AU2014369153B2 - Nrf2 regulators - Google Patents

Nrf2 regulators Download PDF

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Publication number
AU2014369153B2
AU2014369153B2 AU2014369153A AU2014369153A AU2014369153B2 AU 2014369153 B2 AU2014369153 B2 AU 2014369153B2 AU 2014369153 A AU2014369153 A AU 2014369153A AU 2014369153 A AU2014369153 A AU 2014369153A AU 2014369153 B2 AU2014369153 B2 AU 2014369153B2
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Australia
Prior art keywords
methyl
benzo
mmol
triazol
dioxido
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AU2014369153A
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AU2014369153A1 (en
Inventor
Jeffrey Charles Boehm
Thomas Glanmor Davies
Roderick S. Davis
Charlotte Mary Griffiths-Jones
Thomas Daniel Heightman
Jeffrey K. Kerns
Tindy Li
David Norton
Gordon Saxty
Hendrika Maria Gerarda Willems
Alison Jo-Anne Woolford
Hongxing Yan
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Astex Therapeutics Ltd
GlaxoSmithKline Intellectual Property Development Ltd
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Astex Therapeutics Ltd
GlaxoSmithKline Intellectual Property Development Ltd
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Publication of AU2014369153A1 publication Critical patent/AU2014369153A1/en
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Publication of AU2014369153B2 publication Critical patent/AU2014369153B2/en
Priority to AU2017279668A priority Critical patent/AU2017279668B2/en
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    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing aromatic rings
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
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    • C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
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  • Psychology (AREA)
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  • Physical Education & Sports Medicine (AREA)
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  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Ophthalmology & Optometry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
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AU2014369153A 2013-12-18 2014-12-17 Nrf2 regulators Active AU2014369153B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2017279668A AU2017279668B2 (en) 2013-12-18 2017-12-20 Nrf2 regulators

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361917466P 2013-12-18 2013-12-18
US61/917,466 2013-12-18
US201461980091P 2014-04-16 2014-04-16
US61/980,091 2014-04-16
PCT/IB2014/067027 WO2015092713A1 (en) 2013-12-18 2014-12-17 Nrf2 regulators

Related Child Applications (1)

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AU2017279668A Division AU2017279668B2 (en) 2013-12-18 2017-12-20 Nrf2 regulators

Publications (2)

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AU2014369153A1 AU2014369153A1 (en) 2016-05-26
AU2014369153B2 true AU2014369153B2 (en) 2017-09-21

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AU2017279668A Active AU2017279668B2 (en) 2013-12-18 2017-12-20 Nrf2 regulators

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US (2) US10144731B2 (enExample)
EP (1) EP3083614B1 (enExample)
JP (1) JP6630671B2 (enExample)
KR (1) KR102301867B1 (enExample)
CN (1) CN105829305B (enExample)
AU (2) AU2014369153B2 (enExample)
BR (1) BR112016014180A2 (enExample)
CA (1) CA2934216C (enExample)
CL (1) CL2016001516A1 (enExample)
CR (1) CR20160272A (enExample)
DO (1) DOP2016000145A (enExample)
EA (1) EA030431B1 (enExample)
ES (1) ES2784244T3 (enExample)
IL (1) IL245727B (enExample)
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PE (1) PE20160901A1 (enExample)
PH (1) PH12016501151A1 (enExample)
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Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108137557B (zh) 2015-06-15 2021-09-07 葛兰素史密斯克莱知识产权发展有限公司 Nrf2调节剂
CA2988338C (en) 2015-06-15 2024-05-14 Glaxosmithkline Intellectual Property Development Limited Nrf2 regulators
JP2018517732A (ja) * 2015-06-15 2018-07-05 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ Ｎｒｆ２レギュレーター
WO2017060854A1 (en) 2015-10-06 2017-04-13 Glaxosmithkline Intellectual Property Development Limited Biaryl pyrazoles as nrf2 regulators
WO2017060855A1 (en) * 2015-10-06 2017-04-13 Glaxosmithkline Intellectual Property Development Limited Arylcyclohexyl pyrazoles as nrf2 regulators
CN105566241B (zh) * 2016-01-18 2018-05-25 中国药科大学 1-磺酰胺基-4-芳氧基类化合物、制备方法及其医药用途
HUE052269T2 (hu) 2016-02-03 2021-04-28 Rigel Pharmaceuticals Inc NRF2-t aktiváló vegyületek és alkalmazásuk
WO2018104766A1 (en) * 2016-12-06 2018-06-14 Glaxosmithkline Intellectual Property Development Limited 3-(2,3-dihydro-1h-inden-5-yl)propanoic acid derivatives and their use as nrf2 regulators
WO2018109641A1 (en) * 2016-12-12 2018-06-21 Glaxosmithkline Intellectual Property Development Limited 3-carboxylic acid pyrroles as nrf2 regulators
WO2018109642A1 (en) * 2016-12-12 2018-06-21 Glaxosmithkline Intellectual Property Development Limited N-aryl pyrazoles as nrf2 regulators
ES2901617T3 (es) 2016-12-14 2022-03-23 Glaxosmithkline Ip Dev Ltd Bisarilamidas como reguladores de NRF2
US11117905B2 (en) * 2016-12-14 2021-09-14 Glaxosmithkline Intellectual Property Development Limited Bisaryl heterocycles as NRF2 activators
JP2020502129A (ja) * 2016-12-14 2020-01-23 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ Ｎｒｆ２アクチベーターとしての３−オキソ−１，４−ジアゼピニル化合物
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