CN106279309B - 一种林可霉素的纯化方法 - Google Patents
一种林可霉素的纯化方法 Download PDFInfo
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- CN106279309B CN106279309B CN201610415025.7A CN201610415025A CN106279309B CN 106279309 B CN106279309 B CN 106279309B CN 201610415025 A CN201610415025 A CN 201610415025A CN 106279309 B CN106279309 B CN 106279309B
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- lincomycin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
- C07H15/14—Acyclic radicals, not substituted by cyclic structures attached to a sulfur, selenium or tellurium atom of a saccharide radical
- C07H15/16—Lincomycin; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/06—Separation; Purification
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- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
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- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Crystallography & Structural Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Description
萃取剂种类 | 苯甲醇 | 正丁醇 | 二氯甲烷 |
A组分含量(%) | 91.23 | 90.28 | 89.29 |
杂质B组分含量(%) | 2.23 | 1.19 | 1.06 |
收率(%) | 92.12 | 90.13 | 85.26 |
Claims (6)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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CN201510368908 | 2015-06-26 | ||
CN2015103689082 | 2015-06-26 |
Publications (2)
Publication Number | Publication Date |
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CN106279309A CN106279309A (zh) | 2017-01-04 |
CN106279309B true CN106279309B (zh) | 2019-10-18 |
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CN201610415025.7A Active CN106279309B (zh) | 2015-06-26 | 2016-06-14 | 一种林可霉素的纯化方法 |
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CN (1) | CN106279309B (zh) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN108801725B (zh) * | 2018-04-03 | 2020-09-08 | 新宇药业股份有限公司 | 一种盐酸林可霉素中b组分对照品的制备方法 |
CN110878118B (zh) * | 2018-09-06 | 2023-04-18 | 深圳翰宇药业股份有限公司 | 度拉糖肽的纯化方法与纯化试剂 |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1526717A (zh) * | 2003-09-25 | 2004-09-08 | 河北工业大学 | 用苯甲醇-正辛醇二元萃取剂萃取林可霉素的方法 |
CN103724380A (zh) * | 2013-12-25 | 2014-04-16 | 江苏久吾高科技股份有限公司 | 一种林可霉素的提取方法 |
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2016
- 2016-06-14 CN CN201610415025.7A patent/CN106279309B/zh active Active
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1526717A (zh) * | 2003-09-25 | 2004-09-08 | 河北工业大学 | 用苯甲醇-正辛醇二元萃取剂萃取林可霉素的方法 |
CN103724380A (zh) * | 2013-12-25 | 2014-04-16 | 江苏久吾高科技股份有限公司 | 一种林可霉素的提取方法 |
Non-Patent Citations (2)
Title |
---|
提取林可霉素的二元萃取剂的研究;卢珂等;《中国抗生素杂志》;20080625(第06期);338-341 * |
林可霉素发酵液膜分离工艺条件的研究;王振川等;《膜科学与技术》;20080425(第02期);48-53 * |
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Publication number | Publication date |
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CN106279309A (zh) | 2017-01-04 |
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Effective date of registration: 20190809 Address after: 523808 Guangdong city of Dongguan province Hubei Songshan Industrial Park Industrial Road No. 1 Applicant after: Dongyangguang Pharmaceutical Co., Ltd., Guangdong Applicant after: HEC Pharm Co., Ltd. Address before: 523808 Guangdong city of Dongguan province Hubei Songshan Industrial Park Industrial Road No. 1 Applicant before: Dongyangguang Pharmaceutical Co., Ltd., Guangdong |
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Effective date of registration: 20200617 Address after: 443300, No. 62, Binjiang Road, Yidu, Hubei, Yichang Patentee after: HEC PHARM Co.,Ltd. Address before: 523808 Guangdong city of Dongguan province Hubei Songshan Industrial Park Industrial Road No. 1 Co-patentee before: HEC PHARM Co.,Ltd. Patentee before: SUNSHINE LAKE PHARMA Co.,Ltd. |
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Effective date of registration: 20200922 Address after: No.62, Lucheng Binjiang Road, Yidu City, Yichang City, Hubei Province Patentee after: Yichang dongyangguang Biochemical Pharmaceutical Co., Ltd Address before: 443300, No. 62, Binjiang Road, Yidu, Hubei, Yichang Patentee before: HEC PHARM Co.,Ltd. |