CN105457335B - 多孔性吸附介质，含有该介质的吸附装置和层析系统 - Google Patents
多孔性吸附介质，含有该介质的吸附装置和层析系统 Download PDFInfo
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- CN105457335B CN105457335B CN201510744950.XA CN201510744950A CN105457335B CN 105457335 B CN105457335 B CN 105457335B CN 201510744950 A CN201510744950 A CN 201510744950A CN 105457335 B CN105457335 B CN 105457335B
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Classifications
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- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
- B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
- B01D15/1871—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns placed in series
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- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/28—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties
- B01J20/28014—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof characterised by their form or physical properties characterised by their form
- B01J20/28033—Membrane, sheet, cloth, pad, lamellar or mat
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- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
- B01D15/361—Ion-exchange
- B01D15/362—Cation-exchange
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
- B01D15/361—Ion-exchange
- B01D15/363—Anion-exchange
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
- B01D15/3804—Affinity chromatography
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/30—Processes for preparing, regenerating, or reactivating
- B01J20/32—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating
- B01J20/3231—Impregnating or coating ; Solid sorbent compositions obtained from processes involving impregnating or coating characterised by the coating or impregnating layer
- B01J20/3242—Layers with a functional group, e.g. an affinity material, a ligand, a reactant or a complexing group
- B01J20/3268—Macromolecular compounds
- B01J20/328—Polymers on the carrier being further modified
- B01J20/3282—Crosslinked polymers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J47/00—Ion-exchange processes in general; Apparatus therefor
- B01J47/12—Ion-exchange processes in general; Apparatus therefor characterised by the use of ion-exchange material in the form of ribbons, filaments, fibres or sheets, e.g. membranes
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
- Y10T428/00—Stock material or miscellaneous articles
- Y10T428/249921—Web or sheet containing structurally defined element or component
- Y10T428/249953—Composite having voids in a component [e.g., porous, cellular, etc.]
- Y10T428/249987—With nonvoid component of specified composition
Landscapes
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- Organic Chemistry (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
- Peptides Or Proteins (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
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Families Citing this family (69)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP2821135A1 (en) * | 2004-02-05 | 2015-01-07 | EMD Millipore Corporation | Porous adsorptive or chromatographic media |
| FR2902799B1 (fr) | 2006-06-27 | 2012-10-26 | Millipore Corp | Procede et unite de preparation d'un echantillon pour l'analyse microbiologique d'un liquide |
| US9375499B2 (en) | 2006-07-14 | 2016-06-28 | Wisconsin Alumni Research Foundation | Adsorptive membranes for trapping viruses |
| US8569464B2 (en) | 2006-12-21 | 2013-10-29 | Emd Millipore Corporation | Purification of proteins |
| WO2008079302A2 (en) | 2006-12-21 | 2008-07-03 | Millipore Corporation | Purification of proteins |
