TWI727917B - ＴＭＰＲＳＳ６ｉＲＮＡ 組成物及其使用方法 - Google Patents

ＴＭＰＲＳＳ６ｉＲＮＡ 組成物及其使用方法 Download PDF

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TWI727917B
TWI727917B TW103117873A TW103117873A TWI727917B TW I727917 B TWI727917 B TW I727917B TW 103117873 A TW103117873 A TW 103117873A TW 103117873 A TW103117873 A TW 103117873A TW I727917 B TWI727917 B TW I727917B
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nucleotides
rnai agent
double
strand
tmprss6
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TW103117873A
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Chinese (zh)
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TW201536916A (zh
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吉姆 巴特勒
布萊恩 貝當古
卡蘭多達堤爾Ｇ 拉杰夫
馬丁 梅爾
克勞斯 查里斯
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美商阿尼拉製藥公司
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    • A61K31/713—Double-stranded nucleic acids or oligonucleotides
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    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
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TW103117873A 2013-05-22 2014-05-22 ＴＭＰＲＳＳ６ｉＲＮＡ 組成物及其使用方法 TWI727917B (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201361826178P 2013-05-22 2013-05-22
US61/826,178 2013-05-22
US201361912988P 2013-12-06 2013-12-06
US61/912,988 2013-12-06

Publications (2)

Publication Number Publication Date
TW201536916A TW201536916A (zh) 2015-10-01
TWI727917B true TWI727917B (zh) 2021-05-21

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TW103117873A TWI727917B (zh) 2013-05-22 2014-05-22 ＴＭＰＲＳＳ６ｉＲＮＡ 組成物及其使用方法
TW112125688A TW202342750A (zh) 2013-05-22 2014-05-22 ＴＭＰＲＳＳ６ ｉＲＮＡ組成物及其使用方法
TW110108158A TWI853153B (zh) 2013-05-22 2014-05-22 TMPRSS6 iRNA 組成物及其使用方法

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TW112125688A TW202342750A (zh) 2013-05-22 2014-05-22 ＴＭＰＲＳＳ６ ｉＲＮＡ組成物及其使用方法
TW110108158A TWI853153B (zh) 2013-05-22 2014-05-22 TMPRSS6 iRNA 組成物及其使用方法

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US (6) US9783806B2 (enExample)
EP (3) EP3587578A1 (enExample)
JP (5) JP2016520593A (enExample)
KR (3) KR102234623B1 (enExample)
CN (2) CN105452463B (enExample)
AP (1) AP2015008862A0 (enExample)
AU (3) AU2014268529C1 (enExample)
BR (1) BR112015029276B1 (enExample)
CA (2) CA3178370A1 (enExample)
CL (2) CL2015003440A1 (enExample)
EA (1) EA201592225A1 (enExample)
HK (1) HK1221978A1 (enExample)
IL (5) IL293657B2 (enExample)
MY (1) MY181888A (enExample)
RU (1) RU2015154738A (enExample)
SG (2) SG11201510565TA (enExample)
TW (3) TWI727917B (enExample)
UY (1) UY35583A (enExample)
WO (1) WO2014190157A1 (enExample)
ZA (1) ZA202110854B (enExample)

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JP2013529907A (ja) 2010-05-24 2013-07-25 ザ トラスティーズ オブ コロンビア ユニヴァーシティ イン ザ シティ オブ ニューヨーク Ｎｇａｌタンパク質変異体及びその使用
CN103813810B (zh) 2011-03-29 2021-08-03 阿尔尼拉姆医药品有限公司 用于抑制tmprss6基因表达的组合物和方法
CN104105790A (zh) 2011-11-18 2014-10-15 阿尔尼拉姆医药品有限公司 修饰的RNAi试剂
WO2014081980A2 (en) 2012-11-21 2014-05-30 The Trustees Of Columbia University In The City Of New York Mutant ngal proteins and uses thereof
EP3587578A1 (en) 2013-05-22 2020-01-01 Alnylam Pharmaceuticals, Inc. Tmprss6 irna compositions and methods of use thereof
JP6486836B2 (ja) 2013-12-26 2019-03-20 学校法人東京医科大学 遺伝子発現制御のための人工ミミックｍｉＲＮＡおよびその用途
RU2697094C2 (ru) 2013-12-27 2019-08-12 Бонак Корпорейшн ИСКУССТВЕННАЯ мкРНК С СООТВЕТСТВИЕМ ДЛЯ КОНТРОЛЯ ЭКСПРЕССИИ ГЕНОВ И ЕЕ ПРИМЕНЕНИЕ
IL316808A (en) 2014-08-20 2025-01-01 Alnylam Pharmaceuticals Inc Modified double-stranded RNA materials and their uses
WO2016085852A1 (en) * 2014-11-24 2016-06-02 Alnylam Pharmaceuticals, Inc. Tmprss6 irna compositions and methods of use thereof
AU2015368293B2 (en) 2014-12-27 2021-07-22 Bonac Corporation Naturally occuring miRNA for controlling gene expression, and use of same
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HK1249140A1 (zh) * 2015-04-03 2018-10-26 Ionis Pharmaceuticals, Inc. 用於调节tmprss6表达的化合物和方法
JP6892433B2 (ja) 2015-04-03 2021-06-23 ユニバーシティ・オブ・マサチューセッツＵｎｉｖｅｒｓｉｔｙ Ｏｆ Ｍａｓｓａｃｈｕｓｅｔｔｓ 十分に安定化された非対称ｓｉｒｎａ
TWI887656B (zh) * 2015-05-06 2025-06-21 美商阿尼拉製藥公司 第十二因子（哈格曼因子）（Ｆ１２）、激肽釋放素Ｂ、血漿（夫列契因子）１（ＫＬＫＢ１）及激肽原１（ＫＮＧ１）ｉＲＮＡ組成物及其使用方法
CA2995110A1 (en) 2015-08-14 2017-02-23 University Of Massachusetts Bioactive conjugates for oligonucleotide delivery
AU2017210726B2 (en) 2016-01-31 2023-08-03 University Of Massachusetts Branched oligonucleotides
CN108342386B (zh) * 2017-01-22 2022-04-15 广州市锐博生物科技有限公司 一种多聚寡核酸分子及其在多靶标干扰中的应用
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EP3385380A1 (en) * 2017-04-05 2018-10-10 Silence Therapeutics GmbH Products and compositions
JP7406793B2 (ja) 2017-06-23 2023-12-28 ユニバーシティー オブ マサチューセッツ ２テイル自己デリバリー型ｓｉＲＮＡおよび関連方法
CA3091146A1 (en) * 2018-03-21 2019-09-26 Regeneron Pharmaceuticals, Inc. 17.beta.-hydroxysteroid dehydrogenase type 13 (hsd17b13) irna compositions and methods of use thereof
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