CN1058054C - 紫杉烷类双萜的生产方法以及获得以高产量产生紫杉烷类双萜的培养细胞的方法 - Google Patents

紫杉烷类双萜的生产方法以及获得以高产量产生紫杉烷类双萜的培养细胞的方法 Download PDF

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Publication number
CN1058054C
CN1058054C CN94191435A CN94191435A CN1058054C CN 1058054 C CN1058054 C CN 1058054C CN 94191435 A CN94191435 A CN 94191435A CN 94191435 A CN94191435 A CN 94191435A CN 1058054 C CN1058054 C CN 1058054C
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cell
concentration
culture
substratum
compound
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Expired - Lifetime
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CN94191435A
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Chinese (zh)
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CN1119028A (zh
Inventor
行宗敬人
原康弘
东庸介
大西直人
多叶田誉
菅忠三
松原浩一
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Mitsui Chemicals Inc
Mitsui Petrochemical Industries Ltd
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Mitsui Chemicals Inc
Mitsui Petrochemical Industries Ltd
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Priority claimed from JP28489393A external-priority patent/JP3488492B2/ja
Priority claimed from JP6104212A external-priority patent/JPH07308197A/ja
Priority claimed from JP6104211A external-priority patent/JPH07308196A/ja
Priority claimed from JP14682694A external-priority patent/JP3434892B2/ja
Priority claimed from JP6201150A external-priority patent/JPH0856680A/ja
Priority claimed from JP6201151A external-priority patent/JPH0856681A/ja
Priority claimed from JP6252528A external-priority patent/JPH08116981A/ja
Application filed by Mitsui Chemicals Inc, Mitsui Petrochemical Industries Ltd filed Critical Mitsui Chemicals Inc
Publication of CN1119028A publication Critical patent/CN1119028A/zh
Publication of CN1058054C publication Critical patent/CN1058054C/zh
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/04—Plant cells or tissues
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/0018—Culture media for cell or tissue culture
    • C12N5/0025—Culture media for plant cell or plant tissue culture
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms

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  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Botany (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN94191435A 1993-11-15 1994-11-09 紫杉烷类双萜的生产方法以及获得以高产量产生紫杉烷类双萜的培养细胞的方法 Expired - Lifetime CN1058054C (zh)

Applications Claiming Priority (27)

Application Number Priority Date Filing Date Title
JP284893/93 1993-11-15
JP284893/1993 1993-11-15
JP28489393A JP3488492B2 (ja) 1993-11-15 1993-11-15 タキサン型ジテルペン高産生培養細胞の取得方法
JP36156/1994 1994-03-07
JP36156/94 1994-03-07
JP3615694 1994-03-07
JP104211/1994 1994-05-18
JP10421394 1994-05-18
JP104213/94 1994-05-18
JP104212/94 1994-05-18
JP6104212A JPH07308197A (ja) 1994-05-18 1994-05-18 タキサン型ジテルペンの製造方法
JP104213/1994 1994-05-18
JP104212/1994 1994-05-18
JP104211/94 1994-05-18
JP6104211A JPH07308196A (ja) 1994-05-18 1994-05-18 タキサン型ジテルペンの製造方法
JP146826/94 1994-06-28
JP146826/1994 1994-06-28
JP14682694A JP3434892B2 (ja) 1994-06-28 1994-06-28 タキサン型ジテルペンの製造方法
JP201151/1994 1994-08-25
JP6201151A JPH0856681A (ja) 1994-08-25 1994-08-25 タキサン型ジテルペンの製造方法
JP201151/94 1994-08-25
JP201150/1994 1994-08-25
JP201150/94 1994-08-25
JP6201150A JPH0856680A (ja) 1994-08-25 1994-08-25 タキサン型ジテルペンの製造方法
JP252528/94 1994-10-18
JP6252528A JPH08116981A (ja) 1994-10-18 1994-10-18 タキサン型ジテルペンの製造方法
JP252528/1994 1994-10-18

Related Child Applications (3)

Application Number Title Priority Date Filing Date
CN99110153A Division CN1083012C (zh) 1993-11-15 1999-06-30 生产紫杉烷类双萜的方法
CN99110152A Division CN1083011C (zh) 1993-11-15 1999-06-30 获得紫杉烷类双萜的高生产性培养细胞的方法
CN99110151A Division CN1083010C (zh) 1993-11-15 1999-06-30 生产紫杉烷类双萜的方法

Publications (2)

Publication Number Publication Date
CN1119028A CN1119028A (zh) 1996-03-20
CN1058054C true CN1058054C (zh) 2000-11-01