| US8362217B2 (en) | 2006-12-21 | 2013-01-29 | Emd Millipore Corporation | Purification of proteins |
| US9433922B2 (en) | 2007-08-14 | 2016-09-06 | Emd Millipore Corporation | Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same |
| KR101163307B1 (ko) * | 2007-10-26 | 2012-07-05 | 아사히 가세이 케미칼즈 가부시키가이샤 | 단백질의 정제 방법 |
| US20090130738A1 (en) * | 2007-11-19 | 2009-05-21 | Mikhail Kozlov | Media for membrane ion exchange chromatography |
| WO2009145722A1 (en) * | 2008-05-30 | 2009-12-03 | Ge Healthcare Bio-Sciences Ab | Separation method utilizing polyallylamine ligands |
| CN102105213B (zh) | 2008-05-30 | 2013-12-18 | 3M创新有限公司 | 配体官能化基底 |
| EP2294118B1 (en) | 2008-05-30 | 2012-07-04 | 3M Innovative Properties Company | Method of making ligand functionalized substrates |
| SG171446A1 (en) | 2008-12-16 | 2011-07-28 | Millipore Corp | Stirred tank reactor and method |
| DE102009005479A1 (de) * | 2009-01-21 | 2010-07-22 | Sartorius Stedim Biotech Gmbh | Vorrichtung und Verfahren für die Stofftrennung |
| US8382883B2 (en) * | 2009-02-27 | 2013-02-26 | General Electric Company | Membranes comprising amino acid mobile carriers |
| US20100218681A1 (en) * | 2009-02-27 | 2010-09-02 | General Electric Company | Membranes comprising amino acid mobile carriers |
| US9441011B2 (en) | 2009-07-03 | 2016-09-13 | Asahi Kasei Chemicals Corporation | Method for purification of antibody using porous membrane having amino group and alkyl group both bound to graft chain immobilized on porous substrate |
| WO2011017514A1 (en) * | 2009-08-07 | 2011-02-10 | Millipore Corporation | Methods for purifying a target protein from one or more impurities in a sample |
| FR2949780A1 (fr) * | 2009-09-04 | 2011-03-11 | Commissariat Energie Atomique | Procedure d'extraction rapide des hepatotoxines cellulaires de cyanobacteries toxiques |
| DE102009040180A1 (de) * | 2009-09-07 | 2011-03-17 | Dionex Benelux B.V. | Strömungssteuerung bei der räumlichen Chromatografie |
| US8377672B2 (en) * | 2010-02-18 | 2013-02-19 | 3M Innovative Properties Company | Ligand functionalized polymers |
| EP2542889B1 (en) | 2010-03-03 | 2015-03-25 | 3M Innovative Properties Company | Ligand guanidinyl functionalized polymers |
| JP2011225568A (ja) * | 2010-04-20 | 2011-11-10 | Millipore Corp | 第一級アミンによる核酸からのウイルス及び／又はタンパク質の分離 |
| US20120077249A1 (en) * | 2010-04-20 | 2012-03-29 | Millipore Corporation | Separation Of Virus And/Or Protein From Nucleic Acids By Primary Amines |
| US20120006752A1 (en) * | 2010-05-07 | 2012-01-12 | Millipore Corporation | Enhanced Clarification Media |
| US20120006751A1 (en) * | 2010-05-07 | 2012-01-12 | Millipore Corporation | Enhanced Clarification Media |
| CN107312062B (zh) | 2010-05-17 | 2021-03-16 | Emd密理博公司 | 用于纯化生物分子的刺激响应性聚合物 |
| EP4492053A3 (en) * | 2010-05-25 | 2025-03-19 | F. Hoffmann-La Roche AG | Methods of purifying polypeptides |
| KR101997543B1 (ko) | 2010-07-30 | 2019-07-09 | 이엠디 밀리포어 코포레이션 | 크로마토그래피 매질 및 방법 |
| DE102010046817A1 (de) * | 2010-09-28 | 2012-03-29 | Sartorius Stedim Biotech Gmbh | Verfahren zur Abtrennung von Viren aus einem Kontaminanten enthaltenden flüssigen Medium |
| EP2635599A1 (en) * | 2010-11-01 | 2013-09-11 | DSM IP Assets B.V. | Single unit ion exchange chromatography antibody purification |
| EP2659951A4 (en) | 2010-12-27 | 2017-04-26 | Asahi Kasei Chemicals Corporation | Adsorption/separation membrane module, method for producing adsorption/separation membrane module, and partition member |
| EP2545989A1 (en) | 2011-07-13 | 2013-01-16 | InstrAction GmbH | Composite material for chromatographic applications |
