AU2014268529C1 - TMPRSS6 iRNA compositions and methods of use thereof - Google Patents

TMPRSS6 iRNA compositions and methods of use thereof Download PDF

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Publication number
AU2014268529C1
AU2014268529C1 AU2014268529A AU2014268529A AU2014268529C1 AU 2014268529 C1 AU2014268529 C1 AU 2014268529C1 AU 2014268529 A AU2014268529 A AU 2014268529A AU 2014268529 A AU2014268529 A AU 2014268529A AU 2014268529 C1 AU2014268529 C1 AU 2014268529C1
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Australia
Prior art keywords
nucleotides
nucleotide
rnai agent
strand
tmprss6
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AU2014268529A
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AU2014268529A1 (en
AU2014268529B2 (en
Inventor
Brian Bettencourt
James Butler
Klaus CHARISSE
Martin Maier
Kallanthottathil G. Rajeev
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Alnylam Pharmaceuticals Inc
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Alnylam Pharmaceuticals Inc
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Priority to AU2020207874A priority Critical patent/AU2020207874B2/en
Publication of AU2014268529C1 publication Critical patent/AU2014268529C1/en
Priority to AU2023201014A priority patent/AU2023201014B2/en
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
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    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
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    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/34—Spatial arrangement of the modifications
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AU2014268529A 2013-05-22 2014-05-22 TMPRSS6 iRNA compositions and methods of use thereof Ceased AU2014268529C1 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
AU2020207874A AU2020207874B2 (en) 2013-05-22 2020-07-24 TMPRSS6 iRNA compositions and methods of use thereof
AU2023201014A AU2023201014B2 (en) 2013-05-22 2023-02-21 TMPRSS6 iRNA compositions and methods of use thereof

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361826178P 2013-05-22 2013-05-22
US61/826,178 2013-05-22
US201361912988P 2013-12-06 2013-12-06
US61/912,988 2013-12-06
PCT/US2014/039149 WO2014190157A1 (en) 2013-05-22 2014-05-22 Tmprss6 compositions and methods of use thereof

Related Child Applications (1)

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AU2020207874A Division AU2020207874B2 (en) 2013-05-22 2020-07-24 TMPRSS6 iRNA compositions and methods of use thereof

Publications (3)

Publication Number Publication Date
AU2014268529A1 AU2014268529A1 (en) 2015-12-17
AU2014268529B2 AU2014268529B2 (en) 2020-04-30
AU2014268529C1 true AU2014268529C1 (en) 2020-10-01

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AU2014268529A Ceased AU2014268529C1 (en) 2013-05-22 2014-05-22 TMPRSS6 iRNA compositions and methods of use thereof
AU2020207874A Active AU2020207874B2 (en) 2013-05-22 2020-07-24 TMPRSS6 iRNA compositions and methods of use thereof
AU2023201014A Active AU2023201014B2 (en) 2013-05-22 2023-02-21 TMPRSS6 iRNA compositions and methods of use thereof

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AU2020207874A Active AU2020207874B2 (en) 2013-05-22 2020-07-24 TMPRSS6 iRNA compositions and methods of use thereof
AU2023201014A Active AU2023201014B2 (en) 2013-05-22 2023-02-21 TMPRSS6 iRNA compositions and methods of use thereof

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Country Link
US (6) US9783806B2 (enExample)
EP (3) EP3587578A1 (enExample)
JP (5) JP2016520593A (enExample)
KR (3) KR102234623B1 (enExample)
CN (2) CN105452463B (enExample)
AP (1) AP2015008862A0 (enExample)
AU (3) AU2014268529C1 (enExample)
BR (1) BR112015029276B1 (enExample)
CA (2) CA3178370A1 (enExample)
CL (2) CL2015003440A1 (enExample)
EA (1) EA201592225A1 (enExample)
HK (1) HK1221978A1 (enExample)
IL (5) IL293657B2 (enExample)
MY (1) MY181888A (enExample)
RU (1) RU2015154738A (enExample)
SG (2) SG11201510565TA (enExample)
TW (3) TWI727917B (enExample)
UY (1) UY35583A (enExample)
WO (1) WO2014190157A1 (enExample)
ZA (1) ZA202110854B (enExample)

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CN103813810B (zh) 2011-03-29 2021-08-03 阿尔尼拉姆医药品有限公司 用于抑制tmprss6基因表达的组合物和方法
CN104105790A (zh) 2011-11-18 2014-10-15 阿尔尼拉姆医药品有限公司 修饰的RNAi试剂
WO2014081980A2 (en) 2012-11-21 2014-05-30 The Trustees Of Columbia University In The City Of New York Mutant ngal proteins and uses thereof
EP3587578A1 (en) 2013-05-22 2020-01-01 Alnylam Pharmaceuticals, Inc. Tmprss6 irna compositions and methods of use thereof
JP6486836B2 (ja) 2013-12-26 2019-03-20 学校法人東京医科大学 遺伝子発現制御のための人工ミミックｍｉＲＮＡおよびその用途
RU2697094C2 (ru) 2013-12-27 2019-08-12 Бонак Корпорейшн ИСКУССТВЕННАЯ мкРНК С СООТВЕТСТВИЕМ ДЛЯ КОНТРОЛЯ ЭКСПРЕССИИ ГЕНОВ И ЕЕ ПРИМЕНЕНИЕ
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JP6892433B2 (ja) 2015-04-03 2021-06-23 ユニバーシティ・オブ・マサチューセッツＵｎｉｖｅｒｓｉｔｙ Ｏｆ Ｍａｓｓａｃｈｕｓｅｔｔｓ 十分に安定化された非対称ｓｉｒｎａ
TWI887656B (zh) * 2015-05-06 2025-06-21 美商阿尼拉製藥公司 第十二因子（哈格曼因子）（Ｆ１２）、激肽釋放素Ｂ、血漿（夫列契因子）１（ＫＬＫＢ１）及激肽原１（ＫＮＧ１）ｉＲＮＡ組成物及其使用方法
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