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Application Number Title Priority Date Filing Date
CN94191435A Expired - Lifetime CN1058054C (zh) 1993-11-15 1994-11-09 紫杉烷类双萜的生产方法以及获得以高产量产生紫杉烷类双萜的培养细胞的方法
CN99110152A Expired - Lifetime CN1083011C (zh) 1993-11-15 1999-06-30 获得紫杉烷类双萜的高生产性培养细胞的方法
CN99110153A Expired - Lifetime CN1083012C (zh) 1993-11-15 1999-06-30 生产紫杉烷类双萜的方法
CN99110151A Expired - Lifetime CN1083010C (zh) 1993-11-15 1999-06-30 生产紫杉烷类双萜的方法

Family Applications After (3)

Application Number Title Priority Date Filing Date
CN99110152A Expired - Lifetime CN1083011C (zh) 1993-11-15 1999-06-30 获得紫杉烷类双萜的高生产性培养细胞的方法
CN99110153A Expired - Lifetime CN1083012C (zh) 1993-11-15 1999-06-30 生产紫杉烷类双萜的方法
CN99110151A Expired - Lifetime CN1083010C (zh) 1993-11-15 1999-06-30 生产紫杉烷类双萜的方法

Country Status (7)

Country Link
US (3) US5637484A (enExample)
EP (5) EP1348764A1 (enExample)
KR (1) KR0172606B1 (enExample)
CN (4) CN1058054C (enExample)
CA (1) CA2153986C (enExample)
DE (3) DE69431135T2 (enExample)
WO (1) WO1995014103A1 (enExample)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7264951B1 (en) * 1992-02-20 2007-09-04 Phyton, Inc. Enhanced production of taxol and taxanes by cell cultures of Taxus species
CA2163614C (en) 1994-11-25 2002-12-31 Yukihito Yukimune Method of producing a taxane-type diterpene
JP3019736B2 (ja) 1994-12-07 2000-03-13 三井化学株式会社 タキサン型ジテルペンの製造方法
KR960037826A (ko) * 1995-04-27 1996-11-19 김경환 택서스속 식물세포의 반연속식 배양방법
US6248572B1 (en) * 1995-04-27 2001-06-19 Samyang, Genex, Corporation Production of taxol from taxus plant cell culture adding silver nitrate
AU2239897A (en) * 1995-12-12 1997-07-03 Xechem, Inc. Production and screening process for phytochemical production by plant cell cultures
KR100290004B1 (ko) * 1996-01-15 2001-05-15 허일섭 생물반응기에서 주목세포 배양에 의한 탁솔 및 그 유도체의 고수율 생산방법
JP4047929B2 (ja) * 1996-05-24 2008-02-13 ファイトン・インコーポレーテッド タキサス種の細胞培養によるタキサンの増強生産
KR100287465B1 (ko) * 1997-06-25 2001-05-02 나까니시 히로유끼 탁산형 디테르펜의 제조방법
KR100266448B1 (ko) * 1997-06-26 2000-09-15 박종헌 식물세포 배양 중의 온도변화에 의한 택솔의 대량생산 방법
ATE219070T1 (de) 1998-01-14 2002-06-15 Bristol Myers Squibb Co Neue kristallkomplexe von baccatin iii mit imidazol, 2-methylimidazol or isopropanol
HK1049787B (en) 1999-10-01 2014-07-25 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
US6452024B1 (en) 2000-02-22 2002-09-17 Chaichem Pharmaceuticals International Process for extraction and purification of paclitaxel from natural sources
US6946283B2 (en) * 2001-01-05 2005-09-20 William Marsh Rice University Ginkgo biloba levopimaradiene synthase
US7238514B2 (en) * 2001-01-05 2007-07-03 William Marsh Rice University Diterpene-producing unicellular organism
US20030092178A1 (en) * 2001-11-15 2003-05-15 Biospherix, Ltd. Cell culture incubator with dynamic oxygen control
TW200304947A (en) * 2002-02-08 2003-10-16 Bristol Myers Squibb Co Compositions and methods for latering biosynthesis of taxanes and taxane-related compounds
US6759539B1 (en) 2003-02-27 2004-07-06 Chaichem Pharmaceuticals International Process for isolation and purification of paclitaxel from natural sources
EP1498475A1 (en) * 2003-07-18 2005-01-19 Meristem Therapeutics S.A. Continuous plant cell bioreactor and method for continuous plant cell culture
EP1891206B1 (en) * 2005-06-03 2013-07-24 Samyang Genexbio Corporation Mass production of secondary metabolites in plant cell culture by use of a saccharide mixture in the culture medium
WO2007066337A2 (en) * 2005-12-07 2007-06-14 Sepal Pharma Ltd. Jasmonate derivatives, pharmaceutical compositions and methods of use thereof
CA2632653C (en) * 2005-12-07 2014-11-04 Ramot At Tel Aviv University Ltd. Chemical derivatives of jasmonate, pharmaceutical compositions and methods of use thereof in the treatment of cancer
US9284274B2 (en) 2005-12-07 2016-03-15 Ramot At Tel-Aviv University Ltd. Chemical derivatives of jasmonate, pharmaceutical compositions and methods of use thereof
CL2007003174A1 (es) * 2006-11-03 2008-07-18 Valent Biosciences Inc Formulacion que comprende aminoetoxivinilglicina y un agente hidrofobico; metodo para inhibir el etileno en plantas de cultivo que comprende aplicar dicha formulacion.
US9284252B2 (en) 2009-06-09 2016-03-15 Sepal Pharma Ltd. Use of jasmonate ester derivatives for treating benign hyperproliferative skin disorders
CN110105312B (zh) * 2019-06-05 2023-05-09 云南大学 一种7-差向紫杉烷差向化转化形成紫杉烷的方法
WO2024011263A2 (en) * 2022-07-08 2024-01-11 Cibus Us Llc Producing sesquiterpenes and other terpenes using plant-based biomasses