| JP6087287B2 (ja) | 2011-09-30 | 2017-03-01 | 旭化成株式会社 | タンパク質の精製方法 |
| CN103998926B (zh) | 2011-12-15 | 2016-04-06 | 旭化成化学株式会社 | 蛋白质吸附材料 |
| HRP20181846T1 (hr) | 2011-12-22 | 2018-12-28 | Genentech, Inc. | Kromatografija membranom za ionsku izmjenu |
| EP2682168A1 (en) | 2012-07-02 | 2014-01-08 | Millipore Corporation | Purification of biological molecules |
| CN105051055A (zh) * | 2013-02-06 | 2015-11-11 | 新加坡科技研究局 | 通过使用硫代杂环阳离子处理来降低蛋白质制剂中的聚集物水平的方法 |
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| ES2915378T3 (es) | 2013-09-13 | 2022-06-22 | Hoffmann La Roche | Procedimientos para detectar y cuantificar una proteína de célula huésped en líneas celulares |
| JPWO2015041218A1 (ja) * | 2013-09-17 | 2017-03-02 | 株式会社カネカ | 新規抗体精製方法及びそれから得られる抗体（ＮｏｖｅｌＡｎｔｉｂｏｄｙＰｕｒｉｆｉｃａｔｉｏｎＭｅｔｈｏｄａｎｄＡｎｔｉｂｏｄｙｏｂｔａｉｎｅｄｔｈｅｒｅｆｒｏｍ）、並びに陽イオン交換基を用いた新規抗体精製法及びそれから得られる抗体（ＮｏｖｅｌＡｎｔｉｂｏｄｙＰｕｒｉｆｉｃａｔｉｏｎｍｅｔｈｏｄｕｓｉｎｇＣａｔｉｏｎＥｘｃｈａｎｇｅｒａｎｄＡｎｔｉｂｏｄｙｏｂｔａｉｎｅｄｔｈｅｒｅｆｒｏｍ） |
| US9546208B2 (en) | 2014-01-03 | 2017-01-17 | Bio-Rad Laboratories, Inc. | Removal of impurities from protein A eluates |
| EP3094391B1 (en) * | 2014-01-17 | 2024-11-20 | Repligen Corporation | Sterilizing chromatography columns |
| CN106457153B (zh) * | 2014-03-07 | 2019-03-29 | 新加坡科技研究局 | 用于分级分离生物制品的装置和方法 |
| US11680080B2 (en) * | 2014-03-13 | 2023-06-20 | Folim G. Halaka | Purification columns and methods |
| JP6702587B2 (ja) * | 2014-03-14 | 2020-06-03 | ジーイー・ヘルスケア・バイオプロセス・アールアンドディ・アクチボラグ | 生物粒子の精製用分離マトリックス |
| JP2016006410A (ja) * | 2014-05-27 | 2016-01-14 | Jnc株式会社 | クロマトグラフィー担体およびそれを用いたタンパク質精製方法 |
| KR20170004966A (ko) * | 2014-05-28 | 2017-01-11 | 에이전시 포 사이언스, 테크놀로지 앤드 리서치 | 바이러스 감소 방법 |
| US10308678B2 (en) * | 2014-07-25 | 2019-06-04 | Asahi Kasei Medical Co., Ltd. | Cation exchange chromatographic support and method for using same |
| EP3188816B1 (en) | 2014-09-02 | 2021-06-09 | EMD Millipore Corporation | Chromatography media comprising discrete porous bundles of nanofibrils |
| CN104399538A (zh) * | 2014-09-24 | 2015-03-11 | 中国科学院福建物质结构研究所 | 一种化合物、其制备方法及作为离子交换材料的应用 |
| CA2966515C (en) | 2014-12-08 | 2021-04-27 | Emd Millipore Corporation | Mixed bed ion exchange adsorber |
| CN105080623B (zh) * | 2015-08-14 | 2018-02-16 | 中国科学院福建物质结构研究所 | 一种用于分离和/或提取稀土元素的离子交换剂 |
| KR102266006B1 (ko) * | 2015-09-16 | 2021-06-16 | 에보쿠아 워터 테크놀로지스 엘엘씨 | 할로겐화 불순물을 제거하기 위한 이온교환수지의 감마선 조사 |
| GB201602938D0 (en) * | 2016-02-19 | 2016-04-06 | Ucb Biopharma Sprl | Protein purification |
| JP7068316B2 (ja) * | 2016-09-15 | 2022-05-16 | クラヴェゴ ゲーエムベーハー アンド コー カーゲー | 巨大分子の精製のための高分子メッシュの利用 |
| GB201616758D0 (en) * | 2016-10-03 | 2016-11-16 | Ge Healthcare Bio Sciences Ab | Novel chromatography media |
| CN109964123A (zh) * | 2016-11-18 | 2019-07-02 | 捷恩智株式会社 | 抗体的纯化方法 |
| WO2019170635A1 (en) | 2018-03-05 | 2019-09-12 | Chiral Technologies Europe Sas | Composite material for bioseparations |
| CN111818981B (zh) | 2018-03-05 | 2022-07-05 | 欧洲手性技术股份公司 | 用于生物分离的复合材料 |
| CN119881293A (zh) | 2018-03-21 | 2025-04-25 | 沃特世科技公司 | 基于非抗体高亲和力的样品制备、吸附剂、装置和方法 |
| US12485364B2 (en) | 2018-08-10 | 2025-12-02 | Clemson University Research Foundation | Multi-modal ion-exchange membranes for rapid separations |
| US11045773B2 (en) | 2018-08-31 | 2021-06-29 | Pall Corporation | Salt tolerant porous medium |
| US10737259B2 (en) | 2018-08-31 | 2020-08-11 | Pall Corporation | Salt tolerant anion exchange medium |
| WO2020106912A1 (en) | 2018-11-21 | 2020-05-28 | Fujifilm Electronic Materials U.S.A., Inc. | Chemical liquid manufacturing apparatus and manufacturing method of chemical liquid |
| JP7565276B2 (ja) | 2018-12-12 | 2024-10-10 | ドナルドソン カンパニー，インコーポレイティド | 親和性膜及び製造方法 |
