一种乙交酯的纯化工艺 |
CN114181189A (zh) * | 2021-12-16 | 2022-03-15 | 内蒙古久泰新材料有限公司 | 一种环状交酯的纯化方法 |
CN114478470A (zh) * | 2020-10-28 | 2022-05-13 | 中国石油化工股份有限公司 | 一种提纯丙交酯的方法 |
CN115707697A (zh) * | 2021-08-20 | 2023-02-21 | 中国石油化工股份有限公司 | 一种粗乙交酯的提纯方法及所得乙交酯 |
CN116041314A (zh) * | 2023-02-08 | 2023-05-02 | 新沂市永诚化工有限公司 | 一种粗品环酯纯化制备高纯度环酯的工艺 |
CN116410177A (zh) * | 2022-08-30 | 2023-07-11 | 深圳市迈启生物材料有限公司 | 医用乙交酯的制备方法 |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101468978A (zh) * | 2007-12-27 | 2009-07-01 | 常熟市长江化纤有限公司 | 丙交酯的提纯方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE4239781A1 (de) * | 1992-11-26 | 1994-06-01 | Basf Ag | Formkörper aus geschäumten Polylactiden und Verfahren zu ihrer Herstellung |
JPH07165753A (ja) * | 1993-12-08 | 1995-06-27 | Musashino Kagaku Kenkyusho:Kk | ラクチドの精製方法 |
TW500739B (en) * | 1999-06-22 | 2002-09-01 | Mitsui Chemicals Inc | Process for preparing polyhydroxycarboxylic acid |
CN101648938B (zh) * | 2009-09-03 | 2012-07-04 | 宁波博硕倍医疗器械有限公司 | 用于丙交酯的重结晶纯化装置 |
CN101696204A (zh) * | 2009-10-13 | 2010-04-21 | 常熟市长江化纤有限公司 | 丙交酯的提纯方法 |
CN101857585A (zh) * | 2010-05-21 | 2010-10-13 | 常州大学 | 丙交酯连续高真空精馏提纯方法 |
CN106397388B (zh) * | 2016-09-07 | 2019-02-01 | 南京大学科技园发展有限公司 | 一种粗品环酯纯化制备高纯度环酯的工艺 |
-
2016
- 2016-09-07 CN CN201610807374.3A patent/CN106397388B/zh active Active
-
2017
- 2017-09-05 JP JP2019533269A patent/JP2019529531A/ja active Pending
- 2017-09-05 WO PCT/CN2017/100464 patent/WO2018045938A1/zh active Application Filing
-
2019
- 2019-01-17 US US16/251,047 patent/US10570111B2/en not_active Expired - Fee Related
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101468978A (zh) * | 2007-12-27 | 2009-07-01 | 常熟市长江化纤有限公司 | 丙交酯的提纯方法 |
Non-Patent Citations (2)
Title |
---|
姜福美: ""结晶-精馏耦合分离MDI同分异构体的研究"", 《中国优秀硕士学位论文全文数据库 工程科技I辑》 * |
蒋守英: ""L-丙交酯绿色提纯新工艺研究"", 《中国优秀硕士学位论文全文数据库 工程科技I辑》 * |
Cited By (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2018045938A1 (zh) * | 2016-09-07 | 2018-03-15 | 南京大学 | 一种粗品环酯纯化方法 |
WO2019057032A1 (zh) * | 2017-09-21 | 2019-03-28 | 南京大学 | 一种生产乙、丙交酯副产聚合物残渣再利用的工艺方法 |
CN114478470A (zh) * | 2020-10-28 | 2022-05-13 | 中国石油化工股份有限公司 | 一种提纯丙交酯的方法 |
CN114478470B (zh) * | 2020-10-28 | 2024-04-19 | 中国石油化工股份有限公司 | 一种提纯丙交酯的方法 |
CN115707697A (zh) * | 2021-08-20 | 2023-02-21 | 中国石油化工股份有限公司 | 一种粗乙交酯的提纯方法及所得乙交酯 |
CN114014835A (zh) * | 2021-12-09 | 2022-02-08 | 内蒙古久泰新材料有限公司 | 一种乙交酯的纯化工艺 |
CN114181189A (zh) * | 2021-12-16 | 2022-03-15 | 内蒙古久泰新材料有限公司 | 一种环状交酯的纯化方法 |
CN116410177A (zh) * | 2022-08-30 | 2023-07-11 | 深圳市迈启生物材料有限公司 | 医用乙交酯的制备方法 |
CN116410177B (zh) * | 2022-08-30 | 2024-01-30 | 深圳市迈启生物材料有限公司 | 医用乙交酯的制备方法 |
CN116041314A (zh) * | 2023-02-08 | 2023-05-02 | 新沂市永诚化工有限公司 | 一种粗品环酯纯化制备高纯度环酯的工艺 |
Also Published As
Publication number | Publication date |
---|---|
JP2019529531A (ja) | 2019-10-17 |
