CN1056277C - 含颗粒结构的片剂的制备方法 - Google Patents

含颗粒结构的片剂的制备方法 Download PDF

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Publication number
CN1056277C
CN1056277C CN92103956A CN92103956A CN1056277C CN 1056277 C CN1056277 C CN 1056277C CN 92103956 A CN92103956 A CN 92103956A CN 92103956 A CN92103956 A CN 92103956A CN 1056277 C CN1056277 C CN 1056277C
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CN
China
Prior art keywords
disintegrating agent
weight
tablet
granule
amoxicillin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN92103956A
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English (en)
Chinese (zh)
Other versions
CN1067577A (zh
Inventor
L·C·马丁
J·D·罗梅罗
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratorios Beecham SA
SmithKline Beecham Ltd
Original Assignee
Laboratorios Beecham SA
SmithKline Beecham Ltd
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Filing date
Publication date
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Publication of CN1067577A publication Critical patent/CN1067577A/zh
Application granted granted Critical
Publication of CN1056277C publication Critical patent/CN1056277C/zh
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CN92103956A 1991-05-08 1992-05-06 含颗粒结构的片剂的制备方法 Expired - Fee Related CN1056277C (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919109862A GB9109862D0 (en) 1991-05-08 1991-05-08 Pharmaceutical formulations
GB9109862.4 1991-05-08

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CNB991235738A Division CN1155370C (zh) 1991-05-08 1999-11-08 制备药物颗粒的方法

Publications (2)

Publication Number Publication Date
CN1067577A CN1067577A (zh) 1993-01-06
CN1056277C true CN1056277C (zh) 2000-09-13

Family

ID=10694582

Family Applications (2)

Application Number Title Priority Date Filing Date
CN92103956A Expired - Fee Related CN1056277C (zh) 1991-05-08 1992-05-06 含颗粒结构的片剂的制备方法
CNB991235738A Expired - Fee Related CN1155370C (zh) 1991-05-08 1999-11-08 制备药物颗粒的方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
CNB991235738A Expired - Fee Related CN1155370C (zh) 1991-05-08 1999-11-08 制备药物颗粒的方法

Country Status (33)

Country Link
US (3) US6110497A (enExample)
EP (3) EP0787487B1 (enExample)
JP (1) JPH06507396A (enExample)
KR (1) KR100228450B1 (enExample)
CN (2) CN1056277C (enExample)
AP (1) AP328A (enExample)
AT (3) ATE203400T1 (enExample)
AU (1) AU659836B2 (enExample)
BR (1) BR9205948A (enExample)
CA (1) CA2102630C (enExample)
CZ (1) CZ291795B6 (enExample)
DE (3) DE69233239T2 (enExample)
DK (1) DK0585252T3 (enExample)
ES (3) ES2212034T3 (enExample)
FI (1) FI110354B (enExample)
GB (1) GB9109862D0 (enExample)
GR (1) GR3036937T3 (enExample)
HU (1) HU219348B (enExample)
IE (1) IE921472A1 (enExample)
IL (1) IL101795A (enExample)
MA (1) MA22522A1 (enExample)
MX (1) MX9202118A (enExample)
MY (1) MY111879A (enExample)
NO (1) NO312224B1 (enExample)
NZ (1) NZ242625A (enExample)
PT (1) PT100458B (enExample)
SA (1) SA92130069B1 (enExample)
SG (1) SG55163A1 (enExample)
SK (1) SK282333B6 (enExample)
TW (1) TW240172B (enExample)
WO (1) WO1992019227A2 (enExample)
YU (1) YU49069B (enExample)
ZA (1) ZA923272B (enExample)

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ATE203400T1 (de) 2001-08-15
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NZ242625A (en) 1994-08-26
MX9202118A (es) 1993-03-01
DE69233464T2 (de) 2006-04-13
US6352720B1 (en) 2002-03-05
CN1265882A (zh) 2000-09-13
PT100458B (pt) 1999-07-30
PT100458A (pt) 1993-08-31
EP0783889A1 (en) 1997-07-16
NO934009D0 (no) 1993-11-05
YU47892A (sh) 1994-12-28
CN1155370C (zh) 2004-06-30
IL101795A0 (en) 1992-12-30
IE921472A1 (en) 1992-11-18
HU219348B (en) 2001-03-28
CN1067577A (zh) 1993-01-06
DE69233464D1 (de) 2005-01-27
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MA22522A1 (fr) 1992-12-31
MY111879A (en) 2001-02-28
AU659836B2 (en) 1995-06-01
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DE69231965T2 (de) 2002-04-04
GB9109862D0 (en) 1991-07-03
IL101795A (en) 1996-10-16
US6544558B2 (en) 2003-04-08
CZ291795B6 (cs) 2003-05-14
SG55163A1 (en) 1998-12-21
FI934914L (fi) 1993-11-05
ATE252900T1 (de) 2003-11-15
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