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5244971A (en) * 1975-10-03 1977-04-08 Fuji Jidoki Kk Automatic pile up apparatus of narrow width plates
US5015744A (en) * 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
US5019504A (en) * 1989-03-23 1991-05-28 The United States Of America As Represented By The Secretary Of Agriculture Production of taxol or taxol-like compounds in cell culture
WO1993002067A1 (en) * 1991-07-17 1993-02-04 Nippon Steel Corporation Antitumor compound nsc-lsc1 and production thereof
WO1993017121A1 (en) * 1992-02-20 1993-09-02 Phyton Catalytic, Inc. Enhanced production of taxol and taxanes by cell cultures of taxus species
WO1993023555A1 (en) * 1992-05-21 1993-11-25 The Penn State Research Foundation Cultured taxus tissues as a source of taxol, related taxanes and other novel anti-tumor/anti-viral compounds

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4122208C1 (enExample) * 1991-07-04 1992-07-30 B.A.T. Cigarettenfabriken Gmbh, 2000 Hamburg, De
JPH05244971A (ja) * 1992-03-06 1993-09-24 Nippon Oil Co Ltd タキサン類化合物の製造方法

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5244971A (en) * 1975-10-03 1977-04-08 Fuji Jidoki Kk Automatic pile up apparatus of narrow width plates
US5019504A (en) * 1989-03-23 1991-05-28 The United States Of America As Represented By The Secretary Of Agriculture Production of taxol or taxol-like compounds in cell culture
US5015744A (en) * 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
WO1993002067A1 (en) * 1991-07-17 1993-02-04 Nippon Steel Corporation Antitumor compound nsc-lsc1 and production thereof
WO1993017121A1 (en) * 1992-02-20 1993-09-02 Phyton Catalytic, Inc. Enhanced production of taxol and taxanes by cell cultures of taxus species
WO1993023555A1 (en) * 1992-05-21 1993-11-25 The Penn State Research Foundation Cultured taxus tissues as a source of taxol, related taxanes and other novel anti-tumor/anti-viral compounds

Also Published As

Publication number Publication date
EP1063300B1 (en) 2003-09-03
EP0683232A4 (enExample) 1995-11-29
EP1054065B1 (en) 2002-07-31
CN1251391A (zh) 2000-04-26
EP0683232B1 (en) 2001-02-14
CN1248629A (zh) 2000-03-29
DE69433120D1 (de) 2003-10-09
CA2153986A1 (en) 1995-05-26
CN1083012C (zh) 2002-04-17
DE69426692T2 (de) 2001-06-21
EP1063299A2 (en) 2000-12-27
CN1119028A (zh) 1996-03-20
CN1083011C (zh) 2002-04-17
KR960700044A (ko) 1996-01-19
CA2153986C (en) 2002-12-31
KR0172606B1 (ko) 1999-02-01
EP1054065A1 (en) 2000-11-22
HK1029807A1 (en) 2001-04-12
US5968789A (en) 1999-10-19
EP1063300A3 (en) 2002-01-02
DE69433120T2 (de) 2004-07-01
DE69431135T2 (de) 2003-03-27
EP0683232A1 (en) 1995-11-22
EP1063299A3 (en) 2002-01-02
CN1083010C (zh) 2002-04-17
US6403343B2 (en) 2002-06-11
DE69431135D1 (de) 2002-09-05
EP1063300A2 (en) 2000-12-27
EP1348764A1 (en) 2003-10-01
WO1995014103A1 (en) 1995-05-26
DE69426692D1 (de) 2001-03-22
US5637484A (en) 1997-06-10
HK1030021A1 (en) 2001-04-20
US20020012976A1 (en) 2002-01-31
CN1248630A (zh) 2000-03-29

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