US10570111B2 (en) | 2020-02-25 |
CN106397388B (zh) | 2019-02-01 |
WO2018045938A1 (zh) | 2018-03-15 |
US20190152939A1 (en) | 2019-05-23 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN106397388B (zh) | 一种粗品环酯纯化制备高纯度环酯的工艺 | |
Yu et al. | PLA bioplastic production: From monomer to the polymer | |
CN105622567A (zh) | 高产率乙交酯的制备方法 | |
CN106397389A (zh) | 一种全绿色合成乙交酯的工艺方法 | |
CN102659590A (zh) | 废聚乳酸材料在离子液体环境下的醇解回收方法 | |
CN110511205B (zh) | 一种高纯度乙交酯的制备方法 | |
CN102731357B (zh) | 高纯度n,n′-二环己基硫脲的制备方法 | |
CN109134230B (zh) | 一种由木糖、葡萄糖、木聚糖、微晶纤维素及玉米秸秆催化转化制备d-构型过量的乳酸的方法 | |
CN107501098A (zh) | 苯甲酸重副产物苯甲酸苄酯的脱色方法 | |
CN104592024A (zh) | 一种废聚乳酸材料的醇解回收方法 | |
CN108047171B (zh) | 基于多相催化剂的甲酸转移加氢乙酰丙酸制备γ-戊内酯的方法 | |
CN102702143A (zh) | 2-乙酰呋喃的制备方法 | |
JP5280656B2 (ja) | ポリ乳酸の解重合方法 | |
CN116874460A (zh) | 一种一卤碳酸乙烯酯的制备方法 | |
JPWO2003091238A1 (ja) | ラクチドの製造方法 | |
CN115678030B (zh) | 一种制备金属-有机框架材料的力化学方法 | |
JP2015145345A (ja) | 環状α−ヒドロキシカルボン酸2量体エステルの製造方法 | |
CN101817737A (zh) | 醋酸的回收方法 | |
CN112574165B (zh) | 一步转化生成丙交酯的方法 | |
CN112010834B (zh) | 一种一步合成乙交酯的方法 | |
KR101778761B1 (ko) | 폴리알킬렌 카보네이트 입자의 제조 방법 | |
CN204874355U (zh) | 一种制备丙交酯的装置 | |
CN110845302A (zh) | 一种基于聚碳酸乙烯酯制备乙二醇的方法 | |
CN219010196U (zh) | 一种聚乙醇酸废料的回收系统 | |
CN108613531B (zh) | 一种丙交酯熔融态干燥的方法 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
C06 | Publication | ||
PB01 | Publication | ||
C10 | Entry into substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
TA01 | Transfer of patent application right | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20181018 Address after: 210093 Hankou Road, Drum Tower District, Nanjing, Jiangsu Province, No. 22 Applicant after: Nanjing University Asset Management Co., Ltd. Address before: 210093 No. 22, Hankou Road, Nanjing, Jiangsu Applicant before: Nanjing University |
|
TA01 | Transfer of patent application right | ||
TA01 | Transfer of patent application right |
Effective date of registration: 20181204 Address after: 210023 Innovation Building of Nanda Science Park, No. 8 Yuanhua Road, Qixia District, Nanjing City, Jiangsu Province Applicant after: NANJING UNIVERSITY TECHNOLOGY PARK DEVELOPMENT CO., LTD. Address before: 210093 Hankou Road, Drum Tower District, Nanjing, Jiangsu Province, No. 22 Applicant before: Nanjing University Asset Management Co., Ltd. |
|
GR01 | Patent grant | ||
GR01 | Patent grant | ||
TR01 | Transfer of patent right | ||
TR01 | Transfer of patent right |
Effective date of registration: 20190703 Address after: 477150 No. 08 Jindan Avenue, Dancheng County, Zhoukou City, Henan Province Patentee after: Jindan Biological New Materials Co., Ltd. Address before: 210023 Innovation Building of Nanda Science Park, No. 8 Yuanhua Road, Qixia District, Nanjing City, Jiangsu Province Patentee before: NANJING UNIVERSITY TECHNOLOGY PARK DEVELOPMENT CO., LTD. |