| CN109881483B (zh) * | 2019-01-24 | 2021-12-17 | 浙江理工大学 | 一种利用金属-有机框架材料功能化改性聚丙烯/纤维素水刺无纺布的方法及其应用 |
| EP4385618A1 (en) | 2022-12-16 | 2024-06-19 | Chiral Technologies Europe SAS | Composite material for bioseparations |
| CN120586667A (zh) * | 2024-03-05 | 2025-09-05 | 苏州纳微科技股份有限公司 | 复合膜材及其制备方法与应用 |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1159770A (zh) * | 1994-07-28 | 1997-09-17 | 米利波尔公司 | 多孔复合膜及其制法 |
| CN1168699A (zh) * | 1994-10-28 | 1997-12-24 | 马普科技促进协会 | 新型蛋白激酶npk-110 |
| CN1771260A (zh) * | 2003-02-28 | 2006-05-10 | 英国龙沙生物医药股份有限公司 | 用蛋白质a和离子交换层析来纯化抗体 |
| CN1925898A (zh) * | 2004-02-27 | 2007-03-07 | 通用电气健康护理生物科学股份公司 | 纯化抗体的工艺 |
| CN1960803A (zh) * | 2004-02-05 | 2007-05-09 | 米利波尔公司 | 多孔的吸附或色谱介质 |
Family Cites Families (112)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2898310A (en) | 1956-08-08 | 1959-08-04 | Pfaudler Permutit Inc | Highly-basic anion exchange resins from epihalohydrins and tertiary - amino containing alkylenepolyamines |
| GB932660A (en) | 1960-06-22 | 1963-07-31 | Wolfen Filmfab Veb | Process for the manufacture of anion-selective diaphragms |
| US3462429A (en) | 1964-11-25 | 1969-08-19 | Us Army | 2-(3-(morpholinopropyl)amino)ethanethiol or its acid addition salts |
| US3527712A (en) | 1967-03-07 | 1970-09-08 | Marine Colloids Inc | Dried agarose gel,method of preparation thereof,and production of aqueous agarose gel |
| US3926864A (en) | 1971-06-21 | 1975-12-16 | Ionics | Ion exchange membranes having a macroporous surface area |
| US3714010A (en) | 1972-01-06 | 1973-01-30 | Us Interior | Preparation of anion exchange membranes from cellulosic sheets |
| US4335017A (en) | 1975-12-15 | 1982-06-15 | United Kingdom Atomic Energy Authority | Composite materials comprising deformable xerogel within the pores of particulate rigid supports useful in chromatography |
| HU177419B (en) | 1978-07-13 | 1981-10-28 | Chinoin Gyogyszer Es Vegyeszet | Process for preparing threedimensional,retentive polymers consisting of cyclodextrin and polyvinylalcohol units,capable of forming inclusion complexes in the form of bead,fibre or mainly block |
| DE3172839D1 (en) | 1980-09-11 | 1985-12-12 | Atomic Energy Authority Uk | Improvements in or relating to composite materials |
| IL65131A0 (en) | 1982-02-28 | 1982-04-30 | Yeda Res & Dev | Process for the production of agarose-polyaldehyde beads and their biological applications |
| US4431545A (en) | 1982-05-07 | 1984-02-14 | Pall Corporation | Microporous filter system and process |
| CH660852A5 (de) | 1982-11-23 | 1987-05-29 | Aligena Ag | Dynamische membranen, die sich als duenne polymerschichten auf poroesen, polymeren traegermaterialien befinden. |
| US4861705A (en) | 1983-01-31 | 1989-08-29 | Yeda Research And Development Company, Ltd. | Method for removing components of biological fluids |
| US4512896A (en) | 1983-02-07 | 1985-04-23 | Yale University | Transfer of macromolecules from a chromatographic substrate to an immobilizing matrix |
| AU580548B2 (en) | 1983-02-14 | 1989-01-19 | Cuno Incorporated | Polymer modified polysaccharide |
| US4496461A (en) | 1983-06-17 | 1985-01-29 | Amf Incorporated | Chromatography column |
| US4743373A (en) | 1983-06-17 | 1988-05-10 | Cuno Incorporated | Chromatography column |
| US4540625A (en) | 1984-01-09 | 1985-09-10 | Hughes Aircraft Company | Flexible air permeable non-woven fabric filters |
| US4618533A (en) | 1984-11-30 | 1986-10-21 | Millipore Corporation | Porous membrane having hydrophilic surface and process |
| JPS6255084A (ja) | 1985-04-04 | 1987-03-10 | ジエネツクス・コ−ポレイシヨン | 生体の固定化方法及びそれから得られた不溶化生体複合体 |
