AU2014268529C1 - TMPRSS6 iRNA compositions and methods of use thereof - Google Patents

TMPRSS6 iRNA compositions and methods of use thereof Download PDF

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Publication number
AU2014268529C1
AU2014268529C1 AU2014268529A AU2014268529A AU2014268529C1 AU 2014268529 C1 AU2014268529 C1 AU 2014268529C1 AU 2014268529 A AU2014268529 A AU 2014268529A AU 2014268529 A AU2014268529 A AU 2014268529A AU 2014268529 C1 AU2014268529 C1 AU 2014268529C1
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Australia
Prior art keywords
nucleotides
nucleotide
rnai agent
strand
tmprss6
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Ceased
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AU2014268529A
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English (en)
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AU2014268529B2 (en
AU2014268529A1 (en
Inventor
Brian Bettencourt
James Butler
Klaus CHARISSE
Martin Maier
Kallanthottathil G. Rajeev
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Alnylam Pharmaceuticals Inc
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Alnylam Pharmaceuticals Inc
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Publication of AU2014268529A1 publication Critical patent/AU2014268529A1/en
Publication of AU2014268529B2 publication Critical patent/AU2014268529B2/en
Priority to AU2020207874A priority Critical patent/AU2020207874B2/en
Application granted granted Critical
Publication of AU2014268529C1 publication Critical patent/AU2014268529C1/en
Priority to AU2023201014A priority patent/AU2023201014B2/en
Priority to AU2026201214A priority patent/AU2026201214A1/en
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • A—HUMAN NECESSITIES
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/11—Antisense
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/31—Chemical structure of the backbone
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/34—Spatial arrangement of the modifications
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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AU2014268529A 2013-05-22 2014-05-22 TMPRSS6 iRNA compositions and methods of use thereof Ceased AU2014268529C1 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
AU2020207874A AU2020207874B2 (en) 2013-05-22 2020-07-24 TMPRSS6 iRNA compositions and methods of use thereof
AU2023201014A AU2023201014B2 (en) 2013-05-22 2023-02-21 TMPRSS6 iRNA compositions and methods of use thereof
AU2026201214A AU2026201214A1 (en) 2013-05-22 2026-02-18 TMPRSS6 iRNA compositions and methods of use thereof

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361826178P 2013-05-22 2013-05-22
US61/826,178 2013-05-22
US201361912988P 2013-12-06 2013-12-06
US61/912,988 2013-12-06
PCT/US2014/039149 WO2014190157A1 (en) 2013-05-22 2014-05-22 Tmprss6 compositions and methods of use thereof

Related Child Applications (1)

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AU2020207874A Division AU2020207874B2 (en) 2013-05-22 2020-07-24 TMPRSS6 iRNA compositions and methods of use thereof

Publications (3)

Publication Number Publication Date
AU2014268529A1 AU2014268529A1 (en) 2015-12-17
AU2014268529B2 AU2014268529B2 (en) 2020-04-30
AU2014268529C1 true AU2014268529C1 (en) 2020-10-01

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AU2014268529A Ceased AU2014268529C1 (en) 2013-05-22 2014-05-22 TMPRSS6 iRNA compositions and methods of use thereof
AU2020207874A Active AU2020207874B2 (en) 2013-05-22 2020-07-24 TMPRSS6 iRNA compositions and methods of use thereof
AU2023201014A Active AU2023201014B2 (en) 2013-05-22 2023-02-21 TMPRSS6 iRNA compositions and methods of use thereof
AU2026201214A Pending AU2026201214A1 (en) 2013-05-22 2026-02-18 TMPRSS6 iRNA compositions and methods of use thereof

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AU2020207874A Active AU2020207874B2 (en) 2013-05-22 2020-07-24 TMPRSS6 iRNA compositions and methods of use thereof
AU2023201014A Active AU2023201014B2 (en) 2013-05-22 2023-02-21 TMPRSS6 iRNA compositions and methods of use thereof
AU2026201214A Pending AU2026201214A1 (en) 2013-05-22 2026-02-18 TMPRSS6 iRNA compositions and methods of use thereof

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US (6) US9783806B2 (enExample)
EP (3) EP3587578A1 (enExample)
JP (5) JP2016520593A (enExample)
KR (3) KR102365809B1 (enExample)
CN (2) CN105452463B (enExample)
AP (1) AP2015008862A0 (enExample)
AU (4) AU2014268529C1 (enExample)
BR (1) BR112015029276B1 (enExample)
CA (3) CA3279634A1 (enExample)
CL (2) CL2015003440A1 (enExample)
EA (1) EA201592225A1 (enExample)
HK (1) HK1221978A1 (enExample)
IL (6) IL285780B (enExample)
MY (1) MY181888A (enExample)
RU (1) RU2015154738A (enExample)
SG (2) SG11201510565TA (enExample)
TW (4) TWI853153B (enExample)
UY (1) UY35583A (enExample)
WO (1) WO2014190157A1 (enExample)
ZA (1) ZA202110854B (enExample)

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IL303831A (en) * 2011-11-18 2023-08-01 Alnylam Pharmaceuticals Inc Adapted RNAI factors
EP2925337B1 (en) * 2012-11-21 2019-07-03 The Trustees of Columbia University in the City of New York Mutant ngal proteins and uses thereof
EA201592225A1 (ru) 2013-05-22 2016-04-29 Элнилэм Фармасьютикалз, Инк. КОМПОЗИЦИИ НА ОСНОВЕ iRNA TMPRSS6 И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
US10612020B2 (en) 2013-12-26 2020-04-07 Tokyo Medical University Artificial mimic miRNA for controlling gene expression, and use of same
WO2015099187A1 (ja) 2013-12-27 2015-07-02 株式会社ボナック 遺伝子発現制御のための人工マッチ型ｍｉＲＮＡおよびその用途
IL316808A (en) 2014-08-20 2025-01-01 Alnylam Pharmaceuticals Inc Modified double-stranded RNA materials and their uses
WO2016085852A1 (en) 2014-11-24 2016-06-02 Alnylam Pharmaceuticals, Inc. Tmprss6 irna compositions and methods of use thereof
US11027023B2 (en) 2014-12-27 2021-06-08 Bonac Corporation Natural type miRNA for controlling gene expression, and use of same
US11142769B2 (en) 2015-03-27 2021-10-12 Bonac Corporation Single-stranded nucleic acid molecule having delivery function and gene expression regulating ability
HK1249140A1 (zh) * 2015-04-03 2018-10-26 Ionis Pharmaceuticals, Inc. 用於调节tmprss6表达的化合物和方法
WO2016161388A1 (en) 2015-04-03 2016-10-06 University Of Massachusetts Fully stabilized asymmetric sirna
KR20250107273A (ko) * 2015-05-06 2025-07-11 알닐람 파마슈티칼스 인코포레이티드 인자 ＸＩＩ(하게만 인자)(Ｆ12), 칼리크레인 Ｂ, 혈장(플레처 인자) 1(ＫＬＫＢ1) 및 키니노겐 1(ＫＮＧ1) ｉＲＮＡ 조성물 및 그의 이용 방법
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US10478503B2 (en) 2016-01-31 2019-11-19 University Of Massachusetts Branched oligonucleotides
CN108342386B (zh) * 2017-01-22 2022-04-15 广州市锐博生物科技有限公司 一种多聚寡核酸分子及其在多靶标干扰中的应用
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