EA030431B1 - РЕГУЛЯТОРЫ Nrf2 - Google Patents

РЕГУЛЯТОРЫ Nrf2 Download PDF

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Publication number
EA030431B1
EA030431B1 EA201691259A EA201691259A EA030431B1 EA 030431 B1 EA030431 B1 EA 030431B1 EA 201691259 A EA201691259 A EA 201691259A EA 201691259 A EA201691259 A EA 201691259A EA 030431 B1 EA030431 B1 EA 030431B1
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EA
Eurasian Patent Office
Prior art keywords
methyl
benzo
dioxido
phenyl
dihydro
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EA201691259A
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English (en)
Russian (ru)
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EA201691259A1 (ru
Inventor
Джеффри Чарльз Боэм
Томас Гленмор Дэвис
Элисон Джо-Энн Вулфорд
Шарлотт Мэри Гриффитс-Джоунз
Хендрика Мария Герарда Виллемс
Дэвид Нортон
Гордон Саксти
Томас Дэниел Хейтман
Тинди Ли
Джеффри К. Кернс
Родерик С. Дэвис
Хунсин Янь
Original Assignee
Глэксосмитклайн Интеллекчуал Проперти Дивелопмент Лимитед
Астекс Терапьютикс Лимитед
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Publication of EA201691259A1 publication Critical patent/EA201691259A1/ru
Publication of EA030431B1 publication Critical patent/EA030431B1/ru

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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4192—1,2,3-Triazoles
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    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/554—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D515/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D515/04—Ortho-condensed systems

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  • Psychology (AREA)
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  • Ophthalmology & Optometry (AREA)
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  • Gastroenterology & Hepatology (AREA)
  • Psychiatry (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EA201691259A 2013-12-18 2014-12-17 РЕГУЛЯТОРЫ Nrf2 EA030431B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361917466P 2013-12-18 2013-12-18
US201461980091P 2014-04-16 2014-04-16
PCT/IB2014/067027 WO2015092713A1 (en) 2013-12-18 2014-12-17 Nrf2 regulators

Publications (2)

Publication Number Publication Date
EA201691259A1 EA201691259A1 (ru) 2016-11-30
EA030431B1 true EA030431B1 (ru) 2018-08-31

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EA201691259A EA030431B1 (ru) 2013-12-18 2014-12-17 РЕГУЛЯТОРЫ Nrf2

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US (2) US10144731B2 (enExample)
EP (1) EP3083614B1 (enExample)
JP (1) JP6630671B2 (enExample)
KR (1) KR102301867B1 (enExample)
CN (1) CN105829305B (enExample)
AU (2) AU2014369153B2 (enExample)
BR (1) BR112016014180A2 (enExample)
CA (1) CA2934216C (enExample)
CL (1) CL2016001516A1 (enExample)
CR (1) CR20160272A (enExample)
DO (1) DOP2016000145A (enExample)
EA (1) EA030431B1 (enExample)
ES (1) ES2784244T3 (enExample)
IL (1) IL245727B (enExample)
MX (1) MX370410B (enExample)
PE (1) PE20160901A1 (enExample)
PH (1) PH12016501151A1 (enExample)
SG (1) SG11201604611SA (enExample)
WO (1) WO2015092713A1 (enExample)

Families Citing this family (33)

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ES2910938T3 (es) * 2015-06-15 2022-05-17 Glaxosmithkline Ip Dev Ltd Reguladores de NRF2
PT3307739T (pt) * 2015-06-15 2021-01-04 Glaxosmithkline Ip Dev Ltd Reguladores de nrf2
AU2016280235A1 (en) * 2015-06-15 2017-12-14 Astex Therapeutics Limited Nrf2 regulators
WO2017060855A1 (en) * 2015-10-06 2017-04-13 Glaxosmithkline Intellectual Property Development Limited Arylcyclohexyl pyrazoles as nrf2 regulators
US10364256B2 (en) 2015-10-06 2019-07-30 Glaxosmithkline Intellectual Property Development Limited Biaryl pyrazoles as NRF2 regulators
CN105566241B (zh) * 2016-01-18 2018-05-25 中国药科大学 1-磺酰胺基-4-芳氧基类化合物、制备方法及其医药用途
WO2017136589A1 (en) 2016-02-03 2017-08-10 Rigel Pharmaceuticals, Inc. Nrf2 activating compounds and uses thereof
WO2018104766A1 (en) * 2016-12-06 2018-06-14 Glaxosmithkline Intellectual Property Development Limited 3-(2,3-dihydro-1h-inden-5-yl)propanoic acid derivatives and their use as nrf2 regulators
WO2018109642A1 (en) * 2016-12-12 2018-06-21 Glaxosmithkline Intellectual Property Development Limited N-aryl pyrazoles as nrf2 regulators
JP2020500919A (ja) * 2016-12-12 2020-01-16 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ Ｎｒｆ２レギュレーターとしての３−カルボン酸ピロール
EP3555068B1 (en) * 2016-12-14 2020-12-02 GlaxoSmithKline Intellectual Property Development Limited 3-oxo-1,4-diazepinyle compounds as nrf2 activators
JP2020502136A (ja) * 2016-12-14 2020-01-23 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドＧｌａｘｏｓｍｉｔｈｋｌｉｎｅ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ Ｄｅｖｅｌｏｐｍｅｎｔ Ｌｉｍｉｔｅｄ Ｎｒｆ２レギュレーターとしてのビスアリールアミド
WO2018109643A1 (en) * 2016-12-14 2018-06-21 Glaxosmithkline Intellectual Property Development Limited Bisaryl heterocycles as nrf2 acti
ES2908941T3 (es) * 2016-12-15 2022-05-04 Glaxosmithkline Ip Dev Ltd Triazoles unidos a éter como reguladores de NRF2
EP3555104B1 (en) 2016-12-15 2021-11-24 GlaxoSmithKline Intellectual Property Development Limited Nrf2 compounds
EP3576726A1 (en) 2017-02-06 2019-12-11 Massachusetts Institute Of Technology Methods and products related to glutaminase inhibitors
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