CN105829305B - Nrf2调节剂 - Google Patents

Nrf2调节剂 Download PDF

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Publication number
CN105829305B
CN105829305B CN201480069879.3A CN201480069879A CN105829305B CN 105829305 B CN105829305 B CN 105829305B CN 201480069879 A CN201480069879 A CN 201480069879A CN 105829305 B CN105829305 B CN 105829305B
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methyl
base
benzo
phenyl
dihydro
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CN105829305A (zh
Inventor
J.C.贝姆
T.G.戴维斯
A.J.伍尔福德
C.M.格里菲思-琼斯
H.M.G.威廉斯
D.诺顿
G.萨克斯蒂
T.D.海特曼
T.李
J.K.克恩斯
R.S.戴维斯
H.严
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Astex Therapeutics Ltd
GlaxoSmithKline Intellectual Property Development Ltd
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Astex Therapeutics Ltd
GlaxoSmithKline Intellectual Property Development Ltd
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CN201480069879.3A 2013-12-18 2014-12-17 Nrf2调节剂 Active CN105829305B (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361917466P 2013-12-18 2013-12-18
US61/917,466 2013-12-18
US201461980091P 2014-04-16 2014-04-16
US61/980,091 2014-04-16
PCT/IB2014/067027 WO2015092713A1 (en) 2013-12-18 2014-12-17 Nrf2 regulators

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CN105829305A CN105829305A (zh) 2016-08-03
CN105829305B true CN105829305B (zh) 2018-11-30

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EP (1) EP3083614B1 (enExample)
JP (1) JP6630671B2 (enExample)
KR (1) KR102301867B1 (enExample)
CN (1) CN105829305B (enExample)
AU (2) AU2014369153B2 (enExample)
BR (1) BR112016014180A2 (enExample)
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Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3307739T (pt) * 2015-06-15 2021-01-04 Glaxosmithkline Ip Dev Ltd Reguladores de nrf2
ES2910938T3 (es) * 2015-06-15 2022-05-17 Glaxosmithkline Ip Dev Ltd Reguladores de NRF2
CN107709306A (zh) * 2015-06-15 2018-02-16 葛兰素史密斯克莱知识产权发展有限公司 Nrf2调节剂
US10364256B2 (en) 2015-10-06 2019-07-30 Glaxosmithkline Intellectual Property Development Limited Biaryl pyrazoles as NRF2 regulators
JP2018529744A (ja) * 2015-10-06 2018-10-11 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ Ｎｒｆ２レギュレーターとしてのアリールシクロヘキシルピラゾール
CN105566241B (zh) * 2016-01-18 2018-05-25 中国药科大学 1-磺酰胺基-4-芳氧基类化合物、制备方法及其医药用途
CN108699011B (zh) * 2016-02-03 2022-05-06 参宿七制药股份有限公司 Nrf2活化性化合物及其用途
KR20190088404A (ko) * 2016-12-06 2019-07-26 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 3-(2,3-디히드로-1h-인덴-5-일)프로판산 유도체 및 nrf2 조절제로서의 그의 용도
JP2020500919A (ja) * 2016-12-12 2020-01-16 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ Ｎｒｆ２レギュレーターとしての３−カルボン酸ピロール
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