| US6136200A (en) | 1985-06-27 | 2000-10-24 | Polymer Research Corporation | Treatment for paint and lacquer waste water |
| US4980067A (en) | 1985-07-23 | 1990-12-25 | Cuno, Inc. | Polyionene-transformed microporous membrane |
| US4895661A (en) | 1987-01-08 | 1990-01-23 | Filmtec Corporation | Alkali resistant hyperfiltration membrane |
| GB2201904B (en) | 1987-02-14 | 1990-12-19 | Domnick Hunter Filters Ltd | Device for liquid chromatography or immobilised enzyme reaction |
| DE3736087C2 (de) | 1987-10-24 | 1997-03-06 | Serva Feinbiochem Gmbh & Co | Gewebe zur Herstellung von Elektrophoresegelen |
| US5277915A (en) | 1987-10-30 | 1994-01-11 | Fmc Corporation | Gel-in-matrix containing a fractured hydrogel |
| EP0328256A1 (en) | 1988-01-21 | 1989-08-16 | Owens-Corning Fiberglas Corporation | Glass fibers coated with agarose for use as column packing or chromatographic media for bioseparations |
| US5114585A (en) | 1988-03-01 | 1992-05-19 | Gelman Sciences, Inc. | Charged porous filter |
| FR2632309B1 (fr) | 1988-06-07 | 1990-08-24 | Lille Transfusion Sanguine | Procede de purification par voie chromatographique de proteines, notamment de facteur viii, et les produits obtenus |
| JPH02180899A (ja) | 1988-12-31 | 1990-07-13 | Tosoh Corp | 免疫グロブリンの精製方法 |
| US4968532A (en) | 1989-01-13 | 1990-11-06 | Ciba-Geigy Corporation | Process for graft copolymerization on surfaces of preformed substrates to modify surface properties |
| IL89970A (en) | 1989-04-14 | 1994-10-21 | Weizmann Kiryat Membrane Prod | Composite membranes containing a coated layer of crosslinked polyaromatic polymers and/or sulfonated poly (haloalkylenes) |
| GB8913183D0 (en) | 1989-06-08 | 1989-07-26 | Central Blood Lab Authority | Chemical products |
| US4944879A (en) | 1989-07-27 | 1990-07-31 | Millipore Corporation | Membrane having hydrophilic surface |
| US5075432A (en) | 1989-08-11 | 1991-12-24 | Edward Vanzo | Spherical cyclodextrin polymer beads |
| US5009759A (en) | 1989-09-22 | 1991-04-23 | Board Of Regents, The University Of Texas System | Methods for producing agarose gels having variable pore sizes |
| US5328603A (en) | 1990-03-20 | 1994-07-12 | The Center For Innovative Technology | Lignocellulosic and cellulosic beads for use in affinity and immunoaffinity chromatography of high molecular weight proteins |
| GB9011378D0 (en) | 1990-05-22 | 1990-07-11 | Bio Isolates Ltd | Cellulosic sponge adsorbent medium |
| US5096561A (en) | 1990-07-02 | 1992-03-17 | Masud Akhtar | Thin film ionic conductors, methods and devices |
| US5104729A (en) | 1990-08-20 | 1992-04-14 | Monsanto Company | Process for surface modifying a support membrane and product produced |
| US5151189A (en) | 1990-09-17 | 1992-09-29 | Gelman Sciences, Inc. | Cationic charge modified microporous membrane |
| US5137633A (en) | 1991-06-26 | 1992-08-11 | Millipore Corporation | Hydrophobic membrane having hydrophilic and charged surface and process |
| DE69327891T2 (de) | 1992-07-06 | 2000-07-20 | Terumo K.K., Tokio/Tokyo | Material zur Entfernung von pathogener Substanz und mit diesem Material hergestellter Blutfilter |
| JPH0615167A (ja) | 1992-07-06 | 1994-01-25 | Terumo Corp | 多孔性分離膜 |
| US5583162A (en) | 1994-06-06 | 1996-12-10 | Biopore Corporation | Polymeric microbeads and method of preparation |
| US5522994A (en) | 1995-02-01 | 1996-06-04 | Cornell Research Foundation, Inc. | Single column chromatographic determination of small molecules in mixtures with large molecules |
| US5837520A (en) | 1995-03-07 | 1998-11-17 | Canji, Inc. | Method of purification of viral vectors |
| DE69634829T2 (de) | 1995-04-13 | 2006-03-23 | Travenol Laboratories (Israel) Ltd. | Verfahren und vorrichtung zur leukozytenfiltration |
