CN105452463B - Tmprss6 irna组合物及其使用方法 - Google Patents

Tmprss6 irna组合物及其使用方法 Download PDF

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Publication number
CN105452463B
CN105452463B CN201480040477.0A CN201480040477A CN105452463B CN 105452463 B CN105452463 B CN 105452463B CN 201480040477 A CN201480040477 A CN 201480040477A CN 105452463 B CN105452463 B CN 105452463B
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double
nucleotides
stranded rnai
nucleotide
modification
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CN105452463A (zh
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J·巴特勒
B·贝腾考特
K·G·雷杰夫
M·迈尔
K·查里斯
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Alnylam Pharmaceuticals Inc
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Alnylam Pharmaceuticals Inc
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
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CN201480040477.0A 2013-05-22 2014-05-22 Tmprss6 irna组合物及其使用方法 Active CN105452463B (zh)

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Applications Claiming Priority (5)

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US201361826178P 2013-05-22 2013-05-22
US61/826,178 2013-05-22
US201361912988P 2013-12-06 2013-12-06
US61/912,988 2013-12-06
PCT/US2014/039149 WO2014190157A1 (en) 2013-05-22 2014-05-22 Tmprss6 compositions and methods of use thereof

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EP (3) EP2999786A1 (enExample)
JP (5) JP2016520593A (enExample)
KR (3) KR102365809B1 (enExample)
CN (2) CN110317810A (enExample)
AP (1) AP2015008862A0 (enExample)
AU (3) AU2014268529C1 (enExample)
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