| US5531899A (en) | 1995-06-06 | 1996-07-02 | Millipore Investment Holdings Limited | Ion exchange polyethylene membrane and process |
| FR2737730B1 (fr) | 1995-08-10 | 1997-09-05 | Pasteur Merieux Serums Vacc | Procede de purification de virus par chromatographie |
| US5814372A (en) | 1995-10-19 | 1998-09-29 | Millipore Corporation | Process for forming porous composite membrane |
| SE9600590D0 (sv) | 1996-02-19 | 1996-02-19 | Pharmacia Biotech Ab | Sätt för kromatografisk separation av peptider och nukleinsyra samt ny högaffin jonbytesmatris |
| US5814567A (en) | 1996-06-14 | 1998-09-29 | Kimberly-Clark Worldwide, Inc. | Durable hydrophilic coating for a porous hydrophobic substrate |
| US20010009756A1 (en) | 1998-01-06 | 2001-07-26 | Derek Hei | Flow devices for the reduction of compounds from biological compositions and methods of use |
| US5897779A (en) | 1997-02-13 | 1999-04-27 | Minnesota Mining And Manufacturing Company | Spiral wound extraction cartridge |
| FR2772639B1 (fr) | 1997-12-24 | 2000-02-04 | Hospal Ind | Utilisation d'un polymere neutre ou cationique pour prevenir l'activation de la phase contact du sang ou du plasma en contact avec une membrane semi-permeable |
| AU760633B2 (en) | 1998-08-14 | 2003-05-22 | Merck Sharp & Dohme Corp. | Process for purifying human papillomavirus virus-like particles |
| DE19900681B4 (de) * | 1999-01-04 | 2007-04-12 | Sartorius Ag | Verwendung von Anionaustauschermembranen zur Entfernung von Endotoxinen aus Nukleinsäure-haltigen Lösungen |
| EP1147226B1 (en) | 1999-01-27 | 2013-01-23 | Folim G. Halaka | Materials and methods for the purification of polyelectrolytes |
| EP1614459B1 (en) | 1999-02-25 | 2007-07-18 | Pall Corporation | Positively charged membrane |
| DE60012311T2 (de) | 1999-02-25 | 2005-07-21 | Pall Corp. | Negativ geladene membranen |
| CA2366928C (en) | 1999-02-25 | 2009-07-14 | Pall Corporation | Positively charged membrane |
| US6780327B1 (en) | 1999-02-25 | 2004-08-24 | Pall Corporation | Positively charged membrane |
| SE9901825D0 (sv) | 1999-05-20 | 1999-05-20 | Amersham Pharm Biotech Ab | Foamed material filled with inner material |
| ATE327033T1 (de) | 1999-07-30 | 2006-06-15 | Genentech Inc | Geladene filtrationmembranen und deren verwendungen |
| US6497747B1 (en) | 1999-09-24 | 2002-12-24 | Praxair Technology, Inc. | Production and use of improved polyimide separation membranes |
| SE9904197D0 (sv) | 1999-11-22 | 1999-11-22 | Amersham Pharm Biotech Ab | A method for anion exchange adsorption on matrices carrying mixed mode ligands |
| WO2001040448A1 (en) | 1999-12-02 | 2001-06-07 | The General Hospital Corporation | Methods for removal, purification, and concentration of viruses, and methods of therapy based thereupon |
| WO2001048155A2 (en) | 1999-12-29 | 2001-07-05 | Genzyme Corporation | Method using filtration aids for the separation of virus vectors from nucleic acids and other cellular contaminants |
| JP4788056B2 (ja) | 2000-04-13 | 2011-10-05 | Ｊｓｒ株式会社 | ウイルス濃縮材料 |
| EP1286741A1 (en) | 2000-04-28 | 2003-03-05 | Millipore Corporation | Filter cartridges and methods of manufacturing same |
| JP2002045176A (ja) | 2000-05-22 | 2002-02-12 | Jsr Corp | ウイルス濃縮方法 |
| DE10028447A1 (de) | 2000-06-14 | 2001-12-20 | Merck Patent Gmbh | Verfahren zur Herstellung von monolithischen Chromatographiesäulen |
| JP2002210377A (ja) | 2001-01-22 | 2002-07-30 | Tosoh Corp | アニオン交換体、その製造方法及びそれを用いた用途 |
| WO2003007814A1 (en) | 2001-07-18 | 2003-01-30 | Agilex Biosciences, Inc. | Device and method for collecting, transporting and recovering low molecular weight analytes in saliva |
| US7247370B2 (en) | 2001-07-20 | 2007-07-24 | Mcmaster University | Asymmetric gel-filled microporous membranes |
| US6913694B2 (en) | 2001-11-06 | 2005-07-05 | Saehan Industries Incorporation | Selective membrane having a high fouling resistance |
| WO2003046062A1 (en) | 2001-11-21 | 2003-06-05 | Porex Corporation | Discrete hydrophilic-hydrophobic porous materials and methods for making the same |
| US20030201229A1 (en) | 2002-02-04 | 2003-10-30 | Martin Siwak | Process for prefiltration of a protein solution |
| US20030180936A1 (en) | 2002-03-15 | 2003-09-25 | Memarzadeh Bahram Eric | Method for the purification, production and formulation of oncolytic adenoviruses |
| US7073671B2 (en) | 2002-06-07 | 2006-07-11 | Millipore Corporation | Microporous membrane substrate having caustic stable, low protein binding surface |
| US7101947B2 (en) | 2002-06-14 | 2006-09-05 | Florida State University Research Foundation, Inc. | Polyelectrolyte complex films for analytical and membrane separation of chiral compounds |
| DE10228148B4 (de) | 2002-06-24 | 2006-08-24 | Saehan Industries Inc. | Selektive Membran mit hoher Fouling-Beständigkeit |
| WO2004024284A2 (en) | 2002-09-13 | 2004-03-25 | Biogen Idec Inc. | Method of purifying polypeptides by simulated moving bed chromatography |
| US20040127648A1 (en) | 2002-12-31 | 2004-07-01 | Ciphergen Biosystems, Inc. | Sorbent and method for the separation of plasmid DNA |
| AU2004212641B2 (en) | 2003-02-19 | 2009-08-06 | Merck Millipore Ltd. | Composite materials comprising supported porous gels |
| CA2807534A1 (en) | 2003-02-25 | 2005-02-17 | Medimmune Vaccines, Inc. | Methods of producing influenza vaccine compositions |
| JP2004283295A (ja) * | 2003-03-20 | 2004-10-14 | Toray Ind Inc | リガンド固定化材料およびその製造方法 |
| US20040206693A1 (en) | 2003-04-16 | 2004-10-21 | John Charkoudian | Crosslinked cellulosic membrane |
| US20040206694A1 (en) | 2003-04-16 | 2004-10-21 | John Charkoudian | Epoxide-crosslinked, charged cellulosic membrane |
| CN100535007C (zh) * | 2003-08-21 | 2009-09-02 | 诺沃挪第克公司 | 胰高血糖素样肽的纯化 |
| US7318898B2 (en) | 2003-11-18 | 2008-01-15 | Exxonmobil Research And Engineering Company | Polymeric membrane wafer assembly and method |
| EP2821135A1 (en) | 2004-02-05 | 2015-01-07 | EMD Millipore Corporation | Porous adsorptive or chromatographic media |
| US7687619B2 (en) | 2004-02-05 | 2010-03-30 | Millipore Corporation | Room temperature stable agarose solutions |
| EP2821124A1 (en) | 2004-02-05 | 2015-01-07 | EMD Millipore Corporation | Method of forming coated structures |
| US7807823B2 (en) | 2004-02-05 | 2010-10-05 | Millipore Corporation | Method of forming polysaccharide structures |
| US7479223B2 (en) | 2004-02-05 | 2009-01-20 | Millipore Corporation | Porous adsorptive or chromatographic media |
| WO2005113604A2 (en) | 2004-05-14 | 2005-12-01 | Hematech, Llc | Methods for immunoglobulin purification |
| DK1765866T3 (en) * | 2004-06-07 | 2014-03-24 | Therapure Biopharma Inc | ISOLATION OF plasma or serum protein |
| CA2550834C (en) | 2005-06-24 | 2013-04-23 | Innovative Chemical Technologies Canada Ltd. | Clay control additive for wellbore fluids |
| ES2396146T3 (es) | 2005-06-29 | 2013-02-19 | The Procter & Gamble Company | Uso de un producto efervescente para limpiar vajilla manchada mediante lavado a mano |
| CN101437839A (zh) * | 2006-03-20 | 2009-05-20 | 米德列斯公司 | 蛋白质纯化 |
| JP2008021800A (ja) * | 2006-07-12 | 2008-01-31 | Sanyo Electric Co Ltd | 半導体装置およびその製造方法 |
| US9375499B2 (en) | 2006-07-14 | 2016-06-28 | Wisconsin Alumni Research Foundation | Adsorptive membranes for trapping viruses |
| US8382987B2 (en) | 2006-09-27 | 2013-02-26 | Alessandra Luchini | Method for harvesting nanoparticles and sequestering biomarkers |
| US7935518B2 (en) | 2006-09-27 | 2011-05-03 | Alessandra Luchini | Smart hydrogel particles for biomarker harvesting |
| US9433922B2 (en) | 2007-08-14 | 2016-09-06 | Emd Millipore Corporation | Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same |
| US20090130738A1 (en) | 2007-11-19 | 2009-05-21 | Mikhail Kozlov | Media for membrane ion exchange chromatography |
| WO2009145722A1 (en) | 2008-05-30 | 2009-12-03 | Ge Healthcare Bio-Sciences Ab | Separation method utilizing polyallylamine ligands |
| US20120077249A1 (en) | 2010-04-20 | 2012-03-29 | Millipore Corporation | Separation Of Virus And/Or Protein From Nucleic Acids By Primary Amines |
| US20120006751A1 (en) | 2010-05-07 | 2012-01-12 | Millipore Corporation | Enhanced Clarification Media |
| US20120006752A1 (en) | 2010-05-07 | 2012-01-12 | Millipore Corporation | Enhanced Clarification Media |
-
2008
- 2008-08-04 US US12/221,496 patent/US9433922B2/en not_active Expired - Fee Related
- 2008-08-12 SG SG200805944-6A patent/SG150458A1/en unknown
- 2008-08-12 SG SG2012055661A patent/SG183083A1/en unknown
- 2008-08-12 SG SG2012055968A patent/SG183660A1/en unknown
- 2008-08-13 EP EP08162316.7A patent/EP2027921B1/en active Active
- 2008-08-13 EP EP20110150305 patent/EP2319622A3/en not_active Withdrawn
- 2008-08-14 CN CN201510744950.XA patent/CN105457335B/zh not_active Expired - Fee Related
- 2008-08-14 JP JP2008209029A patent/JP5031695B2/ja not_active Expired - Fee Related
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- 2010-04-21 US US12/764,340 patent/US20100200507A1/en not_active Abandoned
-
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- 2011-06-23 US US13/167,291 patent/US20110284446A1/en not_active Abandoned
- 2011-06-23 US US13/167,297 patent/US8137561B2/en not_active Expired - Fee Related
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- 2011-12-29 US US13/339,503 patent/US20120121819A1/en not_active Abandoned
-
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- 2012-02-01 US US13/363,397 patent/US8435406B2/en not_active Expired - Fee Related
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1159770A (zh) * | 1994-07-28 | 1997-09-17 | 米利波尔公司 | 多孔复合膜及其制法 |
| CN1168699A (zh) * | 1994-10-28 | 1997-12-24 | 马普科技促进协会 | 新型蛋白激酶npk-110 |
| CN1771260A (zh) * | 2003-02-28 | 2006-05-10 | 英国龙沙生物医药股份有限公司 | 用蛋白质a和离子交换层析来纯化抗体 |
| CN1960803A (zh) * | 2004-02-05 | 2007-05-09 | 米利波尔公司 | 多孔的吸附或色谱介质 |
| CN1925898A (zh) * | 2004-02-27 | 2007-03-07 | 通用电气健康护理生物科学股份公司 | 纯化抗体的工艺 |
Also Published As
| Publication number | Publication date |
|---|---|
| JP5743795B2 (ja) | 2015-07-01 |
| SG150458A1 (en) | 2009-03-30 |
| SG183660A1 (en) | 2012-09-27 |
| US20120193278A1 (en) | 2012-08-02 |
| EP2027921A2 (en) | 2009-02-25 |
| JP2012018171A (ja) | 2012-01-26 |
| EP2027921A3 (en) | 2011-03-09 |
| EP2319622A2 (en) | 2011-05-11 |
| US20110288277A1 (en) | 2011-11-24 |
| US9433922B2 (en) | 2016-09-06 |
| EP2319622A3 (en) | 2012-05-02 |
| JP2011247903A (ja) | 2011-12-08 |
| US20100200507A1 (en) | 2010-08-12 |
| US8435406B2 (en) | 2013-05-07 |
| US20090050566A1 (en) | 2009-02-26 |
| US8137561B2 (en) | 2012-03-20 |
| CN105457335A (zh) | 2016-04-06 |
| JP2009053191A (ja) | 2009-03-12 |
| US20120121819A1 (en) | 2012-05-17 |
| US20110284446A1 (en) | 2011-11-24 |
| JP5031695B2 (ja) | 2012-09-19 |
| EP2027921B1 (en) | 2020-04-22 |
| SG183083A1 (en) | 2012-08-30 |
| JP5743796B2 (ja) | 2015-07-01 |
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